Undergraduates: Open Research Positions & Projects

Students: contact Dr. Anna Babakhanyan, Science Undergraduate Research advisor, to help identify research laboratories.
Faculty: if you are interested in posting your open research position, please contact  Dr. Anna Babakhanyan.

Research Assistant, MGH IHP SAiL Literacy Lab, Posted Nov 1, 2019

Understanding the Molecular Mechanism and Developing Therapies in Neuromuscular Diseases, Dr. Gupta, HMS, Posted Nov 1, 2019

Research Assistant/Student Programmer, The Speech and Feeding Disorder Lab (Dr. Jordan Green), MGH Institute of Health Professions, Posted Nov 1, 2019

Undergraduate Research Opportunity, Center for Brain/Mind Medicine, BWH, Posted Oct 18, 2019

Undergraduate research opportunity, Dr. Haider lab, Schepens Eye Research Institute, Posted Oct 18, 2019

Undergraduate Research Opportunity in CAR T cell Manufacturing (Novina Lab), Posted Sep 20, 2019

Research Opportunity in functional brain imaging at the Martinos Center for Biomedical Imaging, MGH/HMS, Posted Sep 17, 2019

Undergraduate Research Opportunity in Dr. Robin Hopkins Lab at the Harvard Arnold Arboretum, Posted Sep 17, 2019

Undergraduate Research Opportunity, Dr. Konkle Lab, Department of Psychology, Faculty of Arts and Sciences, Posted Sept 17, 2019

Undergraduate Research Opportunity, Farokhzad Lab, BWH, Posted Sep 17, 2019

Undergraduate Research Opportunity, Dr. George Church Lab, Harvard Medical School, Posted Sep 17, 2019

Undergraduate research opportunity as a Research Assistant,  Health Decision Sciences Center, MGH, Posted Sep 9, 2019 

Undergraduate Clinical Research Opportunity, Cognition and Affect Research and Education Laboratory (CARE Lab), McLean Hospital, Posted Sep 9, 2019

Undergraduate Research Opportunity, Dr. Bind Lab, Department of Statistics, Faculty of Arts and Sciences, Posted Sep 9, 2019

Undergraduate Research opportunity to study Gram-Negative Bacterial Pathogenesis in Dr. Deborah Hung's Lab, MGH, Posted Sep 9, 2019

Undergraduate Research Opportunity in Infectious Disease Biology, Broad Institute, Posted Sep 9, 2019

Undergraduate Research Opportunity, Dr. Zӧllei, Laboratory of Computational Neuroimaging, A.A. Martinos Center, MGH, Posted Sep 9, 2019

Growth of high-temperature superconductor FeSe using molecular beam epitaxy (MBE), Jenny Hoffman Lab, Physics Department, Posted Sep 9, 2019

Undergraduate Research Opportunity, Dr. Fernandez-Godino Lab, MEEI, Posted Sep 9, 2019

Undergraduate Research Opportunity, Dr. Eva-Maria Ratai’s lab, MGH, Posted Sep 4, 2019

Undergraduate lab assistant position, Taute & Mathis labs, Rowland Institute at Harvard, Posted Sep 4, 2019

Undergraduate Research Opportunity in Psychiatry/Psychology, Pizzagalli Lab, at McLean Hospital, Posted Sep 4, 2019

Undergraduate Volunteer Research Assistant Opportunity in Psychiatry/Psychology, Pizzagalli Laboratory at McLean Hospital and HMS, Posted Sep 4, 2019

Undergraduate Research Opportunity in the Henske Lab, HMS, Posted Sep 4, 2019

Undergraduate Research Opportunity, Chung Lab, Mass Eye & Ear, Posted Sep 4, 2019

Undergraduate Research Opportunity, Dr. Hasan’s Lab, HMS, MGH, Posted Sep 4, 2019

Undergraduate Research Opportunity, Student Intern for Dr. Sansevere, Boston Children’s Hospital, Posted Sep 4, 2019

Undergraduate Research Opportunity, The Fruit Fly Fight Club, Kravitz Laboratory, HMS, Posted Sep 4, 2019

Research Opportunity to study the neuronal mechanisms underlying reproduction, Dr. Victor Navarro’s lab, BWH, Posted Sep 4, 2019

Undergraduate research opportunity, Cognitive Neuroscience Group (Dr. Yael Arbel), MGH, Posted Sep 4, 2019

Undergraduate research assistant, Dr. Aizenberg Lab, SEAS, Posted Sep 4, 2019

Undergraduate Research Opportunity, Dr. Chen Lab, Schepens Eye Research Institute, MEE/MGH, Posted Sep 4, 2019

Clinical Research Experience at the Obsessive Compulsive Disorder Institute at McLean Hospital/Harvard Medical School, Posted Sep 4, 2019

Undergraduate Research Assistant, Walsh Lab, Boston Children's Hospital, Posted Sep 4, 2019

Advancing coil design in micromagnetic stimulation, Dr. Bonmassar Lab, AA. Martinos Center Department of Radiology Harvard Medical School Massachusetts General Hospital, Posted Sep 4, 2019

Undergraduate Research Opportunity in 3D Bioprinting, Prof. Jennifer Lewis’ Lab, Harvard University, Posted Sep 3, 2019

Undergraduate research opportunity in Cancer Biology with the Letai Laboratory, Posted Sep 3, 2019

Undergraduate Research Opportunity with the Stroke research, HSPH, Posted Sep 3, 2019

Undergraduate Research Opportunity, Hodi Lab, Dana-Farber Cancer Institute, Posted Sep 3, 2019

Undergraduate Research Opportunity, Dr. Schulman Lab, BIDMC, Posted Sep 3, 2019

Undergraduate Research Opportunity at Spaulding Hospital Cambridge INSPIRE Lab for sensorimotor rehabilitation engineering, Posted Sep 3, 2019

Undergraduate Research Opportunity, Laboratory of Dr. Leo A. Kim, Mass. Eye and Ear/HMS, Posted Sep 3, 2019

Undergraduate research opportunity, Dr. Miller’s Lab, MEEI, Posted Sep 3, 2019

Research Assistant: Genetics and Molecular Biology of Brain Tumors, Badr lab, MGH, Posted Sep 3, 2019

Undergraduate research opportunities in climate dynamics, SEAS, Posted Sep 3, 2019

Computational epigenomics Undergraduate Research Opportunity, Dr. Shi Lab, Boston Children’s Hospital, Posted Sep 3, 2019

Undergraduate Research Opportunity, Brain Aging and Dementia Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, MGH), Posted Sep 3, 2019

Undergraduate Research Opportunity, Dr. Sabina Berretta Lab (Translational Neuroscience Lab., McLean Hospital), Posted Sep 3, 2019

Undergraduate Research Opportunities in Astrophysics, Harvard-Smithsonian Center for Astrophysics, Posted Aug 29, 2019

Undergraduate Research Opportunity, Dr. Ghebremichael Lab, Ragon Institute of MGH, Harvard, MIT, Posted Aug 29, 2019

Undergraduate research opportunity in Dr. Ionescu lab in Harvard School of Dental Medicine, Posted Aug 29, 2019

Undergraduate Research Opportunity, McLean Geriatric Psychiatry Research Program, McLean Hospital, Posted Aug 29, 2019

Undergraduate Research Opportunity, Professor Fishman Lab, Harvard Stem Cell and Regenerative Biology Department, Posted Aug 29, 2019

Undergraduate research opportunity at the Histology Lab, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Posted Aug 29, 2019

Undergraduate Research Opportunity, Shivdasani Lab, Dana-Farber Cancer Institute, Posted Aug 29, 2019

Undergraduate Research Opportunity, Dr. Lois Choi-Kain’s Lab, McLean Hospital, Posted Aug 29, 2019

Undergraduate Research Opportunity, Dr. White Lab, MGH East – CNY, Posted Aug 29, 2019

Research Assistant/Student Programmer, The Speech and Feeding Disorder Lab (Dr. Jordan Green), MGH Institute of Health Professions, Posted Aug 23, 2019

Undergraduate research opportunity at the Laboratory for Computational Neuroimaging, Martinos Center for Biomedical Imaging, MGH, Posted Aug 23, 2019

Undergraduate Research Opportunity in studying role of lncRNAs in bone marrow failure and oncogenesis (Novina Lab), Posted Aug 16, 2019

Undergraduate research volunteer in Anxiety and Traumatic Stress Disorders Lab, Posted Aug 8, 2019

Undergraduate opportunity, Deep learning in MGH Cardiovascular Imaging, Dr. Lu, Posted Aug 8, 2019

Undergraduate Research Opportunity, Obsessive Compulsive Disorder Institute, McLean Hospital, Posted Aug 8, 2019

Undergraduate research in cell- and ionic liquid-based drug delivery, Mitragotri Lab, SEAS, Posted July 17, 2019

Undergraduate research opportunity in hydrogel-based drug delivery, Mitragotri Lab, Posted June 17, 2019

 

2018-2019 Academic Year

Research Opportunity to study the neuronal mechanisms underlying reproduction and metabolism, Dr. Victor Navarro’s lab, BWH, Posted April 23, 2019

Research Assistant, Dr. Pepperberg’s Lab, Harvard University, Posted April 15, 2019

Undergraduate research opportunity at the Laboratory for Computational Neuroimaging, Martinos Center for Biomedical Imaging, MGH, Posted April 2, 2019

Undergraduate summer research internship, Cognitive Neuroscience Group, MGH, Posted March 27, 2019

Undergraduate research opportunity, Brigham and Women’s Hospital, Division of Genetics, Posted March 8 2019

Undergraduate Research Position, Pediatrics and Neuroscience, Lurie Center for Autism, MGH for Children, Posted March 8, 2019

Haplotype-aware de novo assembly of related individuals, G. Church Lab, Posted Feb 21, 2019

Undergraduate Research Opportunity at Spaulding Hospital Cambridge INSPIRE Lab for sensorimotor rehabilitation engineering (term-time, summer, or both), Posted Feb 21, 2019

Undergraduate research opportunity in oral delivery of biological drugs, Mitragotri Lab at Northwestern Building, Posted Feb 7, 2019

Undergraduate Research Opportunity at Wyss Institute, Posted Feb 7, 2019

Undergraduate research opportunity in 3D bacterial motility, Rowland Institute, Posted Feb 7, 2019

Undergraduate research, Arnold Lab, MGH, Charlestown Navy Yard, Posted Jan 29, 2019

Undergraduate research opportunity in diabetes and obesity project at Mitragotri Lab at Northwest Building in Cambridge, Posted Jan 29, 2019

Undergraduate research opportunity on developing breakthrough technologies to promote effective science communication in biomedical research, MEEI, Posted Jan 28, 2019

Research Assistant Positions in Developmental Cognitive Neuroscience – Spring Term 2019, Posted Jan 2, 2019

iGEM Biodesign Bootcamp Wintercession, Posted Nov 19, 2018

Undergraduate Research Opportunity, Dr. Christopher Walsh, Department of Genetics and Genomics, Boston Children’s Hospital, Posted November 16, 2018

Undergraduate Research Opportunity in Soft Robotics Fabrication, Whitesides Research Group, Harvard University, Posted November 16, 2018

Unsupervised Machine Learning as a Window into Psychological Representation, Harvard Vision Sciences Laboratory, Posted October 22, 2018

Undergraduate research opportunities (can take multiple students) – Dr. Kapil Ramachandran’s lab, Harvard Medical School, Posted October 19, 2018

Elucidation of multi-host bacterial pathogenesis in Pseudomonas aeruginosa and development of novel anti-virulence and host therapeutic strategies, MGH, Posted October 19, 2018

Peacebuilding data, evaluation and implementation science, and humanitarian technologies, Harvard Humanitarian Initiative, Posted October 15, 2018

Undergraduate Research Opportunity in lncRNA-directed drug discovery in Melanoma, Novina Lab, Dana-Farber Cancer Institute, Posted October 15, 2018

Undergraduate Research opportunity, Dr. LeBoff’s Lab/ Skeletal Health, Osteoporosis Center, and Bone Density Unit, Brigham and Women’s Hospital, Posted September 28, 2018

Undergraduate Research Opportunity, Sleep Disorders Clinical Research Program, MGH, Posted September 28, 2018

Undergraduate research positions, Mackenzie Mathis' lab, Posted September 28, 2018 

Research Assistant Positions in Developmental Cognitive Neuroscience – Fall Term 2018, Boston Children’s Hospital, Posted September 28, 2018

Undergraduate Research Opportunity, Kwon Lab, Ragon Institute of MGH, MIT and Harvard, Posted September 28, 2018

Hoekstra Laboratory: Undergraduate opportunities, Posted September 28, 2018

Undergraduate Research Opportunity to Investigate Mitochondrial Dysfunction in Retinal Diseases, Saint-Geniez Lab, MEEI, Posted September 28, 2018

Endocrinology Undergraduate Research, Dr. Kaiser, Brigham and Women's Hospital, Posted September 28, 2018

Undergraduate research opportunity in Dr. Ionescu lab in Harvard School of Dental Medicine, Posted September 18, 2018

Undergraduate Research Opportunity, De Bivort Lab, OEB, Posted September 18, 2018

Undergraduate Research Opportunity in Chromatin and Epigenetics, Anna Krichevsky Lab, Harvard Medical School, Posted September 18, 2018

Undergraduate Research Opportunity in Neurobiology of Schizophrenia and Bipolar Disorders, McLean Hospital, Posted September 18, 2018 

Undergraduate Research Opportunity in Computational Biology using Big Data to   identify Genome Variants in human cell lines, Pinello Lab, MGH, Posted September 18, 2018

Undergraduate Research Opportunity in the Henske Lab, BWH, Posted September 18, 2018

Undergraduate Research Opportunity, Dr. Karen Sepucha, Health Decision Sciences Center, MGH, Posted September 18, 2018

Undergraduate Research Opportunity, Dr. Larry Benowitz, Boston Children’s Hospital, Posted September 18, 2018

Undergraduate Research Opportunity in Analogue Seismogram Digitization Citizen Science Project with High-School Students in Japan, Posted September 18, 2018

Research Opportunity, The Emotion and Social Neuroscience Laboratory, Department of Psychiatry, MGH, Posted September 18, 2018

Undergraduate Research Opportunity – Molecular Imaging, Gordon Center for Medical Imaging, MGH, Posted September 18, 2018

Undergraduate Research Opportunity in Biological and Artificial Intelligence (Kreiman Lab), Posted September 11, 2018

Undergraduate Research Opportunity, Dr. Kneeland, Division of Alcohol and Drug Abuse, McLean Hospital, Posted September 11, 2018

Undergraduate Research Assistant, Intestinal Parasites of Madagascar, Golden Planetary Health Lab, Harvard T.H. Chan School of Public Health, Posted September 11, 2018

Undergraduate Research Opportunity in Sleep and Cognition, Posted September 7, 2018

Undergraduate Research Opportunity, Dr. Kevin Houston Lab, Mass Eye and Ear, Posted September 7, 2018

Undergraduate Research Opportunity, Dr. Ciolino Lab, MEEI, Posted September 7, 2018

Undergraduate Researcher, Yu Lab, Ragon Institute of MGH, MIT and Harvard, Posted September 7, 2018

Undergraduate research opportunity at Dr. Vidal lab in Dana-Farber Cancer Institute, Posted September 7, 2018

Research Assistant, Pepperberg Avian Cognition Lab, Harvard University, Posted September 7, 2018

Undergraduate research opportunity in at the Quantitative Musculoskeletal Imaging Group Research (Q-MIG), Dr. Duryea, Radiology Department, Brigham and Women’s Hospital, Posted September 6, 2018

Undergraduate Research Opportunity, Shivdasani Lab, Dana-Farber Cancer Institute, Posted September 6, 2018

Research Opportunity to study the neuronal mechanisms underlying metabolism and reproduction, Dr. Victor Navarro’s lab, BWH, Posted September 6, 2018

Undergraduate Research Opportunity, Dr. X. Sean Li Lab, BCH, HMS, Posted September 6, 2018

Fall/Spring Position, Sleep Matters Initiative, BWH, Posted September 6, 2018

Undergraduate Research Opportunity, Dr. Pfister's visual computation group, Harvard SEAS, Posted September 6, 2018

Undergraduate Research Opportunity, Dr. Salat, Brain Aging and Dementia Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, MGH, Posted September 6, 2018

Machine Learning Approaches to the Study of Neurodegenerative Disease, Fraenkel Lab, MIT, Posted September 6, 2018

Undergraduate Research Opportunity, Ruvkun Lab, MGH, Posted September 6, 2018

Research Opportunity in Dissociative Disorders and Trauma Research Program, Dr. Kaufman group, McLean Hospital, Posted September 6, 2018

Research Assistant for Health Services Research Projects, Dr. Weissman Research Group, BWH, Posted September 6, 2018

Undergraduate Research Opportunity in Neurodegeneration”, Rosenberg Lab, Boston Children’s Hospital, Posted September 6, 2018

Spring or Summer 2019 Undergraduate Clinical Research Intern, Dr. Kong, Chronic Pain and Brain-Imaging Laboratory, MGH Department of Psychiatry, Posted September 6, 2018

Undergraduate Research Opportunity: Drug Sensitivity in Lung Cancer, Dr. Benes Lab, MGH Cancer Center, Posted September 6, 2018

Undergraduate Research Position, Haigis Lab, Harvard Medical School, Posted September 6, 2018

Undergraduate Research Opportunity, Dr. Pandya’s Stroke Modeling Research Team, Center for Health Decision Science at the Harvard T.H. Chan School of Public Health, Posted September 6, 2018

Undergraduate Research Opportunity, Cantor Lab, Dana Farber Cancer Institute, Posted September 6, 2018

Undergraduate Research Opportunity at Dr. Joseph Bonventre Lab, Brigham and Women’s Hospital, Harvard Medical School, Posted September 6, 2018

Undergraduate Research Opportunity in Dr. Fred Winston’s lab, Department of Genetics, HMS, Posted September 6, 2018

Undergraduate Research Opportunity in Harvard-wide Program on Antibiotic Resistance, Dr. Gilmore, Infectious Disease Institute, HMS-MEEI, Posted September 6, 2018

Research Opportunity at the Gershman Computational Cognitive Neuroscience Lab, Department of Psychology, Posted September 6, 2018

Research Assistant Position: Empathy and Aggression, FAS Psychology Department, Posted September 6, 2018

Undergraduate Research Opportunity, Dr. Konstantina Stankovic Laboratory, Massachusetts Eye and Ear, Posted September 6, 2018

Undergraduate Research Intern Position in the Gaab Lab, Boston Children's Hospital, Posted September 6, 2018

Undergraduate Research Opportunity in the Cognitive and Neural Organization Lab, Dr. Konkle, Harvard Department of Psychology, Posted September 6, 2018

Undergraduate Research Opportunity, Drs. Schmider and Soberman, MGH, Posted September 6, 2018

Undergraduate research position, Dr. del Re Lab, Psychiatry Neuroimaging Lab, BWH, Posted September 6, 2018

Undergraduate research opportunities in the study of brain-immune interactions in neurodevelopment, Bilbo Lab, Massachusetts General Hospital/HMS, Posted September 6, 2018

Undergraduate research opportunity in the Cherayil lab, Mucosal Immunology and Biology Research Center, MGH, Posted September 6, 2018

Undergraduate Research Opportunity, Lab of Thomas Michel, Brigham and Women’s Hospital, Harvard Medical School, Posted September 6, 2018

Undergraduate Research Opportunity, Dr. Brucker, Rowland Institute, Posted September 6, 2018

Undergraduate Research Opportunity, Dr. Shioda Lab, MGH, Posted September 6, 2018

Research opportunity, Anxiety and Traumatic Stress Disorders Laboratory, McLean Hospital, Posted August 27, 2018

Undergraduate Research in Psychiatry, Brigham and Women’s Hospital, Posted August 27, 2018

Research opportunity, Dr. Arbel Lab, Cognitive Neuroscience Group, MGH Institute of Health Professions, Posted August 22, 2018

Research Assistant Position: Human and Fruit Fly Models of Neurological Disease, MGH, Posted August 20, 2018

Undergraduate Researcher position, Cash Lab, Posted August 10, 2018

Understanding the Molecular Mechanism and Developing Therapies in Neuromuscular Diseases, Brigham and Women's Hospital, Posted July 18, 2018
 

Posted November 1, 2019

 

Research Assistant, MGH IHP SAiL Literacy Lab

Tiffany Hogan, PhD, Director, SAiL Literacy Lab, MGH Institute of Health Professions

Research Assistant for the SAiL Literacy Lab, primarily working on the research study Orthography and Word Learning (OWL). The purpose of this study is to better understand how children learn spoken and written words. It is a longitudinal investigation of children with typical development and children with language impairment who are in kindergarten through second grade.

Below are some of the responsibilities for this position:

Prepare recruitment materials

Prepare treatment materials

Assess children using standardized clinical tests (all training will be provided)

Data entry and processing

Writing reports

Other tasks as needed

No research skills/experience required.

Research assistants will gain hands on experience assessing children, entering and processing data, as well as being a part of an active research lab.

Looking for 20 hours, either in the morning or afternoon. No evening hours. The current need is until June, the end of the school year, but has the potential for a commitment extension or future work with the lab.

Hourly rate between $13 and $15.

Please submit letter of interest and resume via email to Mary Rasner, Lab Coordinator, mrasner@mghihp.edu

 

 

 

 

Understanding the Molecular Mechanism and Developing Therapies in Neuromuscular Diseases, Dr. Gupta, HMS

PI Information:  Vandana A Gupta, PhD

Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, NRB 168A, 77 Avenue Louis Pasteur, Boston, MA 02115

Ph: 617-525-4452  Email: vgupta@research.bwh.harvard.edu Website: http://guptalab.bwh.harvard.edu/

Project Description: This project is focused on understanding the role of novel genes in neuromuscular development and disease pathology. This is a research position that will involve cloning, bacterial cultures, mammalian cell culture, characterization of mutant zebrafish lines and performing genetic and chemical screens to develop therapeutics. We are looking for a self-motivated and creative student to work in a team as well as independently. No prior research experience is required.

Project Timeline: We are looking for a time commitment of a minimum of 10 hours/week for 6-12 months.

Skills Required: Previous experience with molecular biology or cell culture techniques would be great. However, students with no prior research experience are also encouraged to apply.

Learning Outcome: Research design, experimental skills, data analysis, research presentations, writing scientific papers.

Mentoring: Dr. Gupta will be mentoring students and will be meeting atleast once per week with students. Regular mentoring and training for new skills will be provided.

Funding: Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.

Contact: Email your resume and research interests to Dr. Gupta at

vgupta@research.bwh.harvard.edu

 

 

Research Assistant/Student Programmer, The Speech and Feeding Disorder Lab (Dr. Jordan Green), MGH Institute of Health Professions

PI: Dr. Jordan Green

79/96 13th Street, Boston MA 02129

https://www.mghihp.edu/research/speech-and-feeding-disorders-lab

Questions? Please contact the SFDL Lab Manager, Brian Richburg at brichburg@mghihp.edu

Our lab is looking for someone experienced in Matlab programming to help us maintain and expand a series of scientific scripts in use by the lab. These scripts involve basic signal processing and the calculation of statistics time-series data, including acoustic (audio) and kinematic (movement) signals.

Our lab is dedicated to advancing knowledge and clinical practice through basic and applied research on speech & swallowing disorders. Some of our current projects include tracking facial motor function after facial transplant, studying bulbar symptoms in people with ALS, and using new camera technology to develop assistive communication devices for people with speech impairments.

You can access a list of recent publications here.

Skills required. No prior research experience is required. Students should have experience programming in Matlab including signal processing, and graphic user interface design.

Learning outcome: Students will have the opportunity to apply their programming knowledge to real-world research data related to speech disorders arising from neurologic impairment. Students will gain familiarity with a variety of research methods and data analysis routines for studying facial biomechanics, which may include processing data from: Motion capture, electromagnetic articulography, acoustic analysis and EMG data.

Students would be expected to work approximately 10 hours per week.

After the initial training, students will have weekly meetings with the lab manager. Depending on the project selected, the student may be assigned to work with a Doctoral student or Postdoc on a research project.

Does laboratory provide any funds to pay student’s stipend? Yes, research assistants will be paid an hourly rate of $18.

Please email your resume to Brian Richburg at brichburg@mghihp.edu

 

 

Posted October 18, 2019

Undergraduate Research Opportunity, Center for Brain/Mind Medicine, BWH

Principal Investigators (PIs) Contact Information: Dr. Seth Gale and Dr. Kirk Daffner, Center for Brain/Mind Medicine, Department of Neurology, Brigham and Women’s Hospital (BWH), Harvard Medical School
60 Fenwood Road, Boston MA

Description: We are seeking an undergraduate student to serve as a research volunteer at the BWH Alzheimer Center, a clinical neurosciences group within the Department of Neurology at BWH. Working with the PIs and research assistants, the student will assist in the management and growth of an ongoing research study, the Brain Health Champion (BHC) Study. The BHC study is a multi-modal, technology-supported health coaching intervention for patients with or at-risk for cognitive decline and memory disorders. The chief goal is to help patients implement and adhere to critically important evidence-based health and lifestyle recommendations, including aerobic exercise, dietary recommendations, and cognitively and socially stimulating activities, to improve cognition, function, and quality of life. The BHC Study has completed one successful pilot trial with plans to scale up across multiple BWH clinics.

The student will have an opportunity to participate in educational/academic and patient care activities, including attending conferences and clinical teaching rounds. This position is ideal for an individual interested in a career in health care.

Skills required: No prior research experience is required. Interest in neuroscience or psychology is preferred. Interest working with geriatric/cognitively impaired participants is preferred. Statistical experience, including data analytics in SPSS and/or R, is a plus.

Learning outcome: The student will contribute to research activities related to the BHC Study, including: literature review, participant recruitment, data collection, and data analysis/presentation.

Number of hours: The student is expected to work 5-10 hours per week. Specific days and times are negotiable.

Mentoring: Dr. Seth Gale and research assistant Taylor Krivanek will be mentoring the undergraduate. Students will be encouraged to attend group meetings.

Stipend: This is a volunteering position, but students are encouraged to apply for Harvard fellowships. Work can also be performed for course credit where applicable.

How to apply: If you are interested in this position, please send your resume/CV and a brief email introducing yourself and describing your research interests to: Taylor Krivanek, RA, at tkrivanek@bwh.harvard.edu.

 

 

Undergraduate research opportunity, Dr. Haider lab, Schepens Eye Research Institute

PI name: Neena Haider, Schepens Eye Research Institute,  20 Staniford St, Boston MA, Web: http://www.schepens.harvard.edu/haider

 Description of the project and duties : this will depend on applicant and hours they are available. Applicant will help with ongoing projects and can learn genotyping, animal husbandry, cell culture, functional genomics, and/or cell and molecular biology techniques.

No skills required! We will teach you how to do cutting edge genomic, molecular biology, research.

Learning outcome: laboratory skills, research skills: study design, data analysis method, presentation skills

Number of hours students are expected to work: Negotiable! Minimum 5-10 hours/week

Mentoring: Direct mentoring from the PI, lab manager, and postdoctoral fellow

Does laboratory provide any funds to pay student’s stipend? Students are strongly encouraged to apply to the HCRP and other fellowships or register for a research course credit, and there may be options for lab to provide a stipend.

 Email your interest and resume to:  neena_haider@meei.harvard.edu

 

 

Posted September 20, 2019

Undergraduate Research Opportunity in CAR T cell Manufacturing (Novina Lab)

Contact informationNovinaLAB@dfci.harvard.edualberto_nobili@dfci.harvard.edu

Hospital: Dana-Farber Cancer Institute 
(Note: location = Longwood campus)

Project description and duties: T cells with Chimeric Antigen Receptors (CAR T cells) are engineered lymphocytes which are reprogrammed to deliver a potent immune response upon binding to the surface of tumors. They are a novel technology which in the past ten years has revolutionized the field of cancer immunotherapy thanks to their unprecedented successes in the treatment of hematologic malignancies like leukemias and lymphomas. The Novina Lab has developed a next-gen CAR T cell platform to expand these successes to other malignancies like Multiple Myeloma (MM), Glioblastoma Multiforme (GBM) and Diffuse Intrinsic Pontine Gliomas (DIPG). You will be working under the supervision of scientists and physicians for the production of new CAR T cells batches which will be used in pre-clinical in vitro experiment and in vivo mouse models. The success of these experiment will set the basis for the start of physician-initiated clinical trials at the Dana-Farber Cancer Institute.

Skills required: previous experience in mammalian cell culture is preferred.

Learning outcomes: Students working on this project will learn how to generate CAR T cell by applying our lab’s established Standard Operating Procedures (SOPs). This will allow the students to learn basic wet lab techniques like: media preparation, mammalian cultures passaging, human T cell activation, human T cell viral transduction and batch quality control via flow cytometry. An important aspect of training in the Novina lab is learning to conduct translational research using clinical samples, advanced technologies, computational methods, and humanized model systems. This internship will provide a multi-discipline training environment that leverages basic, clinical, and industry collaborations which will provide a direct insight in the learning of the techniques necessary to develop a career in the field of gene therapy/immunotherapy.

Number of hours students are expected to work: minimum of 12 hours per week (3x4 hours)

Length of the project: minimum of 6 months (the longer the more you will get out of it)

Mentoring: Dr. Novina, scientists and senior postdocs in the lab actively mentor students through weekly meetings, lab group meetings, and one-on-one interactions. You will be welcome to join our lab meetings.

Student stipend: This is a volunteer position or for credit position. We would also be happy to help you apply for relevant fellowships (contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu for more info on fellowships).

How to apply: send a copy of your CV by email to  : NovinaLAB@dfci.harvard.edualberto_nobili@dfci.harvard.edu

 

 

Posted September 17, 2019

Research Opportunity in functional brain imaging at the Martinos Center for Biomedical Imaging, MGH/HMS

Contact information:
Dr. Jonathan Polimeni and Dr. Olivia Viessmann
Athinoula  A. Martinos Center for Biomedical Imaging, MGH, Harvard Medical School

13th Street, CNY75, Charlestown, MA, 02129, USA

Website: https://www.nmr.mgh.harvard.edu/lab/mr-pig

Project description and duties:

Functional Magnetic Resonance Imaging (fMRI) is used to study neuronal activity in the human brain non-invasively. FMRI techniques have been refined and pushed to higher resolution over the last decade with the hope to improve the ability of this technique to accurately measure neuronal function.

A substantial aspect of fMRI is post-acquisition image processing of the data. This involves multiple steps, such as subject motion correction, registrations, filtering and inhomogeneity corrections. The order and combination of these steps changes the “effective” resolution and can make or break our ability to fully harness the information in high-resolution data. This project aims to investigate these image processing steps and their effect on fMRI data quality with the goal of determining an optimal pipeline.

Skills required:

We are looking for a student with a background in either CS, Physics, EE or similar that is interested in learning more about image analysis, fMRI and the human brain. No prior knowledge in neuroscience, fMRI, or fMRI data analysis is required. The student should be comfortable with LINUX/UNIX and either Matlab or Python.

Learning outcomes:

Most of the work will comprise data analysis in Matlab and bash scripting. The student will gain experience in specific software for brain imaging data, handling large data sets, signal processing, and of course MRI. There might be the opportunity to gain experience in academic writing towards the end of the project, for example to write up results for a conference abstract.

Number of hours: We expect the student to work on site one day/week for a couple of hours. The total length of the project is negotiable, for now we anticipate one semester.

Mentoring: The student will be mentored by Olivia Viessmann, who is a postdoctoral research fellow with many years of experience with MRI. The student and mentor can meet weekly, the student is encouraged to attend the weekly group meetings and also has the opportunity to attend scan sessions and experience how MR data is acquired.

Student stipend: No. Students are encouraged to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities. We accept volunteers.

Course credit: TBD.

Application informationStudents should describe their interest in this research and submit their resume to Olivia Viessmann at oviesssmann@mgh.harvard.edu

 

 

Undergraduate Research Opportunity in Dr. Robin Hopkins Lab at the Arnold Arboretum of Harvard University

Contact information: Postdocs: Dr. Antonio Serrato and Dr. Samridhi Chaturvedi

Department: Organismal and Evolutionary Biology Contact: serrato@fas.harvard.edu and schaturvedi@fas.harvard.edu

Location: Weld Hills research building at the Arnold Arboretum of Harvard University.

Lab website: http://hopkins-lab.org/

Project description and duties: Research in the lab focuses on speciation and adaptation in Phlox. The lab is working on projects looking at mating incompatibilities in plants, hybridization between different species of plants and long-term selection experiments. Duties can include growing and taking care of plants, phenotyping them for different traits, imaging samples and possible molecular laboratory work 

Skills required: No prior research experience is required. Some experience in biology, plant science would be helpful but not required.

Learning outcomes: Plant growing, crossing, phenotyping, pollen-pistil imaging. Possibility of learning molecular lab

techniques such as RNA/DNA extraction.

Number of hours: Can be negotiated.

Mentoring: The undergraduate researcher will be mentored by the PI in conjunction with two postdoctoral researchers in the lab.

Course credit: Work can be performed for course credit for qualifying course/programs.

Application information: Interested students should email their resume or questions to Dr. Antonio Serrato:

serrato@fas.harvard.edu and Dr. Samridhi Chaturvedi: schaturvedi@fas.harvard.edu

 

 

Undergraduate Research Opportunity, Dr. Konkle Lab, Department of Psychology, Faculty of Arts and Sciences

Contact Information:  Dr. Ruosi Wang (ruosiwang@g.harvard.edu), Cognitive and Neural Organization Lab (Lab website: https://konklab.fas.harvard.edu). PI: Talia Konkle. Location: 7th floor William James Hall, 33 Kirkland St, Cambridge, MA 02138.

Project description and duties: The student will be a part of the ongoing project investigating how we process high-level properties of objects, such as animacy and size. We use a combination of behavioral and neural methods to explore the temporal dynamics of neural responses that contribute to these processes. The student will help to collect stimuli, run participants in behavioral and EEG (electroencephalogram) experiments.

Requirements:  Attention to details and high level of motivation. Prior experience running behavioral/neuroimaging experiments in psychology is a plus but not required.

Learning outcomes: Students will gain the experience necessary for conducting cognitive research, such as creating stimulus sets, recruiting and testing participants. Students will also learn how to collect EEG data in a laboratory setting.

Number of Hours: Students are expected to work 10-15 hours a week.  Specific days/times are negotiable.

Mentoring: Students are encouraged to attend weekly team research meetings. Also, Dr. Ruosi Wang and Graduate student Emily Josephs will be mentoring the student. The mentorship meetings will happen weekly.

Student stipend: This is a volunteering position, but we encourage students to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Course credit is available for this position.

Application information: Please email your resume and cover letter to Ruosi Wang at ruosiwang@g.harvard.edu.

 

 

Undergraduate Research Opportunity, Farokhzad Lab, BWH

PI: Dr. Omid Farokhzad, Center for Nanomedicine
60 Fenwood Road Boston, MA 02115  Phone: 617-732-6093

E-Mail: ofarokhzad@bwh.harvard.edu   http://farokhzad.bwh.harvard.edu/wp/

Project 1

Project description and duties: The aim of the project is to develop nanoparticles as carriers for mRNA/siRNA delivery and gene therapy.

Skills required: Major in biology/biochemistry or related discipline (juniors or seniors are preferred)

Learning outcomes: You will be gaining the research skills such as study design, data analysis, presentations, and scientific writing etc.

Number of hours: 5 – 10 hours per week (negotiable).

Mentoring: Dr. Yuan Liu (Postdoc in the Farokhzad Lab) will be mentoring the undergraduate. Students are encouraged to attend the group meetings.

Project 2

Project description and duties: The aim of the project is to develop new nanomaterials including 2D nanomaterials and nanoscale metal-organ frameworks for tumor therapy and bacterial killing.

Skills required: Major in materials science/chemistry/biology/biochemistry or related discipline (juniors or seniors are preferred)

Learning outcomes: You will be gaining research skills such as study design, data analysis, presentations, and scientific writing, etc.

Number of hours: 5 – 10 hours per week (negotiable).

Mentoring: Dr. Zhongmin Tang (Postdoc in the Farokhzad Lab) will be mentoring an undergraduate. Students are encouraged to attend group meetings.

Student stipend: Not available from the lab (but students are encouraged to apply for Harvard fellowships:  https://lifesciences.fas.harvard.edu/research-opportunities)

Course credit: Another potential option for some students (typically juniors or seniors) is to conduct research for course credit; however, a student cannot earn course credit and be paid a stipend in the same semester.

How to apply: Please send your resume and statement of research interest to Dr. Wei Tao (wtao@bwh.harvard.edu) in the Farokhzad Lab.

 

 

Undergraduate Research Opportunity, Dr. George Church Lab, Harvard Medical School

Contact information: George Church, Department of Genetics, http://arep.med.harvard.edu/

Alexandra Rudolph, Biological and Biomedical Sciences Ph.D. Candidate, alexandra_rudolph@g.harvard.edu,

 New Research Building 233 (Harvard Medical School)

Project description and duties: Researcher’s main goal will be transferring GetK program from  Python 2.7 to Python 3.7 while retaining full functionality. Further, the researcher will work with lab members to add additional functions to the program to support current needs of the group. For additional description of the rE.coli-57 project and GetK program, please see the “Design, synthesis, and testing toward a 57-codon genome” paper.

Skills requiredPython coding experience required. No prior wet lab research experience required.

Learning outcomes: Building computational skills. Creation of output program. Presentation skills.  Candidate will be involved in subsequent publication of program.

Number of hours: Project will run approximately 6 months. Number of hours/week  is negotiable. 

MentoringAlexandra Rudolph, Akos Nyerges. Mentorship meetings will be once/week. Attendance at group meetings

 is highly encouraged.

Student stipendThe  research group will not pay a stipend to the student. Students are encouraged (but not required) to apply for Harvard fellowships:

https://lifesciences.fas.harvard.edu/research-opportunities

Course creditThe student is welcome to earn course credit for the project  (amount of credit to depend on hours/week decided on with mentors). 

Application informationIf  interested, please email your resume to Alexandra Rudolph at alexandra_rudolph@g.harvard.edu.

 Please ensure resume fully indicates previous coding experience. If being considered for the position, lab will reach out to schedule an additional meeting with the candidate(s). 

 

 

Posted September 9, 2019

Undergraduate research opportunity as a Research Assistant,  Health Decision Sciences Center, MGH 

The Health Decision Sciences Center (HDSC) at Massachusetts General Hospital is committed to improving the quality of decisions made by patients and health care providers about medical tests and treatments. The HDSC is involved in developing, implementing, and evaluating decision aids and decision quality measures to support shared decision making in medical encounters. We are seeking students to support research studies. This is an exceptional opportunity to get experience with cutting edge research focused on patient engagement and delivery of patient-centered care. Students will be supervised by Karen Sepucha, PhD, Director of the Health Decision Sciences Center and Lauren Leavitt, MA, Project Manager. 

Student activities may include: 

• Patient screening for eligibility using the electronic medical record 

• Administering surveys 

• Following up with study participants by phone 

• Identifying issues with recruitment and retention 

• Data collection, entry and analytics 

• Literature review 

• Manuscript contributions (writing, editing, proofing, references) 

• Grant proposal contributions 

Number of hours: negotiable, 5-20 hours/week 

Paid opportunity.

Interested? Send the following to Lauren Leavitt, MA: Research Project Manager via email (ljleavitt@mgh.harvard.edu

• 1 page (maximum) statement describing your research interests and goals and how this experience might help with your development 

• Your CV or Resume 

To learn more about The Health Decision Sciences Center, visit our website: https://mghdecisionsciences.org/ 

 

 

Undergraduate Clinical Research Opportunity, Cognition and Affect Research and Education Laboratory (CARE Lab), McLean Hospital

Contact Information: Dr. Andrew Peckham, McLean Hospital CARE Lab. Email (preferred): adpeckham@mclean.harvard.edu. Phone: 617-855-2946. Location: McLean Hospital (Recreation Building), 115 Mill Street, Belmont, MA 02478.

Project Description and Duties: The student will work in a psychiatric hospital setting with Courtney Beard, PhD, director of the CARE lab, and Andrew Peckham, PhD, postdoctoral research fellow. The student will be a part of ongoing clinical research examining the effectiveness of an intensive Cognitive Behavioral Therapy based partial hospital program for a range of psychological problems (depression, anxiety, personality, psychosis), predictors of treatment response, and other related studies. This position would be an excellent fit for individuals interested in obtaining doctoral training in clinical psychology, psychiatry, or neuroscience. Students for the 2019-2020 year will work on two clinical research projects using EEG to understand impulsivity in psychiatric disorders. This includes an NIMH-funded project testing the efficacy of a computerized cognitive training program for impulsivity, and a Harvard-funded project using a mobile EEG device to assess daily fluctuations in cognition as a predictor of impulsive behavior. Principal experiences include: 1) assisting in running the clinical participants in the study, including recruitment, administration of computerized questionnaires and computerized experimental paradigms, 2) assisting in running clinical participants through EEG sessions to record changes in brain activity; 3) assisting the Research Coordinator in record keeping, data management and archival data collection tasks related to the research program; 4) assisting with literature searches, manuscript preparation, and presentations. More information about our research team can be found here: https://cbeard2.wixsite.com/carelab

Skills Required: Requirements for this position include excellent interpersonal skills, the ability to work independently, professional behavior appropriate for a clinical setting and interacting with psychiatric patients, and an interest in clinical research. Minimum GPA 3.5.

Learning Outcomes:  Students will learn skills necessary for conducting clinical research in an acute psychiatric hospital setting, including recruiting and consenting participants. Students will also have the opportunity to learn how to collect EEG data using both laboratory and ambulatory methods. All students have the opportunity to present a first-author poster based on an independent project. Although primary experiences are firmly with the research team, students also interact with our multidisciplinary clinical staff, including social workers, nurses, psychiatrists, and psychologists. More information about our clinical program at McLean can be found here: https://www.mcleanhospital.org/programs/behavioral-health-partial-hospital-program

Number of Hours: Minimum of 8-16 hours per week (1-2 days). Specific days/times are negotiable. Data collection in the clinical research program takes place between 8:30am and 4pm on weekdays; the program is not open on weekends.

Mentoring: Students will participate in weekly team research meetings, monthly meetings with researchers from other affiliated clinical research programs, and individual weekly supervision meetings with the lab director (Dr. Beard) and postdoctoral fellow (Dr. Peckham). Students will also have the opportunity for mentoring and career development opportunities with other McLean Hospital researchers and clinicians.

Student Stipend: This is a volunteer (non-funded) position. McLean Hospital is T-accessible and located a short distance from the Harvard University campus. We encourage students to consider applying for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities or to consider applying for the T pass program for undergraduate researchers: https://lifesciences.fas.harvard.edu/research-transportation.

Course Credit: If you are eligible to receive course credit for research, we will support you in doing so for this position.

Application Information: If you are interested in applying for this position, please email your resume and a brief cover letter to Dr. Andrew Peckham at adpeckham@mclean.harvard.edu.

 

 

Undergraduate Research Opportunity, Dr. Bind Lab, Department of Statistics, Faculty of Arts and Sciences

Contact information: Marie-Abele Bind, Department of Statistics, Science Center, Room 608, https://scholar.harvard.edu/marie-abele and http://mablab.info.

Project description and duties: (can include a link to published manuscripts describing the work)

Skills required: No prior research experience required. New undergraduate researchers and candidates with basic understanding of probability and statistics, and with some experience in R programming are encouraged to apply.

Learning outcomes: R programming skills, research skills such as study design, statistical analysis methods, presentations, and scientific writing.

Number of hours: Negotiable. Ideally, students are expected to work 5 to 10 hours a week. Length of the project: one semester.

Mentoring: Dr. Bind, Dr. Young Lee, and PhD candidate Alice Sommer will be mentoring the undergraduate. Bi-weekly mentorship meetings. Student can attend group meetings.

Student stipend: Unpaid position. Students are encourage to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities.

Course credit: Students can conduct research for course credit.

Application information: Students should email their resume to Dr. Bind at ma.bind@mail.harvard.edu

 

 

Undergraduate Research opportunity to study Gram-Negative Bacterial Pathogenesis in Dr. Deborah Hung's Lab, MGH

Contact information: Deborah Hung, M.D., Ph.D, Dept. of Molecular Biology  and CCIB; email:hung@molbio.mgh.harvard.edu; Mass. General Hospital, 185 Cambridge St., Boston, MA; lab website: https://ccib.mgh.harvard.edu/hung

Project description and duties:  There is an urgent need to develop novel ways of treating bacterial infections due in part to the increasing prevalence of antibiotic resistance. The Hung Lab at MGH's Department of Molecular Biology and CCIB studies mechanisms of Gram-negative bacterial pathogenesis in the hope of providing insight into possible new paradigms for treating bacterial infections including inhibiting bacterial virulence mechanisms, exploring host targeted therapies, and understanding bacterial susceptibility to conventional antibiotics. Undergraduate researchers will work to explore one or more of these topics using a variety of techniques including molecular cloning, next generation sequencing techniques, and classical and chemical genetics to further elucidate bacterial pathogenesis mechanisms in Pseudomonas aeruginosa, Klebsiella pneumoniae or Salmonellla typhimurium, three clinically relevant Gram-negative bacterial species that are often resistant to antibiotics.

Skills required: No prior research experience is required

Learning outcomes: Students will learn laboratory skills such as molecular cloning, bacterial genetics and next generation sequencing methodologies. Students will gain research skills such as study design, data analysis methods and gain experience giving presentations and polishing their scientific writing skills.

Number of hours:  Students are expected to devote a minimum of 10-20 hours/ week to lab work. The length of the project the student is involved in is negotiable. 

Mentoring: The head of the laboratory, Deborah Hung, will mentor the undergraduate researcher in private meetings that occur every 3-4 weeks while daily mentoring will be overseen by a post-doctoral fellow or research scientist in the group who works closely with the undergraduate researcher. Undergraduate researchers are encouraged to attend group meetings.

Student stipend: available and can be sponsored by Deborah Hung, Faculty Aide Program, Federal Work-Study Program, or through a Harvard fellowship (see:https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: research can be conducted for course credit; however, a student cannot earn course credit and be paid a stipend in the same semester.

Application information: Undergraduates interested in this research opportunity should submit their resume and describe their interest in the lab in an email directed to Deborah Hung at: hung@molbio.mgh.harvard.edu 

 

Undergraduate Research Opportunity in Infectious Disease Biology, Broad Institute

Contact information: Deborah T. Hung, Core Member and Co-Director of the Infectious Disease and Microbiome Program at the Broad Institute of MIT and Harvard 

Email: dhung@broadinstitute.org

Website: https://www.broadinstitute.org/hung-lab

Project description and duties: The Hung laboratory studies bacterial infections, including tuberculosis, with the goal of advancing the diagnosis and treatment of these infections. We use chemical and genetic tools to dissect the biology of bacterial pathogens and their interactions with their hosts. We also use exciting recent advances in molecular biology to develop new methods for detecting pathogens. At the Broad Institute, undergraduate researchers will exploreone of these areas using a variety of techniques including molecular cloning, next generation sequencing techniques, and classical and chemical genetics 

Skills required: No previous experience is required.

Learning outcomes: Students will learn laboratory skills such as molecular cloning, bacterial genetics and next generation sequencing methodologies. Students will gain research skills such as study design, data analysis methods and gain experience giving presentations and polishing their scientific writing skills. 

Expectations: Students are expected to commit from 10 to 20 hours each week to the lab.  Over time, students are expected to become increasingly independent, developing the knowledge and skills that will allow them to play an active role in experimental design, planning, execution, and analysis.

Mentoring: The head of the laboratory, Deborah Hung, will mentor the undergraduate researcher in private meetings that occur every 3-4 weeks while daily mentoring will be overseen by a post-doctoral fellow or research scientist in the group who works closely with the undergraduate researcher. Undergraduate researchers are strongly encouraged to attend group meetings, with opportunities available to present their work.

Student stipend: available and can be sponsored by faculty, Faculty Aide Program, Federal Work-Study Program, or through a Harvard fellowship (see:https://lifesciences.fas.harvard.edu/research-opportunities)

Course credit: research can be conducted for course credit; however, a student cannot earn course credit and be paid a stipend in the same semester.

Application information: Undergraduates interested in this research opportunity should submit their resume and describe their interest in the lab in an email directed to Deborah Hung at: dhung@broadinstitute.org

 

Undergraduate Research Opportunity, Dr. Zӧllei, Laboratory of Computational Neuroimaging, A.A. Martinos Center, MGH

Contact information:  Lilla Zöllei, PhD Assistant Professor of Radiology, HMS Email: lzollei@nmr.mgh.harvard.edu Phone: 617-643-7791  https://scholar.harvard.edu/lillazollei/home
A.A .Martinos Center, 149 13th Street, Charlestown, MA 02129 https://www.nmr.mgh.harvard.edu/lab/lcn

Project description and duties: (can include a link to published manuscripts describing the work)

There are two projects offered. Both of them are related to brain image analysis tool development and deployment regarding infant brain MRI images.

      1. Using our recently developed tool Traculina to compare white matter properties of infant clinical data sets (https://www.ncbi.nlm.nih.gov/pubmed/31132451)
      2. Improving / modifying a deep learning tool to be used to create infant atlas (https://arxiv.org/abs/1908.02738)

Skills required: For the above projects, the student is expected to have an interest in scripting and data analysis. Knowledge of neuroanatomy is helpful.

Learning outcomes: data analysis methods, presentations, scripting

Number of hours students are expected to work, length of the project

Ideally the student would spend 6-8 hrs/ week on this project. Fluctuation in the schedule is understood and is up for a discussion between the student and mentor.

Mentoring: Dr Zöllei will be meeting the student every week. Guidance and help will also be available from a postdoc and RA working on the same project. Additionally, the student is weclome to attend weekly group meetings of the LCN.

Student stipend: Students are encouraged to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Dr Zöllei would be happy to discuss this with relevant faculty members

Application information: Cover letter and CV should be emailed to Dr Zöllei

 

Undergraduate Research Opportunity, Dr. Fernandez-Godino Lab, MEEI

Contact information: Rosario Fernandez-Godino, PhD. Rosario_godino@meei.harvard.edu, Ocular Genomics Institute. Department of Ophthalmology at MEEI-HMS. https://oculargenomics.meei.harvard.edu/labs/fernandez-godino-lab/

Project description and duties: Our lab studies the role of the complement system in the formation of sub-retinal deposits in age-related macular degeneration. We use genome editing techniques to engineer induced-pluripotent stem cells (iPSC) and further differentiate them into ocular cell types to model different eye diseases. We use the cell-based models to understand the mechanisms underlying the disease but also to find potential therapeutic targets.

Skills required: Students are required to have experience culturing cells. Molecular biology experience desired.

Learning outcomes: laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing.

Number of hours students are expected to work, length of the project (if these are negotiable, state so): The students are required to come to the lab at least three times a week, a minimum of two hours each time. The length of the project can vary between 3-12 months.

Mentoring: who will be mentoring the undergraduate, how often are mentorship meetings, and can the student attend group meetings? The student will be mentored by two postdocs and the PI. Mentorship meetings will happen weekly, and the student will also attend the OGI group meetings every week.

Student stipend: We can’t pay an stipend, but I encourage students to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities

Application information: Email your resume and a cover letter to Rosario_Godino@meei.harvard.edu

 

 

Growth of high-temperature superconductor FeSe using molecular beam epitaxy (MBE), Jenny Hoffman Lab, Physics Department

Contact information: PI: Jenny Hoffman, Physics Department, Please contact: Dr. Christian Matt, cmatt@g.harvard.edu, http://hoffman.physics.harvard.edu/

Project description and duties: Thin films of FeSe grown on oxide substrates (e.g. SrTiO3) show tremendously enhanced superconducting properties. Their transition temperature is enhanced by up to a factor of 10. In this project the student will be involved in the growth and development of these exotic thin-film heterostructures which are exciting candidates for all kind of novel electronic devices. The student will learn about substrate (SrTiO3, BaTiO3) preparation and use state of the art instrumentation such as atomic force microscopy and atom probe tomography for substrate characterization. With additional feedback from MBE growth results, the student would develop and improve acid-etching and annealing recipes.

Skills required: The student is required to have a strong math and physics background. Introduction to solid state physics, basic quantum mechanics are advantageous.

Learning outcomes: laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing. For students devoting more than one semester, the goals is to achieve a publon (small publication).

Number of hours: The students are required to devote a minimum of 10 h/week to their research project.

Mentoring: Mentoring will be provided by PI and a graduate student or postdoc in the Hoffman lab. Montorship meetings are flexible but at least once a week. The student is encouraged but not required to attend group meetings.

Student stipend: The student is encouraged to apply for undergraduate research funding: https://uraf.harvard.edu/research-funding

Course credit: Students can conduct research for course credit.

Application information: Please submit your Resume to Christian Matt cmatt@g.harvard.edu

 

 

Posted Sep 4, 2019

Undergraduate Research Opportunity, Dr. Eva-Maria Ratai’s lab, MGH

Project title: In vivo Magnetic Resonance Spectroscopy of Brain Tumors

Contact information: Eva-Maria Ratai, PhD  Department of Radiology, Massachusetts General Hospital,
A. A. Martinos Center for Biomedical Imaging 
Building 149, 13th Street, Room 2301  Charlestown, MA 02129
Phone: (617) 726-1744  Email: eratai@mgh.harvard.edu
lab website https://www.nmr.mgh.harvard.edu/lab/ratailab

Project description and duties: We are looking for Harvard undergraduate students in Life Sciences who are interested in conducting research related to Neuroimaging.

Glioblastomas (GBM) are challenging cancers to treat, and positive clinical outcome in patients with recurrent glioblastoma multiforme continues to be low.  One of the most informative imaging tools to monitor treatment response or treatment failure in brain tumors such as GBM is magnetic resonance imaging (MRI).  MRI is a non-invasive technique primarily used in medical settings to produce high quality images of the inside of the human body. In addition, magnetic resonance spectroscopy (MRS) is a promising imaging technique that enables investigators to determine the presence and amount of specific metabolites. Thus, MRS provides information about the metabolic activity of tumors, and may give physicians critical insight into tumor activity.

Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688017/ and https://www.ncbi.nlm.nih.gov/pubmed/29902200

Skills required: No prior research experience is required 

Learning outcomes: This work will provide the candidate with research experience in neuroimaging. Mentees will learn, study design, data analysis methods (including MATLAB, R, LCModel, FSL, NordicIce, JMP etc.), presentations, and scientific writing. The work may lead to a conference abstract and papers and will aid in her/his future career as neuroscientist or physician.

Number of hours: Negotiable

Mentoring: The student will work under direct supervision of Dr. Eva-Maria Ratai who holds the title of Clinical Spectroscopist at MGH for >15 years. Furthermore, the candidate will work directly with MGH radiologists and neurologists on this project. The candidate will attend weekly group meetings.

Student stipend: Encourage application for Harvard fellowships https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Will support if student arranges it

Application information: Please email resume to eratai@mgh.harvard.edu

 

 

Undergraduate lab assistant position, Taute & Mathis labs, Rowland Institute at Harvard

Contact information: Dr. Katja Taute,  Rowland Institute at Harvard
100 Edwin H Land Blvd, Cambridge, MA 02142  
taute@rowland.harvard.edu  www.tautelab.org

Job description and duties:  The Rowland Institute at Harvard is looking for an undergraduate lab assistant to support the Mathis and Taute labs. The position encompasses 8-10h/week remunerated at $15/h, and is ideal for students seeking to gain exposure to biology labs. The Rowland Institute at Harvard is located on the Charles River near Kendall Sq. A travel stipend is available.

Tasks include

  • -           glassware cleaning,
  • -           sterilizing and disinfection,
  • -           waste management,
  • -           refilling supplies.

Requirements:

  • -           STEM background (ideally biology),
  • -           Attention to detail,
  • -           Reliability.

Training in sterile technique would be advantageous.

Learning outcomes:

  • -           exposure to biology lab environment,
  • -           sterile working techniques,
  • -           wet lab management,
  • -           general and biological laboratory hygiene.

Number of hours:       8-10 h/week

Mentoring:                  Training and supervision will be provided by postdocs in both labs.

Student stipend:         $15/h
Course credit:              no

Application information:

Interested candidates should contact Katja Taute (taute@rowland.harvard.edu) with a CV and a short statement of background and motivation.

 

Undergraduate Research Opportunity in Psychiatry/Psychology, Pizzagalli Lab, at McLean Hospital

 

Contact informationPI: Emily Belleau, Ph.D. and Diego Pizzagalli, Ph.D. will serve as supervisors. Dr. Belleau is a clinical psychologist and researcher. She is an Instructor of Psychiatry at Harvard Medical School and an Assistant Neuroscientist at McLean Hospital. Dr. Pizzagalli is a Professor of Psychiatry at Harvard Medical School and a Board of Honors Tutor member in the Psychology Department at FAS. He is the Director of the Laboratory for Affective and Translation Research (LATN), and the Center for Depression, Anxiety and Stress Research (CDASR) at McLean Hospital, which is where the research volunteer will work. McLean is the primary psychiatric teaching hospital of Harvard Medical School, and is recognized as the #1 Best Psychiatric Hospital in the country by U.S. News and World Report.

Contact for applicants: David Crowley, Manager of Lab Research Operations; phone: 617-855-4432, email: djcrowley@mclean.harvard.edu, address: McLean Hospital, 115 Mill St., Belmont, MA, 02478.

Website: cdasr.mclean.harvard.edu

Project description and duties:

Volunteer positions are available in the Laboratory for Affective and Translational Neuroscience (LATN), at McLean Hospital, directed by Diego A. Pizzagalli, Ph.D.  LATN is part of McLean’s Center for Depression, Anxiety and Stress Research, which embraces a multi-disciplinary approach to improve our understanding of the psychological, environmental, and neurobiological factors associated with affective disorders (http://cdasr.mclean.harvard.edu/).

We are currently seeking volunteers to help with a study in which we are examining the impact of stress on neurobiology in adolescents, and what makes some teens more vulnerable to experiencing depression. Adolescence is a particular sensitive window of development that is marked by heightened stress reactivity and vulnerability to developing mental health problems, such as depression. Accordingly, understanding stress-related neural dysfunction may be a valuable pathway for identifying individuals at risk for prolonged/recurrent major depressive episodes and facilitating ways to prevent MDD relapse at a critical developmental stage. With the use of functional magnetic resonance imaging (fMRI), we are examining neural functioning before, during, and after stress in female adolescents with and without MDD. Another aim is to investigate whether stress-related neural abnormalities in those with MDD predict changes in depressive symptoms three-month post-scan. Understanding neural dysfunction related to poor stress recovery in adolescent MDD may have implications for establishing MDD biomarkers that lead to earlier detection and intervention.

Volunteers will be involved in all aspects of the research including participant recruitment, observing and conducting phone screening, helping run participants through the study pipeline including conducting informed consent and guiding teen participants through the “mock scanner” to help make them comfortable with the scanning environment, as well as database management. The opportunity to learn and conduct data analyses are also available (questionnaire data, behavioral data, fMRI) , but will require a greater level of  time commitment to the lab in order to be trained on these types of analyses. Skills required: Candidates must be highly motivated and reliable. You will receive in-depth training in all the skills you’ll need to contribute to the research project. Our research focuses on humans with clinical mental health concerns, so experience working with human subjects in a research or therapeutic setting is preferred.  Experience conducting laboratory research in any discipline will also be desirable. 

Learning outcomes: laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing.  Specific learning outcomes will vary depending on your time commitment and on what interests and talents you bring with you.

Time commitment: . It is expected that volunteers will work 8-15 hours a week in the lab. Students will receive a considerable amount of training, so preference is given to applicants who can return for more than one semester. Traveling to and from McLean Hospital takes an additional 35 minutes via public transportation, so students should consider whether this can fit in their schedule before they apply.

Mentoring: Mentoring is an important part of the lab’s mission.  Students will work directly and continuously with Dr. Belleau, under the guidance of Dr. Pizzagalli. 

Student stipend: Our laboratory cannot provide any payment.  Students may apply to a variety of Harvard resources for supplemental financial support.

Course credit: Students may apply for course credit in PSY 910r or Neuorbio 98r.

Application information: Please visit the  “Current Openings” page on the lab’s web site at https://cdasr.mclean.harvard.edu/about/current-openings-2/to download the LATN Student Visitor Application form, and then send the completed form along with a copy of your CV to David Crowley at djcrowley@mclean.harvard.edu.

 

 

Undergraduate Volunteer Research Assistant Opportunity in Psychiatry/Psychology, Pizzagalli Laboratory at McLean Hospital and HMS

Contact information

PI: Matthew Sacchet, Ph.D., Instructor in Psychiatry, Harvard Medical School, is the supervising faculty member. McLean Hospital biography: https://www.mcleanhospital.org/biography/matthew-sacchet

Senior supervising faculty member: Diego Pizzagalli, Ph.D., Professor of Psychiatry, Harvard Medical School, is the senior supervising faculty member. Dr. Pizzagalli is a Board of Honors Tutor member in the Psychology Department at FAS.

Research location: Laboratory for Affective and Translation Research (LATN) in the Center for Depression, Anxiety and Stress Research (CDASR; directed by Dr. Pizzagalli) at McLean Hospital. McLean Hospital is the primary psychiatric teaching hospital of Harvard Medical School and is recognized as the #1 Best Psychiatric Hospital in the country by U.S. News and World Report.

Contact for applicants: David Crowley, Manager of LATN Research Operations; phone: 617-855-4432, email: djcrowley@mclean.harvard.edu, address: McLean Hospital, 115 Mill St., Belmont, MA, 02478.

Laboratory website: cdasr.mclean.harvard.edu

Project title  Mindfulness meditation and mental health

Description of project

Mindfulness meditation is a contemplative practice that targets the development of present-centered awareness and acceptance of psychological phenomena. Mindfulness is widespread in clinical psychology, the workplace, and general wellness and is associated with myriad health-related benefits. Mindfulness meditation-based therapies have been shown to be helpful for reducing depression and anxiety, in both community and psychiatric samples. To date little is understood regarding the psychological and biological mechanisms of action of mindfulness meditation for depression and anxiety. Understanding the mechanisms of action of mindfulness promises to provide a foundation for improved treatments. The objective of the current study is to advance our understanding of mindfulness meditation for depression and anxiety by investigating cognitive, affective, behavioral, neural, and psychoneuroimmunological (including epigenetic) effects of mindfulness practice. The project includes acquisition of magnetic resonance imaging (MRI) and electroencephalography (EEG) data from depressed and anxious patients before and after they have completed a mindfulness-based intervention or one of several control interventions. The project promises to provide new insights into the psychological and biological mechanisms of action of mindfulness meditation for depression and anxiety that will contribute to improved mindfulness-based treatments and thus better outcomes and reduced suffering for individuals with mental illness.

Description of student involvement

Interested students may become involved in this study in a number of ways across all phases of the research study, including but not limited to supporting aspects of protocol development, participant recruitment, and data acquisition (e.g., collecting EEG, blood samples, questionnaires, interviews from study participants, behavioral and cognitive tests). Depending on the interests, goals, and skills of prospective students and the duration of involvement it may be possible for students to take on additional opportunities including data analysis, software programming, paper writing, and increasingly self-directed projects. Such projects may be based on the current study dataset or datasets previously collected. If of interest to the participating student, the faculty project leader is prepared to provide mentorship toward application to graduate programs, including in research and/or clinical fields.

Skills required: Candidates must be highly motivated and reliable. Students will receive in-depth training in all necessary skills to contribute to the research project. Our research focuses on humans with clinical mental health concerns, so experience working with human subjects in a research or therapeutic setting is preferred while not required. Experience conducting laboratory research in any discipline is also preferred while not required.

Learning outcomes: Students will gain experience with laboratory and research skills including within the domains of study design, data analysis, presentation, and scientific writing. Specific learning outcomes will vary depending on what role the student contributes, which will be dictated by the student’s interests and talents. See also above section “Description of student involvement”.

Time commitment: Volunteers are expected to contribute 10 to 15 hours per week for at least two semesters.  Students will receive considerable training, so preference will be made for applicants who can contribute for two or more semesters. Traveling to and from McLean Hospital may take an additional 35 minutes via public transportation, so students should consider whether this can fit in their schedule before they apply.

Mentoring: Mentoring is an important part of the lab’s mission. Students will work directly and continuously with Dr. Sacchet, under the senior guidance of Dr. Pizzagalli. Students will be encouraged to attend general lab meetings as well.

Student stipend: Our laboratory cannot provide any payment.  Students may apply to a variety of Harvard resources for supplemental financial support (e.g., Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities)

Course credit: Students may apply for course credit (e.g., PSY 910r or Neuorbio 98r).

Application information: Please visit the  “Current Openings” page on the lab’s web site at https://cdasr.mclean.harvard.edu/about/current-openings-2/ to download the LATN Student Visitor Application form, and then send the completed form along with a copy of your CV to David Crowley at djcrowley@mclean.harvard.edu

 

 

Undergraduate Research Opportunity in the Henske Lab, HMS
PI: Dr. Elizabeth (Lisa) Henske, MD, Professor of Medicine
Brigham and Women’s Hospital, Harvard Medical School
Location: 45 Francis Street, Thorn Building, (Elevator D) Room 826, Boston, MA 02115
Website: https://www.henskelab.org/

Project Description: The Henske Laboratory is focused on the cell biology and biochemistry of rare genetic diseases, including Tuberous Sclerosis Complex (TSC) and lymphangioleiomyomatosis (LAM).  Dr. Henske is a medical oncologist who follows LAM and TSC patients in addition to directing a research laboratory.  Our mission is to translate research discoveries into improved care as quickly as possible, to improve the lives of those affected by these devastating diseases.  TSC is an autosomal dominant syndrome causing seizures, autism, and tumors of the brain, heart, kidney, skin, and lung.  LAM is a destructive, progressive cystic lung disease that affects almost exclusively women and can lead to lung collapse and respiratory failure.  LAM is caused by TSC2 gene mutations in benign tumor cells that metastasize to the lung.   The TSC proteins inhibit the activity of the mammalian target of Rapamycin (mTOR) kinase.

Some of the research topics covered in the lab:

•          Employing high-throughput screening methodologies to identify novel therapies for TSC and LAM.

•          Developing relevant in vivo models that recapitulate the clinical manifestations of TSC and LAM

•          Understanding how benign-appearing LAM cells metastasize to the lungs

•          Understanding the role of estrogen in the female-predominance of LAM

•          Studying how nutrients, such as lipids, glucose, and amino acids, are utilized by tumor cells that are deficient in the TSC2 protein

Links to published manuscripts and reviews describing our work:

https://www.ncbi.nlm.nih.gov/pubmed/27226234

https://www.ncbi.nlm.nih.gov/pubmed/27753446

https://www.ncbi.nlm.nih.gov/pubmed/28498820

https://www.ncbi.nlm.nih.gov/pubmed/28512249

https://www.ncbi.nlm.nih.gov/pubmed/25185584

https://www.ncbi.nlm.nih.gov/pubmed/25780943

https://www.ncbi.nlm.nih.gov/pubmed/24296756

https://www.ncbi.nlm.nih.gov/pubmed/21746920

Skills required: Prior research experience preferred but not required.

Learning outcome: students will acquire skills in experimental design, experimental techniques, lab data analysis, presentations, and scientific writing.  If warranted based on their contributions, students will be co-authors on scientific manuscripts. 

Number of hours: negotiable

Mentoring: Mentoring will be primarily provided by postdoctoral fellows in the laboratory. The student      will also have regular meetings with Dr. Henske, and attend weekly lab meetings and journal clubs and will have opportunities to present at the lab meetings and journal clubs.

Funding:  The Laboratory does not have funds to pay student stipends, but students are encouraged to apply to the HCRP and other fellowships or  register for a research course credit.

To Apply: Please email your resume to Dr. Henske at (ehenske@bwh.harvard.edu) with a cover letter including a brief outline of your interests, goals, and anticipated time availability.

 

 

Undergraduate Research Opportunity, Chung Lab, Mass Eye & Ear

Contact information: Yoojin Chung, PhD yoojin_chung@meei.harvard.edu
Eaton-Peabody laboratories Mass Eye & Ear
243 Charles St Boston MA 02114
https://researchers.masseyeandear.org/details/294

Project description and duties: Ongoing research in our group is aimed at improving perceptual performance with cochlear implants, particularly binaural implants. While normal-hearing listeners excel at understanding speech in noisy and reverberant environments, hearing-impaired and cochlear-implant patients often have difficulties in these adverse environments, even if they do well when facing a single speaker in a quiet room. To understand these differences between normal listeners and cochlear implant will require an integrated knowledge of the auditory processing of speech, binaural processing in the auditory brainstem, and how these mechanisms are altered by development and pathology. We are currently looking for a student to assist with histological processing of brain and cochlea tissue harvested from animals with differing degree of auditory experience during development.

Skills required: No prior research experience is required.

Learning outcomes: Students will learn techniques for histological processing of brain and cochlea including immunohistochemistry techniques. They can also participate in on-going neurophysiological experiments and assist with data analysis. There will be opportunities for presentation during the group meetings.

umber of hours: Flexible.

Mentoring: Students will be directly supervised by the PI. Students will be expected to attend bi-weekly group meetings, also encouraged to participate in journal club and department seminar series.

Student stipend: Students are welcome to volunteer, for funding please apply with the Harvard URAF fellowships: HCRP, PRISE, etc. Contact Research Advisor, Dr. A. Babakhanyan for more info at ababakhanyan@fas.harvard.edu

 

Undergraduate Research Opportunity, Dr. Hasan’s Lab, HMS, MGH

Contact information: Prof. Tayyaba Hasan, Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 40 Blossom Street, Bartlett Hall 314-B, Boston, MA 02114.

http://hasanlab.mgh.harvard.edu/ | http://wellman.massgeneral.org/faculty-hasan-pi.htm

Project description and duties: Photodynamic and Nanotechnologies for light-activated therapy- Therapeutics and Imaging

Most cancer-related deaths are associated with the multitude of disseminated metastatic lesions that occur throughout the body. These lesions are often far too small and widespread to detect and resect, and may become resistant to therapeutic intervention. Our long-term goal is to develop effective cancer therapy by using light-activated multifunctional drugs. Students will use state-of-the-art optical imaging to gain insights into the bio-physical barriers in drug delivery into tumors and learn synthesis of nanoscale drug carriers.

Project 1: Nanoscale drug delivery vehicles facilitate multimodal therapies of cancer by promoting tumor-selective drug release. The Hasan lab recently developed a photoactivatable multi-inhibitor nano-liposome that imparts light-induced cytotoxicity in synchrony with photo-initiated and sustained release of inhibitors that suppress tumor regrowth and treatment escape signaling pathways. Students will test this technique on state-of-the-art tumor cell cultures to develop and optimize spatiotemporal control of drug release whilst reducing systemic drug exposure and associated toxicities.

Project 2: Recent advances in 3-D cell cultures, organoids, and organ-on-chips promise to accelerate biomedical drug discovery without relying on experimental animals. The Hasan lab aims to develop, test, and apply various 3-dimensional tumor cell model for the development of photodynamic therapy. Students will conduct engineering molecular probes for multifocal imaging of complex biological samples and application of a unique video-rate hyperspectral microscopic imaging system.

Project 3: Study of photodynamic therapy induced immunological responses and development of high-resolution imaging.

This project is a unique combination of imaging and studying special effect of upregulation of immune system post photodynamic therapy treatment.

Project 4: Use of photochemical and photodynamic techniques for diagnostics and treatment of infections.

Students are encouraged to do a PUBMED search to look into these projects into bit more detail.  Link: https://www.ncbi.nlm.nih.gov/pubmed/?term=tayyaba+hasan

Skills required: Students with previous research experience or no research experience, both are welcomed in our lab.

Learning outcomes:  Laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing.

This opportunity will support career growth and provide with a sense of direction.

Number of hours/ Length of project: The work hours for the students are negotiable depending on the students’ interest, enthusiasm and performance. Their schedule will be considered while making this decision.

Mentoring: Students will be mentored by post-doctoral candidates in the laboratory.

The students can get involved in our weekly group meeting and other project related meetings. Students are required to be in constant touch with their mentors to resolve any issues or concerns, so to have a smooth internship and learning process.

Student stipend: Kindly apply for Harvard fellowships:https://lifesciences.fas.harvard.edu/research-opportunities

Funding sources for undergraduates conducting term-time research include the Harvard College Research Program (Fall deadline 9/17/19), the Faculty Aide Program, and the Federal Work-Study Program.

Course credit: NA

Application information:  Email your resume to Bernadette Vijayakanthan (bvijayakanthan@mgh.harvard.edu) and Mallika Priya (mpriya@mgh.harvard.edu).

 

 

Undergraduate Research Opportunity, Student Intern for Dr. Sansevere, Boston Children’s Hospital

 Contact information: Dr. Arnold Sansevere Department of Neurology Division of Epilepsy
333 Longwood Ave, 4th Floor  Boston, MA 02115
http://www.childrenshospital.org/research/researchers/s/arnold-sansevere

Project description and duties:

Electrographic seizures are common in critically ill neonates and children. Continuous EEG monitoring is necessary to their detection. In addition to the use of EEG for detection of seizures, the background provides important information for prognosis. Furthermore, advanced signal processing with quantitative EEG can aid in seizure detection and signals that indicate cerebral injury.

Student interns will abstract medical records of critically ill patients at high risk of seizure. Research places a focus on the impact of seizures, and seizure burden on developmental outcome. Our group in currently looking at the use of advanced signal processing to detect seizures and indicators of brain injury. The student will also be trained to interpret raw EEG and quantitative EEG in critically ill patients with a focus on indicators for seizure, development of seizure, and poor prognosis. The link below contains links to publications by Dr. Sansevere.

http://www.childrenshospital.org/research/researchers/s/arnold-sansevere

 Skills required:

  • Our lab accepts interns at all levels of study. We will train our interns on the specific projects.
  • Role primarily includes medical record abstraction
  • Includes screening for the appropriate targeted patient
  • Provides the experience of building a database and assisting with data entry using the RedCap database
  • No prior research experience required
  • Experience with REDCap is a plus

Learning outcomes:

  • Medical terminology
  • Clinical research skills and knowledge of good clinical practice
  • Data analysis methods using SPSS
  • Scientific writing of abstracts for professional conferences
  • Presentation of professional conference

Number of hours: Typically, student interns complete about 8-10 hours per week (during the school year), however we can always work with students to develop a schedule that fits with their academic commitments.

Mentoring: who will be mentoring the undergraduate, how often are mentorship meetings, and can the student attend group meetings?

Student interns will be under the direction of Dr. Sansevere, and will work with a postdoctoral clinical research fellow Dr. Melissa DiBacco. Students will meet with Dr. Sansevere weekly, and will work with Dr. DiBacco daily. Student interns are welcome to attend weekly lectures and monthly grand-round lectures if their schedules permit.

Student stipend: We do not have internal lab funding to pay a stipend. Students are encouraged to apply for fellowships through Harvard or other opportunities through organizations that would pay you a stipend. Harvard fellowship opportunities can be found at: https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Most interns in our lab are taking a research course for credit. We will need a letter of confirmation stating the dates of the semester and that the student will receive credit for the research conducted.

Application information: Interested applicants can send an email to Dr. Melissa DiBacco at Melissa.dibacco@childrens.harvard.edu explaining their interest and a copy of their resume.

 

 

Undergraduate Research Opportunity, The Fruit Fly Fight Club, Kravitz Laboratory, HMS

Contact information: Edward A. Kravitz, Department of Neurobiology, Harvard Medical School; contact: edward_kravitz@hms.harvard.edu ; Harvard Medical School, Armenise 1, rm 353; http://www.hms.harvard.edu/bss/neuro/kravitz/

Project description and duties: Male and female fruit flies (Drosophila melanogaster) fight in same sex pairings. Male fights go to higher intensity levels and end up in the formation of hierarchical relationships, while female fights commonly are at lower intensity levels and do not establish hierarchies. Our laboratory is using state of the art genetic tools that allow us to go to single identified neuron levels in brain in order to examine: the circuitry involved in triggering aggression in both sexes and examining the factors important in going to higher levels of intensity of aggression during fights. We manipulate all of these elements in freely behaving animals. Our plans for the immediate future are to record optogenetically from the neurons involved. As in all species, substances like amines (serotonin and dopamine) and peptides are important modulators of aggression. We have identified and partially worked out the circuitry involved with single pairs of serotonin neurons that facilitate going to higher levels of aggression in male fights (see Curr Biol. 2019 Jul 8;29(13):2145-2156)

Skills required: Desirable prerequisites are Introductory Genetics and Neurobiology, and we prefer students who might be interested in working on an honors thesis in the future. If interested please send a cv and names of potential recommenders to Dr. Kravitz.

Learning outcomes: Students will be given their own projects that will be part of the overall laboratory project. They will learn behavioral, genetic and immunohistochemical methods, present regular laboratory seminars, and attend local and national meetings in later years. Most students will generate a literature publication on their studies.

Number of hours students are expected to work, length of the project (paid or unpaid): We are interested in having one or two undergraduates working with us part time during the academic year (unpaid—up to 6 hrs per week) and full time (paid) in summers.

Mentoring: Students will work directly with a post-doctoral fellow and will be considered regular members of our laboratory.  This involves attending and delivering talks at weekly lab meetings, carrying fly stocks, performing and analyzing experiments, etc.

Student stipend: See above.

 

 

Research Opportunity to study the neuronal mechanisms underlying reproduction, Dr. Victor Navarro’s lab, BWH

Contact information:

Victor M Navarro. Medicine (Endocrinology), BWH 221 Longwood Ave, Boston

Tel: +1 617 525 6566 Fax: +1 617 582 6193

Email: vnavarro@bwh.harvard.edu Lab website: http://navarrolab.bwh.harvard.edu

Project description and duties:

Our lab focuses on the characterization of the central factors that regulate reproduction and metabolism including, but not limited to, Kiss1 neurons using a variety of genetic mouse models and viral delivery approaches. The student will be involved in the study of the neuronal mechanisms that the regulate reproductive axis, along with the neuronal circuitry that links different brain areas involved in reproduction. They will be involved in the development and maintenance of mouse colonies, performing anatomical studies, and the determination of gene and protein expression in the brain (PCR, in situ hybridization, immunohistochemistry, etc.). Characterization of a number of biological parameters that define reproductive functions will be required (e.g. fertility assessments, daily monitoring of puberty onset, body weight, behavior, etc.). The student will be expected to work in collaboration with other members of the lab but in an independent manner. Students will be encouraged to present their data at local and regional meetings, analyze their data and prepare them for publication.

Skills requiredPassion, dedication, commitment and ability to work with live mice. No prior research experience is required. Some coursework in neuroscience or biology would be helpful. Experience with MATLAB is a plus but not mandatory.

Learning outcomesThe student that joins our lab is expected to acquire knowledge of neuroanatomy and physiology of the neuronal networks that govern the endocrine system. Students will gain experience in the handling of mice and maintenance of animal colonies as well as in the planning and performing of experimental protocols, analysis and interpretation of results and presentation of the data in lab meetings and conferences.

Number of hours students are expected to work:  Negotiable
MentoringThe student will be mentored by myself and senior postdocs in the lab. Weekly meetings will be held.
Does laboratory provide any funds to pay student’s stipendNo stipend is provided so the student is encouraged to apply for fellowships.
Email your resume to vnavarro@bwh.harvard.edu
 

 

 

Undergraduate research opportunity, Cognitive Neuroscience Group (Dr. Yael Arbel), MGH Institute of Health Professions

Contact information: Dr. Yael Arbel, co-director Cognitive Neuroscience Group, Department of Communication Sciences and Disorders, MGH IHP, 79 13th Street, Boston, MA 02129. CNGLEAD@MGHIHP.EDU;  https://www.mghihp.edu/research/cognitive-neuroscience-group

Project description and duties: We are looking for a student to assist with data analysis of Eye-tracking and EEG data, and to conduct a literature review. No previous research experience is needed.

The Cognitive Neuroscience Group is a collaborative research group that uses behavioral and neuroscience methods to examine the relationship between learning, language ability, and cognitive factors. We use electrophysiological and eye tracking data to study typical and atypical learning across the lifespan and in different disorders (e.g., Developmental Language Disorder). The research assistant will have the opportunity to contribute to several research projects, including two federally funded projects focusing on the neural function associated with learning in typically developing children and children with developmental language disorders.

Duties: The research assistant will assist with data analysis of behavioral, eye-tracking, and EEG data, and will conduct a literature review related to attention and learning. EEG signal processing will include the use of Matlab based tool boxes for artifact detection/correction, latency jitter correction, and Principal Component Analysis (PCA). 

Skills required: excellent communication skills (verbal and written), background knowledge in cognitive neuroscience, ability to work independently and in a team. Preferred skills include: coding in Matlab, signal processing, eye-tracking data analysis, statistical analysis using SPSS or R, creating scripts in Excel and other programing. No research experience is required.

Learning outcome: The RA will receive training in data analysis of behavioral, EEG, and eye-tracking data. The RA will participate in weekly lab meetings that will include presentations by PIs, and students at all levels (PhD, graduate, undergraduate). The RA will gain understanding of research design related to the study of learning in individuals with typical and atypical cognitive profiles. The RA will have the opportunity to present at the biweekly CNG meetings and to participate in scientific writing

The RA is expected to work 10 hours per week on site. Our lab is located at the MGH Institute of Health Professions in the Charlestown Navy Yard in Boston.

Mentoring: The RA will be mentored by the Dr. Arbel and will interact with CNG members. The RA will attend weekly lab meetings, and weekly mentorship meetings with the PI.

Student stipend: Please apply for funding through the Harvard College Research Program (Fall deadline 9/17/19) https://uraf.harvard.edu/research-funding

 

 

Undergraduate research assistant, Dr. Aizenberg Lab, SEAS
Principal Investigator: Prof. Joanna Aizenberg
Amy Smith Berylson Professor of Materials Science
Professor of Chemistry & Chemical Biology
John A. Paulson School of Engineering and Applied Sciences
Email: jaiz@seas.harvard.edu
Lab website: https://aizenberglab.seas.harvard.edu/

Project 1. A water droplet deposited on a lubricated surface forms an annular wetting ridge near its base by syphoning oil from its vicinity. The shape of the wetting ridge and its dependence on viscosity, lubrication film thickness and droplet size is not fully understood. This work experimentally characterizes the dependence of the shape of the wetting ridge to the aforementioned parameters. The outcomes of this study will provide new understanding in the mechanics/motion of water droplets on lubricated surfaces.

Skills required: No prior research experience is required.

Learning outcome: Fluid mechanics, drop shape analyzer, image analysis, Matlab

Number of hours: Negotiable (2-4 h/wk expected)

Mentor: Solomon Adera  Postdoc (The Aizenberg Group)  Email: sadera@seas.harvard.edu

Funding availability: Yes. The student can also get course credit.

If interested, please email Solomon Adera (sadera@seas.harvard.edu)

 

Project 2. SLIPS condensation

Abstract: Vapor condensation is a ubiquitous phenomenon both in nature and in industry. In nature, we observe condensation when dew forms on a lawn grass in the morning hours. In industry, it is a useful in power generation, distillation, air conditioning, environmental control and refrigeration systems. Due to the high surface energy of metals, vapor condenses in a filmwise mode where the condensate forms a continuous liquid film that creates a thermal barrier. If the condensing surface is coated with a low surface energy promoter material, discrete droplets form, grow and shed rapidly due to gravity, allowing for the renucleation of small low-thermal-resistance droplets, in what is termed as dropwise condensation (DWC). Heat transfer rates during dropwise condensation in a saturated environment is 5-7 times higher than the traditional filmwise condensation (FWC). However, promoter coatings are not durable under vapor saturation conditions. Additionally, chemical and topographical inhomogeneities create defects where droplets can pin and transition to FWC. Similarly, microstructured surfaces are generally not suited for continuous dropwise condensation, as condensate can nucleate within the microstructures and remain in the wetting Wenzel state even after coalescence and growth. Only when the surface has nanoscale roughness (~ nm), can droplets form in the favorable non-wetting east-to-remove Cassie-Baxter state. Even then, dropwise and jumping droplet condensation can be achieved only for low supersaturations due to the presence of coalescence and flooding within structures once droplet nucleation densities approach the density of the nanoscale features. Recent advances in microfabrication techniques and functional coating enables a new class of surfaces termed as slippery liquid infused porous surfaces (SLIPS), which are suitable for dropwise condensation of both water and low surface tension fluids. Due to the absence of defects on SLIPS, condensate droplets have extremely low contact angle hysteresis, leading to enhanced shedding and rapid clearing of nucleation sites which increases the heat transfer coefficient. Additionally, the ultralow surface energy of the infused liquid, coupled with its low adhesion and atomically smooth interface enables stable dropwise condensation of low surface tension fluids, which is not possible with traditional hydrophobic promoter coatings. In this work, we will investigate the heat transfer coefficient of FWC, DWC, SLIPS condensation in a pure saturated vapor environment where noncondensable gases are absent.

Skills required: No prior research experience is required.

Learning outcome: Heat transfer, fluid mechanics, thermodynamics, Matlab

Number of hours: Negotiable (2-4 h/wk expected)

Mentor: Solomon Adera, postdoc (The Aizenberg Group), Email: sadera@seas.harvard.edu

Funding availability: Yes. The student can also get course credit.

If interested, please email Solomon Adera (sadera@seas.harvard.edu)

 

Project 3. Water harvesting

Abstract: Water is an abundant natural resource that covers three quarters of the earth’s surface. However, two-thirds of the world’s population is experiencing water shortage as per the 2017 report by the World Health Organization. In a similar report, the United Nations predicted that by 2030, 40% of the world population will experience water shortage. As climate change causes drought and desertification and global water consumption continues to rise due to higher standards of living, the population facing water scarcity is projected to reach 5 billion by 2050. Regions currently considered water-rich will experience water shortage in the coming few decades. This has renewal interest in atmospheric water harvesting (AWH) technology, which is the capture/collection of water that is present in ambient air either as vapor or micro droplets. Recently, enhanced atmospheric water harvesting inspired by the Namib desert beetle has been reported. A millimeter-size bump promotes droplet growth by directing vapor transport towards its apex (i.e., by creating a vapor concentration gradient that assists dewing). Furthermore, if the bumps are micro/nanostructured, functionalized and impregnated with a thin layer of lubrication film, droplet shedding can be facilitated. In this work, we experimentally investigate the effect of the dimensions of the millimeter-size bumps and their spacing on water harvesting.

Skills required: No prior research experience is required.

Learning outcome: Fluid mechanics, thermodynamics

Number of hours: Negotiable (2-4 h/wk expected)

Mentor: Solomon Adera, postdoc (The Aizenberg Group), Email: sadera@seas.harvard.edu

Funding availability: Yes. The student can also get course credit.

If interested, please email Solomon Adera (sadera@seas.harvard.edu)

 

 

 

Undergraduate Research Opportunity, Dr. Chen Lab, Schepens Eye Research Institute, MEE/MGH

Contact information:  Dong Feng Chen, MD, PhD
Department of Ophthalmology, Harvard Medical School
Schepens Eye Research Institute of Massachusetts Eye and Ear, 20 Staniford Street, Boston, MA 02114
Email: Dongfeng_chen@meei.harvard.edu  Tel: 617-912-7490
https://www.masseyeandear.org/research/investigators/c/chen-dong-feng

Project description and duties: 

The project will be focused on the understanding of mechanisms and immune regulation of neurodegeneration associated with retinal disease or injury and to develop a regenerative strategy for treating these disease conditions and reversing vision loss. The duties of the student may involve protein and DNA isolation and analysis, flow cytometry, cell culture, immunohistochemistry, bioinformatic and morphometric analysis, etc. See link to a representative published manuscript as below:

 https://www-ncbi-nlm-nih-gov.ezp-prod1.hul.harvard.edu/pmc/articles/PMC6086830/

Skills required: Are students expected to have any particular laboratory skills, if so which ones? If no prior research experience is required, state so to encourage applications from new undergraduate researchers.

No prior research experience is required but preferred.

Learning outcomes: laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing.

The student will be trained for laboratory skills including protein and DNA isolation and analysis, flow cytometry, cell culture, immunohistochemistry, bioinformatic and morphometric analysis, as well as learn to study design, data analysis, and presentations.

Number of hours students are expected to work, length of the project (if these are negotiable, state so):  negotiable.

Mentoring: Students will work closely on a daily basis with a senior or postdoctoral fellow in the lab; in addition, the PI will meet with the student weekly or as often as needed. The student will be required to attend the weekly lab meetings and give reports as well as formal presentations at the lab meeting.

Student stipend: Students are encouraged to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities or Faculty Aide Program, Federal Work-Study Program

Course credit: Students can also conduct research for course credit (however, a student cannot earn course credit and be paid a stipend in the same semester).

Application information: Email your resume to Dr. Dong Feng Chen at Dongfeng_chen@meei.harvard.edu

 

 

Clinical Research Experience at the Obsessive Compulsive Disorder Institute at McLean Hospital/Harvard Medical School

Contact information: Martha J. Falkenstein, PhD  Staff Psychologist
Administrative Director, Office of Clinical Assessment and Research
McLean Hospital OCD Institute
Instructor in Psychology, Department of Psychiatry, Harvard Medical School
EMAIL: mfalkenstein@mclean.harvard.edu
Lab website: https://www.mcleanhospital.org/programs/ocd-institute#research

Project description and duties:

The Obsessive Compulsive Disorder Institute (OCDI) at McLean Hospital is accepting applications for Student Visitors and/or Academic Credit Students interested in receiving clinical research training. The student will work with Martha Falkenstein, PhD, Jacob Nota, PhD, and Jason Krompinger, PhD, members of the research and clinical staff and faculty in Harvard Medical School. The student will be a part of the OCDI’s ongoing clinical research examining mechanisms underlying OCD and related conditions, as well as the effectiveness of our intensive/residential cognitive behavioral treatment program. The OCDI’s research mission is to excel in naturalistic clinical research that will directly improve the effectiveness of treatment for OCD and related conditions. For more information about the type of work we do, please see: https://www.mcleanhospital.org/programs/ocd-institute#research

This position would be an excellent fit for applicants interested in obtaining doctoral training in clinical or counseling psychology or psychiatry, and/or preparation for research assistant positions after graduation. Mentorship is an important part of our mission, and our previous students have been accepted into top graduate schools and earned authorship on presentations and papers.

Principal experiences include:

  • running the clinical participants through various study protocols
  • assisting in data management and archival data collection tasks related to the research program
  • assisting with literature searches, manuscript preparation, and presentations
  • participating in weekly research meetings; the student will meet with the principal investigators in both one-on-one and group formats

Prior experience with research and clinical populations is preferred, but not required.

We are located at the North Belknap building on McLean’s campus, accessible via MBTA 73 bus or Fitchburg Line commuter rail to Waverley Square stop. McLean is a short walk or is accessible via the McLean shuttle.

Skills required: Prior experience with research and clinical populations is preferred, but not required.

Learning outcomes: Research skills such as study design, data analysis methods, presentations, scientific writing, and learning how to interact with research participants who are patients in our psychiatric hospital program.

Number of hours At least 8 hours per week

Mentoring: who will be mentoring the undergraduate, how often are mentorship meetings,  and can the student attend group meetings?

Student stipend: Please note that we do not have the funds to pay students’ stipends and encourage students to apply for any relevant fellowships or register for research course credit.

Course credit: We can offer course credit

Application information: To apply, please send cover letter and CV/resume to: mfalkenstein@mclean.harvard.edu We will begin reviewing applicants for Fall semester immediately.

 

 

 

Undergraduate Research Assistant, Walsh Lab, Boston Children's Hospital

Laboratory Description: The Walsh Lab focuses on the genetics of neurodevelopment, and has previously identified genes through genetic sequencing and characterization of rare patients with cerebral malformations. The lab also focuses on the basic biology of neurodevelopment and uses combined sequencing tools to ask questions about neurodevelopment, such as about lineage of specific cell types. Currently seeking motivated undergraduate research assistant to join our team, we are located in Longwood Medical Area in the CLS building, and have had multiple undergraduate research assistants before.

http://www.walshlab.org/

Positon Description:

-       10-12 hrs/week for 2 semesters, with possible opportunity for full-time research work during summer if interested

-     Volunteer opportunity, but can be paid if Federal Work-Study student, will assist with applying for research funding for summer students; could also receive course credit for work

-       Work with MD/PhD student on specific, developed project on the genetics of neurodevelopment using mouse model; opportunity for co-authorship, and to develop personal project

-     Will be mentored directly by MD/PhD student in laboratory, but will also meet with PI on occasion

-       No previous research experience required, though previous laboratory experience is a plus; should have some background in science courses (intro biology and intro biology laboratory). We will teach you all the skills you need.

-     Ideal position for students interested in preparing for MD/PhD, PhD, or interested in preparing for MD programs with an interest in basic science research

-       Keywords: Neurodevelopment, Genetics, Imaging/Microscopy

If you are interested, please send and email with a CV to Christopher.Walsh@childrens.harvard.edu, and shyam_akula@hms.harvard.edu

 

 

Advancing coil design in micromagnetic stimulation, Dr. Bonmassar Lab, AA. Martinos Center Department of Radiology Harvard Medical School Massachusetts General Hospital

Micromagnetic stimulation (uMS) has several advantages over electrical stimulation. First, uMS does not require charge-balanced stimulation waveforms as in electrical stimulation. In uMS, neither sinks nor sources are present when a current is induced by the time-varying magnetic field, thus mMS does not suffer from charge buildup as can occur with electrical stimulation. Second, magnetic stimulation via µMS is capable of activating neurons with specific axonal orientations. Moreover, as the probes can be completely insulated from the brain tissue, we expect to significantly reduce the problem of excessive power deposition into the tissue during magnetic resonance imaging (MRI). uMS technology was first developed in our laboratory and is entirely based on commercial components off the shelf, which are readily available to researchers. However, commercial inductors are designed to maximize efficiency (Q-factor), which consists in trapping the generated magnetic field to minimize its losses. Furthermore, they do not allow for multiple coil design in small and complex 3D geometries as it is often needed in neuroscience applications.We will show uMS coils developments based on a new thin-film technology at the Center for Nanoscale Systems (CNS) Harvard University.

Requirements: The research is entirely performed at the Center for Nanoscale Systems (CNS), which requires training to gain access. More information on CNS can be found on the website: https://cns1.rc.fas.harvard.edu/. The skills that will be acquired by the students after completing the training and after performing research work are similar to the ones needed to manufacture MEMS. Students interested in this type of research and working at CNS are invited to contact us to learn the various options offered.

To apply contact: Dr. Giorgio Bonmassar, giorgio.bonmassar@mgh.harvard.edu
AbiLab Building 75, Third Ave Charlestown, MA 02129 Tel. (617) 726-0962 Fax (617) 726-7422
http://www.nmr.mgh.harvard.edu/abilab/

 

 

Posted Sep 3, 2019

Undergraduate Research Opportunity in 3D Bioprinting, Prof. Jennifer Lewis’ Lab, Harvard University

PI Name and Affiliation: Prof. Jennifer Lewis - Harvard John A. Paulson School of Engineering and Applied Sciences & The Wyss Institute for Biologically Inspired Engineering

Lab Website: https://lewisgroup.seas.harvard.edu/

Lab Location: 58 Oxford St. Cambridge, MA 02138

Project Description: 3D bioprinting of cancer-on-chip models

Skills Required:

·         Eagerness to learn.

·         Ability to work in a fast-paced laboratory setting.

·         Previous cell culture experience is preferable.

Learning Outcomes: The undergraduate researcher would be expected to assist in the bioprinting of 3D cancer models and gradually take on an independent project. Laboratory skills will include immunostaining, confocal microscopy, image analysis, and flow cytometry.

Number of hours: Minimum of 10-12 hours per week with at least one 4 hour block of time.

Length of the project: At least 6 months, and students who can commit to Summer 2020 would be highly preferred.

Mentoring: The undergraduate researcher will work closely with Postdoctoral Fellow Dr. Daniel Reynolds.

Student Stipend: This is an unpaid position. Interested students are encouraged to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities or research course credit.

Application information: please send CV/Resume to Dr. Daniel Reynolds at dreynolds@seas.harvard.edu

 

 

Undergraduate research opportunity in Cancer Biology with the Letai Laboratory

Contact information: Anthony Letai, Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School.  anthony_letai@dfci.harvard.edu. Located in Mayer Building in Longwood area.  https://letailab.dana-farber.org/

Project description and duties: Identifying therapeutic vulnerabilities in primary patient tumors. https://www.ncbi.nlm.nih.gov/pubmed/25723171

Skills required: Some experience in mammalian cell culture preferred.

Learning outcomes: Mammalian cell culture, high throughput fluorescent imaging, automated image analysis.

Number of hours Negotiable

Mentoring: Tony Letai, MD, PhD, and Patrick Bhola, PhD

Student stipend: Not for school year.  Yes for summer job. Encourage application for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Will support if student arranges it.

Application information: Please email resume to anthony_letai@dfci.harvard.edu and patrick_bhola@dfci.harvard.edu

 

 

Undergraduate Research Opportunity with the Stroke research, HSPH

Contact information: Ankur Pandya, PhD, Health Policy and Management (HSPH), anpandya@hsph.harvard.edu, 718 Huntington Ave 2nd floor (Longwood), https://www.hsph.harvard.edu/ankur-pandya/

Project description and duties: We are looking for a student to join the Stroke microsimulation for Health outcomes and Interventions to Evaluate policies for Long-term Decision-making (SHIELD) TEAM.
Stroke is a leading cause of death, disability, and healthcare costs in the United States. We are developing and applying the SHIELD model to quantify the key tradeoffs among health benefits, risks, and costs for any feasible stroke prevention or treatment policies. Example publications:

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2702211

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148106

https://jamanetwork.com/journals/jama/fullarticle/2396476

Skills required: No prior research experience is required. Familiarity with working with data, coding in R or C++, and literature reviews could help.

Learning outcomes: Public health research skills such as cost-effectiveness analysis and risk prediction modeling study design, in addition to essential research skills such as literature reviews and scientific manuscript/presentation preparation. Note we are not a wet lab nor do we conduct any research with human subjects -- instead, we work with secondary data and simulation modeling to evaluate the cost-effectiveness of stroke prevention and treatment policies.

Number of hours: 5 hours/week for at least 2 semesters (summer included).

Mentoring: The undergraduate will work closely with Dr. Pandya and Harvard PhD students on the project in addition to several academic physicians from Harvard Medical School and Weill Cornell Medical College who collaborate with the SHIELD modeling team. Student can attend weekly group research meetings, and have mentoring meetings 2-4 times per month with Dr. Pandya.

Student stipend: We can pay $15-20 per hour depending on tasks being performed.

Course credit: No expected to be applicable unless circumstances call and allow for it.

Application information: Email your resume and a short statement of interest to Dr. Pandya at anpandya@hsph.harvard.edu

 

 

Undergraduate Research Opportunity, Hodi Lab, Dana-Farber Cancer Institute

PI: F. Stephen Hodi, M.D., Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana 5th floor

Email: Stephen_hodi@dfci.harvard.edu

Telephone: (617) 632-5053

Description of the project and duties:

Our laboratory investigates human immunology and the development of immune therapies to treat cancer.  Two primary areas of potential projects and investigation exist. 

The first is to conduct screening and functional studies utilizing samples from patients receiving immune therapy to dissect what characteristics are involved with effective treatment and resistant mechanisms to immune therapy.  This involves standard and developed techniques assessing peripheral blood and biopsied tumor tissues.  Work will include analyses of peripheral blood specimens by CyTof to determine immunologic changes and competence.  Much of the work is utilizing samples from patients receiving immune checkpoint blockade.  This work may also include computational biology analyses working with data scientists to understand novel patterns of biologic responses from the datasets generated.

The second project involved improving our understanding of the interactions of angiogenesis (new blood vessel formation) and immune regulation.  Factors that are involved in making new blood vessels suppress particular parts of the immune system.  The blood vessels are also the gatekeepers in allowing immune cells to home into the tumor microenvironment.  Through various serologic screening methods we are able to identify candidate protein targets that have the potential dual roles of promoting new blood vessel formation (angiogenesis) and at the same time suppress the immune responses against tumors.   The laboratory efforts will involve assessing such factors with the goal to develop combinatorial approaches to treat patients with cancer.  Basic techniques of immunoblotting, cell culture may be used.  In addition, working with biomedical engineers to establish and utilize in vitro 3-dimensional platforms to study the effects of these agents on immune cell trafficking across blood vessels as well as the effects on innate immunity (e.g. myeloid cells).

The students with these projects will be conducting experiments to answer these questions.  This work would include and not limited to cell culture, immune assessments including flow cytometry, CyTof, immuno-blotting, cytokine functional assays, ELISAs, ELISPOTs, computer algorithms for computational biology working with data scientists.  It would be expected that the students will be taught how to perform these techniques and learn how to conduct this work with supervision.  Depending on the interest, a student may lead a project or portion of a project.  The student may also have opportunities to present at lab meetings or other scientific conferences, and become an author on publications.

•Skills required. (Are students expected to have any laboratory skills, if so what are they?) If no prior research experience is required, state so and it will encourage students to apply.

No prior research experience is necessary.

Learning outcome: laboratory skills, research skills: study design, data analysis method, presentations, scientific writing, etc.

The desire is for this experience to provide a foundation for developing laboratory technical skills, scientific methods, and experimental design.  In addition, exposure to the field of immunology and immune therapy.

 Number of hours students are expected to work, length of the project (if it is negotiable, state so)

Understanding the schedules of students, this is flexible.  We have a variety of project opportunities where the hours and time commitment can vary while still being productive and educational.  It would be important to have some dedicated time period (e.g 3-4 hours) in order to plan and participate in experiments as part of the educational experience.

Mentoring: who will be mentoring student day to day, how often are mentorship meetings, etc.

The student will have a PhD level staff scientist to guide, oversee, and instruct the daily activities.  The student would meet to review progress and for teaching every 1-2 weeks with the laboratory lead.

 Does laboratory provide any funds to pay student’s stipend? If not state that students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.

A moderate stipend may be possible and happy to discuss.  Encourage if interested and time permissive to consider research course credit with committed time for scientific development.

What information students need to submit and contact information for submitting this information: (ex. Email your resume to Dr. Smith at ….)

Please feel free to email inquiries and resume if available to Dr. Hodi at Stephen_hodi@DFCI.Harvard.edu

 

 

 

Undergraduate Research Opportunity, Dr. Schulman Lab, BIDMC

Contact information:  Sol Schulman, MD, PhD.

Divisions of Hemostasis and Thrombosis and Hematology and Oncology
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Center for Life Sciences, Room 950 
3 Blackfan Circle  Boston, MA 02215  sschulm1@bidmc.harvard.edu
https://hemostasis.bidmc.org/people/sol-schulman-md-phd/

Project description and duties:

Tissue factor (TF) binds blood coagulation factor VII/VIIa to initiate blood coagulation in humans. Inappropriate TF procoagulant activity underlies substantial human suffering, including that due to myocardial infarction, venous thromboembolism, cancer-associated thrombosis, and stroke. TF expression and activity must therefore be carefully regulated in vascular tissues to enable hemostasis following injury but prevent pathologic thrombosis. Despite decades of close investigation, the mechanisms by which TF expression and procoagulant activity are regulated on the vascular cell surface remain incompletely understood. We combine functional genomics, human and rodent genetics, cell biology, and protein biochemistry to dissect the TF-dependent initiation of blood coagulation. Because the contribution of cellular TF is not captured by clinical coagulation testing, these critical modifiers of human bleeding and thrombotic risk remain undetected in human populations.

Skills required: No prior research experience is required, though always welcome.  Additional opportunities are available for students with a background in computer programming (ie python).

Learning outcomes: Students will learn standard and state of the art laboratory techniques and analytical methods.  Students will be encouraged to take ownership of a feasible project with close mentorship and a goal to develop increasing independence over time as skills develop.  Students will gain experience presenting data in written and oral form.

Number of hours students are expected to work, length of the project.  Hours expected are variable.  In general it is expected that more senior students will have more time to commit to the laboratory during the academic year.  Committed students early in their training are especially encouraged, particularly if they seek to perform paid research over summers with the goal that the work will develop into a research for credit and thesis project in the junior/senior year.

Mentoring: who will be mentoring the undergraduate, how often are mentorship meetings, and can the student attend group meetings? Dr. Schulman will be the primary source of mentorship with weekly meetings and regular availability on demand.  Additional laboratory staff will provide a valuable resource for supplemental training regarding specialized techniques, etc. Students will be encouraged to attend and present at group and divisional meetings.

Student stipend: Can the research group pay a stipend to the student?

Students will not be paid during the academic year, but will be assisted in applying for summer research funding and can be supported through alternative sources if necessary.

Course credit: Another potential option for some students (typically juniors or seniors) is to conduct research for course credit; however, a student cannot earn course credit and be paid a stipend in the same semester.

My goal is that students will perform research for credit in the Junior and Senior year.

Application information: Detail the information students need to submit and the contact information for submitting this information:

Interested applicants should send your resume to Dr. Schulman at sschulm1@bidmc.harvard.edu

 

 

Undergraduate Research Opportunity at Spaulding Hospital Cambridge INSPIRE Lab for sensorimotor rehabilitation engineering

Dr. Randy Trumbower, PT, PhD; Asst Professor, Department of Physical Medicine & Rehabilitation at Harvard Medical School, Co-Director, Spinal Cord Injury Division

Contact: Stella Barth, clinical research assistant sbarth@partners.org 617-952-6822

Spaulding Hospital Cambridge, 1575 Cambridge Street, Cambridge, MA 02138  (half a mile down the street from the Science Center, also accessible via the MBTA 69 bus)

www.inspire-lab.org/

http://spauldingrehab.org/research-and-clinical-trials/INSPIRE_Lab/

Description of the project and duties: Specific projects for students are flexible and will depend on student interests and current staff projects; this is a dynamic and multidisciplinary lab that brings together physical therapy and engineering to better understand motor recovery after neurological injury

Observational and hands-on research experience are available; interested students will have the opportunity to interact with clinical research participants during study visits

Hiring for term-time, summer, or both

http://spauldingrehab.org/research-and-clinical-trials/INSPIRE_Lab/research

Skills required: No prior research experience necessary, just enthusiasm for the mission of the lab: to INSPIRE persons living with paralysis to move

All volunteers must complete onboarding through Spaulding Rehabilitation Network and online CITI training

Learning outcomes: Students will gain exposure to multiple ongoing clinical trials involving motor recovery after spinal cord injury. Depending on student interests and current staff projects, students may gain exposure to the following: recruitment and screening of study participants, scheduling participants, maintaining IRB documents and participant data, EMG data collection and analysis, Optotrak motion capture system and force plate data analysis, physical therapy assessments, engineering, MATLAB, coding, monitoring vital signs, saliva and blood processing and storage, managing lab purchases and expenses

Research skills: study design, engineering for research, an understanding of how clinical trials involving human subjects are run, research specimen collection and processing, literature review, data processing and analysis

Number of hours: Flexible hours, term-time and summer opportunities available, part-time or full-time volunteering

We are particularly interested in students who are able to make a long-term commitment (at least a few months) to helping the lab

Mentoring: Students will work directly with one or more of the following depending on research interests and current staff projects: postdoctoral fellows, engineers, physical therapists, clinical research coordinator and or clinical research assistant

This is an unpaid research opportunity. Students are encouraged to apply to HCRP, fellowships, and other funding sources

Please submit contact information, a CV or resume, and a brief statement of interest or cover letter (including term-time / summertime availability) to Stella Barth at sbarth@partners.org

 

 

Undergraduate Research Opportunity, Laboratory of Dr. Leo A. Kim, Mass. Eye and Ear/HMS

Contact information: Leo A. Kim, M.D., Ph.D., Department of Ophthalmology, leo_kim@meei.harvard.edu

Project description and duties: Our laboratory is currently looking for undergraduate researchers interested in investigating translationally relevant basic science questions looking at the pathophysiology of ocular diseasesSpecifically, our laboratory is interested in pathologic angiogenesis as it affects the retina and eye, as well as epithelial-mesenchymal transition as a complication of retinal detachment and eye traumaIn addition, we are investigating mechanisms of retinal toxicity of commonly used systemic medicationsThe research opportunity entails the use of both in vitro and animal models, as well as uncovering the cell signaling mechanisms underlying these processes in the eye. A list of laboratory publications is available herehttps://publons.com/researcher/1652681/leo-kim/

Skills required: No prior research experience is required.

Learning outcomes: Mentees will learn wet laboratory skills, study design, data analysis methods, presentations, and scientific writing.

Number of hours: Negotiable and variable as determined by the needs of the undergraduate.

Mentoring: Direct mentoring will be provided weekly by Dr. Leo Kim, a clinician-scientist at Mass. Eye and EarDaily mentoring by a senior research associate will be provided.

Student stipend: Previous undergraduate members of the laboratory have been awarded multiple research fellowships through Harvard and new students are encouraged to apply: https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Previous undergraduate members of the laboratory have received course credit.

Application information: Please email your contact information and a CV directly to Dr. Leo Kim at leo_kim@meei.harvard.edu

 

 

Undergraduate research opportunity, Dr. Millers Lab, MEEI

Contact information: John B Miller at the Retina Department, John_Miller@meei.harvard.edu, Mass Eye and Ear 243 Charles Street and 800 Huntington Ave,

Project description and duties: Conducting clinical research at Mass Eye and Ear, which includes recruiting patients, conducting visual tests and learning about the most recent technological advances in eye imaging.

Skills required: No prior experience needed.

Learning outcomes: clinical research skills, study design, data analysis methods, presentations, and scientific writing.

Number of hours Students are expected to work between 10-20 hours a week

Mentoring: Undergraduate will be mentored by Dr. Miller and the research fellow in the group. Mentorship meetings will be once every two weeks and student can attend group meetings at Mass Eye and Ear to learn further about ophthalmology

Student stipend: Unpaid position

Course credit: Can earn a course credit

Application information: Please email your resume and questions to Raviv_katz@meei.harvard.edu

 

Research Assistant: Genetics and Molecular Biology of Brain Tumors, Badr lab, MGH

We are seeking volunteer-based Research Assistants to join our group focused on brain tumor research at Massachusetts General HospitalThe lab, which is part of the MGH Neurology Department, is located in Charlestown, MA (149 13th Street, Charlestown, MA 02129). Our lab is focused on studying molecular aspects governing self-renewal and tumor initiation in brain tumor initiating cells and using this knowledge to develop targeted therapies for brain tumors.

We are seeking highly motivated students looking to gain hands-on experience in molecular biology, cell biology and cancer genetics. The incumbent of this position will receive daily mentorship, will be encouraged to attend local conferences, and participate in lab meetings, journal clubs etc. The student researcher will work on studying gene regulation and the molecular biology of brain tumors, particularly in the context of lipid and fatty acid metabolism. Previous experience in molecular biology techniques is desired but not required. Part-time candidates should be able to commit to a minimum of 20 hours/week.

Some of the key techniques involved in this research include:

  1. Mammalian tissue culture, including maintenance and propagation of primary patient-derived cancer (stem) cells as well as common laboratory cell lines
  2. RNA or protein isolation from cells. Quantitative RT-PCR on RNA or western blots on proteins.
  3. Cell based assays such as cell viability, flow cytometry and measurement of bioluminescence or fluorescence
  4. Implantation of tumor cells in mice, optical imaging of tumors and testing of new therapeutics in these mouse models.

    For more information about the project, please check our recent manuscript here, or visit our webpage.

Interested individuals should email a Resume and a brief description of research interest and career goals to Dr. Christian E. Badr (badr.christian@mgh.harvard.edu).

 

Undergraduate research opportunities in climate dynamics, SEAS

Project description: Harvard undergraduate students with a strong background in physics and math are invited to join us for research projects either during the summer or the academic year. Students will learn about and participate in climate dynamics research activities, including the study of climate variability and climate change, both natural and man-caused. Possible project topics range from global warming, El Nino, the large-scale oceanic thermohaline circulation, and cold past climates such as ice ages, and the preceding warm climates with implications to future climate change as well. Typical projects involve python/ Matlab programming and the analysis of climate models or observations. More information on our web page: http://www.seas.harvard.edu/climate/eli/Level2/research.html
Skills required: Strong background in physics and math, e.g., physics 15abc and math/ applied math 21ab, plus preferably CS50 or equivalent. Additional more advanced physics and math/ applied math courses are also very helpful, e.g., 100 level physics courses and applied math 104, 105, 120 etc.
Learning outcomes: a combination of some of the followings: climate dynamics, programming, simulation, data science
Number of hours: flexible
Mentoring: PI plus potentially also a graduate student.
Stipend: yes, possibly via https://www.seas.harvard.edu/climate/eli/oceanography-committee/
Course credit: possible in principle
Application information: email with cv, list of courses, anything else that the student feels is relevant.
Please contactEli Tziperman
Prof of Oceanography and Applied Physics
Department of Earth and Planetary Sciences and School of Engineering and Applied Sciences
eli@eps.harvard.edu
http://www.seas.harvard.edu/climate/eli

 

 

Computational epigenomics Undergraduate Research Opportunity, Dr. Shi Lab, Boston Childrens Hospital

Contact information: Dr. Yang Shi, Cell Biology department, yang_shi@hms.harvard.edu, http://www.harvardshilab.org/

Project descriptionand duties: integrative epigenomic data analysis and computational tools development

Skills required: basic knowledges in molecular biology, (epi)genetics, statistics, programming skills (R, Shell)

Learning outcomes: abilities to analyse, represent big data, and generate hypothesis from big data .

Number of hours students are expected to work, length of the project: negotiable

Mentoring: Dr. Lei Gu (Instructor at HMS, bioinformatician), how often are mentorship meetings is negotiable, and the student can attend group meetings.

Studentstipend: Encourage students to apply for Harvard fellowships

Application information: Email your resume to Dr. Gu at Leigu@broadinstitute.org

 

 

Undergraduate Research Opportunity, Brain Aging and Dementia Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, MGH)

Contact information: David Salat, MGH Radiology, salat@nmr.mgh,harvard.edu, 149 13th St, Charlestown MA, https://scholar.harvard.edu/bandlab/home

Please note that this work is at the Charlestown campus of MGH and not main hospital. Directions to our Center can be found here:

https://www.nmr.mgh.harvard.edu/about/directions

Project description and duties: Our laboratory examines brain imaging correlates of age related disease including cerebrovascular and Alzheimer's disease. Student researchers would become familiar with methods in neuroimaging research and clinical applications including involvement in participant study visits and would contribute to ongoing research through processing and analysis of existing and incoming imaging data.

See recent manuscripts from our laboratory:

https://www.sciencedirect.com/science/article/pii/S2213158218301748

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534349/

https://www.sciencedirect.com/science/article/pii/S2213158217300220

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321862/

Skills required: No prior research experience is required. Some experience in neuroscience, computer science, and/or biomedical engineering would be helpful but not required.

Learning outcomes: Neuroimaging data acquisition, processing, and analysis methods and basic and clinical applications of brain imaging, basic scripting/programming for data processing, neuroimaging research study design, study presentation, and scientific writing.

Number of hours It is expected that a minimum of 5 hours per week in the laboratory for one academic year would be necessary for training and completion of a limited project. However, there is some flexibility to this.

Mentoring: The PI (David Salat) will mentor in conjunction with senior lab members. The student would be invited to group meetings which occur twice weekly. Mentorship meetings are quarterly.

Student stipend: No stipend will be provided from the research group. We would encourage proposals for a stipend through the Faculty Aide Program, Federal Work-Study Program, or through Harvard fellowships.

Course credit: Work can be performed for course credit for qualifying course/programs.

Application information: Interested students should email their resume or questions to David Salat: salat@nmr.mgh.harvard.edu

 

Undergraduate Research Opportunity, Dr. Sabina Berretta Lab (Translational Neuroscience Lab., McLean Hospital)

Contact information: Sabina Berretta, M.D., s.berretta@mclean.harvard.edu, Division of Basic Neuroscience, McLean Hospital, https://www.mcleanhospital.org/biography/sabina-berretta

Project description and duties: Dr. Berretta and her group focus on the pathophysiology of psychiatric symptoms, using a combination of human brain postmortem work, in vitro and animal studies

Skills required: No prior research experience is required

Learning outcomes: laboratory skills including protein and mRNA detection and quantitative microscopy, research skills such as study design, data analysis methods, presentations, and scientific writing.

Number of hours students are expected to work are negotiable. Because of the nature of our studies, we require at least one semester and no less than 12 hours/week

Mentoring: Students will meet with Dr. Berretta on a regular basis and will work alongside and under the direct supervision of a senior researcher. They are encouraged to attend weekly lab meetings and to present their work at least once during their internship. Other possibilities to present their research at McLean Research Day and Harvard Psychiatry Day (if appropriate) can also be considered.

Student stipend: A stipend may be available for non-credit students with some relevant lab experience. Students are also encouraged to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities

 

Coursecredit: Another potential option is to conduct research for course credit; however, a student cannot earn course credit and be paid a stipend in the same semester.

Application information: Please email your resume and a cover letter to Dr. Sabina Berretta (s.berretta@mclean.harvard.edu)

 

Posted Aug 29, 2019

 

Undergraduate Research Opportunities in Astrophysics, Harvard-Smithsonian Center for Astrophysics

The Harvard-Smithsonian Center for Astrophysics (CfA, http://www.cfa.harvard.edu/), located at 60 Garden Street opposite the Quadrangle, is one of the world’s great centers for research in astrophysics, with over 300 scientists and access to powerful astronomical observatories worldwide and in space. The Harvard-Smithsonian has at any one time 10s of senior scientists interested in working with undergraduates and have defined their projects here: https://astronomy.fas.harvard.edu/files/astronomy/files/cfa_research_undergrad_2019.pdf

 

 

Harvard has several programs to provide partial support for student research, described at: http://uraf.harvard.edu/ If you have questions about getting involved in research at the CfA, please do not hesitate to contact me. Best wishes, Karin Öberg, Director of Undergraduate Studies, Astrophysics Professor of Astronomy Harvard University koberg@cfa.harvard.edu 617-496-9062 P-346

 

Undergraduate Research Opportunity, Dr. Ghebremichael Lab, Ragon Institute of MGH, Harvard, MIT

Contact information: Dr. Musie Ghebremichael, musie_ghebremichael@dfci.harvard.edu, 400 Technology Square, Cambridge, http://www.ragoninstitute.org/portfolio-item/ghebremichael/

Project description and duties: The research focus of the lab focuses on mathematical/statistical modelling of HIV/TB Data.

Skills required: Knowledge of  R or Python is a plus

Learning outcomes: Data analysis methods, presentations, and scientific writing.

Number of hours students are expected to work, length of the project: Negotiable

Mentoring: Student will meet with the PI weekly and will present findings to other lab members

Student stipend: Non paid position. Students are encouraged to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities

Course credit:  Students can conduct research for course credit

 Application information: Please email a CV or resume and a description of previous experience, research motivation, and career goals to Dr Ghebremichael

 

 

Undergraduate research opportunity in Dr. Ionescu lab in Harvard School of Dental Medicine

PI name: Andreia Ionescu, Department: Developmental Biology, Harvard Medical School

Contact information:

Tel: 617-432-1358,

Email: andreia_ionescu@hms.harvard.edu
Location: 200 Longwood Ave, REB 414, Dev Bio

Lab website: https://hsdm.harvard.edu/ionescu-lab

 

Description of the project and duties

Cartilage traumatic lesions heal poorly due to the low regenerative/repair ability of the resident cells and a shortage of a blood supply that could deliver both potential progenitor cells as well as biomolecules that could help with repair. In children, injuries to the growth plate cartilage result in growth arrest, formation of a “bony bar” and limb length discrepancies. In adults, injuries to the articular cartilage lead to the development of Osteoarthritis (OA), a painful joint disease, characterized by progressive and irreversible deterioration of the articular cartilage. Novel therapeutic strategies are needed to prevent cartilage degeneration and to stimulate the endogenous progenitor cells to help with regeneration and healing.

Dr. Ionescu’s lab seeks to discover new biomarkers to help label, identify and study the endogenous cartilage stem cells for either growth plate or articular cartilage. We have recently discovered a novel marker for growth plate cartilage stem cells. By performing lineage tracing, IHC, cell isolation and RNA-seq, we seek to label, characterize and follow the trajectory of these stem cells during postnatal development and in response to injury. This is a new area of research, which, if successful, it would support the development of bioengineering strategies for physeal cartilage regeneration.

Student duties: The student will perform various experiments such as lineage tracing analysis, fluorescence microscopy, histological assessment of cartilage degeneration/regeneration, immunofluorescence with tyramide amplification for various stem cell markers. The student is expected to come in time, prepare necessary materials for their experiments, generate data, and make well-documented laboratory notebook for record keeping and data analysis. The students will participate in various laboratory meetings and discussions.

Skills required: We prefer students to have basic molecular biology/histology laboratory skills, but it is not required. No prior research experience is necessary. We will provide experimental and theoretical trainings to gain their research skills.

Learning outcome: The student will acquire knowledge and expertise on stem cells and cartilage regeneration via experiments, literature reading, and scientific discussions. The student will have opportunity to present their work during weekly project meetings and lab meetings. Depending on the progress on the project, the student will be considered to become co-author on the publication.

Number of hours students are expected to work, length of the project: We expect that the student will  spend ~16 hours per week. However, it is negotiable based on students’ needs. The project will be 1-2 semester length but can be extended with new discoveries and student’s performance and needs.

Mentoring: The student will be primarily mentored by a postdoctoral fellow in Dr. Ionescu’s group, who will be responsible for scientific, technical and experimental training of the student. Dr. Ionescu will also work closely with the student and provide scientific guidance and mentoring.

Stipend: The laboratory does not provide funding to pay student’s stipend. We encourage students to register for a research course credit and for their senior thesis. In addition, Dr. Ionescu will work very closely with the student to support their fellowship applications such as the HCRP and other fellowship opportunities (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu). In the past, we have had a very high success rate of our undergraduates securing fellowship funding.

If you are interested in, please send your resume to andreia_ionescu@hms.harvard.edu to set up a meeting.

 

 

Undergraduate Research Opportunity in lncRNA-directed drug discovery in Melanoma (Novina Lab)

Contact informationleon_wertlamas@dfci.harvard.eduNovinaLAB@dfci.harvard.edu

Hospital: Dana-Farber Cancer Institute 

(Note: location = Longwood campus)

Project description and duties:

Long non-coding RNAs (lncRNAs) are a special class of genes which only make RNAs but do not code for proteins. Although many of them have been implicated in cancer and other diseases, very little is understood about these lncRNAs function. To discover how lncRNAs work, we developed a specialized lncRNA-based assay (called Y3H) which systematically defines disease key lncRNA-protein interactions. We have  also developed a platform to screen for drugs that disrupt these key lncRNA-protein interactions, which we anticipate will become a novel class of RNA-directed drugs. Students will operate both platforms and perform downstream experiments with the identified targets and drugs, to obtain lead drug candidates for oncologic and hematologic diseases.

Skills required: none required, but some lab experience is preferred

Learning outcomes:

Students working on this project will learn basic RNA and protein biochemistry and molecular biology techniques (e.g. cloning, cell culturing, transfection, flow cytometry) and state-of-the-art experimental techniques, (e.g. robotics, next-generation sequencing, and high-throughput drug discovery platforms). An important aspect of training in the Novina lab is learning to conduct translational research using clinical samples, advanced technologies, computational methods, and humanized model systems. This internship will provide a multi-discipline training environment that leverages basic, clinical, and industry collaborations which will provide diverse career opportunities.

Number of hours students are expected to work: minimum of 10 hours per week

Length of the project: minimum of 6 months (the longer the more you will get out of it)

Mentoring: Dr. Novina, Dr. Wert-Lamas, and other senior postdocs in the lab actively mentor students through weekly meetings, lab group meetings, and one-on-one interactions. You will be welcome to join our lab meetings.

Student stipend: This is a volunteer position or for credit position. We would also be happy to help you apply for relevant fellowships (contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu for more info on fellowships).

How to apply: send a copy of your CV by email to  : leon_wertlamas@dfci.harvard.eduNovinaLAB@dfci.harvard.edu

 

 

Undergraduate Research Opportunity, McLean Geriatric Psychiatry Research Program, McLean Hospital

Contact information: Dr. Forester and Rose May, rmay@mclean.harvard.edu, Mclean Hospital

Project description and duties:

The Geriatric Psychiatry Research Program, directed by Dr. Brent P. Forester, addresses cutting edge research questions in the areas of dementia and mood disorders using new neuroimaging techniques, clinicopathological correlations, and other study methods. Current studies include a number of Sponsor-led Alzheimer's Disease clinical drug trials, longitudinal analyses of older adults with depression and bipolar disorder, and neuroimaging studies focused on cerebral blood volume and brain network mapping in patients with Alzheimer’s disease.

This internship is geared towards students interested in gaining both clinical and research experience. Our interns are expected to be able to interact directly with patients in our studies. For example, our interns get the opportunity to provide companionship to patients while they receive their IP infusions, gaining invaluable clinical experience while simultaneously learning firsthand about the different stages of Alzheimer’s disease. They also are expected to enter data from study visits into our database and assist in the data analysis process for several of our studies (see other responsibilities listed below).

Our program views this internship as a learning experience for our student visitors. As such, in addition to intern responsibilities, students will also have the opportunity to observe study visits, learn how to administer neuropsychological batteries, speak with PIs about future career directions, attend grand rounds at the hospital, and learn about the research process.

Skills required:

  • Strong desire and willingness to learn
  • Interest in research, medicine, psychiatry, clinical psychology, neuroscience, biology, or psychology
  • Ability to come onto site for at least 10 hours a week (schedule is flexible!)
  • Comfortable interacting directly with study participants (clinical experience is preferred but not required)
  • Previous research experience
  • Proficient computer skills
  • Ability to learn new database and stats programs if needed

Learning outcomes:

  • Learn how to administer neuropsychological batteries
  • Media design and upkeep
  • Shadow study visits and learn about the research process
  • Attend didactic learning sessions

Number of hours: 10 hours/week

Mentoring: Mentorship opportunities are available

Student stipend: N/A

Course credit: Case-by-case basis

Application information: Please contact Rose May at rmay@mclean.harvard.edu or (617) 855-3192 if you are interested in applying!

 

 

Undergraduate Research Opportunity, Professor Fishman Lab, Harvard Stem Cell and Regenerative Biology Department

Contact information: Dr. Mark C. Fishman, Harvard Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Sherman Fairchild Building, Lab Website

Project description and duties: Zebrafish studies on genetics of social behavior

Skills required: No prior experience required

Learning outcomes: laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing.

Experimental design, methodologies for genetic and behavioral analysis

Number of hours Can be discussed

Mentoring: Mentoring by Professor Fishman and post-docs in the lab

Student stipend: None

Course credit: Yes

Application information:  Brief paragraph on interest, major, and courses taken to date. Email to Emily Andrews (emily_andrews@fas.harvard.edu)

 

 

Undergraduate research opportunity at the Histology Lab, Martinos Center for Biomedical Imaging, Massachusetts General Hospital

PI: Jean Augustinack, Ph.D.

Department of Radiology, Martinos Center for Biomedical Imaging

149 13th St. Suite 2301

Charlestown, MA 02129

jean@nmr.mgh.harvard.edu

The student will contribute to a histology project that aims to map neuropathology of Alzheimer’s disease in human brain in a preclinical phase, using a whole pipeline of tissue processing and a variety of different histological stains. The histologic stains will be correlated with high resolution ex vivo MRI to improve neurodegenerative disease diagnosis in in vivo neuroimaging. Additional projects may include manually labeling brain structures in in vivo MRI to produce and improve anatomical boundaries in brain parcellation software. Depending on the student researcher's interest, skill, and work habits, the work can also focus on new avenues of preclinical research in Alzheimer’s disease.

Prior experience working in a laboratory is desired but not required.

The student will gain experience in neuroanatomy, histology and general tissue processing of the human brain. Depending on progress and interest, the student may also assist with preparing conference abstracts and publications.

Project duration and hours per week are negotiable.

Dr. Augustinack will mentor the undergraduate student. There will be opportunity to participate in weekly group meetings, give presentations, and receive one-on-one mentoring as needed.

Students are encouraged to apply to the Harvard College Research Program and other fellowships or register for research course credit.

Please email a resume and a short (one paragraph) description of your research interests and career goals to Dr. Augustinack (jean@nmr.mgh.harvard.edu).

 

 

Undergraduate Research Opportunity, Shivdasani Lab, Dana-Farber Cancer Institute

Contact information:     Ramesh A. Shivdasani, MD, PhD Professor of Medicine ramesh_shivdasani@dfci.harvard.edu
44 Binney Street, Dana 720  
Boston, MA 02215  Ph. (617) 632-5746  www.shivdasanilab.dana-farber.org

Project description and duties: The laboratory studies how transcription factors and chromatin states act to generate and maintain unique cell identities. The dominant model is the mouse gastrointestinal tract, where the group investigates molecular mechanisms of embryonic development and the gene regulatory basis of adult stem cell functions. Recent publications (some with undergraduate authors) include

https://www.ncbi.nlm.nih.gov/pubmed/24413398

https://www.ncbi.nlm.nih.gov/pubmed/27111282

https://www.ncbi.nlm.nih.gov/pubmed/27212235

https://www.ncbi.nlm.nih.gov/pubmed/27524622

https://www.ncbi.nlm.nih.gov/pubmed/28648363

https://www.ncbi.nlm.nih.gov/pubmed/29321178

https://www.ncbi.nlm.nih.gov/pubmed/30366903

https://www.ncbi.nlm.nih.gov/pubmed/30905509

https://www.ncbi.nlm.nih.gov/pubmed/31263286

A well-defined project will be crafted based on students’ particular interests, skills, and time commitment. 

Skills required: Working familiarity with research laboratory environments (through prior exposure such as a high school or college summer internship) and at least two of the following college courses completed: Biochemistry, Cell Biology, Genetics, Developmental Biology.

Learning outcomes: Mastery of technical skills in routine molecular biology, cell biology, animal handling, and microscopy. Students will also develop core research skills in framing a project, designing controlled experiments, analyzing and interpreting data, presenting research findings, and scientific writing (e.g., honors thesis, publication in scientific journals, descriptions for a lay audience).

Number of hours: Negotiable. A useful guideline is >10 hrs/week.

Mentoring: Direct mentoring will be provided by a senior postdoctoral fellow, with Dr. Shivdasani’s active involvement. Student can attend (and make oral presentations in) group meetings.

Student stipend: Students are encouraged (and supported) to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Juniors and seniors may earn academic credit and are especially encouraged to consider basing an honors thesis on research conducted in the laboratory.

Application information: Please email Dr. Shivdasani at ramesh_shivdasani@dfci.harvard.edu

 

 

Undergraduate Research Opportunity, Dr. Lois Choi-Kain’s Lab, McLean Hospital

Contact information: The Principal Investigator is Dr. Lois W. Choi-Kain, Gunderson Personality Disorders Institute, McLean Hospital / Harvard Medical School.

Please contact Gabs Ilagan at gilagan@partners.org with any questions.

Project description and duties:

We are looking for an undergraduate research assistant to support research on developing accessible and affordable pathways to care for individuals with borderline personality disorder (BPD), a prevalent psychiatric disorder characterized by interpersonal sensitivity, affective instability, and impulsivity. Our group is located on McLean Hospital’s main campus (115 Mill St, Belmont, MA 02478), with many clinical activities centered around our Cambridge location (625 Mt Auburn St, Cambridge, MA 02138). Our group, formerly headed by the late Dr. John Gunderson, holds a vested interest in the dissemination of good psychiatric management (GPM), a “generalist”, easily learned intervention to treat BPD against a backdrop of expensive and often inaccessible care models. We are also interested in comorbidities of BPD, including PTSD, and are collaborating with partners in Germany and at McLean Hospital to conduct a trial of dialectical behavior therapy for PTSD with a focus on psychophysiological responses to exposure treatment. Particularly high-yield days for a student to come in would be on Tuesdays at McLean Hospital and Fridays at our Cambridge location, although there is flexibility with this schedule.

 

We are looking for a highly motivated student with a demonstrated interest in psychiatric disorders to assist with data analysis and literature-review-based research (e.g., systematic reviews/meta-analyses). Ongoing projects include a study of the interplay of social cognitive, neuropsychological, and attachment factors in BPD, a review of “generalist” treatments for BPD, brief treatment options for BPD, and a systematic review and meta-analysis of smartphone-based interventions for BPD and related symptomatology. In addition, we will require assistance with office administrative duties related to the responsible conduct of research.

Skills required: Demonstrated interest in clinical work (e.g., medicine, clinical psychology, clinical social work) is strongly recommended as the position provides ample opportunities for shadowing diagnostic interviews, clinical rounds, case discussions, and supervision meetings featuring footage of individual sessions. Previous experience in literature review and statistical techniques relating to biomedical and psychological research is desired, but not required.

Learning outcomes: research skills (e.g. data presentation, scientific writing)

Number of hours: 10 hours/week for Fall 2019

Mentoring: Dr. Lois Choi-Kain will be mentoring the undergraduate. Mentorship meetings would be weekly depending on the day the student is working. Students can attend group meetings.

Student stipend: Unpaid

Course credit: Possible

Application information: Send a resume and cover letter with detail on past experiences and how this position would help you achieve your future professional goals to Gabs at gilagan@partners.org.

 

Undergraduate Research Opportunity, Dr. White Lab, MGH East – CNY

Contact information: Kristin White – Cutaneous Biology Research Center, MGH

Massachusetts General Hospital
Cutaneous Biology Research Center
Building 149, 13th Street
Charlestown, MA 02129
Tel: (617) 726-4440
Fax: (617) 724-4453
Email:
kristin.white@cbrc2.mgh.harvard.edu

http://dms.hms.harvard.edu/BBS/fac/WhiteKristin.php

Project description and duties: Our lab is interested in taking on an undergraduate research student to investigate the regulation and physiological impact of a novel form of stem cell quiescence that occurs in the Drosophila nervous system. We recently published a paper describing the entry of neural stem cells into a quiescent state during the G2 phase of the cell cycle, in contrast to a canonical G0 quiescence that occurs in G1 phase (Harding & White, Dev Biol 2019). An undergraduate researcher taking on this project would perform genetic crosses, nervous system tissue dissections and immunostaining of fixed Drosophila embryos, as well as confocal microscopy and image analysis. The student would also be responsible for common lab duties including passage of fly stocks and capping fly food vials, as well as presentation of their ongoing work at group meetings. A student joining our lab would gain experience with Drosophila as a model organism and learn about the embryonic development of Drosophila. The fly is an ideal model system for short to medium-term student research projects due to its rapid development and the wide availability of genetic and molecular tools.

Skills required: No previous experience is required. However, some coursework related to basic genetic and molecular biology principles (including gene regulation and cell cycle dynamics) would be beneficial.

Learning outcomes: An undergraduate researcher would be expected to gradually take on independent responsibility for experimental design over the course of the project, providing them with valuable skills in time management and experimental planning. Laboratory skills would include tissue fixation and preparation for immunostaining, genetics, confocal microscopy and quantitative image analysis. The student would also be expected to present their findings as updates at group meetings, as well as in one-on-one meetings with the PI. Depending on the research progress and outcomes, the student would be encouraged to materially contribute to a scientific publication by writing up their results and interpretations.

Number of hours Minimum 10-12 hours per week, length of the project is open pending research findings. This time commitment may be different for students interested in applying their research to course credit.

Mentoring: The undergraduate student would be directly mentored by a 5th year Harvard BBS graduate student. Mentoring meetings with the graduate student would occur weekly or as needed, research update meetings with the PI would occur on a weekly basis. The student would be expected to attend weekly group meetings, within scheduling constraints.

Student stipend: This position is unpaid – the research group will not be providing a stipend. Students may choose to work in the lab as a volunteer or for course credit. Interested students are encouraged to apply for Harvard undergraduate research fellowships – both the mentor and PI are available to aid students in putting together an application for the September deadline. https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: This lab is Harvard affiliated, so research conducted here may qualify for course credit pending approval by the student’s concentration advisor.

Application information: Interested students are encouraged to send their resume to Dr. Kristin White (kristin.white@cbrc2.mgh.harvard.edu). Applicants will be interviewed by the mentor and PI to discuss potential project lengths and scheduling before joining the lab.

 

 

Posted Aug 23, 2019

Research Assistant/Student Programmer, The Speech and Feeding Disorder Lab (Dr. Jordan Green), MGH Institute of Health Professions

PI: Dr. Jordan Green

79/96 13th Street, Boston MA 02129

https://www.mghihp.edu/research/speech-and-feeding-disorders-lab

Questions? Please contact the SFDL Lab Manager, Brian Richburg at brichburg@mghihp.edu

Description of the project and duties (link to published manuscripts describing the work)

The Speech and Feeding Disorders Lab is looking for someone experienced in Matlab programming to help us maintain and expand a series of scientific scripts in use by the lab. These scripts involve basic signal processing and the calculation of statistics time-series data, including acoustic (audio) and kinematic (movement) signals.

The SFDL is dedicated to advancing knowledge and clinical practice through basic and applied research on speech & swallowing disorders. Some of our current projects include tracking facial motor function after facial transplant, studying bulbar symptoms in people with ALS, and using new camera technology to develop assistive communication devices for people with speech impairments.

You can access a list of recent publications here.

Skills required: No prior research experience is required. Students should have experience programming in Matlab including signal processing, 3D biomechanical analysis, and graphic user interface design.

Learning outcome: Students will have the opportunity to apply their programming knowledge to real-world research data related to speech disorders arising from neurologic impairment. Students will gain familiarity with a variety of research methods and data analysis routines for studying facial biomechanics, which may include processing data from: Motion capture, electromagnetic articulography, acoustic analysis and EMG data.

Mentoring: who will be mentoring student, how often are mentorship meetings, etc.:

Students would be expected to work approximately 10 hours per week.

After the initial training, students will have weekly meetings with the lab manager. Depending on the project selected, the student may be assigned to work with a Doctoral student or Postdoc on a research project.

Compensation: Yes, research assistants will be paid an hourly rate of $15.

To apply: please email your resume to Brian Richburg at brichburg@mghihp.edu

 

 

 

 

Undergraduate research opportunity at the Laboratory for Computational Neuroimaging, Martinos Center for Biomedical Imaging, MGH

PI: Anastasia Yendiki, Ph.D.

Martinos Center for Biomedical Imaging

149 13th St. Suite 2301

Charlestown, MA 02129

ayendiki@mgh.harvard.edu

http://scholar.harvard.edu/a-y

The student researcher will contribute to a project that aims to map connections in the human brain, based on a combination of in vivo diffusion MRI brain scans with prior information from microscopic resolution ex vivo MRI and optical imaging. Brain pathways will be labeled manually to produce training data for an automated image analysis algorithm. Algorithms developed by our team learn the anatomical neighborhood of the pathways from such training data and then reconstruct the same pathways automatically in novel data sets. Depending on the student researcher's interests and skills, the work can focus more on neuroanatomical exploration of the in vivo and ex vivo data, software development, or both.

Prior experience working in a Unix-based computer environment is desired but not required.

The student will gain experience in neuroanatomy and in the analysis of neuroimaging data. Depending on progress and interest, the student may also assist with preparing conference abstracts and publications.

Project duration and hours per week are negotiable.

The student will be mentored by Dr. Yendiki and a postdoctoral research fellow. There will be opportunities to participate in weekly group meetings, give presentations, and receive one-on-one mentoring as needed.

One of our past interns has described her experience here:

https://lifesciences.fas.harvard.edu/blog/undergraduate-researcher-profile-nivedita-ravi-neuroimaging-project

Students are encouraged to apply to the HCRP and other fellowships or register for research course credit.

Please email a resume and a short (one paragraph) description of your research interests and career goals to Dr. Yendiki (ayendiki@mgh.harvard.edu). 

 

Posted Aug 8, 2019

Undergraduate research volunteer in Anxiety and Traumatic Stress Disorders Lab

 

Elizabeth Olson, Ph.D.

Anxiety and Traumatic Stress Disorders Laboratory (ADLab)

Center for Depression, Anxiety and Stress Research (CDASR)

McLean Hospital / Harvard Medical School

115 Mill St., Belmont, MA

https://cdasr.mclean.harvard.edu/atsd/

 

Description of project and duties: Our lab has multiple current neuroimaging and behavioral projects investigating decision-making and reward processing in trauma-exposed populations.

https://www.ncbi.nlm.nih.gov/pubmed/30449518

https://www.ncbi.nlm.nih.gov/pubmed/30409390

https://www.ncbi.nlm.nih.gov/pubmed/28294462

 

I am hoping to find an undergraduate student volunteer who is interested in helping with various components of these projects, including helping with recruiting and phone screening research participants, data collection and analysis, literature reviews, and manuscript preparation. Prior research experience is not necessary, but personal maturity, sensitivity, attention to detail, time management, and communication skills are essential.

 

Minimum time commitment is four hours per week for one semester; students who can commit more time are preferred.

Mentoring: Participants will meet with Dr. Olson for at least one hour per week.

This is a student visitor (volunteer) position. Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.

 

To apply, email your CV to Dr. Olson: eaolson@mclean.harvard.edu

 

 

Undergraduate opportunity, Deep learning in MGH Cardiovascular Imaging, Dr. Lu

We are looking for an outstanding undergraduate students for medical imaging-based deep learning research at the Cardiovascular Imaging Research Center at Massachusetts General Hospital and Harvard Medical School.

Current projects apply deep learning to predict health outcomes (e.g. heart attack) from medical imaging (e.g. CT and x-ray). We work with high quality trial datasets of tens of thousands of patients with imaging and adjudicated outcomes (ROMICAT II Hoffmann U et al. NEJM 2012; PROMISE Douglas PS et al. NEJM 2015; Framingham Heart Study Hoffmann U et al. JAMA Cardiology 2017; REPRIEVE Hoffmann U, Lu MT et al Am Heart J 2019; NLST Berg CD et al NEJM 2011). See our recent publication using AI to predict mortality from chest x-rays in JAMA Open: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2738349.

Prerequisites:

  • Enthusiasm for applying deep learning to improve health
  • Coding experience (CS50 equivalent or higher)
  • Experience with or commitment to learn PyTorch (preferred) and/or Tensorflow
  • Able to work in a collaborative team environment
  • Excellent verbal and written communication skills

We are located near the Charles/MGH Red Line station at

165 Cambridge St, Suite 400

Boston, MA 02114

https://goo.gl/maps/FKbGFWrb8wUi1pp6A

Students will be mentored by Michael Lu, MD, MPH, Assistant Professor of Radiology and Director of Research, MGH Cardiovascular Imaging. Research course credit, stipend, and length of project are negotiable. Please send CVs to Dr. Lu at mlu@mgh.harvard.edu

 

 

Undergraduate Research Opportunity, Obsessive Compulsive Disorder Institute, McLean Hospital

Contact information: Jacob Nota, PhD, Department of Psychiatry, Harvard Medical School, jnota@mclean.harvard.edu, McLean Hospital, https://www.mcleanhospital.org/programs/ocd-institute

Project description and duties: Research examining the relations between biological circadian rhythms, sleep, and obsessive-compulsive disorder (OCD; https://www.ncbi.nlm.nih.gov/pubmed/25603315). This new line of research represents a novel pathway to understanding and treating one of the most disabling mental health disorders. The study involves collection of melatonin samples in order to measure biological circadian rhythms in individuals participating in intensive residential treatment for OCD. The research assistant will spend between 8 and 16 hours a week facilitating data collection, documentation, and assisting with subsequent data cleaning/analysis. Because of the necessities of the study, there is a need for availability during evening and night hours (e.g., between 1800 and 0400).

Skills required: Prior research experience is desirable but not required. Attention to detail and intrinsic motivation to be involved in research is required.

Learning outcomes: This position would be an excellent fit for applicants interested in obtaining doctoral training in clinical or counseling psychology or psychiatry, and/or preparation for research assistant positions after graduation. Mentorship is an important part of our mission, and our previous students have been accepted into top graduate schools and earned authorship on presentations and papers.

This project is expected to be ongoing for one year. A minimum 8 hours per week commitment is needed (with these hours being able n the evening and night). For interested parties, up to 16 hours a week may be available.

Mentoring: the research assistant will participate in weekly research meetings. The student will also meet with the principal investigator in one-on-one format every week.

Student stipend: Currently the position is not eligible for a stipend and is on a volunteer basis. Interested students are encouraged  to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities or research course credit

Application information: please send CV/resume  to:

Jacob Nota, Ph.D. at jnota@mclean.harvard.edu

We will begin reviewing applicants for Fall semester immediately.

 

 

Posted July 17, 2019

Undergraduate research opportunity in cell- and ionic liquid-based drug delivery, Mitragotri Lab at Northwestern Building, SEAS

PI: Prof. Samir Mitragotri

Department: John A. Paulson School of Engineering and Applied Sciences

Lab location: B154, Northwest Building, 52 Oxford St, Cambridge, MA 02138, https://drugdelivery.seas.harvard.edu

Project description and duties: The Mitragotri lab focuses on the development of advanced drug delivery systems. Cell-based therapies have been increasingly recognized as promising interventions for many diseases. One aspect of my research is to leverage cells for targeted or localized drug delivery. Particularly, we are interested in manipulating the interactions between the carrier cells and nanoparticles for tunable drug delivery.  A second aspect of my research focuses on using ionic liquids for topical/transdermal drug delivery. Particularly, we are interested in elucidating how formulation parameters influence the delivery performance of ionic liquids. The student will be involved in nanoparticle synthesis and characterization, cell culture, ionic liquid synthesis, and formulation development. He or she will also be trained on experimental design of drug formulations and in vitro and in vivo characterization during this process.  

Skills required: Passion and dedication to research in biomedical area. No prior research experience is necessary.

Learning outcomes:

  • Nanoparticle fabrication and characterization.
  • Cell culture.
  • Ionic liquid synthesis and characterization.
  • Formulation development and characterization.
  • Characterization techniques: DLS, NMR, FTIR, HPLC, spectrophotometer, microscopy;
  • Experimental design, data processing and analysis, presentations etc.

Number of hours: Hours will be flexible, but we are looking for students who can start asap and hopefully continue for at least 6 months.

Mentoring: Dr. Zongmin Zhao, a postdoctoral researcher will mentor the students. His research experience can be found by https://scholar.google.com/citations?user=Yr9TK8QAAAAJ&hl=en

Student stipend: No stipend is provided. Students are encouraged to apply for fellowships.

Contact information: Interested undergraduate students can send a CV and contact information to Dr. Zongmin Zhao (zmzhao@g.harvard.edu).

 

 

Posted June 17, 2019

Undergraduate research opportunity in hydrogel-based drug delivery, Mitragotri Lab at Northwestern Building

PI: Prof. Samir Mitragotri

Department: John A. Paulson School of Engineering and Applied Sciences

Lab location: B154, Northwest Building, 52 Oxford St, Cambridge, MA 02138, https://drugdelivery.seas.harvard.edu

Project description and duties: Our lab focuses on the development of advanced drug delivery systems. Using drug-loaded hydrogels as depots to realize the long-term, slow release is desirable for treatment of multiple diseases.  The student will be involved in the development of development of nano sized drug crystals, along with the hydrogel synthesis. Small molecular synthesis, polymer modification and relevant characterization will also be involved. He or she will also be trained on experimental design of drug formulation and in vitro and in vivo release during this process.   

Skills required: Passion and dedication to research in biomedical area. No prior research experience is necessary.

Learning outcomes:

  • Biomacromolecule modification, small molecular synthesis and hydrogel-material preparation;
  • Drug and small molecule crystallization;
  • Drug release study (in vitro and in vivo); 
  • Characterization techniques: NMR, FTIR, HPLC, GPC, spectrophotometer, microscopy;
  • Experimental design, data processing and analysis, presentations etc.

Number of hours: Hours will be flexible, but we are looking for students who can start asap and hopefully continue for at least 3 months. Students who can commit for Summer 2019 are highly preferred.

Mentoring: Dr. Yongsheng Gao, a postdoctoral researcher will mentor the students. His research experience can be found by https://is.gd/f9hs4S

Student stipend: No stipend is provided. Students are encouraged to apply for fellowships.

Contact information: Interested undergraduate students can send a CV and contact information to Dr. Yongsheng Gao (yongshenggao@seas.harvard.edu).

 

 

 

Posted April 23, 2019

Research Opportunity to study the neuronal mechanisms underlying reproduction and metabolism, Dr. Victor Navarro’s lab, BWH

Contact informationVictor M Navarro. Medicine (Endocrinology), BWH 221 Longwood Ave, Boston
Tel: +1 617 525 6566 Fax: +1 617 582 6193
Email: vnavarro@bwh.harvard.edu Lab website: http://navarrolab.bwh.harvard.edu

Project description and dutiesOur lab focuses on the characterization of the central factors that regulate reproduction and metabolism including, but not limited to, Kiss1 neurons using a variety of genetic mouse models and viral delivery approaches. The student will be involved in the study of the neuronal mechanisms that regulate the reproductive and metabolic axis, along with the neuronal circuitry that links different brain areas involved in both reproduction and feeding behavior. He or she will be involved in the development and maintenance of mouse colonies, performance of anatomical studies, and determination of different gene and protein expressions in the brain (PCR, in situ hybridization, immunohistochemistry, etc.). The characterization of a number of biological parameters that define reproductive and metabolic functions will be required (e.g. fertility assessments, daily monitoring of puberty onset, body weight, behavior, food intake etc.). The student will be expected to work in collaboration with other members of the lab but in an independent manner. He/she will be encouraged to present their data at local and regional meetings, analyze their data and prepare them for publication.

Skills requiredPassion, dedication, commitment and ability to work with live mice. No prior research experience is required. Some coursework in neuroscience or biology would be helpful. Experience with MATLAB is a plus but not mandatory.

Learning outcomesThe student that joins our lab is expected to acquire knowledge of neuroanatomy and physiology of the neuronal networks that govern the endocrine system. He or she will gain experience in the handling of mice and maintenance of animal colonies as well as in the planning and performing of experimental protocols, analysis and interpretation of results and presentation of the data in lab meetings and conferences.

Number of hours students are expected to workNegotiable
MentoringThe student will be mentored by myself and senior postdocs in the lab. Weekly meetings will be held.
Does laboratory provide any funds to pay student’s stipendNo stipend is provided so the student is encouraged to apply for fellowships.
Email your resume to vnavarro@bwh.harvard.edu

 

 

Posted April 15, 2019

Research Assistant, Dr. Pepperberg’s Lab, Harvard University

PI name: Irene Pepperberg
Department: Psychology
Contact information:
Pepperberglabmanager@gmail.com
Location: Harvard University’s William James Hall, 33 Kirkland St., Cambridge
Lab website:
https://alexfoundation.org/

Duties: We are currently investigating concepts of exclusion, delayed gratification, mirror recognition, vocal development, and probabilistic reasoning. Research assistants are responsible for assisting in daily care and the training and testing of African Grey parrots on cognitive and communicative tasks.

Care includes but is not limited to the following: cleaning, feeding, and watering of animals as assigned; and observation of animals for abnormalities and sickness. Training in handling, care, and protocols will be provided. Prior experience in a research lab is not necessary.
Publications can be viewed at the following link:
https://alexfoundation.org/links-2/

Position requires a minimum commitment of 6 hours per week for at least one full semester.
The lab is staffed from 9am to 8pm, seven days per week, including holidays.

The PI, Dr. Pepperberg, is in the lab at least three hours per day, and when she is not present, senior students and/or the lab manager are present to provide direction

Volunteers, work/study, research credit or HCRP funding preferred, but students can earn up to a total of $599/yr (Jan 1-Dec 31) from The Alex Foundation.

To apply, please email lab manager Roni Hyman at pepperberglabmanager@gmail.com to request an application.

Publications:

Clements, K. A., Gray, S. L., Gross, B., & Pepperberg, I. M. (2018, March 12). Initial Evidence for

Probabilistic Reasoning in a Grey Parrot (Psittacus erithacus). Journal of Comparative Psychology.

Advance online publication. http://dx.doi.org/10.1037/com0000106

Pepperberg, I.M., Gray, S.L., Mody, S., Cornero, F.M., & Carey, S. (2018). Logical reasoning by a Grey parrot? A case study of the disjunctive syllogism. Behaviour, 1-37. https://doi.org/10.1163/1568539X-00003528

 

Posted April 2, 2019

Undergraduate research opportunity at the Laboratory for Computational Neuroimaging, Martinos Center for Biomedical Imaging, MGH

PI: Anastasia Yendiki, Ph.D.

Martinos Center for Biomedical Imaging

149 13th St. Suite 2301

Charlestown, MA 02129

ayendiki@mgh.harvard.edu

http://scholar.harvard.edu/a-y

The student researcher will contribute to a project that aims to map connections in the human brain, based on a combination of in vivo diffusion MRI brain scans with prior information from microscopic resolution ex vivo MRI and optical imaging. Brain pathways will be labeled manually to produce training data for an automated image analysis algorithm. Algorithms developed by our team learn the anatomical neighborhood of the pathways from such training data and then reconstruct the same pathways automatically in novel data sets. Depending on the student researcher's interests and skills, the work can focus more on neuroanatomical exploration of the in vivo and ex vivo data, software development, or both.

Prior experience working in a Unix-based computer environment is desired but not required.

The student will gain experience in neuroanatomy and in the analysis of neuroimaging data. Depending on progress and interest, the student may also assist with preparing conference abstracts and publications.

Project duration and hours per week are negotiable.

The student will be mentored by Dr. Yendiki and a postdoctoral research fellow. There will be opportunities to participate in weekly group meetings, as well as receive one-on-one mentoring as needed.

One of our past interns has described her experience here:

https://lifesciences.fas.harvard.edu/blog/undergraduate-researcher-profile-nivedita-ravi-neuroimaging-project

Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.

Please email a resume and a short (one paragraph) description of your research interests and career goals to Dr. Yendiki (ayendiki@mgh.harvard.edu).

 

 

 

Posted March 27, 2019

 

Undergraduate summer research internship, Cognitive Neuroscience Group, MGH Institute of Health Professions

Contact information: Dr. Yael Arbel, co-director Cognitive Neuroscience Group, Department of Communication Sciences and Disorders, MGH IHP, 79 13th Street, Boston, MA 02129. IHPCNG@MGHIHP.EDU; https://www.mghihp.edu/research/cognitive-neuroscience-group

Project description and duties: The Cognitive Neuroscience Group is a collaborative research group that uses behavioral and neuroscience methods to examine the relationship between learning, language ability, and cognitive factors. We use electrophysiological and eye tracking data to study typical and atypical learning across the lifespan and in different disorders (e.g., Developmental Language Disorder, Aphasia, Traumatic Brain Injury). The research assistant will have the opportunity to contribute to several research projects, including two federally funded projects focusing on the neural function associated with learning in typically developing children and children with developmental language disorders.

Duties: The research assistant will be involved in all aspects of data collection and analysis: literature review, task design, recruitment events, interaction with research participants, scoring and analysis of behavioral data as well as EEG signal processing. EEG signal processing will include the use of Matlab based tool boxes for artifact detection/correction, latency jitter correction, and Principal Component Analysis (PCA).

Skills required: excellent communication skills (verbal and written), ability to work independently and in a team. Preferred skills include: coding in Matlab, signal processing, eye-tracking data analysis, statistical analysis using SPSS or R, creating scripts in Excel and other programing. No research experience is required.

Learning outcome: The RA will receive training in behavioral and EEG data collection and data analysis. Training in eye-tracking data acquisition and analysis is also possible. The RA will participate in weekly lab meetings that will include presentations by PIs, and students at all levels (PhD, graduate, undergraduate). The RA will gain understanding of research design related to the study of learning in individuals with typical and atypical cognitive profiles. The RA will have the opportunity to present at the biweekly CNG meetings and to participate in scientific writing

The RA is expected to work 15-20 hours per week (preferably 3-4 days a week; weekends may be included) for 10 weeks, starting June 3rd, 2019. Our lab is located at the MGH Institute of Health Professions in the Charlestown Navy Yard in Boston. The RA is expected to spend at least 15 hours a week on site.

Mentoring: The RA will be mentored by the Drs. Arbel, Zipse, and Vallila Rohter, and will interact with CNG members in training, meetings, and data collection sessions. The RA will attend weekly lab meetings, and weekly mentorship meetings with the PI.

Student stipend: Funds are available to support 1-2 interns. However, additional RA positions are available for students who receive funds through the HCRP or other fellowships. https://lifesciences.fas.harvard.edu/research-opportunities

Yael Arbel, CCC-SLP, Ph.D. Associate Professor
Department of Communication Sciences and Disorders
yarbel@mghihp.edu  (617) 643-4821

School of Health and Rehabilitation Sciences
MGH Institute of Health Professions
Charlestown Navy Yard
36 1st Avenue, Boston MA 02129

 

 

Posted March 8, 2019

Undergraduate research opportunity, Brigham and Women’s Hospital, Division of Genetics

PI name: Natasha Frank, M.D.

Department: Brigham and Women’s Hospital, Division of Genetics

Contact information: Fiona Harrington
Operations Coordinator
Division of Genetics
Brigham and Women’s Hospital
0168A New Research Building
77 Avenue Louis Pasteur
Boston, MA 02115
Phone: 617-525-7584  Email: FAHARRINGTON@BWH.HARVARD.EDU

 

Location: Brigham and Women’s Hospital
0168F New Research Building
77 Avenue Louis Pasteur
Boston, MA 02115  Phone: 617-525-8111  Email: NYFRANK@BWH.HARVARD.EDU
Lab website: http://franklab.bwh.harvard.edu

Description of the project and duties:

The Frank Lab in the Division of Genetics at Brigham and Women’s Hospital, Harvard Medical School invites applications for a graduate/undergraduate research assistant. The successful applicant will use standard molecular biology techniques (PCR, Western blotting, immunohistochemistry, tissue culture, cloning, etc.) to further projects involving stem cell therapy for eye disease, stem cells for regenerative wound healing, and targeting of therapy-resistant cancer stem cells. In addition, they will have the opportunity to engage in research involving 3D printing and to learn bioinformatics techniques for data analysis and visualization.

Interested candidates are encouraged to view our publications in this area:

1. Frank NY, et al. Journal of Biological Chemistry. 2003 Nov 21; 278 (47): 47156 – 65. Regulation of progenitor cell fusion by ABCB5P-glycoprotein, a novel human ATP-binding cassette transporter.

2. Ksander BR, et al. Nature. 2014 Jul 17; 511 (7509) : 353-7. ABCB5 is a limbal stem cell gene required for corneal development and repair.

3. Schatton T, et al. Cell Reports. 2015 Sep 8;12 (10) : 1564-74. Abcb5 identifies immunoregulatory dermal cells.

Skills required: Consideration will be given to highly motivated students pursuing a degree in the biomedical sciences or related field. Prior lab experience is preferred but not required.

Learning outcome: The trainees will acquire basic laboratory skills such as PCR, Western blotting, immunohistochemistry, tissue culture, cloning, etc., research skills: study design, data analysis method, presentations, scientific writing, etc.

Number of hours students are expected to work, length of the project: it is negotiable

Mentoring: The trainee will be mentored by the PI and postdoctoral fellow Catherine Lee, Ph.D.

Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.

Please send a cover letter detailing interest and a current CV/resume to Dr. Natasha Frank (NYFRANK@BWH.HARVARD.EDU).

 

 

 

Undergraduate Research Position, Pediatrics and Neuroscience, Lurie Center for Autism, MGH for Children

Evan Bordt, PhD; Postdoctoral Fellow in the lab of Dr. Staci Bilbo, PhD; Pediatrics and Neuroscience, Lurie Center for Autism, Massachusetts General Hospital for Children

Contact: ebordt@mgh.harvard.edu, http://bilbolab-harvard.org

Project: The Bilbo Lab focuses on the study of neuroimmune interactions in brain development, using pre-clinical models. We collaborate with clinical research groups to translate our findings to human populations. We are particularly interested in the role of immune molecules in both normal and disrupted brain development, based on evidence from human and animal studies that immune system dysfunction or inflammation may be critical in neurodevelopmental disorders, including schizophrenia, cognitive and mood disorders, and autism. A particular focus is on the resident immune cells of the brain, microglia, including their development and function in response to early life inflammatory signals. Our lab is interested in the field of immunometabolism, with a particular focus on the role of mitochondrial alterations (i.e. bioenergetics) in microglial functions.

We are recruiting undergraduate scholars to get involved with several aspects of our projects aimed at determining the role of neural-glial and neural-immune interactions in brain and behavioral outcomes, including cellular and molecular analyses of microglial function, behavioral analyses in rodent models, and the processing and analysis of data for collaborative clinical (human) studies at the Lurie Center for Autism. There will also be many opportunities for interacting with and shadowing clinicians at the Lurie Center, one of the largest clinical care centers for Autism and related disorders in the world.

Skills Required: Wet lab skills in molecular biology (e.g. qPCR, ELISA, Westerns) are preferred but not required. An understanding, respect, and acceptance of the use of live animals in research is absolutely required.

Learning outcomes: Students will learn skills in rodent handling and behavior, and in cellular, molecular, cell culture, and microscopy techniques, and will have the opportunity to present at lab meetings and/or conferences, and to gain authorship on manuscripts as warranted.

Hours: Flexible hours, term-time and summer opportunities available, part-time or full-time volunteering. The lab is in the Charlestown Navy yard campus, building 114. A free shuttle from MGH main campus runs every 15 min.

Mentoring: The Bilbo lab consists of many postdoctoral fellows, students, technicians, and undergraduate researchers. We are very much a team, and mentoring and teamwork are key components of our lab culture. The student will be closely mentored by Dr. Bordt, in addition to the overall team approach, and will also meet with Dr. Bilbo. There are weekly lab meetings on Thursdays at 3:00, for which the student is encouraged to attend (but not required).

Funding: This is an unpaid research opportunity. Students are encouraged to apply to the HCRP for funding (email Dr. Babakhanyan at ababakhanyan@fas.harvard.edu for more info), and we are happy to help with the preparation of applications.

To apply: Please send CV and cover letter briefly explaining why you would like to get involved in research to ebordt@mgh.harvard.edu.

 

 

 

Posted Feb 21, 2019

Haplotype-aware de novo assembly of related individuals, G. Church Lab

 

George Church Lab (http://arep.med.harvard.edu/gmc/)

Wyss Institute for Biologically Inspired Engineering and Harvard Medical School, affiliated with Harvard-MIT HST, Broad Institute, MIT Media Lab

Scientific question​. Humans are diploid, and hence there exist two versions of each chromosome, one inherited from the mother and the other from the father. Determining the DNA sequences of these two chromosomal copies---called haplotypes---is important for many applications ranging from population history to clinical questions. Existing sequencing technologies cannot read a chromosome from start to end, but instead deliver small pieces of sequence (called reads). Like in a jigsaw puzzle, the underlying genome sequences are

reconstructed from the reads by finding the overlaps between them. However, current standard approaches cannot produce the sequences of both haplotypes but “collapse” them to obtain one consensus sequence. We develop algorithms to solve the genome assembly for diploids, that is, “to simultaneously solve two jigsaw puzzles with very similar yet different images”. Furthermore, we want to incorporate the pedigree information in the underlying model to generate diploid assemblies for related individuals. At the application side, the main

question is how much read data is required for related individuals as opposed to single individual.

Approach​. Due to the sequencing errors in the reads, heterozygous and repetitive genomic regions, the assembly problem is challenging. Over the past few decades, researchers solved it by casting it as an overlap graph problem, where nodes are the reads and edges represent the overlap between reads. To detect regions where the two haplotypes differ (called heterozygosity), we look for simple local structures called bubbles. A bubble is a type of directed acyclic subgraph with single distinct source and sink vertices that consists of

multiple edges (with the same direction) between these pair of vertices. Once bubbles have been identified, they are simplified by removing structures most likely resulting from sequencing errors. The resulting bubbles can then be used to solve the “phasing problem”: find two paths that correspond to the sought haplotypes for every individual in a pedigree.

Tasks.

1. Investigate local structures (bubbles) in assembly graphs.

2. Formalize the problem of removing erroneous structures due to sequencing errors.

3. An efficient algorithm to detect bubbles that represent regions of heterozygosity.

4. Develop an efficient approach for phasing bubble chains in a joint framework for

Pedigrees

Relevant papers.

1. A graph-based approach to diploid genome assembly, ISMB 2018/Bioinformatics

(https://academic.oup.com/bioinformatics/article/34/13/i105/5045759)

2. Read-based phasing of related individuals, ISMB 2016/ Bioinformatics

(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908360/)

Requirements.

1. Programming: C++, python, shell scripting

2. Basic knowledge of bioinformatic tools

3. Enthusiasm to solve the problem

Possible to work remotely, with regular meetings on the MIT/Harvard campus.

What you will get:

- Extensive mentorship in computational methods

- Knowledge of how, conceptually, we can solve biological problems using computational methods.

- The opportunity to work in a diverse environment that includes people with vastly different, but complementary skill sets.

- Responsibility and satisfaction of owning your own project.

You will be directly working with postdoc:

Shilpa Garg, Algorithms in Computational Genomics, HMS

Candidates will be called for a short discussion (interview) to access your creativity,

reasoning, and problem solving skills.

Please contact Shilpa Garg (shilpa_garg@hms.harvard.edu, shilpa.garg2k7@gmail.com)

and include your CV if you’re interested in inventing the future of biology using computational

techniques.

 

 

Undergraduate Research Opportunity at Spaulding Hospital Cambridge INSPIRE Lab for sensorimotor rehabilitation engineering (term-time, summer, or both)

Dr. Randy Trumbower, PT, PhD; Asst Professor, Department of Physical Medicine & Rehabilitation at Harvard Medical School, Co-Director, Spinal Cord Injury Division

Contact: Stella Barth, clinical research assistant sbarth@partners.org 617-952-6822

Spaulding Hospital Cambridge, 1575 Cambridge Street, Cambridge, MA 02138  (half a mile down the street from the Science Center, also accessible via the MBTA 69 bus)

www.inspire-lab.org/

http://spauldingrehab.org/research-and-clinical-trials/INSPIRE_Lab/

Description of the project and duties: Specific projects for students are flexible and will depend on student interests and current staff projects; this is a dynamic and multidisciplinary lab that brings together physical therapy and engineering to better understand motor recovery after neurological injury

Observational and hands-on research experience are available; interested students will have the opportunity to interact with clinical research participants during study visits

http://spauldingrehab.org/research-and-clinical-trials/INSPIRE_Lab/research

Skills required: No prior research experience necessary, just enthusiasm for the mission of the lab: to INSPIRE persons living with paralysis to move

All volunteers must complete onboarding through Spaulding Rehabilitation Network and online CITI training

Learning outcomes: Students will gain exposure to multiple ongoing clinical trials involving motor recovery after spinal cord injury. Depending on student interests and current staff projects, students may gain exposure to the following: recruitment and screening of study participants, scheduling participants, maintaining IRB documents and participant data, EMG data collection and analysis, Optotrak motion capture system and force plate data analysis, physical therapy assessments, engineering, MATLAB, coding, monitoring vital signs, saliva and blood processing and storage, managing lab purchases and expenses

Research skills: study design, engineering for research, an understanding of how clinical trials involving human subjects are run, research specimen collection and processing, literature review, data processing and analysis

Number of hours: Flexible hours, term-time and summer opportunities available, part-time or full-time volunteering

We are particularly interested in students who are able to make a long-term commitment (at least a few months) to helping the lab

Mentoring: Students will work directly with one or more of the following depending on research interests and current staff projects: postdoctoral fellows, engineers, physical therapists, clinical research coordinator and or clinical research assistant

 

This is an unpaid research opportunity. Students are encouraged to apply to HCRP, fellowships, and other funding sources

Please submit contact information, a CV or resume, and a brief statement of interest or cover letter (including term-time / summertime availability) to Stella Barth at sbarth@partners.org

 

 

Posted Feb 7, 2019

Undergraduate research opportunity in oral delivery of biological drugs, Mitragotri Lab at Northwestern Building

PI: Prof. Samir Mitragotri
Department: John A. Paulson School of Engineering and Applied Sciences
Lab location: B154, Northwest Building, 52 Oxford St, Cambridge, MA 02138, https://drugdelivery.seas.harvard.edu

Project description and duties: Oral drug delivery is considered a desirable administration route and offers multiple advantages for patients. However, the natural barriers present in the gastrointestinal tract (GI) prompts many challenges for an effective oral delivery. The project focuses on exploiting ionic liquids as a drug carrier for GI delivery application. The students will be trained on synthesizing range ionic liquids and using analytical techniques to evaluate the products. Students will also be investigating how those ionic liquids interact with biological drugs, cells and animal tissues.

Skills required: No prior research experience is necessary, though being comfortable with wet lab skills would be a plus.

Learning outcomes:

-Chemical synthesis and analysis by NMR, FTIR, HPLC, spectrophotometer

- Light, fluorescence, confocal laser scanning microscopy (CLSM)
- ELISA
- Cell and animal tissue handling, histology

- experimental design, data processing and analysis, presentations etc.

Number of hours: hours will be flexible, but we are looking for students who can start asap and hopefully continue for at least 6 months. Students who can commit for Summer 2019 are highly preferred.

Mentoring: Dr. Pavimol Angsantikul a Postdoctoral Fellow will be mentoring the students. More details about her research experience- https://tinyurl.com/yc7u7l9b

Student stipend: No. Students are encouraged to apply to HCRP or other fellowships.

Contact information: Interested undergraduate students can send a CV and contact information to Dr. Pavimol Angsantikul (angsantikul@g.harvard.edu).

 

 

Undergraduate Research Opportunity at Wyss Institute

This project is a collaboration between the labs of George Church and David Walt at the Wyss Institute in Longwood.

Lab Websites:

http://arep.med.harvard.edu/

http://waltlab.bwh.harvard.edu/drw/

Description of the project and duties: This project involves the investigation of extracellular vesicles (also called exosomes), both in terms of their basic biology, and their applications to the diagnosis of neurodegenerative disease. The team working on this project is multidisciplinary and employs a large range of techniques including: stem cell culture and differentiation, high throughput sequencing (RNA-Seq), computational analysis, protein biochemistry, and new techniques for ultrasensitive protein detection.

https://wyss.harvard.edu/david-walt-and-george-church-receive-grant-from-chan-zuckerberg-initiative-to-enable-better-diagnosis-and-monitoring-of-parkinsons-disease/

Skills required. Molecular biology experience required. Experience with mammalian cell culture, RNA work, or protein biochemistry helpful but not required. Programming experience and computational skills analyzing high throughput sequencing data would also be helpful but are not required.

Learning outcome: The student will learn a lot of cutting edge experimental techniques and potentially have opportunities for independent sub-projects, once comfortable with initial techniques. Juniors may consider doing an undergrad thesis in the lab. A previous Harvard undergrad working with us on this project has written a thesis and won a Hoopes Prize for it, was a co-author on several publications, and presented her work at an international conference.

Number of hours students are expected to work: Students are expected to work at least 15 hours per week, on average, during the semester, and full time during the summer. The length of the project is flexible. Although there is no obligation, we are interested in having students potentially continue on in our lab as Research Assistants after graduation for a year or two as a way to gain more research experience and make a larger contribution to the project.

Mentoring: The student will be mentored as part of a team but be primarily mentored by a postdoctoral fellow. There will be regular meetings (about once a week) to discuss research plans, and lots of hands-on instruction in the beginning.

Funding: HCRP and other fellowships or register for a research course credit. Students are encouraged to apply for their own funding, although funding from the lab may be available.

Email your resume and a paragraph about why you are interested in this opportunity to Dima (email: dterovanesyan@fas.harvard.edu)

 

 

Undergraduate research opportunity in 3D bacterial motility, Rowland Institute

The Taute lab at Rowland Institute is offering a funded undergraduate research opportunity focused on studying the motility behavior of well-known bacterial pathogens using high throughput 3D tracking. Motility and chemotaxis are known to contribute to virulence in a number of bacterial pathogens, but neither the underlying mechanisms nor the species’ basic motility behaviors are well understood. Do pathogens exhibit specific motility strategies? How do motility behaviors adapt to lab environments that mimic the physical complexity of the host? How do the bacteria manage to navigate chemical gradients?

The undergraduate researcher will be advised by a postdoc in the lab and will receive training in the following areas:

  • Wet lab and microbiological lab skills,
  • advanced light microscopy,
  • quantitative data analysis,
  • Matlab programming.

Candidates should bring along

  • enthusiasm for interdisciplinary experimental science,
  • strong analytical skills and no fear of quantitative analysis,
  • experience in one or more of the training areas listed above.

The project is funded by the Rowland Foundation Postdoctoral Fellow and Undergraduate Program for the duration of 12 months and will commence as soon as a suitable candidate is identified. The successful candidate

  • will start training in the lab as soon as possible,
  • should be committed to conducting summer research on the project,
  • will be remunerated at a rate of $15/h (810 h/week during the semester, up to 35 h/week during the summer, possible support for Harvard summer housing).

Interested candidates should contact postdoc Marianne Grognot (grognot@rowland.harvard.edu) with a CV, an academic transcript, and a statement of motivation (max. 1 page).

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

 

 

Posted Jan 29, 2019

Undergraduate research, Arnold Lab, MGH, Charlestown Navy Yard

Project 1. The Alzheimer’s Clinical Translational Research Unit (ACTRU, www.actru.org) takes a multidisciplinary, basic science to clinic translational approach to designing patient-oriented experimental and clinical trials for aging and dementia. These involve advanced digital health assessments, neuroimaging, and ultra-sensitive molecular biomarker detection technologies in blood, cerebrospinal fluid and brain tissue.  We have a number of projects available for Harvard students, split between wet lab and computer based projects.

Project 2. Defining the role of circular RNA in Alzheimer’s Disease: Circular RNAs are widely expressed in brain, and may play a functional role in regulation of gene expression.  The Arnold lab has found that a circular RNA derived from the IGF2R gene is more highly expressed in brain samples with Alzheimer’s Disease pathology than brains without pathology.  This project will be a wet lab project using qPCR in brain tissue, and cell culture experiments to examine if there may be a functional link between the IGF2R circular RNA and signaling pathways altered in Alzheimer’s Disease.  Supervisor: Dr. Becky Carlyle

Project 3. Exploring methods for the examination of individual differences in Alzheimer’s Disease Brain tissue. Alzheimer’s Disease is a complex neurodegenerative disease driven by intersecting cycles of protein misfolding, oxidative stress and inflammation.  Liquid chromatography mass-spectrometry proteomics from our group and others have shown that there may be substantial individual differences in the activity in these pathways in Alzheimer’s Disease.  In this project you will perform exploratory data analysis on mass spectrometry data from clinically well characterized brain tissue, followed by comparison of different methods of dimension reduction, machine learning and deep learning for the exploration of individual differences and identification of protein modules that may correlate with different aspects of Alzheimer’s Disease.  This is a computer based project and some experience with R and / or MATLAB is required. Supervisors: Dr Becky Carlyle and Dr Hamed Azami

Project 4. Analytical approaches for EEG and MEG techniques in neurology. Alzheimer’s disease affects the interaction between neurons in the brain in patterns that may vary with disease progression.  These interactions can be recorded by electroencephalogram (EEG) and magnetoencephalography  (MEG) techniques.  This project will investigate the ability of classical and novel graph based approaches to analysis of multivariate EEG and MEG signals to understand the interdependency of activity recorded at different sites.  This is a computer based project and ideal candidates would have a background in mathematics and some experience in MATLAB. Supervisor: Dr Hamed Azami

If interested, contact Becky Caryle at BCARLYLE@mgh.harvard.edu

 

Undergraduate research opportunity in diabetes and obesity project at Mitragotri Lab at Northwest Building in Cambridge

PI: Samir Mitragotri, John A. Paulson School of Engineering and Applied Sciences, Northwest Building, B153, 52 Oxford St, Cambridge, MA 02138, https://drugdelivery.seas.harvard.edu

The selected undergraduate students will have opportunity of learning and training in synthetic chemistry, characterization, analysis and understanding biological impact of the as synthesized materials. The aims of the ongoing projects are to design and develop oral delivery of peptide that control blood glucose level and helps to reduce body weight.

Skills required. No prior research experience is required! We are looking for students to mentor who has a strong desire and interest on learning drug delivery tool and techniques.

Learning outcome: laboratory skills: chemical synthesis and analysis by NRM, IR, HPLC, LC-MS, UV; research skills: study design, data analysis method, presentations, scientific writing, etc.

We do not expect a student maintain a typical fixed duration within a certain period of time rather we maintain pretty flexible time-frame considering the fact that undergraduate students are under huge load of class and assignments. The project is years long, however a student with a minimum commitment for 3 months are encouraged to apply. We can negotiate the timing and duration.

Mentoring: Md Nurunnabi a Postdoctoral Fellow will be mentoring the students. More details about his research- https://tinyurl.com/y8rmogfh

The students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.

Interested undergraduate students are requested to send a CV and contact information to Dr. Nurunnabi (mnurunnabi@g.harvard.edu).

 

 

 

Posted Jan 28, 2019

Undergraduate research opportunity on developing breakthrough technologies to promote effective science communication in biomedical research, MEEI

PI name: Joseph F. Arboleda-Velasquez, M.D., Ph.D.
Department: Department of Ophthalmology at Harvard Medical School

Contact Information: joseph_arboleda@meei.harvard.edu

Location: Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114. Two blocks from the MGH T-stop on the Red Line.

Description of the project and duties: The student will work to develop innovative software and website tools to transform science communication in biomedical research.

Skills required. Students are expected to have experience in software, website development, programming, coding and database building.

Learning outcome: Student will learn to design strategies to overcome barriers in science communication, increase software and programming skills, and learn to work towards user-ready product development.

Number of hours students are expected to work: hours will be flexible but it will be important that the student can start now and commit for Summer 2019 and hopefully continue through the year.

Mentoring: Dr. Arboleda-Velasquez will personally mentor the student via meetings and via participation in group meetings.

Does laboratory provide any funds to pay student’s stipend?

Yes, this is a paid position. Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.

What information students need to submit and contact information for submitting this information:  Please email Dr. Arboleda-Velasquez with a statement of interest.

 

Posted Jan 2, 2019

 

Research Assistant Positions in Developmental Cognitive Neuroscience – Spring Term 2019

Dr. Charles Nelson Harvard Medical School / Boston Children’s Hospital

The Nelson Lab in the Laboratories of Cognitive Neuroscience, located in the Longwood Medical Area, is currently looking for volunteer undergraduate research assistants to work on a broad range of research studies. Our studies focus on several lines of research, including the early identification of autism, the effects of early adversity on brain and behavioral development, and the development of facial recognition and emotion. Each study uses a variety of neuroimaging tools, including electrophysiology, functional near infrared spectroscopy, and magnetic resonance imaging, along with a variety of behavioral tools, including eye tracking and standardized developmental assessments.

The research assistants will gain familiarity with our research methods and may have the opportunity to gain hands-on experience testing infants and/or children and participate in lab meetings and journal clubs (schedule dependent). Primary responsibilities will include assisting with data entry, study visits, and processing behavioral and/or brain-based measures.

These positions are ideal for anyone considering medical school or future graduate study in experimental or developmental psychology or cognitive neuroscience.

Requirements: ability to work with children, familiarity with PC and Mac, self-motivated, and enthusiasm for developmental research. Applicants for these positions must be able to commit at least 10 hours/week during the spring semester. Ideal applicants will be able to continue to assist with studies in the summer and/or following fall semester. Course credit may be given or work study funds may also be used.

To apply, please complete an online application form: https://redcap.tch.harvard.edu/redcap_edc/surveys/?s=V6UudY and upload a statement of interest, along with a CV or resume. To learn more about the research conducted in our lab, visit our website: http://www.childrenshospital.org/research/labs/nelson-laboratory/ongoing-research 

 

Posted November 19, 2018

iGEM BioDesign Bootcamp Wintercession  

Program takes place from Jan 19 - 26 (during J-term). 

The week will consist of:

- Learning key concepts in synthetic biology and CS

- Conducting wet-lab experiments

- Programming mathematical models 

- Project design

- Fun social activities

Apply here by Tues, Nov. 27. It's a relaxing, yet challenging week. (Housing will be open, and it won't conflict with your classes -- there's no reason not to apply!) Let us know of any questions, and tell your friends! The application is open to all, and no previous laboratory or iGEM experience is required. 

 

 

Posted November 16, 2018

Undergraduate Research Opportunity, Dr. Christopher Walsh, Department of Genetics and Genomics, Boston Children’s Hospital

3 Blackfan Circle (Longwood Medical Area), walshlab.org

The project involves using large scale sequencing and high throughput validation methods to try to understand how non-coding regions of the genome are involved in brain development and disorders. We have used targeted methods to sequence thousands of patient samples with Autism to try to understand whether certain noncoding regions of the genome seem involved in the condition.

Now we are in the phase of developing and using a modified high throughput screening method to test functionally how different regulatory sequences work in the context of brain development. After being trained, undergraduate students would assist in the method development and/or use the method to answer very interesting complementary questions. The work builds on the results from a previous study in the lab that can be found here: https://www.cell.com/cell/fulltext/S0092-8674(16)31169-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867416311692%3Fshowall%3Dtrue

 

Skill required: No prior research experience required, though being comfortable with wet lab skills would be a plus

Learning Outcome: Basic wet lab skills including gel electrophoresis and cloning, cell culture, optimizing and performing highly multiplex functional assays, study design, presentation skills, optional opportunities to learn about bioinformatics, high performance computing, and automation

Number of hours: The remainder of the fall semester will mostly involve orientation and learning the basics of the project. During the Fall semester, students will be expected to spend 10-15 hours a week in lab

Student Stipend: Not provided by the lab – students are encouraged to apply for HCRP and other Harvard Fellowships (contact Dr Babakhanyan at ababakhanyan@fas.harvard.edu), or research course credit

Mentoring: Students will be mentored by a PhD Graduate Student in the BBS program, with support from a Postdoc

Contact: If you are interested or have any questions, please send a copy of your CV to Taehwan Shin:  tshin@g.harvard.edu

 

 

Undergraduate Research Opportunity in Soft Robotics Fabrication, Whitesides Research Group, Harvard University

Dr. Markus Nemitz, Department of Chemistry and Chemical Biology, mnemitz@gmwgroup.harvard.edu, 12 Oxford Street, www.gmwgroup.harvard.edu

Description of the project and duties: Most robotic systems are hard, that is, composed of metallic structures with joints based on conventional bearings. Although hard robots capable of movement often possess limb-like structures similar to those of animals, more often, structures not found in nature – for example, wheels and treads – are used. Mobile elements of hard robots are often modeled on the limbs of animals or insects, and some locomotive systems (hexapods) use the passive compliance of air within pneumatic cylinders to move quickly on rough terrain.

The tentacles of squid, trunks of elephants, and tongues of lizards and mammals are such examples; there structures are muscular hydrostats. Squid and starfish are highly adept locomotors; their modes of movement have not been productively used in conventional hard robotics. These soft actuators rely on elastomeric structures and fibril arrangements of muscles that result in bending, elongation, or contraction without significant changes in the overall volume of the structure.

Using biomimetic principles based on these characteristics we are developing partially or entirely “soft” robots, fabricated in materials (predominantly elastomeric polymers) that do not use a rigid skeleton to provide mechanical strength, and are actuated pneumatically. Soft robots are simpler to make and less expensive than conventional hard robots, and may, in some respects, be more capable of complex motions and “cooperative function” (that is, safe operation around humans).

We are currently exploring the opportunity of embedding soft circuits into soft materials. The successful applicant would help with the design, fabrication, and testing of soft devices in the Whitesides Research Group under supervision of Dr. Markus Nemitz (postdoctoral fellow). http://robotics.sciencemag.org/content/3/16/eaar7986

Skills requires: (ideally) experience in computer aided design (CAD) such as Autodesk Inventor. No other research experience is required.

Number of hours students are expected to work: Negotiable (min. ~7h/week)

Length of project: ~2 weeks

Mentoring: Markus Nemitz (postdoctoral fellow) will be the mentor

How often are mentorship meetings: twice a week

Student stipend: No. Students are encouraged to apply to the HCRP and other fellowships.

Application information: Please email your CV to mnemitz@gmwgroup.harvard.edu

Learning outcome: soft device design, 3D printing, soft lithography

 

 

Posted October 22, 2018

Unsupervised Machine Learning as a Window into Psychological Representation, Harvard Vision Sciences Laboratory

Principle Investigator: Dr. George Alvarez alvarez@wjh.harvard.edu
Affiliation: Harvard Vision Sciences Laboratory (Psychology Department)
33 Kirkland Street, Cambridge, Massachusetts https://visionlab.harvard.edu/VisionLab/index.php

How does the brain translate physical stimuli (light, sound, pressure, chemicals) into meaningful structures of information that better guide behavior? This is the central question this research seeks to answer. Noting the success of deep convolutional neural networks in the modeling of representation in primate visual cortex, we aim to go further by addressing a core outstanding query at the heart of representational learning: how to learn without labels?  To do so, we’ve turn to a number of unsupervised machine learning algorithms (variational autoencoders, generative adversarial networks), drawing on methods from psychology and neuroscience alike to compare the behavior of our models to the behavior of human subjects. We find that despite learning a set of features without explicit category labels, these algorithms are nonetheless capable of drawing ethologically relevant distinctions in complex, multidimensional inputs. In future work, we hope to expand the breadth and efficacy of our methods, better illuminating similarities and differences between human and machine representation, and perhaps in so doing, to use our understanding of human representation to facilitate crosstalk with artificial intelligence. To this end, we welcome a diverse spectrum of interest, and are actively seeking research assistants from a wide range of backgrounds. For more information, please feel free to contact us!

Number of Hours Per Week: 10-20 (Negotiable)
Requirements: None (But some sort of computational background is helpful!)
Interested: send your resume to Colin Conwell conwell@g.harvard.edu

 

Posted October 19, 2018

Undergraduate research opportunities (can take multiple students) – Dr. Kapil Ramachandran’s lab, Harvard Medical School

Dr. Kapil Ramachandran, Junior Fellow at Harvard Society of Fellows, Harvard Medical School Department of Cell Biology, Kapil_ramachandran@hms.harvard.edu,

Project description: https://www.nature.com/articles/nsmb.3389

https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30455-6

http://science.sciencemag.org/content/355/6332/1361

The Ramachandran lab studies a new mechanism of protein degradation specific to the nervous system that generates a novel form of neuromodulation (Ramachandran and Margolis 2017, Nature Structural and Molecular Biology; Ramachandran et al 2018, Molecular Cell). This is accomplished by a neuronal-specific proteasome complex that is bound to neuronal plasma membranes and degrades nascent proteins across the membrane into extracellular signaling peptides. We seek to understand the molecular principles that codify this newfound signaling system in the brain with the long-term goal of elucidating its function. Initial studies will focus on the molecular properties of this process using protein engineering, electron microscopy, CRISPR screening, proteomics, and biochemical analyses to reveal the components and dynamics of this system.

Skills required: We seek highly motivated students that are excited to learn in the lab and immerse themselves in the biology. Theoretical understanding of biochemistry and molecular biology is a significant bonus. Any or all of the following skills would be highly beneficial – mammalian cell culture, neuronal cell culture, molecular cloning (Gibson, mutagenesis), protein engineering, protein purification, CRISPR/Cas9 engineering, experience with lentiviral production. We encourage students from diverse educational and personal backgrounds to apply, especially those from historically underrepresented backgrounds.

Students will acquire a diverse repertoire of skills in biochemistry and neurobiology and molecular biology. Most importantly, students will learn about how to design well-controlled experiments at the bench, conduct rigorous data analysis, and interact with a team of researchers. Students who contribute data that helps make a figure in a manuscript will be authors on the manuscript. It is expected that students will present their work at group meetings and undergraduate research symposia.

Undergraduate students will be expected to work 15-20 hours per week and it would be required for students to stay for at least two terms and highly desirable if students would work full-time in the summers and stay for additional terms if possible and a good match. All students will personally be mentored and trained by Dr. Ramachandran. Regular mentorship meetings will be once a week, where the student and Dr. Ramachandran will discuss research progress in addition to career development plans.

Students may receive course-credit or do thesis research in the lab or obtain funding through HCRP fellowships. We will also consider Federal work-study students.

To apply to this position, email your CV and a description of research interests to Kapil_ramachandran@hms.harvard.edu. Letters of reference from previous employers or research experiences, when possible, will be taken into consideration.

 

Elucidation of multi-host bacterial pathogenesis in Pseudomonas aeruginosa and development of novel anti-virulence and host therapeutic strategies, MGH

Principal Investigator: Dr. Laurence Rahme, rahme@molbio.mgh.harvard.edu
Massachusetts General Hospital and Harvard Medical School
50 Blossom Street, Thier Research Building, Boston, MA 02114 https://laurence-rahme-5y35.squarespace.com/

Etiological agents of acute, persistent, or relapsing infections, such as Pseudomonas aeruginosa (PA), are often refractory to antibiotics due to multidrug resistance and/or antibiotic tolerance.  We have identified various novel virulence-related genes and their role in pathogenicity in several infection models.  The genes identified encode proteins involved in transcriptional and post-translational control, efflux systems, biosynthetic enzymes, virulence effectors as well as proteins of unknown function. One of the major virulence factors we identified is the LysR-type transcriptional regulator, Multiple Virulence Factor Regulator (MvfR). MvfR.  We first identified in plant hosts that it controls the 4-hydroxy-2-alkylquinolines (HAQs) quorum sensing (QS) system.  Our MvfR regulon studies have revealed an unprecedented PA virulence mechanism and identified a new indispensable player in PA cell density-dependent QS virulence network.  We aim to continue to elucidate the biological role and activity of many of the HAQs molecules whose functions remain unknown and whose synthesis is controlled by MvfR, using various in vivo (burn infection, lung infection) and cell culture (cystic fibrosis, macrophages, neutrophils) models.  We have also targeted the MvfR-regulated QS virulence pathway in a high-throughput screen to isolate robust molecules that specifically inhibit PA pro-acute virulence molecules HHQ, PQS and pyocyanin, without affecting its growth or viability to mitigate selective resistance, and showed their efficacy in limiting virulence.  In the host system, we have also pioneered work that show that MvfR-regulated QS molecule, 2-AA promotes “host tolerance training” by epigenetic reprogramming.  This is the first demonstration that QS molecules can target the host epigenome.  We have also successfully conducted biomarker discovery work in human cohort studies.  Our approach investigating both the bacterial and host mechanisms provides additional critical insights for the development of next-generation clinical therapeutics to more effectively treat refractory and deleterious bacterial-human infections.

Hours and duration of the position: Negotiable

Required skills/experience: No prior research experience required, no specific lab skills required.

Student stipend: To be negotiated. For info on Harvard Fellowships supporting research stipend contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu 

To apply email your one page science resume to Dr. Laurence Rahme, rahme@molbio.mgh.harvard.edu

 

Posted October 15, 2018

 

Peacebuilding data, evaluation and implementation science, and humanitarian technologies, Harvard Humanitarian Initiative

Faculty: Dr. Pham Phuong, ppham@hsph.harvard.edu 

14 Story Street, Cambridge, MA 02138 http://hhi.harvard.edu/research  

The Harvard Humanitarian Initiative (HHI), based within at the Department of Global Health and Population at the Harvard T.H. Chan School of Public Health, is the largest and most influential University-wide academic and research center in humanitarian crisis and leadership in the world. HHI fosters interdisciplinary collaboration to:

  • Improve the effectiveness of humanitarian strategies for relief, protection, and prevention;
  • Instill human rights principles and practices in these strategies;
  • Educate and train the next generation of humanitarian leaders
    Based at the Harvard Humanitarian Initiative (HHI) and Brigham and Women’s Hospital (BWH), the “Peace and Human Rights Data” and “Evaluation and Implementation Science” programs leverage rigorous, mixed-method research methodologies to better inform decision-making and programming seeking to address the needs of the world’s most vulnerable populations. Over the past several years, our research teams have conducted over 150,000 interviews in conflict and post-conflict environments, assessing community perceptions of social reconstruction, mental health, peacebuilding, justice and accountability, and security. Currently, our programs have ongoing projects in the Central African Republic, Colombia, Democratic Republic of the Congo, Iraq, Philippines, Rwanda, and Uganda.

Hours per week:
-10 hours/week for Freshman and Sophomores during academic terms
15-20 hours/week for Junior and Seniors during academic terms
Up to 40 hours/week during the summer

Time commitment is negotiable, upon arrangement with individual student.

Requirements: 

  • Previous research experience in human rights, public health, political science, and / or international affairs is preferred.
  • Proficiency in a foreign language, such as French is preferable but not required.
  • An interest in transitional justice, peacebuilding, and post-conflict reconstruction is desirable.

To apply, please email to kcoughlin6@bwh.harvard.edu  and ppham@hsph.harvard.edu

 

Undergraduate Research Opportunity in lncRNA-directed drug discovery in Melanoma, Novina Lab, Dana-Farber Cancer Institute

Contact information: NovinaLAB@dfci.harvard.edu, leon_wertlamas@dfci.harvard.edu
Hospital: Dana-Farber Cancer Institute (Note: location = Longwood campus)

Project description and dutiesLong non-coding RNAs (lncRNAs) are a special class of genes which only make RNAs but do not code for proteins. Although many of them have been implicated in cancer and other diseases, very little is understood about these lncRNAs function. To discover how lncRNAs work, we developed a specialized lncRNA-based assay (called Y3H) which systematically defines lncRNA-protein interactions. We are also developing a platform to screen for drugs that disrupt these lncRNA-protein interactions, which we anticipate will become a novel class of RNA-directed drugs.

Skills required: none required, but some lab experience is preferred

Learning outcomesStudents working on this project will learn basic RNA and protein biochemistry and molecular biology techniques (e.g. cloning, cell culturing, transfection, flow cytometry) and state-of-the-art experimental techniques, (e.g. robotics, next-generation sequencing, and high-throughput drug discovery platforms). An important aspect of training in the Novina lab is learning to conduct translational research using clinical samples, advanced technologies, computational methods, and humanized model systems. This internship will provide a multi-discipline training environment that leverages basic, clinical, and industry collaborations which will provide diverse career opportunities.

Number of hours students are expected to work: minimum of 10 hours per week
Length of the project: minimum of 6 months (the longer the more you will get out of it)
Mentoring: Dr. Novina and by senior postdocs in the lab actively mentor students through weekly meetings, lab group meetings, and one-on-one interactions. You will be welcome to join our lab meetings.
Student stipend: This is a volunteer position or for credit position. We would also be happy to help you apply for relevant fellowships (contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu for more info on fellowships).

How to apply: send a copy of your CV by email to : NovinaLAB@dfci.harvard.edu, leon_wertlamas@dfci.harvard.edu

 

Posted September 28, 2018

Undergraduate Research opportunity, Dr. LeBoff’s Lab/ Skeletal Health, Osteoporosis Center, and Bone Density Unit, Brigham and Women’s Hospital

Contact information: Dr. Meryl S. LeBoff, Department of Endocrinology, mleboff@bwh.harvard.edu, 221 Longwood Avenue, Boston, MA 02115
https://www.brighamandwomens.org/medicine/endocrinology-diabetes-and-hypertension/skeletal-health-osteoporosis-bone-density

Project description and dutiesThe Skeletal Health and Osteoporosis Center: The Skeletal Health and Osteoporosis Center and Bone Density Unit is directed by Meryl S. LeBoff, MD, who founded this Center at Brigham and Women's Hospital (BWH) in 1987. Since that time, it has become a multifaceted program including research, education, clinical care, and a bone densitometry unit that is noted for its standards of good reproducibility. The Skeletal Health and Osteoporosis Center and Bone Density Unit seeks to meet the goals of the Partners HealthCare System: to provide the highest quality care with the best possible outcomes.

Student Duties: The student will have the opportunity to form and test hypotheses, create analysis plans, review outcomes, create paper proposals, and familiarize oneself with the largest Vitamin D randomized controlled trial, VITamin D and OmegA-3 TriaL (VITAL).

Research Project: Dr. LeBoff has been the principal investigator on two NIH-sponsored R01 grants: 1) VITAL: Effects on Bone Structure and Architecture and 2) VITAL: Fractures, Vitamin D and Genetic Markers. These are two ancillary studies to the large VITAL study, which is a 2x2 factorial randomized controlled trial investigating the effects of supplemental vitamin D and/ or omega-3 fatty acids for the primary prevention of cancer and cardiovascular disease in over 25,000 older adults from all 50 states. VITAL: Effects on Bone Structure and Architecture is an ancillary study conducted among a subcohort of VITAL participants (n=771) at the Harvard Catalyst Clinical and Translational Science Center to test effects of supplemental vitamin D alone on musculoskeletal outcomes at baseline and after two years of follow-up. The goal of VITAL: Fractures, Vitamin D and Genetic Markers is to determine whether vitamin D supplements alone are effective in prevention of fractures and whether vitamin D levels and genetic variation in vitamin D receptor and metabolism and absorption modify effects of supplemental vitamin D on incident fractures and bone health outcomes.

Skills required: Proficiency in Microsoft Excel, Powerpoint, Word, knowledge of statistics, strong writing skills, database management

Learning outcomes:

  1. Research skills such as study design, data analysis methods, presentation, literature review, and scientific writing
  2. Knowledge of musculoskeletal measures including bone density, body composition measures, and physical performance measures
  3. Understanding of vitamin D metabolism, including genetics and biomarkers of vitamin D and bone remodeling

Number of hours: Negotiable

Mentoring: Dr. LeBoff will be mentoring the undergraduate, with weekly mentor meetings in addition to regular lab meetings.

Student stipend: Not available through the lab, but you can apply to Harvard fellowships (contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu to find out more)

Course credit: Yes

Application information: Email your resume, cover letter, and writing sample to Elle Murata atemurata@bwh.harvard.edu and Dr. Meryl LeBoff at mleboff@bwh.harvard.edu

 

Undergraduate Research Opportunity, Sleep Disorders Clinical Research Program, MGH

Contact information: Julia Purks, jpurks@mgh.harvard.edu, 617-643-6026 (PI: John Winkelman, MD PhD)

Project description and duties: Data analysis for ongoing clinical studies in sleep medicine

Skills required: Proficiency in excel and other statistical programs, detail-oriented, organized

Learning outcomes: Data analysis methods, knowledge of sleep disorders and sleep medicine, shadowing opportunities

Number of hours: 4 hours/week; can be negotiated

Mentoring: Mentored by Dr. John Winkelman, shadowing opportunities in MGH Neurology and Psychiatry

Student stipend: To be negotiated. For info on Harvard Fellowships supporting research stipend contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu

Application Information: Email your resume to Julia Purks at jpurks@mgh.harvard.edu, along with a brief message stating your interest in the position

 

Undergraduate research positions, Mackenzie Mathis' lab 

We are a research team that combines cutting edge technological and deep learning approaches to understand how the brain creates adaptive behaviors. We use mice as a model system and teach them to use a robotic joystick, then we record their brain activity using two-photon microscopy. We also build deep learning tools for data analysis and for tracking their behaviors. For examples of recent work, see our lab website: http://www.mousemotorlab.org/ . We are interested in recruiting two undergraduate researchers, one to work on deep learning approaches to quantifying behavior (see coverage of our recent work in The Atlantic: https://goo.gl/44fkks and on NVIDIA's developer site: https://goo.gl/a99rNn ), and another to work with us on training mice to perform joystick-based tasks.

Requirements and Expectations: Skills required: Python programming experience for the deep learning position (and desired but not required for the animal experiments). Hours: Students are expected to work 10 hours per week.

Project Length: minimum of 6 months.
Additional Information: Our lab is located at the Rowland Institute, very close to the red line T-stop (reduced T-passes can be obtained). Learning outcomes: machine learning, computer programming, data analysis methods, animal behavior, and presentation skills.

Mentoring: You will be mentored by Dr. Mackenzie Mathis, and by postdocs in the lab.

Student Stipend: This is a volunteer or for credit position. We would also be happy to help you apply for relevant fellowships, particularly for research during the summer. For info on Harvard fellowships please contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu.

To apply: send a copy of your CV by email to Dr. Mackenzie Mathis at mathis@rowland.harvard.edu

 

 

Research Assistant Positions in Developmental Cognitive Neuroscience – Fall Term 2018, Boston Children’s Hospital
Dr. Charles Nelson Harvard Medical School / Boston Children’s Hospital

The Nelson Lab in the Laboratories of Cognitive Neuroscience, located in the Longwood Medical Area, is currently looking for volunteer undergraduate research assistants to work on a broad range of research studies. Our studies focus on several lines of research, including the early identification of autism, the effects of early adversity on brain and behavioral development, and the development of facial recognition and emotion. Each study uses a variety of neuroimaging tools, including the electrophysiology, functional near infrared spectroscopy, and magnetic resonance imaging, along with a variety of behavioral tools, including eye tracking and standardized developmental assessments.

The research assistants will gain familiarity with our research methods and may have the opportunity to gain hands-on experience testing infants and/or children and participate in lab meetings and journal clubs (schedule dependent). Primary responsibilities will include assisting with data entry, study visits, and processing behavioral and/or brain-based measures.

These positions are ideal for anyone considering medical school or future graduate study in experimental or developmental psychology or cognitive neuroscience.

Requirements: ability to work with children, familiarity with PC and Mac, self-motivated, and enthusiasm for developmental research. Applicants for these positions must be able to commit at least 10 hours/week during the fall semester. Ideal applicants will be able to continue to assist with studies in the spring semester.

Course credit may be given or work study funds may also be used. For info on Harvard research fellowships to support student stipend contact Dr. Anna Babakhanyan at ababakhanyan@fas.harvard.edu.

To apply, please complete an online application form: https://redcap.tch.harvard.edu/redcap_edc/surveys/?s=V6UudY  and upload a statement of interest, along with a CV or resume. To learn more about the research conducted in our lab, visit our website: http://www.childrenshospital.org/research/labs/nelson-laboratory/ongoing-research.

 

 

Undergraduate Research Opportunity, Kwon Lab, Ragon Institute of MGH, MIT and Harvard

Contact information: Principle Investigator: Doug Kwon MD, PhD
Department: Ragon Institute  Email: dkwon@mgh.harvard.edu
Assistant: Candace Gregg Email: cgregg@mgh.harvard.edu
400 Technology Square, Cambridge MA 02139  kwonlab.org   

The Kwon Laboratory is focused on applying new technologies to the study of immune responses against HIV at mucosal surfaces. The student will work closely with a team of researchers in our lab (the “FGT (female genital tract) Team”) to study the impact of the microbiome and other mucosal immune factors that impact HIV risk in young women in South Africa. This project continues on work we have recently published (Anahtar et al, Immunity 2015; Gosmann et al, Immunity 2016) that demonstrates that cervicovaginal bacteria can have a significant impact on the immune system in the FGT and that this can modulate the risk of acquiring HIV. The project will involve translational bench and computational work.

By the end of the student’s time in the lab, we expect they will have acquired an understanding of: basic immunology and HIV pathogenesis; the critical role of mucosal tissues in HIV transmission and disease progression; laboratory methods used for patient-based studies of cellular immunology, the microbiome, metagenomics, and transcriptional profiling; and the impact of HIV on the lives of patients in developed and developing regions.

 

Skills required: Are students expected to have any particular laboratory skills, if so which ones? If no prior research experience is required, state so to encourage applications from new undergraduate researchers.

Previous research experience and laboratory skills are not required.

 

Learning outcomes: laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing.

 

Number of hours students are expected to work: Negotiable.

Mentoring: who will be mentoring the undergraduate, how often are mentorship meetings, and can the student attend group meetings?

The student will be overseen by a postdoc or graduate student in the lab, have  monthly meetings with the PI and attend weekly group meetings.

Student stipend: Our lab does not offer a stipend for undergraduate researchers. Please contact Dr. Babakhanyan to obtain information about Harvard student fellowships at ababakhanyan@fas.harvard.edu.

Course credit: We welcome applicants hoping to gain course credit or perform thesis research.

Application information: Applicants are asked to send their resume and a 500-word personal statement that articulates why they want this position, how this experience will enhance their learning, and how this research experience would connect to their future goals. Students should include details about the skills they will bring to the position and to include examples from relevant experiences.

Email application materials to: Doug Kwon dkwon@mgh.harvard.edu & Candace Gregg cgregg@mgh.harvard.edu

 

 

Hoekstra Laboratory: Undergraduate opportunities

Project title:  The neurobiology and evolution of mouse vocalization behavior

Project description: The Hoekstra Lab is looking for a talented undergraduate to contribute to a new project on the genetics and evolution of mouse vocalization. The successful candidate will be mentored by Postdoctoral Fellow Nick Jourjine and, under his mentorship, help develop computational approaches to analyze and compare vocalizations within and between mouse species, as well as aid in recording vocalizations from mice of various ages. Experience with MATLAB or python is preferred, but the position is open to anyone with an interest in computer science, evolutionary biology, or animal behavior.

Funding:   Volunteer or for credit basis, although applying for school research funding will be encouraged. This is a great opportunity for students who are thinking about writing a senior thesis. For more questions about Harvard funding options contact Dr. Anna Babakhanyan ababakhanyan@fas.harvard.edu

Email: Nick Jourjine, jourjine.nicholas@gmail.com


Project title:   Convergent morphological evolution in forest mice

Project description and duties:

In the Hoekstra lab, we are interested in understanding the genetics of behavioral and morphological adaptations found in wild populations and species of Peromyscus mice. This project will study populations of the deer mouse, Peromyscus maniculatus, that appear to be forest-adapted, having long tails, whiskers, and other traits that might aid an arboreal lifestyle (see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324611/). Using museum specimens of deer mice acquired from across North America, students would X-ray, measure, and analyze traits of interest for members of these populations. Our goal is to determine whether (and to what degree) tree-dwelling deer mice from different parts of the continent exhibit the same morphological traits, thereby suggesting a history of convergent evolution.

Students would be mentored directly by a graduate student (Brock Wooldridge), and also frequently interact with other members of the lab, attend lab meetings, and participate in paper discussions. Day-to-day work would take place either in the MCZ imaging specimens and cataloguing data, or in the dry lab analyzing images and interpreting results. No experience working with museum specimens or image processing is required, although experience with R is helpful. An appreciation for natural history and a background in evolutionary biology/IB is encouraged. Students should also be extremely conscientious and have a great attention to detail. This project hast the potential to expand and become a senior thesis if the fit is right. If you are interested, please contact Brock (twooldridge@g.harvard.edu) with your CV/resume.

Funding: Volunteer or for credit basis, although applying for school research funding will be encouraged. This is a great opportunity for students who are thinking about writing a senior thesis. For more questions about Harvard funding options contact Dr. Anna Babakhanyan ababakhanyan@fas.harvard.edu

Email your resume to: Brock Wooldridge, wooldridge@g.harvard.edu

 

 

Undergraduate Research Opportunity to Investigate Mitochondrial Dysfunction in Retinal Diseases, Saint-Geniez Lab, MEEI

PI name: Dr. Magali Saint-Geniez, Department: Ophthalmology, MEEI
Website: https://www.masseyeandear.org/research/investigators/s/saint-geniez-magali

Location: Research will be conducted at the Schepens Eye Research Institute, 20 Staniford Street, Boston MA 02143, located 2 blocks from the Government Center Green line and the Charles Street MEEI Red line stops.

Description of the project and duties: Dr. Saint-Geniez lab is focused on characterizing and targeting novel molecular pathways involved in common retinal degenerative diseases. In particular, our group is investigating the underlying pathogenic roles of metabolic dysfunction and oxidative damage in photoreceptors (the light-sensitive cells in the retina) and retinal pigment epithelium (the main cellular support for photoreceptors), and is evaluating the therapeutic benefits of novel metabolic regulators using multidisciplinary approaches, including molecular and metabolic biology on cellular and animal models. Our research is predominantly centered on Macular Degeneration and Retinal Detachment for which we have established in vitro and in vivo models and have access to clinical samples/data. Students will assist in the exploration of a novel pathogenic process promoting mitochondrial and metabolic defect in retinal cells.

Skills required: Prior research experience is not required but we are looking for highly motivated individuals. Basic laboratory skills and cell culture experience is a plus.

Learning outcome: The student will receive training in experimental design, troubleshooting, data analysis of standard techniques in the lab including in vitro and ex vivo model of retinal pathologies, adenovirus-mediated gene modulation, crispr gene editing, high-resolution respirometry, mitochondrial function and mtDNA damage quantification. Students will be encouraged to present at lab meeting and to attend local conferences.

Number of hours students are expected to work: Weekly hours are negotiable.

Mentoring: The student will be directly supervised and mentored by Dr. Saint-Geniez. Additional day-to-day supervision will be provided by Dr. Mariana Rosales (post-doctoral fellow) and the other lab members.

Compensation: The lab will not provide a stipend initially but highly productive students will be considered for funding following the training period. Students are encouraged to apply to the HCRP/PRISE and other fellowships (for more info email Anna Babakhanyan at ababakhanyan@fas.harvard.edu) or register for a research course credit. Guidance for fellowship application will be provided.

Interested students should email Dr. Saint-Geniez with a statement of interest and their anticipated time availability (email: magali_saintgeniez@meei.harvard.edu)

 

Endocrinology Undergraduate Research, Dr. Kaiser, Brigham and Women's Hospital

Our laboratory provides a rich intellectual environment of physicians and scientists focused on neuroendocrinology and reproductive endocrinology. An elaborate neural network integrating internal and external signals governs the onset of puberty and subsequent fertility. The precise nature and components of this network are not well established, but it is clear that puberty is triggered by the central increase in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which stimulates the secretion of the pituitary gonadotropins, necessary for the activation of gonadal function. Our laboratory uses a translational approach to study the hormones and genes involved in the neuroendocrine regulation of reproductive development, puberty onset and subsequent fertility. Out approaches include studies of: 1. Hypothalamic and pituitary cell models and in vitro studies; 2. In vivo mouse models; and 3. Patients with clinical reproductive disorders.

Potential Student Roles: (1) Assist with reproductive phenotyping of genetically modified mouse models (e.g., pubertal markers, estrous cyclicity); (2) Assist with human genetic studies, including review of human patient clinical data to correlate with genetic findings with clinical phenotypes, and DNA sequencing and sequence analysis, including analyses of exome sequence data; (3) Contribute to laboratory studies of human inducible pluripotent stem cell (hiPSC)-derived hypothalamic neurons that have been genetically modified by CRISPR-Cas9.

Hours: negotiable
Funding: contact Dr. Babakhanyan to learn more about Harvard fellowships supporting undergraduate researchers, ababakhanyan@fas.harvard.edu

Contact: Send your resume to Dr. Rona Carroll, Director of Laboratory of Reproductive Neuroendocrinology, Brigham and Women's Hospital, Laboratory of Neurooncology, email: rcarroll@bwh.harvard.edu

 

Posted September 18, 2018

Undergraduate research opportunity in Dr. Ionescu lab in Harvard School of Dental Medicine

PI name: Andreia Ionescu, Department: Developmental Biology, Harvard Medical School

Contact information: Tel: 617-432-1358, Email: andreia_ionescu@hms.harvard.edu
Location: 200 Longwood Ave, REB 414, Dev Bio  
Lab website: https://hsdm.harvard.edu/ionescu-lab

 

Description of the project and duties

Cartilage traumatic lesions heal poorly due to the low regenerative/repair ability of the resident cells and a shortage of a blood supply that could deliver both potential progenitor cells as well as biomolecules that could help with repair. In children, injuries to the growth plate cartilage result in growth arrest, formation of a “bony bar” and limb length discrepancies. In adults, injuries to the articular cartilage lead to the development of Osteoarthritis (OA), a painful joint disease, characterized by progressive and irreversible deterioration of the articular cartilage. Novel therapeutic strategies are needed to prevent cartilage degeneration and to stimulate the endogenous progenitor cells to help with regeneration and healing.

Dr. Ionescu’s lab seeks to discover new biomarkers to help label, identify and study the endogenous cartilage stem cells for either growth plate or articular cartilage. We have recently discovered a novel marker for growth plate cartilage stem cells. By performing lineage tracing, IHC, cell isolation and RNA-seq, we seek to label, characterize and follow the trajectory of these stem cells during postnatal development and in response to injury. This is a new area of research, which, if successful, it would support the development of bioengineering strategies for physeal cartilage regeneration.

Student duties: The student will perform various experiments such as lineage tracing analysis, fluorescence microscopy, histological assessment of cartilage degeneration/regeneration, immunofluorescence with tyramide amplification for various stem cell markers. The student is expected to come in time, prepare necessary materials for their experiments, generate data, and make well-documented laboratory notebook for record keeping and data analysis. The students will participate in various laboratory meetings and discussions.

Skills required: We prefer students to have basic molecular biology/histology laboratory skills, but it is not required. No prior research experience is necessary. We will provide experimental and theoretical trainings to gain their research skills.

Learning outcome: The student will acquire knowledge and expertise on stem cells and cartilage regeneration via experiments, literature reading, and scientific discussions. The student will have opportunity to present their work during weekly project meetings and lab meetings. Depending on the progress on the project, the student will be considered to become co-author on the publication.

Number of hours students are expected to work, length of the project: We expect that the student will  spend ~16 hours per week. However, it is negotiable based on students’ needs. The project will be 1-2 semester length but can be extended with new discoveries and student’s performance and needs.

Mentoring: The student will be primarily mentored by a postdoctoral fellow in Dr. Ionescu’s group, who will be responsible for scientific, technical and experimental training of the student. Dr. Ionescu will also work closely with the student and provide scientific guidance and mentoring.

Stipend: The laboratory does not provide funding to pay student’s stipend. We encourage students to register for a research course credit and for their senior thesis. In addition, Dr. Ionescu will work very closely with the student to support their fellowship applications such as the HCRP and other fellowship opportunities (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu). In the past, we have had a very high success rate of our undergraduates securing fellowship funding.

If you are interested in, please send your resume to andreia_ionescu@hms.harvard.edu to set up a meeting.

 

Undergraduate Research Opportunity, De Bivort Lab, OEB
Contact information: Ben de Bivort, OEB, debivort@oeb.harvard.edu,
Location: Northwest Labs 248, Lab website: debivort.org

Project description and duties: We are currently studying how thermal preference in fruit flies changes over the seasons and across geographic locations. The project involves testing the thermal preference of wild-caught fruit flies using an established assay, performing DNA extraction, PCR, and gel electrophoresis to recover species identities, and general fly husbandry to maintain stocks.

Skills required: Previous experience with fruit flies, pipetting, and sterile technique is preferred, but all interested applicants are welcome to apply.

Learning outcomes: Broadly applicable molecular techniques, familiarity with using model organisms to study behavior, experimental design

Number of hours: 10 - 15 hrs per week is ideal, but the hours are negotiable depending on circumstances

Mentoring: A 5th year graduate student and 2nd year graduate student will be the mentors. They will be working side-by-side with the undergraduate researcher. The undergraduate researcher is welcome and highly encouraged to attend group meetings, but it is not required.

Student stipend: $15/hr or up to $3000 a year through the Faculty Aide Program

Course credit: Course credit is also available if desired.

Application information: Please email your resume/CV and a cover letter to debivort@oeb.harvard.edu and/or jakhundzade@g.harvard.edu. The cover letter should be a paragraph about your interests, any previous relevant experience, and a couple of sentences on what you would like to gain from this experience.

 

Undergraduate Research Opportunity in Chromatin and Epigenetics, Anna Krichevsky Lab, Harvard Medical School

Contact information: Dr. Anna Krichevsky,AKRICHEVSKY@bwh.harvard.edu, Dr. Evgeny Deforzh, evgenydeforzh@gmail.com, 60 Fenwood Road, Neurology Department, 9th floor.

Project description and duties: Epigenetic Regulation of the promising molecule for drug development against Glioblastoma (miR10b).

1) Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b.El Fatimy R1, Subramanian S1, Uhlmann EJ1, Krichevsky AM2.Mol Ther. 2017 Feb 1;25(2):368-378.

2) Therapeutic potential of targeting microRNA10b in established intracranial glioblastoma: first steps toward the clinic. Nadiya M Teplyuk, 1 Erik J Uhlmann, 1 Galina Gabriely, 1 Natalia Volfovsky, 2Yang Wang, 1 Jian Teng, 3 Priya Karmali, 4 Eric Marcusson, 4 Merlene Peter, 1Athul Mohan, 1 Yevgenya Kraytsberg, 1 Ron Cialic, 1 E Antonio Chiocca, 5Jakub Godlewski, 5 Bakhos Tannous, 3 and Anna M Krichevsky 1. EMBO Mol Med. 2016 Mar; 8(3): 268–287.

Skills required: No particular skills is required

Learning outcomes: ChIP-seq, Chromatin Conformation Capture (4c-Seq),RNA and DNA FISH, CrispR editing: study design, wet lab, data analysis, presentation.

Number of hours students are expected to work: Negotiable.

Mentoring: Evgeny Deforzh (Postdoctoral Fellow) will be the mentor, how often are mentorship meetings: every week, and can the student attend group meetings: yes. Student stipend: No

Course credit: Another potential option for some students (typically juniors or seniors) is to conductresearch for course credit; however, a student cannot earn course credit and be paid a stipend in the same semester.

Application information: Email your resume to Dr. Evgeny Deforzh evgenydeforzh@gmail.com

 

Undergraduate Research Opportunity in Neurobiology of Schizophrenia and Bipolar Disorders, McLean Hospital

Contact information: Mei-Hua Hall, Ph.D., mhall@mclean.harvard.edu, Psychosis Neurobiology Laboratory <https://www.mcleanhospital.org/biography/mei-hua-hall>

Project description: The Psychosis Neurobiology Lab has acquired an analyzing array of clinical, neurophysiological and behavioral data in patients with schizophrenia and bipolar spectrum disorders, including: (1) EEG and event related potentials (ERPs), (2) neuroimaging, (3) cognition, (4) function recovery measures, (5) clinical symptoms and characterization, and (6) electronic health records. We are interested in applying multimodal or machine learning approaches to understand and characterize the neurobiological mechanisms underlying schizophrenia and bipolar disorders and to connect patients’ neurobiological and clinical profiles with their functional recovery trajectories. The overarching goal is to develop individually tailored and effective treatments.

Duties: The student will be applying statistical or machine learning approaches for extracting features from datasets most relevant to functioning recovery performance (good vs. poor).

Skills required: Programming (Python) or biostatistical skills would be extremely useful (though not strictly required).

Learning outcomes: Neuroscience, data analysis methods, research presentations. Depending on progress and interest, the student may also involve in conference presentation and publications.

A time commitment of a minimum of 10 hours/week for 6-12 months.

Mentoring: the PI will be responsible for mentoring. Will meet formally on a weekly basis to discuss project, planning, data etc. The student will also interact with lab members in training and meetings.

Student stipend: A stipend is possible, but student would be strongly encouraged to apply to the HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu ) and other fellowships or register for a research course credit.

Application information: Interested applicants can email their CV/resume and a cover letter to Dr. Hall at mhall@mclean.harvard.edu

 

Undergraduate Research Opportunity in Computational Biology using Big Data to   identify Genome Variants in human cell lines, Pinello Lab, MGH

Contact information: Luca Pinello, Massachusetts General Hospital http://pinellolab.org/
Note: location = MGH Charlestown Campus
Contact: lpinello@mgh.harvard.edu

Project description and duties: Human cell lines from different tumors or organs have specific genome variations (mutations, insertions, deletions, etc.) that cause each cell line behave in a different way. Whole-genome sequencing is a technology used to read the sequence of the genome of a cell line and to identify these genome variations. Unfortunately, whole-genome sequencing is expensive and has not been performed for many cell lines. However, inexpensive technologies that profile a small portion of the genome (e.g. ChIP-seq, RNA-seq, DHS, etc.) are available via consortia like ENCODE and Roadmap Epigenomics.  The candidate will work alongside the PI and a postdoc to use data from multiple sources to recreate whole genome sequences which will be used to identify high-quality genome variants for each cell line.

This project will provide exposure to genomic and epigenomic data, give experience to accessing data in popular databases, and will provide an introduction to standard variant calling pipelines. These skills are critical for future work in genomic-oriented labs, preparing candidates for important roles in industry or academic labs.

Examples of recent work: http://main.pinellolab.partners.org/publications/

Skills required: No research experience is required, but some programming experience would be extremely useful.

Learning outcomes: big data, computer programming, genomics, data analysis methods, presentations, scientific writing.

Number of hours students are expected to work: Negotiable, ~10 hours per week

Length of the project: Negotiable, minimum of 2 months

Mentoring: You will be mentored by Dr. Pinello and by a postdoc in the lab. We expect to have biweekly meetings. You will be welcome to join our weekly lab meetings and journal clubs.

Student stipend: Students are encouraged (and supported) to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities. Contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu.

 

How to apply: send a copy of your CV by email to lpinello@mgh.harvard.edu

 

Undergraduate Research Opportunity in the Henske Lab, BWH

PI: Dr. Elizabeth (Lisa) Henske, MD, Professor of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Location: 45 Francis Street, Thorn Building, (Elevator D) Room 826, Boston, MA 02115 https://www.henskelab.org/

Project Description: The Henske Laboratory is focused on the cell biology and biochemistry of rare genetic diseases, including Tuberous Sclerosis Complex (TSC) and lymphangioleiomyomatosis (LAM).  Dr. Henske is a medical oncologist who follows LAM and TSC patients in addition to directing a research laboratory.  Our mission is to translate research discoveries into improved care as quickly as possible, to improve the lives of those affected by these devastating diseases.  TSC is an autosomal dominant syndrome causing seizures, autism, and tumors of the brain, heart, kidney, skin, and lung.  LAM is a destructive, progressive cystic lung disease that affects almost exclusively women and can lead to lung collapse and respiratory failure.  LAM is caused by TSC2 gene mutations in benign tumor cells that metastasize to the lung.   The TSC proteins inhibit the activity of the mammalian target of Rapamycin (mTOR) kinase.

Some of the research topics covered in the lab:

  • Employing high-throughput screening methodologies to identify novel therapies for TSC and LAM.
  • Developing relevant in vivo models that recapitulate the clinical manifestations of TSC and LAM
  • Understanding how benign-appearing LAM cells metastasize to the lungs
  • Understanding the role of estrogen in the female-predominance of LAM
  • Studying how nutrients, such as lipids, glucose, and amino acids, are utilized by tumor cells that are deficient in the TSC2 protein

Links to published manuscripts and reviews describing our work:

https://www.ncbi.nlm.nih.gov/pubmed/27226234

https://www.ncbi.nlm.nih.gov/pubmed/27753446

https://www.ncbi.nlm.nih.gov/pubmed/28498820

https://www.ncbi.nlm.nih.gov/pubmed/28512249

https://www.ncbi.nlm.nih.gov/pubmed/25185584

https://www.ncbi.nlm.nih.gov/pubmed/25780943

https://www.ncbi.nlm.nih.gov/pubmed/24296756

https://www.ncbi.nlm.nih.gov/pubmed/21746920

Skills required: Prior research experience preferred but not required.

Learning outcome: students will acquire skills in experimental design, experimental techniques, lab data analysis, presentations, and scientific writing.  If warranted based on their contributions, students will be co-authors on scientific manuscripts. 

Number of hours: negotiable

Mentoring: Mentoring will be primarily provided by postdoctoral fellows in the laboratory. The student      will also have regular meetings with Dr. Henske, and attend weekly lab meetings and journal clubs and will have opportunities to present at the lab meetings and journal clubs.

Funding:  The Laboratory does not have funds to pay student stipends, but students are encouraged to apply to the HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu )  and other fellowships or register for a research course credit.

To Apply: Please email your resume to Dr. Henske at (ehenske@bwh.harvard.edu) with a cover letter including a brief outline of your interests, goals, and anticipated time availability.

 

Undergraduate Research Opportunity, Dr. Karen Sepucha, Health Decision Sciences Center, MGH

Contact information: Karen Sepucha, PhD
Health Decision Sciences Center, Massachusetts General Hospital, https://mghdecisionsciences.org/
Contract person: Felisha Marques, MPH fmarques@mgh.harvard.edu 617-724-3295

Project description and duties: The Health Decision Sciences Center (HDSC) at Massachusetts General Hospital is committed to improving the quality of decisions made by patients and health care providers about medical tests and treatments. The HDSC is involved in developing, implementing, and evaluating decision aids and decision quality measures to support shared decision making in medical encounters. We are seeking students to support research studies. This is an exceptional opportunity to get experience with cutting edge research focused on patient engagement and delivery of patient-centered care. Students will be supervised by Karen Sepucha, PhD, Director of the Health Decision Sciences Center and Felisha Marques, MPH, Senior Clinical Research Coordinator.

Student activities may include:

  • Patient screening for eligibility using the electronic medical record
  • Administering surveys
  • Following up with study participants by phone
  • Identifying issues with recruitment and retention
  • Data collection, entry and analytics
  • Literature review
  • Manuscript contributions (writing, editing, proofing, references)
  • Grant proposal contributions

Skills required: Prior research experience is required

Learning outcomes: Research skills such as study design, data analysis methods, patient engagement

Number of hours students are expected to work, length of the project (if these are negotiable, state so): We can work with the student and their schedule to decide on the number of hours per week.

Mentoring: who will be mentoring the undergraduate, how often are mentorship meetings, and can the student attend group meetings? Karen Sepucha, PhD and Felisha Marques, MPH will be overseeing the student intern

Student stipend: This is a non-paid internship, student who would like to be paid through Harvard fellowships are encouraged to apply to the HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu )

 

Interested?  Send the following to Felisha Marques, MPH via email (fmarques@mgh.harvard.edu)

  • 1 page (maximum) statement describing your research interests and goals and how this experience might help with your development
  • Resume

To learn more about The Health Decision Sciences Center, visit our website: https://mghdecisionsciences.org/

 

Undergraduate Research Opportunity, Dr. Larry Benowitz, Boston Children’s Hospital

Contact information: Dr. Larry Benowitz, Neurosurgery, larry.benowitz@childrens.harvard.edu, Center for Life Sciences, 3 Blackfan Cir, room 13071 http://www.childrenshospital.org/research/researchers/b/larry-benowitz

 

Project description and duties: We are looking for multiple undergraduate students to work with postdoctoral fellows starting this fall. Our lab is studying the mechanisms of optic nerve injury and regeneration. Listed below is information regarding individual projects:

 

Dr. Kimberly Wong (kimberly.wong@childrens.harvard.edu): Our lab has found that mobile zinc is elevated in retinal neurons after optic nerve injury, which contributes to the death of retinal ganglion cells. Chelation of zinc protects ganglion cells from dying and allows for axon regeneration. My project seeks to understand if mobile zinc triggers a microglial injury response in the retina after optic nerve injury, and to identify effects of microglia on survival and axon regeneration of retinal ganglion cells. We are also studying the earliest changes in cellular DNA that determine whether cells will live or die and/or be able to regenerate axons.

 

Dr. Nicholas Hanovice (Nicholas.hanovice@childrens.harvard.edu): My project is focused on identifying the injury-mediated retrograde signaling events that culminate in the buildup of mobile Zinc in retinal interneurons and how multiple types of retinal neurons interact to facilitate RGC degeneration after optic nerve crush.

 

Dr. Silmara de Lima (silmara.delima@childrens.harvard.edu): Previous studies from our lab have shown that under appropriate stimulation retinal ganglion cells - the projection neurons that send visual information from the eye to the brain - are able to regenerate long axons and reconnect with some brain targets. However, for this connection to be completely functional, multiple cellular changes must occur. One of these is myelination, the formation of the membranous sheath that enwraps the axons and is produced by glial cells called oligodendrocytes. This sheath insulates the axons so the electrical signal, the action potential, is propagated quickly and accurately along the axons. We are studying how this process takes place on regenerating axons and ultimately we plan to stimulate remyelination along the entire length of regenerating axons after nerve injury.

 

If interested please submit your CV/resume (include relevant course work and previous lab experience) to Dr. Larry Benowitz (larry.benowitz@childrens.harvard.edu) and the postdoc you are interested in working with.

 

Requirements: No prior research experience needed. However, an interest in life sciences research and good communications skills are required. The student is expected to work for minimum 10 hours a week for a commitment of at least 1 semester (duration is flexible, but longer commitments of 2 or more semesters are preferred and highly encouraged).

 

Learning outcomes: The student will be exposed to background literature in the field and will be involved in all aspects of data collection and analysis, including sample preparation, image acquisition, and analysis of neuron survival and axon regeneration. Training will include learning experiment design, data analysis, and statistics. The student will participate in weekly lab meetings in which lab members of all levels will participate (PI, PhD, and undergraduate).

 

Mentoring: The student will be mentored by the PI and postdoc under whom they work. The student will interact with other members of the lab during training and project meetings, as well as weekly mentorship meetings.

 

Funding: Students are encouraged to apply to the HCRP fellowship and other fellowships, or to register for a research course credit (contact Dr. Anna Babakhanyan, Research Advisor for more information at ababakhanyan@fas.harvard.edu).

 

 

Undergraduate Research Opportunity in Analogue Seismogram Digitization Citizen Science Project with High-School Students in Japan

Contact information:

Miaki Ishii, Professor of Earth and Planetary Sciences

20 Oxford Street, Cambridge, MA 02138.

ishii@eps.harvard.edu

Project description and duties: The seismology group has been developing a software, DigitSeis, to convert scanned images of analogue paper seismograms into research-quality time series information.  We are rolling out a citizen science project to involve high-school students in Japan to use the software to digitize seismograms in collaboration with teachers in Japan.  We are seeking a student to help with this citizen science project.  The student will gain experience in using the DigitSeis software and interaction with high-school students and teachers in Japan.  The student will also benefit from learning about historical seismology and efforts to preserve and use the data.

Project Page (in Japanese): http://seismology.harvard.edu/research/DigitSeisJapan/index.html

DigitSeis Page: http://seismology.harvard.edu/research/DigitSeis.html

Skills required: Fluency in written and spoken Japanese and interest in learning and using the DigitSeis software are required. Skills in MATLAB programming and web page development would be a plus, but ability to collaborate, solid work ethics, and positive attitude take priority. 

Number of hours: Schedules can be determined on an individual basis, but 8-12 hour weekly commitment is recommended (can be a mix of in-person and remote work). 

Mentoring: The student will be primarily mentored by Prof. Miaki Ishii with help from another undergraduate lab member, Thomas Lee, and can expect weekly one-on-one meetings to discuss research and professional development goals.  The student will also be encouraged to participate in the weekly group meeting to broaden seismological perspective and interact with the group members.

Student pay: $11/hour

Application information: If interested, please send a resume and brief statement about your interest in working with us to Miaki Ishii (ishii@eps.harvard.edu).

 

Research Opportunity, The Emotion and Social Neuroscience Laboratory, Department of Psychiatry, MGH

Contact information: Please contact Wisteria Deng, ywdeng@mgh.harvard.edu. 149 13th Street, Charlestown Navy Yard, Martinos Center. For more information, visit http://holtlab.wixsite.com/esnlab

Project description and duties: The intern will assist with one or more studies that examine the neural and/or behavioral basis of abnormalities in emotional processes and social perception and/or behavior in schizophrenia and related conditions. He or she may be involved in acquiring and organizing research data, recruiting and characterizing eligible subjects, and administering and scoring interviews/questionnaires. The position is an excellent one for someone interested in learning more about clinical neuroscience, neuroimaging and/or research in psychology and psychiatry.

Skills required: Good interpersonal skills, maturity and problem-solving abilities. proficiency in Word, Excel and Powerpoint. Knowledge of MATLAB or UNIX (or similar programming languages) would be a plus.

Learning outcomes: The intern will become highly familiar with the scientific objectives and procedures of a clinical research program in psychiatry. Specifically, the intern will have a thorough exposure to neuroimaging (e.g., functional MRI) and cognitive neuroscience methods used to investigate open questions about the biology of psychosis and related conditions, as well as novel neuroscience-based approaches (e.g. virtual reality) for treating symptoms of schizophrenia.

Number of hours students are expected to work, length of the project: 10-16 hours per week. 1 or 2 years commitment is preferred.

Mentoring: The student will receive direct mentoring from the principal investigator of the laboratory, Dr. Daphne Holt, and other members of the lab, including post-doctoral fellows and research coordinators.

Student stipend: No stipend will be paid, but students are encouraged to apply for Harvard fellowships (contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu) for more info: https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Another potential option for some students (typically juniors or seniors) is to conduct research for course credit; however, a student cannot earn course credit and be paid a stipend in the same semester.

 

Application information: Please email a resume, a statement of interest and goals, transcript (unofficial) and contact information for three references to Wisteria Deng at ywdeng@mgh.harvard.edu).

 

 

Undergraduate Research Opportunity – Molecular Imaging, Gordon Center for Medical Imaging, MGH

PI: Pedro Brugarolas, PhD, Assistant Professor of Radiology

Harvard Medical School, Gordon Center for Medical Imaging, Massachusetts General Hospital

Contact info: Pedro Brugarolas, PhD pbrugarolas@mgh.harvard.edu    Lab website  

Lab location: Massachusetts General Hospital, 55 Fruit St, Bulfinch 051, Boston, MA 02114

Department website

Description of the project and duties:

The candidate will work alongside the PI and a postdoc producing and characterizing new radioactive and non-radioactive small molecules for medical imaging. The goal of the lab is to develop new radiotracers for positron emission tomography (PET) and characterize them in animal models of disease. See Development of a PET tracer for potassium channels to image demyelination for an example of the work.

Requirements: 1 semester of general chemistry with lab. Desired: 1 semester of organic chemistry with lab. Previous research experience in a chemistry or biochemistry lab.

Learning outcome: Students will learn the fundamentals of radiochemistry and PET imaging. Students will learn how to work safely in a radiochemistry lab. Students will also learn methods to generate and characterize small molecules including HPLC, NMR, etc.

Number of hours students are expected to work, length of the project:

Term and hours are negotiable. Preference will be given to students interested in working 12+ months to allow them to master techniques and produce results. During summers, students are encouraged to spend 25+ hours a week in the lab. During the school year, students are encouraged to attend lab meetings and spend time in the lab as their schedule permits (minimum 8h/week).

Mentoring: Students will work alongside a postdoc (1 student per postdoc). As they become proficient in certain tasks, students will gain independence. Students may not work alone in the lab. Postdoc will provide day-to-day supervision. PI will meet with the student regularly (once or twice a week) to review progress and assist with the research questions.

Funding:  Students are encouraged to apply to the HCRP and other fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu) or register for a research course credit. Limited funding may be available from the lab.

Interested? Please send CV/resume and interests to Dr. Pedro Brugarolas at pbrugarolas@mgh.harvard.edu

 

Posted September 11, 2018

Undergraduate Research Opportunity in Biological and Artificial Intelligence (Kreiman Lab)

Contact information: Gabriel Kreiman, Boston Children’s Hospital http://klab.tch.harvard.edu
Note: location = Longwood campus
Contact: klabcoordinator@gmail.com, gabriel.kreiman@tch.harvard.edu

Project description and duties: Our lab is interested in elucidating how neural circuits compute and building biologically-inspired Artificial Intelligence. To this end, we combine behavioral measurements, invasive neurophysiological recordings in the human brain and computational neuroscience models. The main topics of investigation center around visual recognition, learning, and memory. Within visual recognition, current projects include studying the mechanisms of pattern completion, visual search, context and task dependence, spatiotemporal integration and building machines that can see and interpret the world the way we do. Within learning and memory, current projects include studying real life memories, understanding how medial temporal lobe circuits lead to memory consolidation, and building biologically plausible models for episodic memory formation.

Examples of recent work: http://klab.tch.harvard.edu/publications/publications.html

Skills required: Programming experience would be extremely useful (though not strictly required).

Learning outcomes: machine learning, computer programming, data analysis methods, presentations, scientific writing.

Number of hours students are expected to work: minimum of 10 hours per week

Length of the project: minimum of 6 months (the longer the more you will get out of it)

Mentoring: You will be mentored by Prof. Kreiman and by either a graduate student or postdoc in the lab. We expect to have biweekly meetings. You will be welcome to join our lab meetings.

Student stipend: This is a volunteer position or for credit position. We would also be happy to help you apply for relevant fellowships (contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu for more info on fellowships), particularly for research during the summer.

How to apply: send a copy of your CV by email to gabriel.kreiman@tch.harvard.edu

 

 

Undergraduate Research Opportunity, Dr. Kneeland, Division of Alcohol and Drug Abuse, McLean Hospital

Contact information: Elizabeth Kneeland, PhD (ekneeland@partners.org). Division of Alcohol and Drug Abuse, McLean Hospital

Project description and duties: Students would be involved in ongoing research projects at the Division of Alcohol and Drug Abuse at McLean Hospital with Drs. Roger Weiss, Kathryn McHugh and Elizabeth Kneeland. Responsibilities include recruiting potential study participants from hospital clinics and the local community, supervising research participants in the completion of study protocols, data management, and other administrative tasks.

Skills required: Prior lab experience preferred.

Learning outcomes: Research skills such as study design and implementation, data management and analysis methods, interacting with research participants in a clinical setting, and working within an interdisciplinary team.

Number of hours: 8-16 hours/week

Mentoring: Weekly research and laboratory meetings with research staff; professional development meetings with research fellow (Elizabeth Kneeland).

Student stipend: Lab does not provide student stipend. Students can volunteer, apply to the HCRP (contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu for more info) or they can register for a course-credit.

 

 

Undergraduate Research Assistant, Intestinal Parasites of Madagascar, Golden Planetary Health Lab, Harvard T.H. Chan School of Public Health

Contact information: Dr. Christopher Golden, Department of Nutrition, https://www.hsph.harvard.edu/christopher-golden/

 

Project description and duties: We are looking for a research assistant to get trained in reading fecal sample slides to document the presence and enumerate intestinal parasites from a cohort of 5,000 Malagasy people. This will be a phenomenally interesting project as prevalence rates are higher than 30% in most samples and you will learn how to identify the intestinal parasites from Dr. Jamie Maguire, one of the world’s leading experts at Brigham and Women’s Hospital. The undergraduate researcher is responsible for organizing, processing, and creating the fecal sample slides, as well as identifying, enumerating, and creating a database of intestinal parasites.

Skills required: Some background in microscopy is welcomed. No other skills required except a great attitude and a passion for research.

Learning outcomes: The student will be trained by one of the world’s leading experts in intestinal parasite microscopy and will have the opportunity to document the prevalence of a variety of parasites from a population in Madagascar. After the conclusion of the lab research, the student would be welcomed to learn how to write up and co-author the results as a peer-reviewed scientific research article.

Number of hours students are expected to work: 6-10+ hours per week; minimum one-semester commitment with two semesters or more preferred.

Mentoring: Dr. Christopher Golden and Dr. Jamie Maguire, informal meetings as schedule allows, approximately 2-4 times per month. Much of this work will be independent following daily training.

Student stipend: $15/hour

Course credit: Available to candidates who meet certain qualifications, especially if interested in a GHHP secondary.


Application information: Email a CV and cover letter describing the student’s interest in the position and background experience to golden@hsph.harvard.edu

 

 

Posted September 7, 2018

Undergraduate Research Opportunity in Sleep and Cognition

Contact information: Dr. Robert Stickgold, Associate Professor and Director of the Center for Sleep and Cognition at HMS and BIDMC (http://sleepandcognition.org/), 375 Longwood Ave, Boston, MA 02215. If interested, write to rstickgold@hms.harvard.edu.

Project description and duties: The Center for Sleep and Cognition at BIDMC is seeking students for fall 2018 to study the impact of sleep and sleep deprivation on a range of behavioral and cognitive tasks, including memory, under the direction of Dr. Robert Stickgold. Students will gain experience in a number of hands-on techniques, including the administration of cognitive tests, high-density electroencephalograph (EEG) recording and polysomnography (PSG) to allow for the analysis of sleep stages. Students may also benefit from learning about experimental design as new projects are developed over the course of the year, and may have the opportunity to assist with overnight sleep deprivation studies. 

Skills required: Previous research experience is a plus, but ability to collaborate, and solid work ethics and positive attitude take priority.  

Learning outcomes: laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing. Mentorship through the lab can include assistance with senior thesis writing and guidance in grad/med school applications.

Number of hours: Schedules can be determined on an individual basis, but 8-12 hour weekly commitment is recommended (can be a mix of in-person and remote work). Six months minimum commitment. 

Mentoring: Students will be primarily mentored by Dr. Tony Cunningham and can expect weekly one-on-one meetings to discuss research and professional development goals. Students are also welcome to attend full lab meetings, and will have the opportunity for direct meetings with Dr. Stickgold.

Student stipend: None from the lab. You are welcome to apply for Harvard fellowships, contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu

Course credit: Credit for laboratory research courses (e.g., Neurobiology 91r) can be arranged.

Application information: If interested, please send a resume and brief statement about your interest in working with us to Dr. Stickgold (rstickgold@hms.harvard.edu).

 

 

Undergraduate Research Opportunity, Dr. Kevin Houston Lab, Mass Eye and Ear

Contact information: Dr.Kevin Houston, Assistant Scientist, Schepens Eye Research Institute.  20 Staniford St.

Boston Ma, 02114

kevin_houston@meei.harvard.edu  http://www.schepens.harvard.edu/faculty/houston.html

Project description and duties: Students will have the opportunity to work on the Boston Blink-netic Project: A collaboration between the Boston Keratoprosthesis Lab and the Vision Rehabilitation Center of Excellence at Mass Eye and Ear which aims to reanimate paralyzed eyelids using magnetic force.  Students would assist our project engineer in production of the biocompatible eyelid prosthesis devices providing the opportunity to learn soft lithography techniques.  Opportunity to work with research subjects with eyelid disorders exists.  Skills learned would benefit students interested in ophthalmology, optometry and/or medical device engineering.

Skills required: Mid-level skills with MS excel are preferred.  

Learning outcomes: laboratory skills, presentations, and scientific writing.

Number of hours students are expected to work, length of the project:  This is a 2 year project with a 1 year minimum commitment.  Days per week are negotiable.  

Mentoring: Students will be mentored by Dr. Kevin Houston, Assistant Scientist and clinical vision rehabilitation specialist at Mass Eye and Ear, and Dr. Eleftherios Paschalis, Assistant Scientist and director of the Keratoprosthesis Laboratory at Mass Eye and Ear.   Mentorship meetings will formally occur once every 2 weeks, but an open door policy is maintained by both mentors.  Students will also be allowed to attend project meetings, institute research meetings, and weekly scientific seminars.  

Student stipend: The position is unpaid. Students may apply for Harvard fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu): https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: Consult with your academic liaison.  

Application information: interested applicants should send their cover letter and resume to Kevin E. Houston, OD, FAAO

Assistant Scientist, Schepens Eye Research Institute, Mass Eye and Ear kevin_houston@meei.harvard.edu 

 

 

Undergraduate Research Opportunity, Dr. Ciolino Lab, MEEI

Contact information: Dr. Joseph B. Ciolino and Department of Ophthalmology,  Schepens Eye Research Institute, Joseph_Ciolino@MEEI.HARVARD.EDU

Project description and duties: Effective treatment of eye diseases is a formidable task because of the presence of the eye barriers and the nature of these diseases. Current primary medical therapy involves an intensive regimen of hourly eyes drops with side effects. We have developed drug-eluting contact lenses (lenses containing therapeutic amounts of the drug) as a viable alternative to achieve sustained and safe drug release. The platform delivery technology provides continuous therapeutic levels of drug to the eye for long periods of time, thereby improving efficacy and patient comfort, eliminating the need for frequent instillations of eye drops, and reducing the treatment burden. The technology has led to several publications (e.g., Joseph B. Ciolino, et.al, Biomaterials, 2014, 432-439) and has been granted  a US patent. The student will assist in optimization of drug-polymer formulations, fabrication of contact lens, and characterization of drug flux.

Skills required: Are students expected to have any particular laboratory skills, if so which ones? If no prior research experience is required, state so to encourage applications from new undergraduate researchers.

Our research group welcomes highly motivated undergraduate students. Hands-on experience in chemistry laboratory skills is preferred. Knowledge of basic organic chemistry concept is required.

Learning outcomes: The student will gain skills in the fabrication of drug-eluting contact lens as well as characterization of drug flux (e.g. HPLC). The student will study rational design of drug-polymer formations. The student will learn to interpret results, evaluate data, draw relevant conclusions, and present data to the team.

Number of hours students are expected to work, length of the project: 6-8 hours per week for one year. These are negotiable.

Mentoring: The student will closely work with postdoctoral fellows in our lab. Once a week for mentorship meeting. The student can attend group meeting. The student is supposed to maintain confidentiality pertaining to any generated research results or intellectual property.

Student stipend: Sponsored by faculty and Faculty Aide Program or HCRP (contact Dr. Babakhanyan at ababakhanyan@fas.harvard.edu for more info on Harvard research fellowships).

 

Undergraduate Researcher, Yu Lab, Ragon Institute of MGH, MIT and Harvard

Contact information: Dr. Xu Yu (MGH, HMS); xyu@mgh.harvard.edu; 400 Technology Sq, Cambridge, MA; http://www.ragoninstitute.org/portfolio-item/yu-lab/

Project description and duties: The candidate will assist in molecular/cellular biological research on pathogenesis and viral persistence during HIV-1 infection. Knowledge gained from these studies will help guide the design of more effective vaccines and treatments against various infectious pathogens, including HIV and Zika virus.

Skills required: Only a willingness to learn new techniques

Learning outcomes: Students will hopefully become proficient in a variety of laboratory techniques including DNA/RNA isolation, cDNA generation, PCR, cloning, and cell culture; they will also gain experience designing experiments, analyzing raw data, and presenting their work at lab meetings.

Number of hours: To be discussed

Mentoring: Students will be mentored by a combination of technicians, post-docs, and Dr. Yu; students will have weekly meetings with Dr. Yu to discuss their experiments, and will be encouraged to attend weekly lab meetings with the whole group.

Student stipend: Stipends from the lab are available, but we also encourage students to apply for Harvard fellowships if possible (https://lifesciences.fas.harvard.edu/research-opportunities)

Course credit: Also available for students not receiving a stipend.

Application information: Please submit resumes and cover letters to Kevin Einkauf (keinkauf@partners.org

 

Undergraduate research opportunity at Dr. Vidal lab in Dana-Farber Cancer Institute

PI name: Marc Vidal, Department: Genetics, Harvard Medical School

Contact information: Tel) 617-632-5114, Email) soong_choi@dfci.harvard.edu, CCSB_Admin@dfci.harvard.edu, marc_vidal@dfci.harvard.edu
Location: 450 Brookline Avenue, Smith 858, Boston, MA 02215 Lab website: https://ccsb.dana-farber.org

Description of the project and duties

Small molecule discovery to target protein-protein interactions (PPIs) of histone deacetylase (HDAC) complex

We are interested in identifying small molecules that disrupt PPIs of the HDAC complex. PPIs are non-conventional drug targets with new emerging opportunities, but with very limited understanding and challenges. We speculated that unbiased functional screening of small molecule libraries against a multi-protein complex can yield insights that can help us to identify the types of inhibitory molecules and their capable PPI targets. We selected the Rpd3 HDAC protein complex from yeast as a model to systemically investigate the question. Based on the primary high-throughput screening of diverse small molecule libraries, we identified 59 small molecules that perturb the function of the Rpd3 HDAC complex. Based on subsequent tests, we identified several prospective PPI disruptors and enzymatic HDAC inhibitors. We are now poised to test all these 59 compounds with a panoply of different molecular biology, genetics, and biophysical tools to fully characterize their protein targets, binding mechanisms, and associated cellular functions associated with specific PPI inhibitions. We will measure the effect of the candidate compounds on reconstituted HDAC PPIs, downstream gene expression, histone acetylation modifications, and other cellular phenotypes particularly using yeasts and cancer-derived cells.

Student duties: The student will perform various experiments such as Western blot, multiple PPI assays, yeast genetics, qPCR, and mammalian cell-based assays. The student is expected to come in time, prepare necessary materials for their experiments, generate data, and make well-documented laboratory notebook for record keeping and data analysis. The students will participate in various laboratory meetings and discussions. He or she will contribute to maintaining clean and safe research environment.

Skills required: We prefer students to have basic molecular biology laboratory skills, but it is not required. No prior research experience is necessary. We will provide experimental and theoretical trainings to gain their research skills.

Learning outcome: The students will learn various molecular, cellular, and genetic laboratory experiments. The Vidal lab is equipped with state-of-arts, high-throughput robotics that students will be able to be exposed to various modern high-throughput experiments.

The student will acquire knowledge and expertise on the emerging field of PPI drug discovery via experiments, literature reading, and scientific discussions. As we study the HDAC protein complex and investigate its role in cancer treatment, the student will learn various topics in the epigenetics and its role cancers. The Vidal lab is a world-class systems biology laboratory that students will be exposed to various topics in interactome mapping, network analysis, high-throughput experiments, and others.

The student will have opportunity to present their works during weekly project meetings and lab meetings. Depending on the progress on the projects, the student will be considered to become a co-author of the publication.

Number of hours students are expected to work, length of the project: We expect that the student spends 15~20 hours per week. However, it is negotiable based on students’ needs. The project will be one semester length but can be extended with new discoveries and student’s performance and needs.

Mentoring: The student will be primarily mentored by Dr. Soon Gang Choi, a postdoc in Marc Vidal’s group at Dana-Farber Cancer Institute and Harvard Medical School. The mentorship meeting will be given for 30 minutes every week. The student’s progress of the project and their personal and scientific topics will be discussed.

The principal investigator of the group, Marc Vidal, will provide his mentorship during weekly project meetings (1hour, Friday).

Stipend: The laboratory does not provide funding to pay student’s stipend. We encourage students to register for a research course credit and for their senior thesis. In addition, we will work very closely with the students to support their fellowship applications such as the HCRP and other fellowship opportunities (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu).

If you are interested in, please send your resume to marc_vidal@dfci.harvard.edu, soong_choi@dfci.harvard.edu, and ccsb_Admin@dfci.harvard.edu to set a schedule for a meeting.

 

 

Research Assistant, Pepperberg Avian Cognition Lab, Harvard University

Contact information: Dr. Irene Pepperberg, Department of Psychology, William James Hall, http://alexfoundation.org/

Project description and duties: Research assistants are responsible for assisting in daily care and the training and testing of African Grey parrots on cognitive and communicative tasks. We are currently investigating concepts of exclusion, delayed gratification, mirror recognition, vocal development, and probabilistic reasoning.

Skills required: Some background in psychology, biology or animal research is helpful but not required; interest in psychology, biology, animal research, or animal care is necessary.

Learning outcomes: Care and handling of African Grey parrots; observation, discussion, and support for ongoing studies; study design and data collection may be possible after a one-semester acclimation period.

Number of hours students are expected to work: 6-10+ hours per week; minimum one-semester commitment with two semesters or more preferred.

Mentoring: Dr. Irene Pepperberg, informal meetings as schedule allows, approximately 1-5 times per week.

Student stipend: Federal Work-Study, plus limited funding available through Faculty Aide Program

Course credit: Available to candidates who meet certain qualifications.
Application information: Email Lab Manager Roni Hyman at pepperberglabmanager@gmail.com to request an application.

 

 

Posted September 6, 2018

Undergraduate research opportunity in at the Quantitative Musculoskeletal Imaging Group Research (Q-MIG), Dr. Duryea, Radiology Department, Brigham and Women’s Hospital

PI name: Jeffrey Duryea, Ph.D., Associate Professor at Harvard Medical School and Brigham and Women’s hospital, Boston, MA

Contact Information: jduryea@bwh.harvard.edu
Department: Radiology
Location: Department of Radiology Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115

Project description and duties: The candidate will work alongside the PI, a postdoc, and a Harvard medical student using Magnetic Resonance Imaging (MRI) data from one of the largest knee osteoarthritis (OA) cohorts in the world. The project will use highly efficient computer-based methods to automatically and quantitatively measure OA-related knee structures on MRI.

The overall goal of this project is to examine the impact of structural changes on loss of cartilage and worsening of knee function. The results of this study will provide new insights into the prognosis, prevention and treatment of knee OA, with the ultimate goal of facilitating the development and assessment of highly needed disease-modifying drugs for OA.

This is a multi-center collaboration. In our lab, the student will work specifically on computer assessment of bone and cartilage.

Skills required: Basic computer skills using the Windows operating system. No prior research experience is required.

Learning outcomes: The student will develop skills such as study design, data assessment and analysis methods, understanding of radiological imaging, and scientific writing. There will be opportunities for co-authorship depending on performance.

Number of hours students are expected to work: Terms and hours are negotiable. Preference will be given to students interested in working 12+ months to allow them to master techniques and produce results. During summers, students are encouraged to spend 10+ hours a week in the lab. During the school year, students are encouraged to attend lab meetings and spend time in the lab as their schedule permits.  Ideally the commitment should be at least 5 hours per week.

Mentoring: Students will work alongside the postdoc and  medical student with close proximity to the PI for day-to-day supervision and mentoring, in addition to participation in group meetings.

Does the research group provide any funds to pay a student stipend? Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit. Limited funding may be available from the lab. Contact Dr. Babakhanyan for more info about fellowships at ababakhanyan@Fas.harvard.edu.

Application information: Students should submit a resume and include a sentence about what their goals are in pursuing this research. Contact: jduryea@bwh.harvard.edu

 

Undergraduate Research Opportunity, Shivdasani Lab, Dana-Farber Cancer Institute

Contact information:    Ramesh A. Shivdasani, MD, PhD, Professor of Medicine

44 Binney Street, Dana 720, Boston, MA 02215, Ph. (617) 632-5746, ramesh_shivdasani@dfci.harvard.edu  www.shivdasanilab.dana-farber.org
 

Project description and duties: The laboratory studies how transcription factors and chromatin states act to generate and maintain unique cell identities. The dominant model is the mouse gastrointestinal tract, where the group investigates molecular mechanisms of embryonic development and the gene regulatory basis of adult stem cell functions. Recent publications (some with undergraduate authors) include

https://www.ncbi.nlm.nih.gov/pubmed/24413398

https://www.ncbi.nlm.nih.gov/pubmed/26057579

https://www.ncbi.nlm.nih.gov/pubmed/26516633

https://www.ncbi.nlm.nih.gov/pubmed/27111282

https://www.ncbi.nlm.nih.gov/pubmed/27212235

https://www.ncbi.nlm.nih.gov/pubmed/27524622

https://www.ncbi.nlm.nih.gov/pubmed/28648363

https://www.ncbi.nlm.nih.gov/pubmed/29321178

A well-defined project will be crafted based on students’ particular interests, skills, and time commitment. 

Skills required: Working familiarity with research laboratory environments (through prior exposure such as a high school or college summer internship) and at least two of the following college courses completed: Biochemistry, Cell Biology, Genetics, Developmental Biology.

Learning outcomes: Mastery of technical skills in routine molecular biology, cell biology, animal handling, and microscopy. Students will also develop core research skills in framing a project, designing controlled experiments, analyzing and interpreting data, presenting research findings, and scientific writing (e.g., honors thesis, publication in scientific journals, descriptions for a lay audience).

Number of hours: Negotiable. A useful guideline is >10 hrs/week.

Mentoring: Direct mentoring will be provided by a senior postdoctoral fellow, with Dr. Shivdasani’s active involvement. Student can attend (and make oral presentations in) group meetings.

Student stipend: Students are encouraged (and supported) to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities. Contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu.

Course credit: Juniors and seniors may earn academic credit and are especially encouraged to consider basing an honors thesis on research conducted in the laboratory.

Application information: Please email Dr. Shivdasani at ramesh_shivdasani@dfci.harvard.edu

 

Research Opportunity to study the neuronal mechanisms underlying metabolism and reproduction, Dr. Victor Navarro’s lab, BWH

Contact information:

Victor M Navarro. Medicine (Endocrinology), BWH 221 Longwood Ave, Boston

Tel: +1 617 525 6566 Fax: +1 617 582 6193

Email: vnavarro@bwh.harvard.edu Lab website: http://navarrolab.bwh.harvard.edu

Project description and duties:

Our lab focuses on the characterization of the central factors that regulate reproduction and metabolism including, but not limited to, Kiss1 and POMC neurons using a variety of genetic mouse models and viral delivery approaches. The student will be involved in the study of the neuronal mechanisms that regulate reproductive axis and metabolic function, along with the neuronal circuitry that links reproduction to energy balance. He or she will be involved in the development and maintenance of mouse colonies, performing anatomical studies, determination of gene and protein expression in the brain (PCR, in situ hybridization, immunohistochemistry, etc) and stereotaxic injections of viral constructs to modify the expression of targeted genes. Characterization of a number of biological parameters that define reproductive and metabolic functions will be required (e.g. fertility assessments, daily monitoring of puberty onset, body weight, food intake, etc). The student will be expected to work in collaboration with other members of the lab but in an independent manner. He/she will be encouraged to present their data at local and regional meetings, analyze their data and prepare them for publication

Skills requiredPassion, dedication, commitment and ability to work with live mice.

No prior research experience is required. Some coursework in neuroscience and molecular biology would be helpful. Experience with MATLAB is a plus but not mandatory.

Learning outcomesThe student that joins our lab is expected to acquire knowledge of neuroanatomy and physiology of the neuronal networks that govern the endocrine system. He or She will gain experience in the handling of mice and maintenance of animal colonies as well as in the planning and performing of experimental protocols, analysis and interpretation of results and presentation of the data in lab meetings and conferences.

Number of hours students are expected to work: Negotiable
Mentoring: The student will be mentored by myself and senior postdocs in the lab. Weekly meetings will be held.
Does laboratory provide any funds to pay student’s stipend?

No stipend is provided so the student is encouraged to apply for fellowships. Contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu.
Email your resume to vnavarro@bwh.harvard.edu
 

Undergraduate Research Opportunity, Dr. X. Sean Li Lab, BCH, HMS

Contact information: Sean Li, Department of Urology and Surgery, Sean.li@childrens.harvard.edu, Enders Research Building Room 1061.4, 300 Longwood Ave, Boston, MA 02115, http://www.childrenshospital.org/research/researchers/l/xue-li

Project description and duties: Genetics and epigenetics of sex differences in cancer (http://advances.sciencemag.org/content/4/6/eaar5598/tab-article-info)

Skills required: Genetics, Molecular biology, bioinformatics are preferred. However, no prior research experience is required.

Learning outcomes: laboratory skills, research skills such as study design, data analysis methods, presentations, and scientific writing.

Number of hours: Negotiable

Mentoring: A senior staff scientist and PI.

Student stipend: Student will be paid by federal grant however, candidates are encouraged to apply Harvard fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu).

Course credit: Students may also conduct research for course credit and/or thesis project.

Application information: please send personal statement, resume, recommendation letters directly to Sean.li@childrens.harvard.edu

 

Fall/Spring Position, Sleep Matters Initiative, BWH

Currently, there is an opportunity to work with our group Sleep Matters Initiative in the fall/spring to promote a sleep health and wellness program. We have been providing these programs as well as conducting research on and for various groups – such as nurses, residents, students and other shift workers – in order to improve their health and safety.

You can also find our information at the following websites:

https://sleep.med.harvard.edu/research/labs/86/harvard+work+hours+health+and+safety+group

https://www.brighamandwomens.org/initiatives/sleep-matters/sleep-matters-initiative

The Harvard Work Hours, Health and Safety Group, now also known as the Sleep Matters Initiative, are part of the Division of Sleep Medicine with Brigham and Women's Hospital and have affiliations with Harvard Medical School. We have conducted sleep research studies with NASA astronauts, medical interns, college students, police, railroad workers, and firefighters and are currently working on tailoring sleep health wellness programs for various populations.

With this trainee position you will:

- Gain networking opportunities

- Gain experience in a casual atmosphere

- Participate in exciting cutting edge public health research

 

This is not a laboratory position, but mainly focuses on administrative duties in regards to sleep research studies. This may or may not include data entry and maintenance, computer work, conducting mailings, subject recruitment, creating/working with surveys, creating advertisements for recruitment, talking on the phone, screening subjects, and any other duties typically involved in research studies of this nature. It is also an unpaid position, but it would be valuable work experience in this field. We are currently looking for someone that would be willing to work ~10-15 hours a week starting in the fall. The position will last approximately 4-5 months. The trainee would be able to work when it is convenient for their schedule.

 

Job Function: Administration, Administrative/Support Services, Advertising, Analyst, Data Management, Data Entry, Health Services/Healthcare, Research

Interested candidates should contact Natalie Viyaran, Research Assistant, nviyaran@bwh.harvard.edu, Phone: 617-525-2622

Sleep Matters Initiative, Division of Sleep and Circadian Disorders, BWH

Landmark Center, 401 Park Drive, Suite 301.17B West, Boston, MA 02215

 

Undergraduate Research Opportunity, Dr. Pfister's visual computation group, Harvard SEAS

Contact information:
- Hanspeter Pfister (Professor), Harvard SEAS, Maxwell-Dworkin Building
- lab website: https://vcg.seas.harvard.edu/
- Donglai Wei (postdoc), Harvard SEAS,

Project description and duties:
We are now working on three major biomedical image analysis projects, where there are fun and challenging computational tasks to be done for advanced undergraduate students.
- Connectomics project ([TED talk][MIT Tech Review] from us and collaborators): design and deploy deep learning models for 3D neural segmentation.
- Embryo cell division tracking: design and deploy deep learning models for geometry detetcion and object tracking.
- Cancer cell clustering: design and deploy deep learning models for cluserting and expert-in-the-loop cell type categorization.

 

Skills required: taken courses in software engineering and machine learning (or computer vision), fluent in Python

Learning outcomes: work on cutting edge research projects. If the contribution to the project is significant enough, we will include you as an author for publishing in top-conference or journal in the field.

Number of hours: negotiable. we have projects with different level of difficulty and students can take different roles depending on his/her schedule.

Mentoring: One of the postdocs in the group will be the main mentor. The student is welcome to attend group meetings.

Student stipend: No. Please apply for school research funding, e.g. https://lifesciences.fas.harvard.edu/research-opportunities
(contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu).

Course credit: We accept students to do undergraduate thesis in the lab

Application information: Email your resume, unofficial transcript and example code (e.g. github account) to donglai@seas.harvard.edu

 

Undergraduate Research Opportunity, Dr. Salat, Brain Aging and Dementia Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, MGH

Contact information: David Salat, MGH Radiology, salat@nmr.mgh,harvard.edu, 149 13th St, Charlestown MA, https://scholar.harvard.edu/bandlab/home

Project description and duties: Our laboratory examines brain imaging correlates of age related disease including cerebrovascular and Alzheimer's disease. Student researchers would become familiar with methods in neuroimaging research and clinical applications including involvement in participant study visits and would contribute to ongoing research through processing and analysis of existing and incoming imaging data.

See recent manuscripts from our laboratory:

https://www.sciencedirect.com/science/article/pii/S2213158218301748

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534349/

https://www.sciencedirect.com/science/article/pii/S2213158217300220

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321862/

Skills required: No prior research experience is required.

Learning outcomes: Neuroimaging data acquisition, processing, and analysis methods and basic and clinical applications of brain imaging, basic scripting/programming for data processing, neuroimaging research study design, study presentation, and scientific writing.

Number of hours It is expected that a minimum of 5 hours per week in the laboratory for one academic year would be necessary for training and completion of a limited project.

Mentoring: The PI (David Salat) will mentor in conjunction with senior lab members. The student would be invited to group meetings which occur twice weekly. Mentorship meetings are quarterly.

Student stipend: No stipend will be provided from the research group. We would encourage proposals for a stipend through the Faculty Aide Program, Federal Work-Study Program, or through Harvard fellowships. Contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu.

Course credit: Course credit can be offered if research in our laboratory at MGH qualifies for this.

Application information: Interested students should email their resume or questions to David Salat: salat@nmr.mgh.harvard.edu

 

Machine Learning Approaches to the Study of Neurodegenerative Disease, Fraenkel Lab, MIT

Contact Information: Ernest Fraenkel, MIT Department of Biological Engineering, fraenkel-admin@mit.edu

Project Description:

Our group seeks to discover new therapeutic strategies for neurodegenerative disorders through approaches grounded in systems biology.  We integrate diverse information, including genomics, epigenomics, proteomics, metabolomics, clinical and behavioral data.  Using machine learning and network algorithms, we identify potential therapeutic targets for these diseases and refine the models by gathering experimental data in disease models.  Current projects include studies of ALS, Alzheimer’s and Huntington’s disease.

Skills Required: No prior research experience is necessary but prior experience in computer programing (especially in R or python) and basic statistics are preferred.

Learning outcomes: The student will learn how to conduct computational research including how to formulate a question, how to discover answers and how to present results (orally and in writing).  In addition, the student will learn data analysis and machine learning methods that are applicable across many research areas.

Number of hours / length of project: Negotiable

Mentoring: The applicant will be mentored by a graduate student from MIT’s Computational and Systems Biology program who is currently working in the Fraenkel Lab. As the student progresses, s/he will be encouraged to present work at group meetings where s/he will have the opportunity to interact with other members of the research group and Dr. Fraenkel.  The frequency of mentorship meetings will be determined by the student and the mentor and will be adjusted as needed. 

Paid position: Funding may be available, depending on the match of the student’s skills and the projects.  Students are also encouraged to apply to the HCRP fellowship and other fellowships, or to register for a research course credit. Contact Dr. Babakhanyan for more info about fellowships at ababakhanyan@Fas.harvard.edu.

Application Information: Email your CV and unofficial transcript to apply.fraenkel@mit.edu

 

 

Undergraduate Research Opportunity, Ruvkun Lab, MGH

PI: Gary Ruvkun, Department of Molecular Biology, Massachusetts General Hospital. Simches 7th Floor, 185 Cambridge St, Boston. https://ccib.mgh.harvard.edu/ruvkun

Project Description and duties: We have projects that explore how RNA interference mechanisms mediate antiviral responses in the nematode C. elegans, in how mitochondria and ribosomes are surveilled for microbial attack, and other bacterial animal interactions. Our mode of exploration is comprehensive genetic analysis, using genome sequencing to discover surprising new genes in pathways.

Lehrbach, NJ and G Ruvkun. 2016. Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. bioRxiv preprint posted online May. 12, 2016; doi: http://dx.doi.org/10.1101/052936.Elife. 2016 Aug 16;5. pii: e17721. doi: 10.7554/eLife.17721. PMID:27528192

Skills required: Best if you have taken a course such as LS1A & B and even better if you have taken a course in bacterial genetics or animal genetics.

Learning outcomes: Modern genomics and genetics. Scientific discoveries.

Number of hours: For a genetics and genomics project, during the screen, you need to find four hour blocks of time for about a week. Then you isolate DNA and make libraries on your own time, wait for the Ilumina genome sequences, and then do computer analysis of the data that emerges. Then the fun begins.

Mentoring: Student will be mentored by a postdoc in the lab, and in addition will have opportunity to learn and collaborate with other researchers in the lab.

Student stipend: Laboratory can provide funding for student stipend. Students are also encouraged to apply for course-credit or Harvard fellowships such as HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu).

Application information: email your resume to Gary Ruvkun ruvkun@molbio.mgh.harvard.edu

 

Research Opportunity in Dissociative Disorders and Trauma Research Program, Dr. Kaufman group, McLean Hospital

PI: Milissa Kaufman, MD, PhD & Lauren Lebois, PhD Department: Psychiatry

Contact information: llebois@mclean.harvard.edu

Location: McLean Hospital, 115 Mill St, Belmont, MA 02478

Website: www.ddtrp.com

Project description:

Failing to recognize one’s mirror image can signal an abnormality in one’s sense of self. In dissociative identity disorder (DID), individuals often report that their mirror image can feel unfamiliar or distorted. They also experience some of their own thoughts, emotions, and bodily sensations as if they are nonautobiographical and sometimes as if instead, they belong to someone else. To assess these experiences, we have designed a computer based behavioral task that implicitly taps into someone’s “sense of self.”  We would like to have ~30 participants with DID and ~30 participants without DID complete this task along with a battery of self report measures to help us empirically document and understand differences in “sense of self” associated with DID. 

Duties:

  • Recruit, screen, and schedule potential participants with and without DID
  • Guide participants through the research procedures at McLean Hospital (e.g., consent, computer task, questionnaires etc.)
  • Optional: assist in data analysis, submission of conference poster(s), and/or publication(s)

Skills required:

  • Prior research experience not required, but preferred
  • Excellent interpersonal skills are required for working with the study participants.
  • Good oral and written communication skills.
  • Excellent organization skills and ability to prioritize a variety of tasks.
  • Careful attention to detail.
  • Ability to demonstrate professionalism and respect for subjects rights and individual needs.

Learning outcomes: laboratory skills, human subjects research skills such as study design, conduct, data analysis methods, presentations, and scientific writing.

Number of hours students are expected to work: 8-10 hrs/week

Length of the project: Fall semester with the potential to extend into spring semester

Mentoring: Dr. Lebois will be mentoring the student - mentorship meetings 1x/week.  The student will also interact with other lab members in training, meetings, and data collection sessions.  If they would like, they also have the opportunity to attend weekly lab meetings, patient case conferences, and talks at McLean Hospital.

Student stipend: Lab will not provide a stipend, please register for course-credit or apply for HCRP and other fellowships (for questions contact Undergraduate Research Advisor Dr. Anna Babakhanyan ababakhanyan@fas.harvard.edu).

Application information: Please submit a cover letter and a resume to Dr. Lebois at llebois@mclean.harvard.edu

 

Research Assistant for Health Services Research Projects, Dr. Weissman Research Group, BWH

PI: Dr. Joel Weissman, PhD, Professor of Surgery (Health Policy) at Harvard Medical School and Deputy Director, Chief Scientific Officer at Center for Surgery and Public Health.

Contact Information: 617-525-7727

Location: 1620 Tremont St, 4-020, Center for Surgery and Public Health, Boston 02120

https://www.brighamandwomens.org/research/center-for-surgery-and-public-health/overview

Project description: One or two research assistants are needed for at least two projectsOne project is an NIH-funded study focusing on advanced care planning (ACP) discussions between patients and providers.  ACP refers to discussions around patient values and preferences for their care, including end of life discussions.  This study uses both quantitative and qualitative methods, that includes quantitative data analysis of Medicare claims data and qualitative data collection through interviews, case studies and focus groups. The overarching goal is to examine the use of ACP discussions, barriers and facilitators to their use, and their impact on the intensity and outcomes of care received by seriously ill patients nearing the end of life.  The second project is developing a research agenda around patients with dementia who undergo surgery. 

Duties: This is an opportunity for students who are interested in improving patient care. The research assistants will get an opportunity to indulge in and help with several phases of the study. The specific tasks will include literature review, coding of the qualitative transcripts, small-scale survey of clinicians within the institution, participant recruitment, and similar other tasks as required.

Skills required: The RAs must have a basic level of proficiency in Microsoft Word and Microsoft Excel, and a familiarity with literature search on databases such PubMed and Google Scholar.  Preferred skills: synthesizing literature and summarizing information from various sources; interpreting basic quantitative data such as frequencies, mean, mode and ratios; writing up reports.

Learning outcomes: The RAs will gain experience in several key components of a research study. RAs will receive training in conducting literature review and qualitative data analysis. Through participation in recruitment, surveys and project meetings, they will gain an understanding of research design and methods. The RAs will have the opportunity to present her/his work at the project meetings and to participate in scientific writing.

Number of hours: The RAs are expected to work approximately 12-14 hours per week. This is negotiable and will vary with the amount of work required in a particular week. Total duration of work is also negotiable and will depend on the progress of the work. However, we expect to engage the RAs for about 4-6 months.

Mentoring: The RAs will be mentored by the PI, Dr. Weissman or other key investigators depending on the task. The RAs will attend some project meetings, and a bi-weekly mentorship meeting with the PI.

Student stipend: Dr. Weissman will provide funds to support the RAs for a period of 4-6 months at a rate of $14/hour.  Students eligible for Work-Study are encouraged to apply. 

Application information: Please submit a cover letter and a resume to Dr. Weissman at jweissman@partners.org .

 

Undergraduate Research Opportunity in Neurodegeneration”, Rosenberg Lab, Boston Children’s Hospital

Contact information: Paul Rosenberg and Department of Neurology, paul.rosenberg@childrens.harvard.edu, Center for Life Science, www.hms.harvard.edu/dms/neuroscience/fac/rosenberg.php

Project description and duties: (https://www.ncbi.nlm.nih.gov/pubmed/29709465). We are seeking to understand the basis for the synaptic dysfunction in chronic neurodegenerative diseases such as Huntington’s disease, and Alzheimer’s disease.

Skills required: Prior lab experience is recommended but not essential.

Learning outcomes: study design, data analysis, cell and molecular biology methods, presentations, and scientific writing.

Number of hours students are expected to work, length of the project: negotiable

Mentoring: postdoctoral fellow, principal investigator, weekly mentorship meetings, can attend group meetings.

Student stipend:

May be a paid position: (sponsored by faculty, Faculty Aide Program, Federal Work-Study Program, or encourage students to apply for Harvard fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu): https://lifesciences.fas.harvard.edu/research-opportunities

Course credit: possible; students are encouraged to complete a senior thesis.

Application information: Email your resume to Dr. Rosenberg Paul.Rosenberg@childrens.harvard.edu

 

Spring or Summer 2019 Undergraduate Clinical Research Intern, Dr. Kong, Chronic Pain and Brain-Imaging Laboratory, MGH Department of Psychiatry

Contact information: PI: Jian Kong, MD, MS, MPH, Chronic Pain and Brain-Imaging Laboratory, MGH Department of Psychiatry
Location: 120 2nd Street, Charlestown, MA 02129 Lab website: https://www.nmr.mgh.harvard.edu/user/5823
Contact name: Georgia Wilson, BA, Clinical Research Coordinator, gjwilson@mgh.harvard.edu Tel. 617-726-5004

Description and duties:

The focus of this position will be interacting with clinical research participants while getting unique hands-on experience with state-of-the-art medical technologies. Major responsibilities will include working with chronic pain patients and healthy adults for several NIH-funded projects. Such projects will employ functional neuroimaging techniques, including fMRI, to understand the mechanisms of pain processing and modulation by brain stimulation (tDCS) under the supervision of PI Jian Kong. Undergraduate clinical researchers will be trained to operate MRI machines, administer brain stimulation to participants, and utilize virtual reality technology. Past research assistants have gone on to attend graduate, medical, and dental school, as this experience serves as an excellent stepping stone for a diverse set of career paths.

Principal duties and responsibilities:

  1. Assisting with study MRI sessions
    1. Accompanying participants to MRI sessions and helping them acclimate to the MRI environment
    2. Loading subjects into the MRI machine
    3. Preparing study equipment for MRI scans
  2. Assisting with Quantitative Sensory Testing during behavioral and MRI sessions
    1. Training in the operation of machines and devices that apply thermal and/or mechanical stimuli to subjects in order to measure their pain sensitivity
    2. Assisting in the set up and operation of tDCS (transcranial direct current stimulation)
  3. Coordinating study visits
    1. Scheduling sessions
    2. Using online calendars and software to coordinate patient sessions with the availability of testing rooms, MRI scanners, and other equipment
    3. Coordinating meetings and testing sessions with study personnel
  4. Recruiting new subjects into the study on an ongoing basis
    1. Researching and implementing new recruitment methods
    2. Conducting email and phone screenings of potential subjects

 

Skills required:

  • Excellent telephone and oral/written communication skills
  • Strong writing skills
  • Ability to answer questions from subjects regarding imaging and testing procedures
  • Ability to work independently and as a team member
  • Careful attention to detail
  • Good organizational skills and the ability to multi-task
  • Ability to follow directions and give clear directions to subjects
  • Patience, assertiveness, and ability to take initiative
  • Creativity and problem-solving skills
  • Computer literacy with Word, Excel, and PowerPoint
  • Prior research experience encouraged but not required

Learning outcomes:  Clinical research experience, experience with brain-imaging and brain stimulation technologies, knowledge of study design and implementation, learning to recruit and interact with both healthy subjects and chronic pain patients, experience with research manuscript revision

Number of hours/length of internship: Weekly hours are negotiable; internship will take place for the duration of the spring semester or during the summer.

Mentoring: Mentors will include the principal investigator, Dr. Jian Kong. Clinical research coordinators Georgia Wilson and Joel Park will also serve as mentors for undergraduate interns. Interns will work closely with the research coordinators, and mentorship meetings with Dr. Kong will occur as needed. Student interns will be encouraged to attend lab meetings.

Student stipend: This internship opportunity is unpaid. However, we encourage interested students to apply for a Harvard fellowship (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu) at https://lifesciences.fas.harvard.edu/research-opportunities.

Course credit: Student interns can apply to receive research course credit for this internship.

Application information: If interested, please email Georgia Wilson (gjwilson@mgh.harvard.edu) with your résumé and a writing sample.

 

   Undergraduate Research Opportunity: Drug Sensitivity in Lung Cancer, Dr. Benes Lab, MGH Cancer Center

Principal Investigator: Cyril Benes, PhD,  cbenes@mgh.harvard.edu

  Location: Massachusetts General Hospital Cancer Center, Charlestown, MA.

  Lab webpage and relevant publications: https://www.massgeneral.org/cancerresearch/research/researchlab.aspx?id=1408

  Project description and duties: Our group is looking for a highly motivated undergraduate student to work during the Fall on a   project involving in vitro studies to determine the effect of different drugs in Lung Cancer.

  Lung cancer remains the leading cause of cancer-related deaths. The discovery of several driver mutations has led to the         development of new therapies and improved the clinical outcome for patients. However, non-small cell lung cancer (NSCLC)   driven by KRAS mutations remains challenging to treat in the clinic due to the lack of direct KRAS inhibitors and the      development of resistance to the available treatments. Therapies aimed at treating this type of tumors mostly target  downstream effector pathways activated by KRAS. There are several ongoing preclinical efforts to find effective drug  combinations that work effectively in KRAS NSCLC tumors as a way to improve tumor growth inhibition.

  Our lab runs a high-throughput drug screening center. We expose cell lines from a broad spectrum of cancers to our large    collection of known and new anticancer therapeutic agents. We characterize the activity of drug combinations to discover  therapeutic applications and biomarkers of response that could be used to select patients most likely to benefit.

  In this project, the student will use a panel of human KRAS NSCLC cell lines and test different drugs including FDA approved  or investigational compounds, to validate drug combinations that effectively reduce the viability or induce apoptosis of these  cell lines. The student will learn to perform short-term drug screenings, viability readout assays e.g. CellTiter-Glo or  Clonogenic assays and depending on the timeline, to implement downstream mechanistic analysis to understand which  genes/proteins are affected in the presence of the different drug combinations.

  Main Questions:

- What are the most effective drug combinations for different subgroups of KRAS mutant NSCLC?

- Are there specific cellular “biomarkers” that predict response of these cells to such combinations?

- What are the main molecular mechanisms affected by these drugs and how do they differ from non-responder cell lines?

  Skills Required: A good theoretical understanding of fundamental molecular/cellular biology. Experience with mammalian    cell culture would be preferred but it is not a requirement.

  Learning Outcomes:

 Laboratory/Research Skills: e.g. tissue culture of human cancer cell lines, drug screening assays, cell staining.

 Data analysis methods: Excel, Prism.

 Assistance in the preparation of lab meeting presentations.

 Others: Basic concepts of Dose-Response in Pharmacology. Literature search.

 Number of hours:  Hours are negotiable but expected at least 10-15 hours/week during the academic year. 

 Project Duration: Preferably September to December 2018, with the possibility to continue during the summer.

 Mentoring: The student will be mentored by Eliane Cortez, a postdoctoral researcher in the lab. Mentorship meetings will  happen on a regular basis depending on the availability of the student. Students are welcome and encouraged to attend the  different meetings and seminars at the Cancer Center department.

 Stipend: Funding from the lab will not be available for this position. Students are encouraged to apply for Harvard Fellowships ( contact Dr. Babakhanyan for more info at aBabakhanyan@fas.harvard.edu) https://lifesciences.fas.harvard.edu/research-    opportunities or alternatively for course credits.

 Contact: Email your resume and research interests to Eliane Cortez at emonteirocortez@mgh.harvard.edu

 

 

Undergraduate Research Position, Haigis Lab, Harvard Medical School

Contact information: Dr. Marcia Haigis is a professor in the Department of Cell Biology at Harvard Medical School, whose research focuses on studying the function and signaling roles of mitochondria during aging and age-related disease. https://haigis.hms.harvard.edu/

Project description and duties: We aim to understand the role of mitochondria in human health, aging, and age-related disease. Students will have the opportunity to learn biochemical and cellular laboratory techniques which will help them understand new molecular mechanisms that allow mitochondria to adapt to stress.

Skills required: Students are not expected to have laboratory skills but will be expected to learn fast and be self-motivated. A basic understanding of chemistry, biology, and biochemistry is desired.

Learning outcomes: Laboratory techniques include mitochondrial assays, Western blotting, tissue culture, and working with mouse models. Students will also engage in experimental design, data analysis, and presentation. Most importantly, students will be encouraged to love what they do and work hard towards our goal of understanding the pivotal role of mitochondrial in human health and disease.

Number of hours: Term and hours are negotiable. Preference will be given to students interested in working 12+ months to allow them to master techniques and produce results. During summers, students are encouraged to spend 25+ hours in the lab. During the school year, students are encouraged to attend lab meetings and spend 15+ hours in the lab as their schedule permits.

Mentoring: Students will work alongside a postdoc or graduate student. As they become proficient in certain tasks, students will gain independence Postdoc or grad student will provide day-to-day supervision. PI will meet with the student regularly to review progress and assist with the directionality of research experiments.

Student stipend: Students are encouraged to apply for undergraduate fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu) or register for a research course credit. Limited funding may be available from the lab.

Application information: Please send a cover letter expressing your interest in working in the lab, alongside a CV/resume to Olivia Rombold at Olivia_Rombold@hms.harvard.edu

 

Undergraduate Research Opportunity, Dr. Pandya’s Stroke Modeling Research Team, Center for Health Decision Science at the Harvard T.H. Chan School of Public Health

Contact information: Ankur Pandya, Assistant Professor of Health Decision Science, Department of Health Policy and Management, 718 Huntington Ave 2nd floor (Longwood area),https://www.hsph.harvard.edu/ankur-pandya/

Project description and duties: Stroke is a leading cause of death, disability, and healthcare costs in the United States. By applying a simulation modeling approach, our research would be able to quantify the key tradeoffs among health benefits, risks, and costs for any feasible stroke prevention or treatment policies. We will build and apply a computer-based micro-simulation model in C++ to evaluate the cost-effectiveness of stroke prevention and treatment policies. The research assistant will be responsible for conducting literature searches to estimate and update model input parameters for stroke nature history, prevention, treatment, and quality measures for stroke care. The research assistant will also assist in the creation of analytic datasets as well as the development of tables and figures of study results for scientific presentations and manuscripts. Two example publications:https://www.ncbi.nlm.nih.gov/pubmed/28490271, https://www.ncbi.nlm.nih.gov/pubmed/25225841

Skills required: No prior research necessary, but students should have an interest in U.S. health policy, economics, statistics, or computer science.

Learning outcomes: Exposure to computer-based simulation modeling and health policy study design, data analysis methods, presentations, and scientific writing.

Number of hours: Negotiable, but 5-10 hours/week would be ideal.

Mentoring: Dr. Pandya will supervise the student and will be available for mentoring on a near-daily basis.

Student stipend: Student stipend is available.

Course credit: If possible, yes.

Application information: Email your resume to Dr. Pandya at anpandya@hsph.harvard.edu

 

Undergraduate Research Opportunity, Cantor Lab, Dana Farber Cancer Institute

Contact information: Harvey Cantor, Benacerraf Professor of Immunology, HMS

Dept. of Cancer Immunology & Virology, Dana-Farber Cancer Institute

450 Brookline Ave, Smith Laboratories, Room 722, Boston MA 02115

https://www.dana-farber.org/find-a-doctor/harvey-cantor/

http://www.dfhcc.harvard.edu/insider/member-detail/member/harvey-cantor-md/

Project description and duties:

The Cantor lab studies the development and function of T-cells and their products in the context of anti-tumor immunity, autoimmunity and anti-viral immunity. 

Bibliography: http://www.ncbi.nlm.nih.gov/pmc/?term=harvey+cantor

Skills required: Prior experience/ coursework in immunology, cell or molecular biology preferred but not essential. Training will be provided.

Learning outcomes: Opportunity to acquire and expand laboratory and research skills including study design, data analysis methods, presentations, and scientific writing.

Number of hours: A minimum of 15h/wk and predictable schedule important for the successful candidate, with the exception of exams/finals, etc. with appropriate notice.

Mentoring: In addition to the PI, each student will be trained, supervised and mentored by a research fellow or senior scientist.

Student stipend: Potential opportunities for student stipend with appropriate time commitment

Can this be a paid position: Applicants are encouraged to apply for financial support. Opportunities include (sponsored by faculty, Faculty Aide Program, Federal Work-Study Program, or Harvard fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu): https://lifesciences.fas.harvard.edu/research-opportunities  

Course credit: Potential opportunities for course credit, honors theses

Application information: Please send cover letter describing research interests and experience along with a resume to aangel@partners.org

 

Undergraduate Research Opportunity at Dr. Joseph Bonventre Lab, Brigham and Women’s Hospital, Harvard Medical School

Contact information:

PI: Joseph Bonventre, MD PhD,  Department: Renal Medicine, Department of Medicine
Contact information: jbonventre@bwh.harvard.eduLocation: 77 Ave Louis Pasture, HIM550, Boston, MA 02115

Project description and duties:

Investigating mechanisms of kidney diseases and developing technologies for detection and treatment of kidney diseases. Stem cells and kidney organoids as models of disease processes.

Skills requiredSome experience with biological, clinical laboratory work would be preferred.

Learning outcomes: Research skills, critical thinking skills, laboratory skills such as study design, data analysis methods, presentations, and scientific writing.

Number of hoursTo be discussed. Students are also encouraged to apply for course-credit or Harvard fellowships such as HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu).

MentoringPI and Postdoctoral Fellow. Active mentorship and participation will be provided.

Application informationEmail your resume with description of your interests and goals to Dr. Nathan Lee at nnlee@bwh.harvard.edu.

 

Undergraduate Research Opportunity in Dr. Fred Winston’s lab, Department of Genetics, HMS

Contact information: Fred Winston, winston@genetics.med.harvard.edu
http://genepath.med.harvard.edu/~winston/  77 Avenue Louis Pasteur, Boston

Project description and duties: Work on studies of eukaryotic chromatin and transcription using yeast as a model system.

Skills required: No prior research experience is required.

Learning outcomes: Students will learn genetic, molecular, and genomic laboratory methods, data analysis methods, and how to give oral presentations and do scientific writing.

Number of hours: negotiable

Mentoring: Students will be mentored by Fred Winston and by a postdoc or senior graduate student. Students will be encouraged to attend group meetings.

Student stipend: Students would be encouraged to apply for Harvard fellowships (Contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu).

 

Undergraduate Research Opportunity in Harvard-wide Program on Antibiotic Resistance, Dr. Gilmore, Infectious Disease Institute, HMS-MEEI

Contact information: Professor Michael S. Gilmore

Departments of Ophthalmology and Microbiology, Harvard Medical School, Mass Eye and Ear Infirmary (MGH Campus)

243 Charles St., Boston, MA 02114 Email: michael_gilmore@meei.harvard.edu, or francois_lebreton@meei.harvard.edu

Website: https://www.masseyeandear.org/research/investigators/g/gilmore-michael-s

The Infectious Disease Institute (IDI) is located in the Massachusetts Eye and Ear Infirmary on the Mass General Campus, adjacent to the Charles MGH stop on the Red Line. The lab is the headquarters for the Harvard-wide Program on Antibiotic Resistance, and is affiliated with Harvard Medical School, the Harvard-wide Microbial Sciences Initiative, and the Broad Institute of Harvard and MIT.

Project description and duties:

We have several undergraduate research opportunities aimed at understanding, and ultimately defeating, antibiotic resistance.  Specifically, we focus on developing new ways to diagnose, treat and prevent multidrug resistant infection caused by what are known as the ESKAPE pathogens. These bacteria are leading causes of hospital acquired infection at nearly all sites, and invariably pose a therapeutic challenge.

One example of a project that illustrates our approach and some of the technologies involved is as follows: The first ‘E’ in ESKAPE stands for Enterococcus. They are hospital-endemic microbes, with resistances reported to all drugs, including last-line vancomycin and daptomycin. Recently (Lebreton et al., Cell, 2017), we showed that the enterococci are distinguished from their ancestors, and appear to have been selected for, by their ability to cope with environmental stress. These attributes, in particular their resistance to disinfection and desiccation, now enable them to uniquely persist in the modern hospital environment. The overarching goal of this project is to characterize the genetic and biochemical basis for this ruggedness, with the objective of exploiting those targets for breaking the hospital infection transmission chain.

Preliminary genomic analyses indicate that factors underlying this ruggedness reside within the subset of genes shared by most enterococci, but absent from their ancestors. All enterococci were found to share 43 “resistance” phenotypes, which distinguished them from ancestral lineages. The specific goal of this undergraduate research experience will be to employ molecular biology and genomic technologies (e.g. Gene Set Enrichment Analysis, targeted mutagenesis…), to associate specific phenotypes, related to enterococcal persistence in the hospital environment, with genes that were gained or lost in evolving from the ancestral phenotype.

In addition to the intrinsic imperviousness of enterococci, highly hospital-adapted, epidemic lineages of species Enterococcus faecalis and faecium (Lebreton et al., mBio, 2013), possess swollen genomes enlarged by the acquisition of resistance plasmids, transposons, pathogenicity islands and other mobile elements. Although mobile elements account for over 25% of the genome of many clinical isolates, the role of all but a handful of genes in hospital adaptation is currently unknown. This will be explored, in collaboration with computational biologist experts at The Broad Institute, using genome-wide, cutting-edge transposon sequencing technologies (TnSeq).

Lebreton F, Manson AL, Saavedra JT, Straub TJ, Earl AM, and Gilmore MS (2017). Tracing the Enterococci from Paleozoic Origins to the Hospital. Cell 169, 849–861.e13.

https://www.ncbi.nlm.nih.gov/pubmed/28502769

Lebreton F, van Schaik W, McGuire AM, Godfrey P, Griggs A, Mazumdar V, Corander J, Cheng L, Saif S, Young S, Zeng Q, Wortman J, Birren B, Willems RJ, Earl AM, Gilmore MS. Emergence of epidemic multidrug-resistant Enterococcus faecium from animal and commensal strains. MBio. 2013 Aug 20;4(4).

https://www.ncbi.nlm.nih.gov/pubmed/23963180

Skills required:

A sound understanding of chemistry and molecular biology are important, as are basic laboratory techniques, i.e. pipetting, sterile technique, making solutions, etc. Attention to detail, ability to follow instructions, and ability to then work independently are important. Prior experience working in a microbiology or molecular biology lab, computational skills (Matlab, Python, R), familiarity with genome sequencing, and an interest in bioinformatics and genomics are often helpful.

Learning outcomes: The IDI will provide training to safely handle pathogens and work in the research laboratory environment. Besides cutting edge techniques and approaches described in the proposal, we will provide extensive guidance to help master identifying important research problems, designing and performing experiments, interpreting data, effectively presenting findings. Students will be mentored in various other research skills, including literature review, experimental design, data analysis, data presentations, and scientific writing.  Our ultimate goal is to 1) meaningfully advance the field, and 2) encourage and prepare students to become productive and successful members of the scientific community. Students will become familiar with standard molecular biology techniques required to produce constructs for heterologous over-expression of proteins.  Items produced from original experiments will be used for protein expression, purification, and functional characterization, the techniques for which the student will also be exposed.  Additionally, methods for bacterial culture, and protein, DNA and surface polysaccharide extraction and analysis will be utilized. Students will be asked to orally present their project background and data at the end of their project to the other group members.

Number of hoursThis depends on the specifics of the project. Students often pursue their research full time in summers, and around courses and other college demands the rest of the year.

MentoringDr. Francois Lebreton (https://www.masseyeandear.org/research/investigators/l/lebreton-francois), an expert in enterococcal genomics and biology, is the main point of contact for projects involving molecular biology, genomics, and pathogenesis. Dr. Paulo Bispo, an expert on molecular diagnostics and clinical microbiology is the main point of contact for research on new diagnostics, infection epidemiology, and development and testing of new antimicrobials. Dr. Ona Miller and Dr. Noelle Bryan are spearheading projects designed to understand the structure and function of components of the bacterial cell wall as facilitators of colonization and transmission, mediators of environmental persistence, and as targets for new antimicrobial development. Prof. Mike Gilmore, Director of the IDI, provides additional direction, oversight and mentoring as needed. Additional postdoctoral fellows and experienced research technicians in the Infectious Disease Institute form a tight-knit community providing daily support and advice.

Fellows and students in the IDI laboratory are in an environment that encourages lively interactions and promotes active and productive exchange of ideas, approaches, and expertise. In addition to weekly lab meetings, they have weekly interactions with faculties and trainees of the Microbial Sciences Initiative, the Department of Microbiology at Harvard Medical School, with computational biology experts at The Broad institute and with clinicians and residents at the Mass Eye and Ear Infirmary (MEEI) and Mass General Hospital (MGH).

Student stipendStudents are encouraged to apply for Harvard fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu): https://lifesciences.fas.harvard.edu/research-opportunities and we are committed to provide guidance and support through the process.

Course creditThe IDI is supportive of students conducting research for course credit, and will work with the College to help develop a suitable plan.

Application informationIf you would like to apply for this position, please email a copy of your resume to Francois Lebreton (francois_lebreton@meei.harvard.edu). In your email, please explain your motivation for applying and detail your prior experience. Applications are considered continuously until all positions are filled.

 

Research Opportunity at the Gershman Computational Cognitive Neuroscience Lab, Department of Psychology

Contact information: Sam Gershman, Department of Psychology and Center for Brain Science, Northwest 295, http://gershmanlab.webfactional.com/

Project description and duties: How does the brain learn useful routines that apply across a variety of different contexts? The delicate balance between maintaining learned action sequences and flexibly modifying them allows allows humans to solve real-life challenges that lie beyond the grasp of the most sophisticated AI systems. The goal of this project is to reverse-engineer the brain algorithm for acquiring and applying action sequences in a multi-task setting. We tackle this question using a combination of probabilistic modeling, reinforcement learning, human behavioral experiments and brain imaging. You will have the opportunity to work on all fronts of the project: developing cognitive and neural circuit models of action sequence learning, designing and performing experiments to evaluate those models, analyzing high-dimensional neural data.

Skills required: Programming experience (preferably JavaScript, Python, MATLAB), basic understanding of probability (Stat 110), basic computer science (Computer Science 50). No prior research experience required.

Learning outcomes: Experience with developing probabilistic models and reinforcement learning algorithms, study design and execution, model-driven analysis and interpretation of behavioral and neural data.

Number of hours: 10 hrs/wk (negotiable)

Mentoring: The student will work closely with a graduate student responsible for the project. Meetings can be daily or less frequent, as needed. The student is strongly encouraged to attend lab meetings.

Student stipend: This is not a paid position. Students are encouraged to apply to HCRP and other fellowships (please contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu).

Course credit: Students can obtain course credit by signing up for an independent research course

Application information: Submit e-mail to gershman@fas.harvard.edu. Please include relevant programming and math background.

 

Research Assistant Position: Empathy and Aggression, FAS Psychology Department

Christelle Ngnoumen and Prof. Ellen Langer, Prof. Mina Cikara, Prof. Leah Sommerville, and Jack Demick / Psychology FAS
Fall 2018 and/or Spring 2019

Research Description: We are seeking undergraduates to assist with research on developing strategies for reducing implicit and explicit bias, particularly as they relate to empathy, aggression, and mental health evaluation.

Duties and Tasks: As a research assistant, you’ll typically work 8 hours per week, during which you’ll engage in tasks such as data collection, data entry, study stimuli creation, and participate in small group meetings.

Requirements and Expectations: Undergraduates with an interest in the cognitive and social sciences. Introductory psychology, cognitive psychology, and/or social psych background preferred. Statistical and/or programming background is a plus although not required. 8 hours weekly expected.

Mentoring: Dr. Langer and Christelle Ngnoumen will be mentoring students and will be meeting at least once per week with students.

Additional Information: Position is volunteer or for course credit through MBB 90r or Psychology 2660r. Students are encouraged to apply for HCRP or other fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu)

Research Location is William James Hall.

If Interested: Please email Christelle at cngnoum@fas.harvard.edu and we can arrange a meeting.

 

Undergraduate Research Opportunity, Dr. Konstantina Stankovic Laboratory, Massachusetts Eye and Ear

Contact information: Dr. Konstantina Stankovic, Department of Otolaryngology, Harvard Medical School; konstantina_stankovic@meei.harvard.edu; Massachusetts Eye and Ear; https://stankovic.hms.harvard.edu/

Project description and duties: We are an auditory neuroscience laboratory dedicated to improving diagnostics, prognostics, and therapeutics for deafness. We are focused on the inner ear because the majority of hearing loss originates in the inner ear. Our approach is interdisciplinary and combines tools of systems neuroscience with molecular biology. Please visit our website (https://stankovic.hms.harvard.edu/) for additional information on the projects you would participate in.

Skills required: Proficiency in Microsoft Office programs, wet lab experience is a plus, proficiency in Adobe Photoshop and Illustrator is a plus

Learning outcomes: laboratory skills, research skills such as study design, data analysis, presentations

Number of hours: flexible

Mentoring: Student will be directly mentored by a graduate student or research fellow in the lab, with Dr. Stankovic's oversight. Mentorship meetings occur once every two weeks; student is welcome to attend weekly lab meetings.

Stipend: Students are also encouraged to apply for course-credit or Harvard fellowships such as HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu).

 

Undergraduate Research Intern Position in the Gaab Lab, Boston Children's Hospital

Principle Investigator: Nadine Gaab, PhD nadine.gaab@childrens.harvard.edu

Description of project. We are looking for motivated undergraduate students to assist with functional magnetic resonance imaging (fMRI) sessions at Boston Children's Hospital (Boston and Waltham locations). Students will observe and help administer developmental assessments with infants and toddlers and get them ready for the scan. In addition, they may also help with the other ongoing studies in the lab such as one investigating reading development in bilingual English-Spanish speakers as well as a tablet-based screener for reading disabilities currently in development (see gaablab.com for more information on each of the studies in the lab).

Skills required. No prior research experience is required. Coursework in Neuroscience/Psychology will be helpful.

Learning outcomes. Students will learn about/get the opportunity to help administer developmental assessments that measure early language abilities and development in infants/toddlers. They will also get some experience with data preprocessing. Students may have the opportunity to pursue a senior thesis with the lab, under the guidance of one of the Post-Docs, if interested.

Number of hours. Students are expected to commit to at least one semester in the lab and to at least 10 hours/week.

Mentoring. Students will be mentored by Research Assistants, who will bring them to study visits and train them on administration/scoring of developmental assessments. Post-Docs will also mentor the students on the basics of data pre-processing and quality checks.

Student stipend. Students are encouraged to apply to the HCRP and other fellowships (please contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu) or register for a research course credit.

Interested applicants should send their resume/CV to Jade Dunstan (jade.dunstan@childrens.harvard.edu).

 

Undergraduate Research Opportunity in the Cognitive and Neural Organization Lab, Dr. Konkle, Harvard Department of Psychology

Contact information: PI: Talia Konkle, Department: Psychology

-location: William James Hall, Northwest Building fMRI scanner -lab website: http://konklab.fas.harvard.edu

-Contact: email Leyla Tarhan at ltarhan@g.harvard.edu

Project description and duties: Ongoing projects investigate the nature of how we visually process different objects, actions, and scales of space. We use a combination of behavioral and neural methods to explore the computations involved and map the brain areas that contribute to these abilities. Undergraduate research assistants will help to collect and edit stimuli, run participants on behavioral experiments, and observe and assist during fMRI experiments.

Skills required: Applicants should be careful and conscientious, with an eagerness to learn. No prior research experience is necessary.

Learning outcomes: Research Assistants will learn to run subjects in behavioral and neuroimaging paradigms. If the student is interested, he or she may also attend weekly lab meetings

(in which we dicuss current research relevant to our interests and present ongoing work), learn basic coding skills,

and help to build small behavioral experiments that extend the lab's current work.

Number of hours students are expected to work, length of the project: minimum of 10 hours/week for at least 1 full semester. Exact schedule is negotiable and depends upon the student's schedule.

Mentoring: Mentoring will be primarily provided by graduate students on whose projects the RA is working. In addition, the RA will have the opportunity to attend weekly lab meetings (see above).

Student stipend: Students are also encouraged to apply for course-credit or Harvard fellowships such as HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu).

Course credit: Available.

Application information: If you're interested in applying, please send a short description of your research and academic background or a resume/CV to Leyla Tarhan at ltarhan@g.harvard.edu.

 

Undergraduate Research Opportunity, Drs. Schmider and Soberman, MGH

Contact: Angie Schmider, Massachusetts General Hospital, Department of Medicine, Division of Nephrology

Charlestown Navy Yard (15 minute walk or 10 minute shuttle ride from North Station, a quick bike ride through Union square or along esplanade on Charles river)

Lab website: http://soberman.mgh.harvard.edu

Project: Using state-of-the art microscopy with computational analyses and biochemical approaches to understand the architecture of the nuclear membrane in myeloid cells from mice and humans and to understand how nuclear membrane proteins have a role in autoimmune diseases.

Skills required: No prior research experience is required.

Learning outcomes: Cell culture, biochemical approaches, superresolution microscopy approaches with computational analyses (MATLAB), data analysis and presentation and critical thinking of peer reviewed manuscripts.

Number of hours required: Days and times are negotiable.

Mentoring: Dr. Angie Schmider will mentor the students and will encourage them to attend and present data at biweekly lab meetings and biweekly journal club meetings.

Student stipend: Students are encouraged to apply for Harvard fellowship (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu): https://lifesciences.fas.harvard.edu/research-opportunities  and students may conduct research to earn course credit.

Application information: Please email your resume to Dr. Schmider: aschmider@partners.org

 

Undergraduate research position, Dr. del Re Lab, Psychiatry Neuroimaging Lab, BWH

There are several projects that could be of interest to the undergraduate student.

  1. Comparison of brain morphometry in individuals with schizophrenia, post-traumatic stress disorder (PTSD) and matched healthy controls
  2. Analysis of white matter tracts in a large number of schizophrenia subjects and matched healthy controls in relation to the microRNA miR137

PI name: Elisabetta del Re, Ph.D.,  Department: Psychiatry
Contact Information: Elisabetta_delre@hms.harvard.edu; 617 967 5569
Location: Psychiatry Neuroimaging Lab, Brigham and Women’s Hospital, Longwood Medical Area

Description of the project and duties: 

Project 1 involves analysis of structural data with the aim of determining brain abnormalities overlap and differences in individuals with PTSD suffering from psychosis and in individuals suffering from schizophrenia. This across diagnostic boundaries comparison is new.

Project 2 combines genetics with white matter and structural analyses of schizophrenia subjects. The aim is to determine whether certain structural or white matter abnormalities that are common in schizophrenia are determined at least in part by genetics, specifically the microRNA137. miR137 is an important player in neurodevelopment and in addition regulates several pathways that are associated with schizophrenia.

Duties include:

  1. Reading and understanding relevant literature
  2. Learning the basics of Linux in order to interface with programs necessary to process neuroimaging data
  3. Learning the processing pipeline of magnetic resonance imaging scans, from acquisition, quality control to data output
  4. Learning and application of the basic tools of statistical analysis necessary to analyze the data

Skills required: Dedication, Passion, Attention to detail

Learning outcomes:

  1. Understanding psychosis and schizophrenia
  2. Ability to read and understand relevant literature
  3. Ability to apply sophisticated algorithms necessary to process MRI scans and working knowledge of Linux
  4. Ability to apply statistical models to analyze data

Number of hours students are expected to work: 8-10 hrs/weekly

Mentoring: Interaction twice weekly without time limit (whatever time is needed)

Does the research group provide any funds to pay a student stipend? No. Students are also encouraged to apply for course-credit or Harvard fellowships such as HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu).

To apply:  email your resume, including description of any previous research experience and GPA.  Sentence about what their goals are in pursuing this research. Contact: Elisabetta_delre@hms.harvard.edu

 

Undergraduate research opportunities in the study of brain-immune interactions in neurodevelopment, Bilbo Lab, Massachusetts General Hospital/HMS

Staci Bilbo, PhD, Pediatrics and Neuroscience, Lurie Center for Autism, Massachusetts General Hospital for Children, Contact: sbilbo@mgh.harvard.edu, http://bilbolab-harvard.org

Project: The Bilbo Lab focuses on the study of neuroimmune interactions in brain development, using pre-clinical models. We collaborate with clinical research groups to translate our findings to human populations. We are particularly interested in the role of immune molecules in both normal and disrupted brain development, based on evidence from human and animal studies that immune system dysfunction or inflammation may be critical in neurodevelopmental disorders, including schizophrenia, cognitive and mood disorders, and autism. A particular focus is on the resident immune cells of the brain, microglia, including their development and function in response to early life inflammatory signals.

We are recruiting undergraduate scholars to get involved with several aspects of our projects aimed at determining the role of neural-glial and neural-immune interactions in brain and behavioral outcomes, including cellular and molecular analyses of microglial function, behavioral analyses in rodent models, and the processing and analysis of data for collaborative clinical (human) studies at the Lurie Center for Autism.  There will also be many opportunities for interacting with and shadowing clinicians at the Lurie Center, one of the largest clinical care centers for Autism and related disorders in the world.

Skills Required:  Wet lab skills in molecular biology (e.g. qPCR, ELISA, Westerns) are preferred but not required.  An understanding, respect, and acceptance of the use of live animals in research is absolutely required.

Learning outcomes:  Students will learn skills in rodent handling and behavior, and in cellular, molecular, cell culture, and microscopy techniques, and will have the opportunity to present at lab meetings and/or conferences, and to gain authorship on manuscripts as warranted.

Hours: A commitment if ~8 hours/week for at least 2 semesters is preferred.  The lab is in the Charlestown Navy yard campus, building 114.  A free shuttle from MGH main campus runs every 15 min.

Mentoring: The Bilbo lab consists of many postdoctoral fellows, students, technicians, and undergraduate researchers.  We are very much a team, and mentoring and teamwork are key components of our lab culture.  The student will be closely mentored by an assigned postdoctoral fellow, in addition to the overall team approach, and will meet weekly with Dr. Bilbo.  There are weekly lab meetings on Thursdays at 3:00, for which the student is encouraged to attend (but not required). 

Funding: Positions are for academic credit or volunteers.  Students are encouraged to apply to the HCRP for funding (email Dr. Babakhanyan at ababakhanyan@fas.harvard.edu for more info), and we are happy to help with the preparation of applications.

To apply:  Please send CV and cover letter briefly explaining why you would like to get involved in research to sbilbo@mgh.harvard.edu.

 

Undergraduate research opportunity in the Cherayil lab, Mucosal Immunology and Biology Research Center, MGH

Bobby J. Cherayil, MD, Assoc. Prof. of Pediatrics (Principal Investigator), Mucosal Immunology and Biology Research Center
Building 114, 16th Street, Charlestown Navy Yard, Charlestown, MA 02129. Phone: 617-726-4170
Email: cherayil@helix.mgh.harvard.edu Web: http://www.massgeneral.org/mucosal-immunology/

The lab is interested in innate immune responses in the gastrointestinal tract, specifically the molecular mechanisms involved in the interactions between intestinal bacteria (commensal and pathogenic) and host epithelial cells and macrophages. Some examples of our research can be found in the publications cited below. One of our current lines of investigation is focused on the role of the YrbE phospholipid transporter in the virulence characteristics of Salmonella Typhi, the causative agent of typhoid fever in humans. These studies provide multiple opportunities for undergraduate research projects, including but not limited to, analyzing the effects of YrbE in invasion, induction of inflammatory responses, typhoid toxin expression and iron-dependent effects on virulence.

Kortman et al., Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens. Eur. J. Immunol. 2015; 45: 2553. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618841/

Trebicka et al., Intestinal inflammation leads to a long-lasting increase in resistance to systemic salmonellosis that requires macrophages but not B or T lymphocytes at the time of pathogen challenge. Inflamm. Bowel Dis. 2015; 21: 2758. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654659/  

Shanmugam et al., Commensal bacteria-induced interleukin 1 secreted by macrophages up-regulates hepcidin expression in hepatocytes by activating the bone morphogenetic protein signaling pathway. J. Biol. Chem. 2015; 290: 30637. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683283/

Chen et al., Commensal bacteria-induced inflammasome activation in mouse and human macrophages is dependent on potassium efflux but does not require phagocytosis or bacterial viability. PLoS One 2016; 11: e0160937. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978417/

Verma and Cherayil. Iron and inflammation – the gut reaction. Metallomics 2017; 9: 101. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321802/   

Skills required: No prior research experience is required. However, some familiarity with basic lab methodology would be helpful.

Learning outcomes: Motivated and hard-working students can expect to learn the concepts of host-bacterial interactions in the gastrointestinal tract, and to acquire technical skills such as tissue culture, handling of bacterial pathogens, analysis of gene expression by quantitative RT-PCR and immunoblotting, cytokine quantitation by ELISA, invasion assays, and generation of gene disruptions in Salmonella. The project will provide experience in formulating scientific hypotheses, design of experiments and data analysis and interpretation, as well opportunities for developing skills in scientific writing and oral presentation.

Time commitment: 6-8 hours per week for a minimum of 3-6 months is expected.

Mentoring will be provided by Dr. Cherayil and post-doctoral fellows in the lab. Students are welcome to attend weekly group meetings. In addition, Dr. Cherayil is happy to meet informally with students whenever needed to discuss progress and problems.

Stipend: The lab cannot provide a stipend. Student are encouraged to apply for Harvard fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu).

If interested, please email resume’ to Dr. Cherayil: cherayil@helix.mgh.harvard.edu     

 

Undergraduate Research Opportunity, Lab of Thomas Michel, Brigham and Women’s Hospital, Harvard Medical School

Description of the Michel Lab and current research: http://michel.bwh.harvard.edu/

Contact information: Thomas Michel, MD, PhD, Professor of Medicine and Biochemistry, Harvard Medical School, Senior Physician in Cardiovascular Medicine, Brigham and Women's Hospital, Member of the Board of Tutors in Biochemical Sciences, Harvard College, Leadership Council Harvard-MIT MD/PhD Program

Address: 75 Francis Street, Thorn Building, room 1210A, Boston, MA 02115, Phone: 617-732-7376
E-mail: thomas_michel@hms.harvard.edu Web page: http://michel.bwh.harvard.edu/

Project description and duties: Thematic areas: cardiovascular signal transduction involving oxidants and nitric oxide signaling in the context of heart failure and vascular disease states.

Skills required: Basic laboratory skills, foundational life sciences courses

Learning outcomes: laboratory skills in cardiovascular cell biology and signal transduction, study design, data analysis methods, presentations, and scientific writing.

Number of hours: ~16 hours/week term-time, full time during summer.

Student stipend: No student stipend for term-time research: offered for credit only. Summer students are encouraged to apply for funding from PRISE, Herschel Smith Fellowship, etc. (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu)

Course credit: MCB/CPB91 or MCB/CPB99

Application information: Please email your resumé and a statement of your research interests to thomas_michel@hms.harvard.edu

 

Undergraduate Research Opportunity, Dr. Brucker, Rowland Institute

Contact information: Robert Brucker, Ph. D., Rowland Junior Fellow, MSI Faculty
Rowland Institute at Harvard University

brucker@rowland.harvard.edu Lab website: Bruckerlab.org
The Rowland Institute at Harvard  100 Edwin H. Land Blvd., Cambridge, MA 02142

Project description and duties: Our research focuses on the interactions of gut microbiomes and xenobiotic compounds. In other words, how do chemicals and pollutants impact the bacteria that live in the guts of animals? We use insects, wasps and bees, to experimentally test the function of the host-microbiome relationship when the host animal is exposed to xenobiotics. We seek a student that is highly motivated, efficient, and reliable to work with us on these exciting projects.

Skills required: Students with one or more years of research experience are encouraged to apply. Comfortable with PCR, sterile technique and microscopes is a plus.

Learning outcomes: Students will learn how experimental design is developed in a research lab, learn molecular lab techniques like quantitative-PCR, microbiology techniques, science communication.

Number of hours Max 10hr/week

Mentoring: Students will be directly mentored by a postdoc and Dr. Brucker, weekly lab meeting attendance is required.

Student stipend: $15/hr, course credit is an option.

To apply, email your resume to Dr. Robert Brucker, brucker@rowland.harvard.edu

 

Undergraduate Research Opportunity, Dr. Shioda Lab, MGH

PI name:  Toshi Shioda, MD, PhD, tshioda@mgh.harvard.edu

Department: MGH Center for Cancer Research

Location: Charlestown, MGH Research Building 149 – 7th Floor

https://www.massgeneral.org/cancerresearch/research/researchlab.aspx?id=1195

Project description and duties: We are interested in genetics and epigenetics of human germline cells, which are the only lineage of cells that can covey genetic information to the next generation. DNA damage introduced into the genome of germline cells may result in creation of irreversible and permanently inherited mutations, which could cause familial diseases. For example, when young cancer patients receive DNA-damaging chemotherapy and survive, or victims of nuclear power plant accidents are exposed to substantial doses of ionizing irradiation, whether their offspring would possibly suffer from new heritable diseases or such a risk is practically negligible is an important, but still unanswered question. On the other hand, the epigenetic mechanisms of gene expression are subjected to a series of almost complete “reset” processes during the early stages of germline development for refreshed start of a new generation of life. Exceptions of the epigenetic resetting in the germline cells include potentially harmful retroviruses parasitizing in human genome in the epigenetically repressed state. Aberrations in the epigenetic resetting in germline cells, involving the endogenous retroviruses or other, functionally important genomic elements, may cause disease predisposition in the next generation. Because access to developing germline cells in human embryos or fetuses are extremely challenging, we are generating cell culture models of human primordial germ cells from normal or genetically engineered induced pluripotent stem cells (iPS cells) and investigating the molecular mechanisms of mutagenesis and the epigenetic resetting in human germline cells, with special emphasis on the relevance to creation of new familial diseases.

Relevant recent publications: https://www.ncbi.nlm.nih.gov/pubmed/29087313 
https://www.ncbi.nlm.nih.gov/pubmed/27486249

PI bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40795267/?sort=dat...

Skills required: No prior research experience is required. Applications from new undergraduate researchers are encouraged.

Learning outcomes: Successful applicants will be immediately involved in the ongoing research projects and receive hands-on trainings of human iPS cell culture and genetic engineering (e.g., CRISPR/Cas9 gene targeting), basic molecular biology (e.g., PCR, Western blotting, lentivirus vector engineering), deep sequencing, and bioinformatics. Undergraduate researchers will be encouraged to present their accomplishments at local, national, or international meetings (oral and poster). They will also be encouraged to participate in original or review publications as co-authors, through which they will learn scientific writing skills.

Number of hours students and length of the project: Undergraduate researchers are requested to secure at least 16 hours per week of work hours for responsible involvement in research. Scheduling will be negotiable and relatively flexible. There is no specific limit of the project length.

Mentoring: The PI (Dr. Toshi Shioda, Associate Professor of Medicine, HMS) will be the direct mentor and meet the undergraduate researchers on every work day to update the project assignments and hands-on trainings. The undergraduate will be encouraged to communicate other lab members during and outside the group meetings.

The Director emeritus of the MGH Cancer Center (Dr. Kurt J. Isselbacher, Professor of Medicine, HMS) will also mentor the undergraduate researchers as needed but at least once a month.

Student stipend: This is a paid position under the MGH Bulfinch Temp mechanism sponsored by the PI.

Undergraduate researchers are encouraged to apply for Harvard fellowships (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu) although it is not a prerequisite of the appointment. https://lifesciences.fas.harvard.edu/research-opportunities

Application information: Applicants should submit a resume and a letter describing the background and reason of the application to the PI by email (tshioda@mgh.harvard.edu) with the subject line “Undergraduate Research at the Shioda Lab.” There is no specific deadline. Applications will be processed in the order as they arrive in the PI’s email inbox, and the recruitment will be closed when the position is filled.

 

Posted August 27, 2018

Research opportunity, Anxiety and Traumatic Stress Disorders Laboratory, McLean Hospital

Principal Investigator: Isabelle Rosso, Ph.D. irosso@hms.harvard.edu
Center for Depression, Anxiety and Stress Research http://cdasr.mclean.harvard.edu/

Description of the project: We are looking for undergraduates or recent college graduates to assist with clinical research studies of posttraumatic stress disorder (PTSD).  The Anxiety and Traumatic Stress Disorders Laboratory uses brain imaging technologies to study the function, structure, and chemistry of the brain in both healthy people and patients suffering from PTSD and anxiety.  We also use behavioral paradigms, including tasks that assess memory or decision-making, so that we can better understand brain-behavior relationships.

 

Research questions of interest to our laboratory include:

* What are the cognitive and brain mechanisms underlying the development of persistent trauma-related mental disorders such as PTSD?

* What are the neural mechanisms underlying risk and resilience for emotional disorders? For example, why do some people develop PTSD after experiencing trauma while other people do not?

* Are there brain “markers” of risk and resilience to trauma?

* What are the brain changes that occur during successful treatment of emotional disorders?

Skills required. No prior research experience is required.  Some coursework in psychopathology, abnormal psychology, or neuroscience would be helpful.  Both undergraduates and recent college graduates are eligible.

Learning outcome: laboratory skills, research skills: study design, data analysis method, presentations, scientific writing, etc.  Student visitors learn to assist lab members utilizing various clinical psychology and neuroscience methods. For example, they may learn some clinical interviewing techniques to do phone screens, and they may learn brain imaging methods.     

Number of hours: Hours are negotiable, depends on arrangement.

Mentoring: Students will be mentored by PHD psychologists.  Meetings occur multiple times per week with a designated PHD supervisor, and also at least once per week with lab members (if student’s availability permits).

Funding is not available for this position.  Students are encouraged to apply to the HCRP fellowship and other fellowships, or to register for a research course credit (contact Dr. Anna Babakhanyan, Research Advisor for more information at ababakhanyan@fas.harvard.edu).

Interested applicants can email their CV/resume and a cover letter to Dr. Isabelle Rosso at irosso@hms.harvard.edu

 

 

Undergraduate Research in Psychiatry, Brigham and Women’s Hospital

PI name: Elisabetta del Re, Ph.D. Department: Psychiatry
Contact Information:
Elisabetta_delre@hms.harvard.edu; 617 967 5569
Location:
Psychiatry Neuroimaging Lab, Brigham and Women’s Hospital, Longwood Medical Area

There are several projects that could be of interest to the undergraduate student:

  1. Comparison of brain morphometry in individuals with schizophrenia, post-traumatic stress disorder (PTSD) and matched healthy controls
  2. Analysis of white matter tracts in a large number of schizophrenia subjects and matched healthy controls in relation to the microRNA miR137

Description of the project and duties:
Project 1
involves analysis of structural data with the aim of determining brain abnormalities overlap and differences in individuals with PTSD suffering from psychosis and in individuals suffering from schizophrenia. This across diagnostic boundaries comparison is new.

Project 2 combines genetics with white matter and structural analyses of schizophrenia subjects. The aim is to determine whether certain structural or white matter abnormalities that are common in schizophrenia are determined at least in part by genetics, specifically the microRNA137, an important player in neurodevelopment and in addition the  the pathways miR137  regulates.

Duties include:

  1. Reading and understanding relevant literature
  2. Learning the basic of Linux in order to interface with programs necessary to process neuroimaging data
  3. Learning the processing pipeline of magnetic resonance imaging scans, from acquisition, quality control to data output
  4. Learning and application of the basic tools of statistical analysis necessary to analyze the data

Skills required: dedication, passion, attention to detail

Learning outcomes:

  1. Ability to read and understand relevant literature
  2. Ability to apply sophisticated algorithms necessary to process MRI scans and working knowledge of Linux
  3. Ability to apply statistical models to analyze data

Number of hours students are expected to work: 8-10 hrs/weekly

Mentoring: Interaction twice weekly without time limit (whatever time is needed)

Does the research group provide any funds to pay a student stipend? Lab will not provide stipend, please register for a course-credit or apply for HCRP and other fellowships (for questions contact Undergraduate Research Advisor Dr. Anna Babakhanyan ababakhanyan@fas.harvard.edu).

To apply: Students should submit resume, where they describe their previous research experience and GPA. They should include a sentence about what their goals are in pursuing this research. Contact: Elisabetta_delre@hms.harvard.edu

 

 

Posted August 22, 2018

Research opportunity, Dr. Arbel Lab, Cognitive Neuroscience Group, MGH Institute of Health Professions

Contact information: Dr. Yael Arbel, co-director Cognitive Neuroscience Group, Department of Communication Sciences and Disorders, MGH IHP, 79 13th Street, Boston, MA 02129.https://www.mghihp.edu/research/cognitive-neuroscience-group

Project description and duties: The Cognitive Neuroscience Group is a collaborative research group that uses behavioral and neuroscience methods to examine the relationship between learning, language ability, and cognitive factors. We use electrophysiological and eye tracking data to study typical and atypical learning across the lifespan and in different disorders (e.g., Developmental Language Disorder, Aphasia, Traumatic Brain Injury). The research assistant will have the opportunity to contribute to two federally funded projects (PI: Dr. Arbel) focusing on the neural function associated with learning in typically developing children and children with developmental language disorders. The projects involve the recording and analysis of Event Related Potentials (ERPs) extracted from EEG recorded from the scalp, and the administration and analysis of cognitive and language tests.

Duties: The research assistant will be involved in all aspects of data collection and analysis: recruitment, interaction with research participants, scoring and analysis of behavioral data as well as EEG signal processing. EEG signal processing will include the use of Matlab based tool boxes for artifact detection/correction, latency jitter correction, and Principal Component Analysis (PCA).

Skills required: The RA must have experience with Matlab. The RA should also be able to create scripts in Excel (or using other tools) for data analysis. Preferred skills include: signal processing, eye-tracking data analysis, statistical analysis using SPSS or R, and programing. No research experience is required.

Learning outcome: The RA will receive training in behavioral and EEG data collection and data analysis. Training in eye-tracking data acquisition and analysis is also possible. The RA will participate in weekly lab meetings that will include presentations by PIs, and students at all levels (PhD, graduate, undergraduate). The RA will gain understanding of research design related to the study of learning in individuals with typical and atypical cognitive profiles. The RA will have the opportunity to present at the biweekly CNG meetings and to participate in scientific writing

The RA is expected to work 15-20 hours per week (preferably 3-4 days a week) for 2 semesters. Our lab is located at the MGH Institute of Health Professions in the Charlestown Navy Yard in Boston. The RA is expected to spend at least 15 hours a week on site.

Mentoring: The RA will be mentored by the Drs. Arbel, Zipse, and Vallila Rohter, and will interact with CNG members in training, meetings, and data collection sessions. The RA will attend weekly lab meetings, and weekly mentorship meetings with the PI.

Student stipend: students are encouraged to apply for Harvard fellowships: https://lifesciences.fas.harvard.edu/research-opportunities (contact Dr. Babakhanyan for more info at ababakhanyan@Fas.harvard.edu).

 

 

Posted August 20, 2018

Research Assistant Position: Human and Fruit Fly Models of Neurological Disease, MGH

Research Assistant Position: Human and Fruit Fly Models of Neurological Disease
Dr. James Walker, Walker Laboratory, Center for Genomic Medicine, Massachusetts General Hospital / Harvard Medical School
Fall 2018 and Spring 2018

 

Dr. Jim Walker's lab (https://www.massgeneral.org/neurology/research/researchlab.aspx?id=1794) invites applications for undergraduate research positions. Projects involving fruit flies (Drosophila) to study neurological diseases including neurofibromatosis type 1 (NF1), sleep disorders and seizures are available. In addition, possibilities exist to use human cell cultures derived from patients and/or using CRISPR gene editing for NF1 studies.

Duties: Will include maintenance of fly stocks and genetic crosses, cell culture, microscopy, CRISPR gene-editing, molecular biology and protein techniques including: DNA/RNA isolation, PCR and sequencing, western blotting.

Requirements and Expectations: Some laboratory experience is preferred (molecular/protein biochemistry), but full training will be given. Must be self-motivated with attention to detail and excellent verbal and written communication skills. Hours are negotiable and flexible, depending on the experiments being conducted at the time. Minimum expectations are 2-3 hours, 2-3 days a week. Length of project will be a minimum of 6 months but can be extended.

Additional Information: Students will learn laboratory skills in genetics, dissection, microscopy, DNA and protein analysis, statistical analyses, and preparing data for publication. Mentoring: the PI will be responsible for mentoring. Will meet formally on a weekly basis to discuss project, planning, data etc. and PI will be on hand throughout working day. Will also be expected to occasionally work with other lab members (to learn/demonstrate techniques and discuss experiments). A stipend is possible, but student would be strongly encouraged to apply to the HCRP (contact Dr. Babakhanyan for more info at ababakhanyan@fas.harvard.edu) and other fellowships or register for a research course credit.

To Apply: Email your resume to Dr. Walker at jwalker@helix.mgh.harvard.edu.

 

Posted August 10, 2018

Undergraduate Researcher position, Cash Lab

We are looking for an undergraduate student interested in neuroscience to work with an MD/PhD (HMS) student starting this fall in the Cash Lab. Projects leverage machine learning approaches for seizure prediction in rodent models of focal epilepsy. We have a variety of ongoing projects related to seizure prediction and closed-loop intervention, including collaborations with the Lieber Lab at Harvard and the Cima Lab at MIT, some of which were led by undergraduates. 

Requirements: 10 hour weekly commitment required (mix in person and remote). Positive mental attitude, independent mindset, scientific curiosity.

Duration: 6 months minimum commitment.

Pluses (but not required): programming abilities (Python, MATLAB, R, C++), experience with rodent physiology or molecular biology.

Pay: $15/hr (HCRP standard).

Benefits: We will provide support for undergraduate research thesis writing, mentorship for grad/med school, authorship on manuscripts. Previous undergrads also received travel support for conferences.

If interested, please send a 1 page resume and 3-4 sentences about your interest in working with us to Senan Ebrahim senan@hms.harvard.edu. Looking forward to working with our next star undergrad!

 

 

Posted July 18, 2018

Understanding the Molecular Mechanism and Developing Therapies in Neuromuscular Diseases, Brigham and Women's Hospital, Posted July 18, 2018

PI Information:  Vandana A Gupta, PhD

Division of Genetics, Brigham and Women's Hospital, Harvard Medical School,

NRB 168A 77 Avenue Louis Pasteur, Boston, MA 02115 Ph: 617-525-4452

Email: vgupta@research.bwh.harvard.edu Website: http://guptalab.bwh.harvard.edu/

Project Description:

This project is focused on understanding the role of novel genes in neuromuscular development and disease pathology. This is a research position that will involve cloning, bacterial cultures, mammalian cell culture, generation of transgenic zebrafish lines and performing small chemical screens to develop therapeutics. We are looking for a self-motivated and creative student to work in a team as well as independently. No prior research experience is required.

Project Timeline: We are looking for a time commitment of a minimum of 10 hours/week for 6-12 months.

Skills Required: Previous experience with molecular biology or cell culture techniques would be great. However, students with no prior research experience are also encouraged to apply.

Learning Outcome: Research design, experimental skills, data analysis, research presentations, writing scientific papers.

Mentoring: Dr. Gupta will be mentoring students and will be meeting atleast once per week with students. Regular mentoring and training for new skills will be provided.

Funding: Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.

Contact: Email your resume and research interests to Dr. Gupta at vgupta@research.bwh.harvard.edu
 

 

Posted May 1, 2018

Research Opportunity cryo-EM analysis of the structure of the hair-cell mechanotransduction channel, HMS Department of Neurobiology

Within the inner ear are fast, sensitive receptor cells, working on a scale of microseconds and nanometers to convert the mechanical stimulus of sound into electrical signals that the brain can understand. In recent years, this process has become better understood, as many proteins involved in the submicroscopic mechanotransduction complex have been identified. Our group in the Neurobiology Department at Harvard Medical School is working to understand the complex, with a combination of electrophysiology, 3D electron microscopy, biochemistry, and single-protein mechanics. We have  openings for one or two students to join this effort.

In one project, we are working to solve the atomic structure of the protein that forms the ion channel of the complex. This project involves synthesizing and purifying protein, preparing for cryo-electron microscopy, and analysis of the single-protein images. Students will gain experience in cell culture, biochemistry, protein engineering and structural biology.  They will help screen for conditions that stabilize the ion channel in one conformation using different approaches and participate in cryo-imaging work.

In another project, we need to understand how the mechanotransduction proteins assemble into a functional complex. We use state-of-the-art biochemical and biophysical techniques such as biolayer interferometry, multi-angle light scattering, microscale thermophoresis and isothermal calorimetry, as well as more conventional methods like co-immunoprecipitation, to understand how different proteins interact with each other to form the mechanotransduction apparatus. Students will help us with DNA cloning, protein synthesis, and cell culture to generate a library of proteins. Students will then participate in the collection and analysis of biophysical and biochemical interaction data to generate an interaction model.

To apply, email: Dr. David P. Corey, Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, dcorey@hms.harvard.edu