Summer research opportunity for undergraduate students, Dr Barteneva (BCH-HMS) in association with Department Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan, Posted Feb 22, 2017
Undergraduate Research Opportunity to study the transcriptional regulatory circuit that combats the generation of osteoarthritis. Location: Lassar Lab in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School Posted Feb 14, 2017
Undergraduate Research at the Laboratory of Computational Neuroimaging, Dr. Zollei, MGH
Faculty: Lilla Zöllei, PhD, Laboratory of Computational Neuroimaging, AA Martinos Center, Radiology, MGH
Bldg 149, 149 13th Street, Charlestown MA 02129 https://www.martinos.org/lab/lcn
Description of the project and duties
Pediatric Neuroimaging: the student will be responsible for analyzing infant brain MRI images as well as designing, testing, debugging and validating related algorithms.
Skills required: coding and / or scripting skills (MATLAB; python; csh/tcsh; C/C++ coding); familiarity with Unix; interest in neuroimaging
Learning outcome: scripting skills, data analysis, oral / written presentations
Number of hours students are expected to work, length of the project: minimum 4 hrs/week and commitment of at least 3 months; potentially negotiable
Mentoring: Dr. Zöllei will personally mentor the students, bimonthly meetings will be organized in order to discuss progress.
Funding: Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit
To apply: contact Dr Zöllei (email@example.com) with a cover letter and resume.
Undergraduate Research Opportunity at Schepens Eye Research Institute/Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School
PI: Hetian Lei, Ph.D. Contact: Hetian_lei@meei.harvard.edu
Description of Projects:
1. Exploration of novel approaches to the treatment of intraocular pathological angiogenesis. VEGF plays a central role in angiogenesis, the process by which new blood vessels grow from pre-existing vasculature, and its receptor VEGFR2 mediates almost all known VEGF-induced output, including neovascularization. New fragile vessels are associated with a number of eye diseases such proliferative diabetic retinopathy (PDR) and neo-vascular age-related macular degeneration (wet AMD). Without timely treatment, the abnormal vessels in these eye diseases leak blood into vitreous, blur vision, destroy the retina and lead to blindness. Inhibition of VEGF-stimulated activation of VEGFR2 with neutralizing VEGF antibodies (ranibizumab & bevacizumab) and a recombinant fusion protein with the partial extracellular domains of VEGFR1 & 2 (aflibercept) has become important therapy to treat abnormal angiogenesis associated with PDR and wet AMD. While these drugs can reduce vessel leakage and angiogenesis, continuous (and potentially harmful) ocular injections are required. In addition, there are number of patients with these eye diseases do not respond to the antiVEGF treatment. Thus, we are exploring a novel therapeutic approach to the intraocular pathological angiogenesis with an AAV-CRISPR/Cas9-based gene therapy.
2. Investigation of the mechanism (s) by which growth factors drive biochemical and cellular responses intrinsic to proliferative vitreoretinopathy (PVR) as well as apply this information to the development of new therapeutic options to prevent PVR. In this research we have demonstrated that non-PDGFs in the vitreous engage their own receptors and thereby increase the level of reactive oxygen species. This change activates Src family kinases that phosphorylate PDGFR and thereby persistently trigger downstream signaling events such as P13K/Akt, which reduces the level of p53. Relaxing the p53 checkpoint potentiates the cell's ability to proliferate and survive, and facilitates the development of proliferative vitreoretinopathy. In this project we will continuously investigate the role of the signaling pathway of PI3K/Akt/MDM2/p53 in the pathogenesis of PVR.
Skills required: No previous research experience is necessary.
Learning outcome: Development of basic science laboratory skills: tissue culture, PCR, Western blotting, immunohistochemistry, work with animal models, etc. In addition, students will learn how to design experiments, write scientific papers, present the data, and analyze data. Consequently, the PI will co-publish a scientific paper with the student.
Number of hours: negotiable
Laboratory funding: The laboratory will fund all consumables, but there is no funding for a stipend. Applicants are encouraged to apply for fellowships.
Contact: please send your CV to Dr. Hetian Lei at Hetian_lei@meei.harvard.edu
Posted March 1, 2017
This summer is a fantastic opportunity for anyone interested in clinical psychology and/or psychopathology to do hands-on research work at the world’s leading research center for the study of Borderline Personality Disorder (BPD).
Apply to work with Lois Choi-Kain, director of the Gunderson Residence treatment facility for women with BPD, on a project investigating a low-cost method to assess reflective functioning in patients with BPD, which in recent years has become a focus of new research and is thought to be an essential feature across all psychopathology.
Work for this project will take place at McLean Hospital at 115 Mill St., Belmont MA. The project will take place over eight weeks this summer. Hours are negotiable, but research assistants should expect to work 15-30 hours a week. The first step in this project, where RAs are most needed, is to transcribe Adult Attachment Interview audio recordings, so that the research team can test a new method of analyzing the transcripts that would be far faster and more efficient than current practice.
This is a fantastic experience to get experience with the AAI (the gold standard for assessing reflective function in the field), get exposure to BPD theory and treatment, and work at one of the world’s leading research centers in clinical psychology. Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit. No funding is available from McLean. Email your resume and contact info to EFFINCH@partners.org.
Undergraduate Research Opportunity at MGH Department of Radiology
PI: Udo Hoffmann MD MPH Professor of Radiology, Harvard Medical School Division Chief, Cardiovascular Imaging Director, Cardiac MR PET CT Program Department of Radiology, Massachusetts General Hospital 165 Cambridge Street, Suite 400, Boston, MA 02114 Phone: 617-726-1255, Fax 617-724-4152 Email: firstname.lastname@example.org
Website: Cardiac PET MR CT Program
Description of Project and Duties: The Cardiac MR PET CT Program is a combined radiology/cardiology clinical research program at the Massachusetts General Hospital and Harvard Medical School. The Program is a thriving multimodality multidisciplinary hub for patient oriented research focused on the translation and implementation of innovative advanced cardiovascular PET, MR, and CT imaging methods; including imaging of coronary atherosclerosis, myocardial structure and function, inflammation, and adipose tissues.
The goal of this project is to determine features in the imaging domain that are associated with cardiovascular risk factors, including smoking and diabetes. The intern candidate will be assisting the mentor in reading, analyzing, segmenting and labeling of coronary artery calcium in CT coronary images as a part of a large clinical trial.
** Students will have the opportunity to interact with the medical faculty and attend clinical conferences (2-3 hour/week) to be exposed to the clinical environment.
Skills Required: The student will be trained to read coronary CT image however, basic knowledge of human anatomy and familiarity with medical images and basic IT understating is preferred.
Learning Outcome: Research Skills, data analysis methods, medical imaging analysis, clinical exposure, inter departmental presentations and poster presentations.
Commitment to Project: 12-15 hours/week (negotiable) for a duration of minimum of one semester with the opportunity to extend over the summer with 15-20 hours/week commitment.
Mentoring: The undergraduate intern will be directly mentored by Dr. Parastou Eslami and indirectly by Dr. Udo Hoffmann (Director of Cardiac PET MR CT Program). The candidate and Dr. Eslami will hold weekly one-to-one meeting to discuss the project details and progress. In addition, there will be a weekly departmental meeting to have further interaction with other members of the center and learn about their on-going projects.
Funding: Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.
If you are interested or for further information, please contact Dr. Parastou Eslami at email@example.com with a paragraph describing your background and why you are interested in this position, along with your resume.
Summer research opportunity for undergraduate students, Dr Barteneva (BCH-HMS) in association with Department Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
PIs: Dr. Natasha Barteneva (BCH-HMS) and professor Ivan Vorobjev (SST, NU)
Project 1 title: Assessment of phytoplankton biodiversity in unique Kazakhstani lakes, including Lake Balkhash and lakes in Korgalzhyn State Nature Reserve, included in the UNESCO world heritage list.
The aim of the project is to assess phytoplankton biodiversity of unique Kazakhstani lakes using a combination of techniques such as flow imaging cytometry, light and fluorescent microscopy, scanning electron microscopy (SEM) and next-generation sequencing. Located in the middle of Eurasian continent, Kazakhstan is a landlocked country encompassing a number of unique freshwater, brackish and saline lakes. In spite of that, many of the Kazakhstani lakes are poorly studied and lack essential and reliable biological monitoring data. Phytoplankton communities are commonly used as biological indicators and their diversity and abundance provide information of the quality and state of aquatic systems. The undergraduate student may join the project in the summer for two months to participate in one of the following research components:
- Studying phycoplankton communities using fluorescent, light and scanning electron microscopy (SEM).
- Application of imaging cytometry (FlowCAM and Imagestream X Mark II) to evaluate phytoplankton abundance and diversity.
Dates: June 19 – August 18, 2017.
1. Dashkova, V., Segev, E., Malashenkov, D., Kolter, R., Vorobjev, I. and Barteneva, N.S. 2016. Microalgal cytometric analysis in the presence of endogenous autofluorescent pigments. Algal Research, 19: 370-380. doi: http://dx.doi.org/10.1016/j.algal.2016.05.013
2. Dashkova, V., Malashenkov, D., Poulton, N., Vorobjev, I. and Barteneva, N.S. 2016. Imaging flow cytometry for phytoplankton analysis. Methods, 112: 188-200. http://dx.doi.org/10.1016/j.ymeth.2016.05.007.
Project 2 title: Analysis of mitotic blockade and apoptosis of normal and cancer cells under the action of microtubule inhibitors.
The aim of the project is to analyze behavior of mitotic cells under the action of microtubule inhibitors. Microtubule inhibitors like paclitaxel and vinorelbine are widely used in anti-cancer chemotherapy (against breast cancer, lung cancer, acute leukemia and some other) however the mechanism(s) of their action at the cellular level is still poorly understood. One of the problems is largely unpredictable effect of such treatments for a large cohort of cancer patients. The undergraduate student may join the project in the summer for two months to participate in one of the following research components:
- Studying mitotic progression under the treatments with microtubule inhibitors by high-throughput time-lapse microscopy using bright-field and fluorescence approaches.
- Analysis of cell proliferation and apoptosis under the treatments with microtubule inhibitors by imaging flow cytometry.
1. Balabiyev A, Kauanova S, Smirnova TA, Tvorogova AV, Vorobjev IA. 2015. Complex analysis of dose-dependent effect of microtubule inhibiting drugs on fibroblasts motility and mitotic progression. 2015 ASCB Annual Meeting abstracts. Molecular Biology of the Cell 26 (25): 920. doi:10.1091/mbc.E15-09-0674
2. Vorobjev I., Barteneva N.S. 2015. Temporal Heterogeneity Metrics in Apoptosis Induced by Anticancer Drugs. Journal Histochemistry and Cytochemistry. 63(7): 494-510. DOI: 10.1369/0022155415583534
3. Vorobjev IA, Barteneva NS. 2017. Multi-parametric imaging of cell heterogeneity in apoptosis analysis. Methods. 112 (1): 105-123. doi: 10.1016/j.ymeth.2016.07.003.
Mentoring: mentoring will be mainly provided by graduate students Veronica Dashkova and Sholpan Kaunova, and Ph.D. scientist Dmitry Malashenkov. The students will also meet/discuss with PIs regularly.
Learning outcome: we are looking for ambitious, heavy-working students, and poster presentation at the end of summer semester is expected outcome.
Funding: Free housing and meals plan at NU, language lessons. All project-related traveling expenses inside Kazakhstan will be covered. May require some external funding to cover flight tickets (air-fare) to Astana.
Application: To apply, email your resume listing course work and prior lab experience, name and contact information of references, and a few sentences to explain why you are interested in the project, to Dr. N. Barteneva. Applications will be reviewed on rolling basis. We will accommodate 2-3 students.
Contact information: Natasha (Natalie) Barteneva, MD, PhD; Lecturer on Pediatrics, Harvard Medical School, Faculty Associate, Microbiology Initiative, Adjunct Professor, Nazarbayev University, firstname.lastname@example.org
Undergraduate Research Position, Viral entry and pathogenesis, Ophthalmology, MEEI
PI and Department: Jaya Rajaiya, Ph.D, Ophthalmology
The cornea is the clear and foremost tissue of the eye that encounters all agents of the environment including infectious organisms. Corneal infection induces corneal inflammation, which can sometimes be severe leading to the loss of clarity, causing blurred vision, or even perforation and loss of the eye. One type of corneal infection is epidemic keratoconjunctivitis (EKC), commonly known as “pink eye”, and caused by adenovirus. Currently there are no specific treatments available for EKC, but a combination of antibiotic and corticosteroid drops are used to prevent secondary bacterial infection and subdue inflammation.
We sought to identify specific host protein binding partners of viral structural proteins during infection, and validate their interactions through a technique called reverse proteomics. We cloned 3 adenovirus genes (penton base, pVI and pIIIa), and identified cellular binding proteins for pIIIa. We identified two high confidence interactors of pIIIa: ubiquitin-specific protease 9x (USP9x) and RAN binding protein 2 (RANBP2), that latter also known as nucleoporin 358, and a component of nuclear pore complex. These host proteins may assist in nuclear export and virus assembly. Further investigation of molecular interactions during viral infection may uncover previously undiscovered roles for viral encoded proteins in the host cellular environment. A clear understanding of the cellular mechanisms, which contribute to corneal inflammation, would help us design specific therapies for the disease.
Skills required: Wet lab experience will be a plus, but if not we will train the candidate. An interest in biological research and problem solving, and good communications skills are required.
Learning outcome – experience with (i) routine techniques such as cloning, western blots, real time PCR, to advanced experimental techniques including immune fluorescence microscopy (ii) designing experiments and data analysis (iii) gaining presentation skills.
Number of hours – 10 per week minimum. Duration of commitment is flexible.
Mentoring – Mentoring will be primarily provided by postdoctoral fellows Dr. JiSun Lee and Dr. Mohamed Ismail. The student will also meet with the PI regularly.
Compensation: Funding options will be discussed during interview process.
Application: To apply, email your resume to Dr. Jaya Rajaiya
Contact information: Jaya_rajaiya@meei.harvard.edu Jaya Rajaiya, Ph.D; Director Post Doctoral Training; Assistant Professor of Ophthalmology
Massachusetts Eye and Ear Infirmary, Harvard Medical School
243 Charles Street, Boston, MA 02114 Tel: 617-573-4022
Undergraduate research opportunity, Dept. of Ophtalmology, Mass Eye and Ear / Schepens Eye Research Institute
PI: Leo A. Kim, M.D., Ph.D. Contact: email@example.com
Description of Projects:
1. Cell death mechanisms underlying retinal toxicity. Our laboratory is evaluating the multiple concurrent cell death mechanisms underlying retinal toxicity due to commonly used medications such as tamoxifen and chloroquine. By understanding regulated cell death mechanisms including apoptosis, pyroptosis, and necroptosis, we may be able to develop methods to protect these medications as well as other degenerative diseases of the retina. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122018/
2. Novel mechanisms of aberrant retinal angiogenesis. Using patient-derived fibrovascular membranes surgically removed from patients with proliferative diabetic retinopathy, our laboratory has been able to discover novel molecular mediators of aberrant angiogenesis within diseases. Elucidating these new pathways may reveal mechanisms beyond vascular endothelial growth factor signaling, that may be potential targets to regulate pathologic ocular angiogenesis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462955/
3. Therapeutic agents for the management of proliferative vitreoretinopathy (PVR). PVR is a blinding complication of retinal detachment most commonly associated with eye trauma. This disease is characterized by growth of scar tissue beneath and over the retina. We have developed an in vitro assay using patient-derived PVR membranes to screen for potential drugs for the treatment of PVR. Additional work will attempt to understand the underlying mechanisms of PVR proliferation, growth, and migration, as well as mechanisms that can lead to drug resistance within these cells.
Skills required: No prior research experience is necessary.
Learning outcome: Development of basic science laboratory skills: PCR, Western blotting, immunohistochemistry, work with animal models, tissue culture, ELISA, etc. Students will also learn how to design experiments, write scientific papers, present papers, and critically analyze data. Eventually, the PI would like to co-publish a scientific paper with the student.
Number of hours: Negotiable.
Laboratory funding: The laboratory will fund all consumables. However, there is no funding for a stipend. Applicants are encouraged to apply for fellowships or apply for a research credit.
Contact: Please send your CV to Dr. Leo Kim at firstname.lastname@example.org.
Undergraduate Research Opportunity to study the transcriptional regulatory circuit that combats the generation of osteoarthritis. Location: Lassar Lab in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School
Osteoarthritis results from the degradation of the articular cartilage in joint tissue. We are probing the transcriptional regulatory circuit that both maintains the health of the articular cartilage and that blocks the degradation of this tissue. We are approaching this issue by identifying the transcription factors that maintain expression of key cartilage genes such as lubricin, which block degradation of this tissue. Techniques to be employed will be bioinformatic identification of lubricin transcriptional regulators and transgenic dissection of lubricin regulatory elements. We are looking for a highly motivated student interested in learning cutting edge molecular biology techniques to work in concert with a postdoc in my lab on this project.
Requirements: Completion of an introductory Molecular Biology laboratory course or 1+ years of prior laboratory experience.
Goals of experience: Experimental design with a focus on good scientific method, data analysis and interpretation of results will be emphasized. Students will gain basic laboratory experience in a variety of laboratory skills including mammalian cell culture, RNA extraction, polymerase chain reaction, transfection of mammalian cells, cloning in mammalian expression vehicles, luciferase assays, gel electrophoresis, and bioinformatics analysis of transcriptional regulatory sequences.
Start date: Spring 2017 semester and continuing at least into Spring 2018 (with potential for summer lab work).
Commitment: 10-12 hrs/week during the term with the potential for summer work. Student must be willing to commit 1+ years to master a variety of molecular biology/cell culture techniques.
Funding: We will both provide funds to a qualified and motivated student and help the student obtain additional stipend support via Harvard undergraduate research grant opportunities (such as http://lifesciences.fas.harvard.edu/research-opportunities and http://seo.harvard.edu/faculty-aide-program)
Contact: Interested students should contact Andrew Lassar (Andrew_Lassar@hms.harvard.edu) with a resume listing their course work and prior lab experience (in or out of class). The laboratory is located at Harvard Medical School in the Longwood Campus.
Undergraduate research assistant opportunity for the Laboratory for Visual Neuroplasticity at Mass Eye and Ear Infirmary and Schepens Eye Research Institute in Boston, MA
PI Name: Lotfi Merabet, OD PhD MPH
Department: Laboratory for Visual Neuroplasticity, Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute, Harvard Medical School
Contact Information: Emma Bailin (617)573-3794 or email@example.com
Location: 20 Staniford Street, 2 West Building, Boston, MA 02114
Lab Website: http://scholar.harvard.edu/merabetlab
Project Description: The lab studies how the brain adapts to blindness and visual impairment. Major research focuses include brain imaging technologies (including MRI and EEG) to investigate structural and functional neuroplasticity. The student will work closely with senior investigators in the lab on assessing performance in visually impaired adolescents using a variety of computer based software. Testing will be carried out at the laboratory as well as at collaborative sites in the Boston area. The student will be responsible for collecting and analyzing data under the guidance of senior investigators. Depending on computer proficiency and analysis skills, there is also the opportunity to participate in brain imaging experiments and data analysis.
Skills Required: Ideal candidates will be pursuing a bachelor’s degree or equivalent in psychology or neuroscience. An interest in working with people with disabilities would be highly desirable. Previous research experience in a neuroscience and or an experimental psychology lab would be ideal, but not required. Strong organizational and communication skills and attention to detail are an important must. The candidate should be self-motivated and able to solve problems independently while also being comfortable working with others. Applicants with a background in programming (e.g. Unix, Python, MATLAB), statistical analysis software (e.g. R, SPSS, STATA) and/or neuroimaging software (e.g. FreeSurfer, FSL, SPM, etc.) are strongly encouraged to apply.
Learning Outcomes: The position offers substantial research experience and potential for co-authorship on publications. The position is ideal for candidates looking to gain research experience in preparation for graduate level studies in neurosciences, psychology, education, or medicine in the future. The undergraduate student can expect to gain extensive experience in behavioral research methodology, psychophysical testing, statistical analysis, brain imaging, and study design experience.
Number of hours: Expected to work about 10 hours a week, depending on the current project. There is flexibility in the expected dates, but at least one year is required (or 2 semesters) and more than one year is highly preferred.
Payment: No funds are currently available from the lab, but students are encouraged to seek external support.
To Apply: Please send a CV and a cover letter to Emma Bailin (firstname.lastname@example.org), with the subject line “Research Assistant position application”. The letter should describe your research experience (if you have any), interests and include why you think you would be a good fit for the lab. Please also include the name and contact information of two references. Applications will be reviewed on rolling basis until the position has been filled.
Undergraduate Research Position, Vaccine and Immunotherapy Center, MGH
PI and Department: Mark C. Poznansky MD, PhD. Director Vaccine and Immunotherapy Center (VIC), MGH Bldg 149 (MGH
East) 13th Street, Charlestown, 02129 www.advancingcures.org
The aim of this project is to develop a new combination immunotherapy for cancer.
Skills required: Wet lab experience would be beneficial.
Learning outcome: (laboratory skills, research skills: study design, data analysis method, presentations, scientific writing, etc.)
The student has a duty to maintain a safe work environment, prepare solutions as requested and keep records in an assigned laboratory notebook. Assist with experimental setup, laboratory experiments, and data acquisition; perform image analysis and record data.
Learn how to understand the principle of flow and mass cytometry, cell culture, animal model work and how to perform ELISA; WESTERN BLOTS; SDS-PAGE.
Learn animal handling, cryosectioning, immunohistochemistry, cell isolation, use of image analysis software, careful data recording.
Give a PowerPoint presentation to lab members on the research process and results achieved.
Hours: Either: Summer internship – 12 weeks full time Or: 10-12 hrs/week, student must be willing to commit 1+ years, as needed, to master a broad range of techniques.
Mentoring: The appropriate VIC senior scientist will be assigned to the student and there will be weekly full lab meetings, team meetings and constant access to the specific mentor.
Funding: The laboratory does not provide funding. Students are encouraged to seek alternative funding support. Undergraduates can either enroll in a course credit at Harvard or apply for funding through the Harvard College Research Program.
Contact: Interested students should contact Phoebe Ingram email@example.com and include a resume highlighting relevant experience as well as a brief description of their status at Harvard and two references.
Undergraduate research opportunity, Dr. Synho Do Lab, Laboratory of Medical Imaging and Computation, Massachusetts General Hospital and Harvard Medical School
Description of the project and duties:
- Precision Medicine Initiative (PMI) has been launched in 2015 to promote development of effective tools to prevent disease and provide personalized treatments. Precision medicine requires observation of all possible health related data, such as biological, environmental, and behavioral influences, which are generated by individual’s differences in genes and lifestyles. Our lab focuses on the development of the Radiology-Pathology-Genetic (R-P-G) data machine learning platform to implement the early stage cancer diagnosis and accurate treatment planning.
The undergraduate researcher will actively play an important role to build essential components of the project: 1) digitalized big and high quality raw data repositories, 2) fast pre-processing and robust data retrieval system from secure storage, 3) intelligent algorithm to find an association map with self-learning capability, and 4) actionable information extraction and visualization of information.
- No prior research experience is required. However, you must have some computer programming skills (Python will be preferred)
- Laboratory skills: Utilizing deep learning in medical images to create the R-P-G platform.
- Research skills: study design, data analysis method, presentations, scientific writing, etc.
Number of hours students are expected to work, length of the project: Negotiable
Mentoring: Dr. Synho Do will mentor students at least once a week.
Students are encouraged to apply to the HCRP and other fellowships or register for a research course credit.
Email your Resume and cover letter to Ms. Catherine Park at firstname.lastname@example.org
Department: Department of Radiology, Massachusetts General Hospital
Contact information: Tel 617-643-0247, Ms. Catherine Park at email@example.com
Location: 25 New Chardon St. 4th Floor, Boston, MA, 02114
Lab website: http://lmic.mgh.harvard.edu/
Dissecting human β-cell differentiation regulatory networks; Douglas A. Melton, Xander University Professor; Harvard Department of Stem Cell & Regenerative Biology
Pancreatic β-cells are essential regulators of glucose homeostasis whose dysfunction leads to diabetes. Diabetic patients could be cured through transplantation of new β-cells, creating an urgent clinical need for their large-scale generation. To this end, our lab has recently developed strategies for generating human stem cell-derived β-like cells (SC-β) that are glucose-responsive and mitigate diabetes in mice.
We are now looking for a highly motivated, independent, and committed student to help us identify the key genes and signals needed to obtain functionally mature SC-β cells useful for replacement therapy. Specifically, we aim to (i) dissect such regulatory networks using epigenomic tools, (ii) test their drivers for roles in β-cell specification and maturation using functional studies in vitro and in vivo, and (iii) elucidate their function mechanisms using biochemical and cell biological techniques.
The ideal candidate would be a student primarily interested in Molecular/Developmental Biology who also has a general interest in human disease treatment.
Requirements: Completion of an introductory Molecular Biology laboratory course or 1+ years of prior laboratory experience.
Start date: Spring 2017 semester and continuing at least into Spring 2018.
Commitment: 10-12 hrs/week during the term. Student must be willing to commit 1+ years as needed to master a broad range of biological techniques.
Contact: Interested students should contact Juan R. Alvarez (firstname.lastname@example.org) and include a resume highlighting relevant experience as well as a brief description of their status at Harvard.
Summer Research in Panama, with Harvard Pfister Lab & Smithsonian Tropical Research Institute
The aim of this project is to assess phylogenetic relationships between species of laboulbenialean fungi that occur on bat flies (Diptera). Laboulbeniales are parasitic fungi that are microscopic in size and occur at the outside of the integument of arthropod hosts. Questions to be addressed include: How diverse are Laboulbeniales fungi on neotropical bat flies? Does morphological identification always match up with molecular data? Do bat fly-associated Laboulbeniales form a monophyletic clade in the order-wide phylogeny? This project is an excellent research opportunity for an undergraduate who wants to gain more lab experience and who is considering going to graduate school.
Skills required: Some experience with DNA extraction protocols and PCR amplification techniques.
Learning outcome: Molecular lab experience; fieldwork; advanced microscopy; concepts in evolution and speciation. There will be an opportunity to present at a Pfister Lab meeting.
Dates: June 1 - July 31 (flexible dates). This is a full-time position.
Location: The research will take place in Gamboa, a small town that is only reachable by a single-lane iron and wood bridge. Many Smithsonian Tropical Research Institute facilities are available here, among them the Bat Lab. The Principal Investigator of this lab, and close collaborator for the project, is Dr. Rachel Page.
Mentoring: The student will work directly with a fifth-year graduate student at the Pfister Lab, Danny Haelewaters.
Applying for (external) support is required.
Haelewaters D, Gorczak M, Pfliegler WP, Tartally A, Tischer M, Wrzosek M, Pfister DH. 2015. Bringing Laboulbeniales into the 21st century: enhanced techniques for extraction and PCR amplification of DNA from minute ectoparasitic fungi. IMA Fungus 6 (2): 363-372.
Haelewaters D, Pfliegler WP, Szentiványi T, Földvári M, Sándor AD, Barti L, Camacho JJ, Gort G, Estók P, Hiller T, Dick CW, Pfister DH. Laboulbeniales (Fungi, Ascomycota) ectoparasites of Central European bat flies (Diptera, Nycteribiidae): distributional data and host associations. [available upon request]
Haelewaters D, van Wielink P, van Zuijlen JW, Verbeken A, De Kesel A. 2012. New records of Laboulbeniales (Fungi, Ascomycota) for The Netherlands. Entomologische Berichten 72 (3): 175-183.
Summer research in the genetics of neuron shape, Dr. Maxwell Heiman lab, Department of Genetics, Harvard Medical School and Boston Children's Hospital
The aim of this project is to use genetic screens in C. elegans to identify factors that shape the nervous system. Questions to be addressed include, How do neurons extend dendrites of the correct length? How do neurons attach to the right neuronal and glial partners? What controls the specificity and positioning of neuron-glia attachments? This project would be an excellent research opportunity for an undergraduate who is considering going to graduate school. Examples of relevant publications include:
Yip Z. C. and Heiman M. G. (2016) Duplication of a single neuron in C. elegans reveals a pathway for dendrite tiling by mutual repulsion. Cell Reports. 15:2109-2117.
Mizeracka K. and Heiman M. G. (2015) The many glia of a tiny nematode: Studying glial diversity using Caenorhabditis elegans. Wiley Interdiscip. Rev. Dev. Biol. 4: 151-160.
Gilleland C. L., Falls A. T., Noraky J., Heiman M. G.*, Yanik M.F.* (2015) Computer-assisted transgenesis of C. elegans for deep phenotyping. Genetics. 201: 39-46. *, co-corresponding.
Heiman M. G. and Shaham S. (2009) DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration. Cell. 137: 344-355.
Skills required. Previous experience with molecular biology methods.
Learning outcome: Methods for genetic manipulation of C. elegans; advanced microscopy; concepts in developmental biology and neurodevelopment. There will also be an opportunity to present at a Heiman lab meeting.
Expected dates are Jun 1 - Aug 14, with some flexibility available. This is a full-time position.
Mentoring: The student will work directly with a fourth-year graduate student, Elizabeth Lamkin.
Applying for external support or course credit is encouraged, but a stipend can be made available.
Please email CV, unofficial transcript, brief description of interests, and two references to email@example.com
CLS 14047, 3 Blackfan Cir, Boston MA
Undergraduate research opportunity, Dr. Howard Berg Lab, MCB and Dept. of Physics.
BL 3063A. The Biological Labs http://www.rowland.harvard.edu/labs/bacteria/
Email: firstname.lastname@example.org Phone: 617-495-0924
The goal of this project is to develop biosensors to measure the concentration of the signaling molecule cyclic diguanosine monophosphate (c-di-GMP) inside individual bacterial cells. c-di-GMP is involved in regulating several important cellular processes, most notably biofilm formation. Biofilms are the leading cause of infections acquired in hospitals and biofilm-based chronic infections are a growing cause of concern for modern medicine. This project will provide fundamental understanding of the molecular mechanisms underlying biofilm formation in bacteria. The undergraduate researcher will work independently on all aspects of this exploratory project, including finding relevant literature, selecting promising approaches, developing strains, setting up imaging apparatus, and carrying out experiments to measure c-di-GMP concentrations in cells under various conditions.
The ideal candidate will be independent, self-driven, and interested in learning about the biophysics of bacterial locomotion and sensing. Previous research experience is not required but exposure to bacterial genetics and/or molecular biophysics is a plus. Familiarity with MATLAB (or other similar programming languages) is beneficial.
Through this project, the student will gain experience in study design, bacterial genetics, methods in single molecule biophysics, data analysis, presentations, and scientific writing. The student will be closely mentored by postdoctoral researcher Dr. Navish Wadhwa and Prof. Howard Berg. Weekly research meetings and biweekly lab meetings will be held to track the research progress. Expected duration of the project is 1 term, with an option to continue in the following terms. Students are encouraged to apply to the HCRP and other fellowships.
Interested candidates should send their resume, and a cover letter highlighting their background and interests to Dr. Navish Wadhwa at email@example.com.
Undergraduate Research Opportunity in Bumble Bee Behavior, Ben de Bivort’s lab, Organismic and Evolutionary Biology
The bumble bee species Bombus impatiens is a crucial pollinator of many Angiosperm species in North America. Bumble bees are highly social insects that live in small colonies (hundreds of individuals). While worker bees often appear interchangeable, our recent work has shown that individual workers within colonies show strong individual differences in behavior, i.e. “personality”. Our lab uses computer vision and machine learning techniques to study the collective behavior of bumblebee colonies and the role of individual personality in social insect colonies. We’re also interested in how environmental stressors such as pesticides affect individual behavior and group success. http://debivort.org/
- Short-term project (2-3 months). The student should be available to begin work in January 2017. The project will be woven into a master thesis on the evolution of personalities in bumble bees.
- Long-term project (Spring semester 2017, potentially extensible over Summer, extension into senior thesis research also possible). The project will mainly focus on the impact of neonicotinoids (pesticides) on the foraging behavior of bumble bees. Students may also have the opportunity to develop an independent research program.
Skills required: The student is expected to be highly motivated, committed and reliable, as well as eager to learn about research in behavior. Prior research experience preferred, but not required. Students with a foundation in biology or ecology are encouraged to apply.
Number of hours: 5-10 hours per week
Funding: The laboratory does not provide funding. Students are encouraged to seek alternative funding support. Undergraduates can either enroll in a course credit at Harvard or apply for funding through the Harvard College Research Program.
Contact Information. Send resume to Claire Guérin and Dr James Crall:
James Crall, PhD; Rockefeller Fdn. Planetary Health Alliance; Postdoctoral Fellow; firstname.lastname@example.org
Claire Guérin, MSc; Erasmus Mundus Association; email@example.com
Research assistants needed for project on global health quality, Harvard Global Health Institute, Harvard Initiative on Global Health Quality, Cambridge, MA
Duties & Responsibilities
The Harvard Global Health Institute (HGHI), through its strategic initiative on quality, The Harvard Initiative on Global Health Quality (HIGHQ), is committed to advancing our understanding of how to improve quality within diverse health systems. HIGHQ partners with health systems to design policies and metrics that drive high-quality healthcare and advance the field of global health quality through 1) advising partnerships, 2) research, 3) policy and 4) education. Our vision is that health systems everywhere are intelligently designed to improve population health.
The Research Assistant will assist in a seminal project to benchmark the state of healthcare quality globally. In collaboration with others, the Research Assistant will conduct thorough reviews of the scientific, peer-reviewed literature on topics such as the quality of care for acute myocardial infarction or stroke in hospitals and the quality of care for hypertension and diabetes in the outpatient setting. The Research Assistant will abstract data from these studies into a large database and will be involved with data compilation and visualization.
Time Status: Part-time / $20.00 per hour; Schedule: 15-20 hours per week
Basic Qualifications: Medical or public health school students preferred, although exceptional undergraduates with an interest in medicine or health policy will also be considered.
Additional Information: This is a 3-6 month appointment with the possibility of renewal.
Contact: Interested candidates should submit their resume to HGHI Executive Director, Ethlyn O’Garro at firstname.lastname@example.org.
Undergraduate Research in Computational Biology opportunity, Duraisingh lab, Harvard School of Public Health
Malaria impacts human evolution in geographical areas where the disease is endemic. Examples include the sickle cell trait, a mutation in a hemoglobin gene that inhibits growth of the malaria parasite in host cells, and the duffy-negative trait, which renders host erythrocytes resistant to invasion by Plasmodium vivax by preventing expression of the Duffy antigen on their surface.
An undergraduate student will assist us in identifying novel factors that might be under selective pressure from malaria by leveraging the thousand genomes project (http://www.internationalgenome.org) and the human exome project (http://evs.gs.washington.edu). The thousand genomes project provides whole genome sequences of individuals from around the world from including regions where malaria is, and is not, endemic. The human exome project provides broader and deeper sampling for the subset of the human genome that is expressed as protein. Enrichment of specific genetic variants in parts of the world where malaria is endemic may reveal novel factors involved in host/parasite interactions. This strategy was employed to provide evidence that CD55, a potential novel malaria receptor, is under selective pressure (Egan et al. Science, 2015, https://www.ncbi.nlm.nih.gov/pubmed/25954012), and we wish to extend this analysis to the rest of the proteins present in red blood cells.
No prior research experience is required. We are looking for a student with a demonstrated interest in computational problem solving and a basic understanding of biology. The student will develop skills in the unix operating system, the R programming language, and in the use of online bioinformatics resources. The student will be supervised by Jonathan Goldberg, a computational biologist with experience from The Boston Biomedical Research Institute, The Broad Institute and the Duraisingh lab at HTHCSPH, and author of the software packages Kinnanote, Protdraw and Corealyze, which are published at https://sourceforge.net.
Undergraduate Research in Molecular & Cell Biology opportunity in the Duraisingh Lab, Harvard School of Public Health
With 250 million infections and 500,000 deaths attributed to malaria each year, malaria is a significant burden on public health in the developing world. The blood stage of infection is responsible for all symptoms of disease. In the Duraisingh lab we investigate the influence red cell physiology has on the virulence of blood stage malaria. Upon infecting a host red cell, the malaria parasite need the host red cell to remain intact for the two days required for the parasite to produce progeny that will initiate the next round of blood stage infection. A growing body of evidence suggests that the malaria parasites excessive digestion of host hemoglobin and new permeability pathways (NPPs) are responsible for maintaining the osmotic stability of the infected red cell. The impact host red cell physiology has on the osmotic stability of malaria infected red cells is not known. It is our aim to identify red cell factors that determine the osmotic stability of malaria infected red cells. This project has the potential to reveal a novel host antimalarial mechanism as well as therapeutic targets for the virulent blood stage of malaria infection.
We are looking for a student who is interested in gaining research experience (or expanding existing experience), can commit 5-10 hours per week in the lab, and has good communication skills.
Skills required – No previously laboratory experience required. An interest in biological research and problem solving, and good communications skills are all that are needed.
Learning outcome – experience with (i) advanced experimental techniques including immune fluorescence microscopy and flow cytometry (ii) experimental design and trouble shooting and (iii) data analysis and presentation.
Number of hours – 5-10 per week. Duration of commitment is flexible.
Mentoring – Mentoring will be primarily provided by postdoctoral fellow Dr. Martha Clark. Formal meetings with Martha will occur once a week. The student will also have the opportunity to engage with PI Dr. Manoj Duraisingh.
Compensation – Compensation options will be discussed during interview process.
Email resume to Dr. Martha Clark – email@example.com
Evolution and Ecology of Underwater Cave Organisms (Big & Small!)
In dark caves in which landlocked marine layer flows beneath a freshwater layer, there are generally few animals. Yet, some of these extreme caves have inexplicably large biomasses of shrimp and members of the Remipedia, a rare crustacean class discovered in 1981. The cave system studied in the Cavanaugh Lab by postdoctoral researcher Joey Pakes is one of these systems having mysteriously high densities of crustaceans. Why and what is feeding all of these animals? Microbes!!
Field and laboratory studies by Pakes combine both microbial and animal evolutionary ecology to better understand the relationships between microbes and crustaceans in these largely inaccessible habitats across Mexico and the Caribbean. In addition, new projects in the lab have developed around United States freshwater cave systems.
Selected students will be trained by and work closely with Postdoctoral Fellow Joey Pakes, who received her AB at Harvard (Winthrop) and PhD at UC Berkeley. Techniques used in the laboratory are shared by many environmental, microbial and medical laboratories. Past students who have worked with Pakes have gone on to graduate school in biology, veterinary, and medical schools. Most recently, her Harvard mentees have presented work at Harvard, Radcliffe, and international conferences!
Selected students may work on one or a combination of the following projects:
1) Genetic and morphological Biodiversity of cave micro-eukaryotes: Requires
a. preparing slides of micro-eukaryotes (e.g., protists) with fluorescent dyes and/or
b. using PCR and sequencing to assess the biodiversity of cave organisms.
2) Biogeography of cave crustaceans: Requires
a. DNA extraction, PCR, sequence generation for analysis of shrimp phylogeography and rates of dispersal.
b. Work in excel, ArchGIS/GOOGLE EARTH, genbank and literature searches are likely. (The student may also learn phylogenetic and population genetic analysis. )
3) Are cave environments stable? A micro-climate study: Requires
a. Using your programming knowledge to analyze long term environmental data collected in underwater caves.
4) History of Cave Science: While cave diving has only been popular since the 1970s and safe diving practices were not developed until much later, caves has been appreciated as biological hotspots since the Voyage of the Beagle. This project aims to combine early and recent research to answer questions about known caves like, Where are they? What geologic and chemical characteristics do they share? Who lives inside of them?
a. Help us create and catalogue the history of cave research using library science in person and on line.
b. Then, mine data from these historical works to put current knowledge into context.
Specific qualifications applicants should have
Availability to begin work in 2017 Winter Session or Spring Semester:
For projects 1 and 2: Life Sciences 1a or Life and Physical Science A required. Coursework covering the following topics is desirable but not essential: evolution, invertebrate biology, microbial diversity, biological oceanography, geochemistry, or ecology.
For projects 3 and 4: Have you used google scholar, pubmed or Hollis for a class assignment or taken CS50? Anyone with these skills and an interest in caves is encouraged to apply!
For all projects, a background in one or more of the following would be preferred: Excel, ArchGIS, Adobe product suite, a programming language (e.g., R).
Time Commitment: 6-9 hours per week. This commitment includes an hour of weekly meeting and an hour to read literature or prepare new protocols at home.
If interested: Please send firstname.lastname@example.org an email with subject line “Interest in Undergraduate Research.” In the body of the email, please let me know why this research interests you and how your background might help our research team.
Should you care to see some pictures of an anchialine cave animals and learn more about Joey's PhD field research, check out this narrated slideshow hosted by the UC Museum of Paleontology http://ucmp.berkeley.edu/blog/archives/1731.
Undergraduate Research Fellow in Alzheimer’s Disease Lab, MGH
Our research uses advanced brain imaging technology to the understand degenerative changes that occur in the brain of patients with Alzheimer’s disease.
Skill required: Students are expected to be self-motivated and eager to learn about neuroscience research. No prior research experience is required. Students with a foundation in biology, chemistry, physics, psychology, neuroscience, computer science, or engineering are encouraged to apply.
The undergraduate student fellow can expect to gain valuable knowledge in clinical research, data analysis methods, and study design in addition to presentation and laboratory skills.
The Principle Investigator will work with the student to determine appropriate mentorship, which will be tailored to the interests and needs of the student.
The length of the project and number of hours per week dedicated to the lab are negotiable.
To apply, please send your resume and a brief description of your scientific interested to the study coordinator at email@example.com and firstname.lastname@example.org
Massachusetts General Hospital
Martinos Center, Brain Aging and Dementia (BAnD) Laboratory
149 13th Street, Charlestown, MA 02129
Phone: 617-643-7721; Email: email@example.com
Undergraduate research opportunity, Division Endocrinology, Diabetes and Hypertension, BWH.
Students will gain an understanding of the normal physiology of puberty and reproduction through the use of various basic and translational models to understand the underlying mechanisms leading to disordered pubertal timing and altered reproduction. Current projects focus on the mechanism of Makorin Ring Finger Protein 3 (MKRN3), the first loss-of-function mutation described in children with central precocious (early) puberty, by Dr. Kaiser’s lab in 2013. Using a recombinant adeno-associated virus overexpressing Mkrn3, the goal of the current project is to attempt to delay pubertal onset in prepubertal rodents and cause suppression of the hypothalamic-pituitary-gonadal (HPG) axis in postpubertal rodents. In vitro studies using various cell lines will also be used to understand the impact of Mkrn3 on other important neuroendocrine players in the HPG axis.
Skills required: No prior laboratory skills required.
Goals of experience: Experimental design with a focus on good scientific method, data analysis and interpretation of results will be emphasized. Students will gain basic laboratory experience in a variety of laboratory skills including mammalian cell culture, RNA extraction, polymerase chain reaction, gel electrophoresis, western blot, immunohistochemistry as well as experience in rodents through animal handling and husbandry, reproductive phenotyping, tissue collection and surgical procedures.
Number of hours students are expected to work, length of the project:
The number of hours students are expected to work is flexible. The length of the project can be modified to fit the needs of the student, it can range from a semester to a full year commitment.
Mentoring: Dr. Kaiser provides mentoring and oversight for the overall project while direct mentoring will be conducted by a post-doctoral research fellow (Stephanie Roberts, MD).
Does laboratory provide any funds to pay student’s stipend? No, students are encouraged to either enroll in a course credit at Harvard (see your concentration advisor) or apply to student fellowships (HCRP, PRISE, etc.)
Application: To apply send resume directly to Dr. Kaiser at firstname.lastname@example.org.
Contact information: Ursula B. Kaiser, M.D.
Chief, Division of Endocrinology, Diabetes, and Hypertension
Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School
221 Longwood Avenue
Boston, MA 02115
Undergraduate research opportunity, Division of Endocrinology, Diabetes and Hypertension, BWH.
Dr. Kaiser’s laboratory research focuses on understanding the neural network controlling puberty onset. Puberty is triggered by the central increase in secretion of a neuropeptide, gonadotropin-releasing hormone (GnRH), which stimulates pituitary gonadotropin secretion necessary for activation of gonadal function. Our group recently reported loss-of-function mutations in the makorin ring finger protein 3 (MKRN3) gene in association with central precocious puberty. The aim of this project is to determine the role and mechanisms of action of Mkrn3 in puberty onset. For these studies, we are using a combination of in vivo and in vitro approaches. A genetically modified mouse model will be used to determine the physiological role of Mkrn3 in the regulation of puberty onset. The mechanism of action of Mkrn3 will be studied by using hypothalamic-like neurons differentiated from genetically manipulated human induced pluripotent stem cells (hiPSCs).
Skills required: No prior research experience is required.
Learning outcome: The student will be involved in both in vivo and in vitro approaches to answering important biological questions. They will learn basic molecular and biochemical techniques (PCR, RT-qPCR, Western blot analysis, immunohistochemistry), mammalian cell culture techniques (including hiPSCs, hiPSCs cell differentiation) and reproductive physiology analysis in mice. They will also learn how to design a research experiments, analyze data and present their results. They will have the opportunity to attend weekly lab meeting and Endocrine division conferences.
Number of hours students are expected to work, length of the project:
Number of hours students are expected to work is flexible, depending of the student’s availability.
Mentoring: The student will be directly mentored by a post-doctoral research fellow (Lydie Naule, PhD) on a daily basis and will receive overall supervision by Dr. Ursula Kaiser.
Does laboratory provide any funds to pay student’s stipend? No. Students are encourage to apply for research course credit (see your concentration advisor) or research fellowships (HCRP, PRISE, etc).
Application: To apply, email your resume to Dr. Ursula Kaiser at UKaiser@partners.org.
Contact information: Ursula B. Kaiser, M.D.
Chief, Division of Endocrinology, Diabetes, and Hypertension
Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School
221 Longwood Avenue
Boston, MA 02115
Undergraduate research opportunities in translational genetics and neurodevelopment (Yu Lab)
The Yu lab (Division of Genetics and Genomics, Boston Children's Hospital) is seeking talented undergraduate students interested in genomics and neurobiology research.
Our group studies the genetic and neurobiological underpinnings of autism and other neurodevelopmental disorders. For example, we have conducted the largest screen to date for gene knockouts in humans that lead to autism, mining whole exome and genome data from tens of thousands of autistic individuals and controls. Students will have the opportunity to work on a range of projects, ranging from in silico bioinformatics and gene hunting to bench-based neurobiological studies of candidate genes (involved in nitric oxide signaling, axon guidance, neurotransmitter signaling) arising from these analyses. We are also conducting a clinical translational research study of the use of genome sequencing in the neonatal intensive care unit.
Skills required: Projects are available for students with experience and/or interest in genetics, molecular biology, neurobiology, bioinformatics/computational biology, and translational medicine. Techniques include molecular biology, biochemistry, cell culture, neuronal culture, in situ hybridization, ChIP-seq, genome engineering, next-generation sequencing (NGS), NGS analysis and interpretation. Students will be mentored directly by a postdoctoral fellow and supervised by the PI.
Interested candidates can send a cover letter, resume/CV, and two references to Dr. Yu. Students are encouraged to apply for course credit, work-study, and fellowships; laboratory covers summer stipends not covered by Harvard summer research awards. Salaried positions may be available depending on experience.
Contact: Tim W. Yu, MD, PhD
Assistant Professor, Harvard Medical School | Division of Genetics and Genomics, Boston Children's Hospital | Member, Kirby Program in Neurobiology | Associate Member, Broad Institute
Center for Life Sciences Building, Room 14048
Undergraduate Research Opportunity Dr. Bonmassar lab, AA. Martinos Center, MGH
The project consists in designing, building and testing microscopic coils (size of neurons) for magnetic stimulation for investigating nervous system functions. Previous work can be found in:
No prior research experience is required. Duties include complete training and manufacture full functional microcoils for neuroscience research.
Learning outcome: The student will have access to the state-of-the-art facilities in the Center for Nanoscale Systems (CNS) at Harvard University and learn different techniques for manufacturing biomedical devices at micro and nano scale , the skills learned will include clean room operations, photolithography, reactive ionic etching, deposition techniques, and metrology techniques such as scanning electron microscope, etc.. The student will also acquire research skills such as study design, numerical simulations with the Finite Element Method to study the electromagnetic fields generated by the microscopic coils, presentations at weekly meetings, scientific writing of manuscripts in biomedical engineering journals, etc.
Mentoring: Dr. Bonmassar will be mentoring the HU student through weekly mentorship meetings.
Please send a resume to Prof. Bonmassar at email@example.com.
Location: AA Martinos Center, Harvard Medical School, Charlestown, MA 02129
Giorgio Bonmassar, Ph.D.
AA. Martinos Center | Massachusetts General Hospital
Harvard Medical School
Building 75, Third Ave
Charlestown, MA 02129
Tel. (617) 726-0962
Undergraduate Research Opportunity in Neurodegeneration, Dr. Walsh lab
The Walsh lab has been at the forefront of studies on the role of soluble protein aggregates in neurodegenerative disease. Currently, we are working to establish a knowledge base that will allow the development of rationally designed interventions to slow or halt Alzheimer’s disease. In line with this, the student will have the opportunity to work on a number of exciting and translational projects aimed at understanding nervous system degeneration from a proteinopathic standpoint. Duties: From day one, the student will work closely with a postdoctoral fellow to develop research skills necessary to function independently. Responsibilities include, but are not limited to, cell culture and aseptic technique, recombinant protein purification and aggregation, agarose and polyacrylamide gel electrophoresis, plate-based immunoassays, immunochemistry and protein chromatography. References: Soluble Tau Protein Fragments, Soluble β-Amyloid Protein in Alzheimer’s Brains, Mediator of β-Amyloid Protein Neurotoxicity.
Skills Required:There are no specific skill requirements per se, but prior wet lab research experience and/or an understanding of basic biochemistry is preferred. However, all applications will be considered.
Learning Outcome: With the aid of senior research staff, the student will be expected to i) establish proficiency with various cell, molecular and biochemical methods, ii) develop experimental design skills, iii) analyze and interpret quantitative and qualitative data, iv) organize and present data in a coherent manner, and v) work closely with other students and scientists in a collaborative environment.
Time Dedication: The student is expected to spend a minimum of 12 hours/week in lab. The duration of the opportunity will depend on a number of factors and is open to discussion.
Mentor: The student will have the opportunity to work closely with postdoctoral fellows on a day-to-day basis. Additional weekly meetings with the PI will also be organized.
Compensation: Funding is not available during the school term, but stipend may be available for students who wish to work during the summer months.
Contact Information: Interested students should submit a resume and statement of interest to Grant Corbett, Ph.D. at firstname.lastname@example.org. Please include ‘Undergraduate Research Opportunity’ in the title of your message. Thank you.
Dominic M. Walsh, Ph.D., Associate Professor of Neurology
Laboratory for Neurodegenerative Research
Ann Romney Center for Neurologic Diseases
Brigham & Women’s Hospital and Harvard Medical School
Building for Transformative Medicine (10002O)
60 Fenwood Road
Boston, MA 02115
Undergraduate research opportunity, Dr. Walker Lab, Center for Human Genetic Research, MGH
Projects involving fruit flies (Drosophila) to study neurological diseases including neurofibromatosis type 1 (NF1), schwannomatosis and Alzheimer’s Disease are available. Will include maintenance of fly stocks and genetic crosses, microscopy, molecular biology and protein techniques including: DNA/RNA isolation, PCR and sequencing, western blotting.
Skills required: some laboratory experience is preferred (molecular/protein and/or Drosophila genetics), but full training will be given. Must be self-motivated with attention to detail and excellent verbal and written communication skills.
Learning outcome: students will learn laboratory skills in genetics, dissection, microscopy, DNA and protein analysis, statistical analyses, preparing data for publication
Hours are negotiable and flexible – depending on the experiments being conducted at the time. Minimum expected: 2-3 hours, 2-3 days a week. Length of project: minimum of 6 months but can be extended.
Mentoring: the PI will be responsible for mentoring. Will meet formally on a weekly basis to discuss project, planning, data etc. and PI will be on hand throughout working day. Will also be expected to occasionally work with other lab members (to learn/demonstrate techniques and discuss experiments).
Funding: possible stipend, but student would be strongly encouraged to apply to the HCRP and other fellowships or register for a research course credit.
To apply, email your resume to Dr. Walker email@example.com
Dr. James (Jim) Walker
Center for Human Genetic Research (CHGR)
Massachusetts General Hospital
Simches Research Building
185 Cambridge Street
Boston, MA 02114
CHGR Web site: http://chgr.org/index-faculty_walker.html
Undergraduate Research Opportunity in the Laboratory of Ronald Neppl, Department of Orthopedic Surgery, Brigham and Women’s Hospital, HMS
In healthy individuals, lean muscle accounts for 38 – 54% and 28 – 39% of total body mass in men and women respectively. These ranges are quite broad and are dependent upon multiple factors including age, physical activity level, overall health, and genetic makeup. In addition to its clear role in movement and locomotion, muscle is also a reservoir of glucose acting to buffer blood-glucose levels, a source of lactate and alanine for gluconeogenesis in the liver, as well as a major endocrine organ regulating the metabolic demands of adipose tissue, brain and bone. An ever increasing body of evidence links physical activity and the maintenance of lean muscle mass with a decreased risk of chronic disease as well as premature morbidity and mortality. A gradual loss of muscle mass with advancing age is physiologically normal. However, in a subset of individuals its increasingly rapid progression results in Sarcopenia, a major contributor to Frailty Syndrome. Effecting upwards of 5 million Americans per year, Cachexia is characterized by an excessive loss of muscle mass and increased mortality. It is now recognized as a complex metabolic condition associated with an underlying illness or chronic disease such as renal failure, cancer, rheumatoid arthritis, and AIDS. The Neppl Research Group is focused on the molecular regulation of skeletal muscle homeostasis in health and disease. Our overarching goal is to understand how ncRNAs control the essential processes of myogenesis and hypertrophic growth, and how perturbations in these processes may lead to a disease state resulting in muscle atrophy. Using traditional biochemical and molecular biology techniques, in vivo and in vitro model systems, as well as next generation RNA sequencing, we seek to discover and understand the biological roles these ncRNAs play in the maintenance of lean muscle mass.
Skills Required: No prior research experience is required. Only a desire to learn and work as a part of a team. Students with basic laboratory skills (e.g. DNA or protein gel electrophoresis, buffer preparation, etc.) are encouraged to apply.
Hours: The number of hours per week is negotiable.
Learning Outcome: The student will learn laboratory and research skills, project and study design, as well as data analysis methodologies and presentation skills.
Mentoring: The student will have a weekly mentorship meeting with the PI, and will work closely with Postdoctoral Fellows in the lab. The PI has an open door policy, and actively performs experiments with the Fellows.
Required information: Please email your resume/CV along with a brief statement regarding your interest in musculoskeletal research and what you hope to learn.
The PI will work with you and the appropriate institution (e.g. HMS, BWH, etc.) in securing stipend funds.
Ronald L Neppl, Ph.D.
Department of Orthopedic Surgery
Brigham and Women’s Hospital
Harvard Medical School
60 Fenwood Rd. Building for Transformational Medicine, Rm 5016J, Boston MA 02115
Lab webpage: www.nepplresearchgroup.org
Undergraduate research opportunity Dr. Ursula Kaiser Laboratory, Brigham and Women's Hospital
An increasing body of evidence has demonstrated that several G protein-coupled receptor (GPCR)–ligand pairs are critical for normal human reproductive development and function. Patients harboring genetic insults in either the receptors or their cognate ligands have presented with reproductive disorders characterized by varying degrees of GnRH deficiency. These disorders include idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann Syndrome (KS). Mutations in PROKR2 have been identified in patients with hypogonadotropic hypogonadism or Kallmann syndrome, characterized by GnRH deficiency. However, the molecular mechanisms through which these mutations cause disease are not fully understood. Several of these mutations are in amino acids in the 4th or 6th transmembrane domain of PROKR2, which are highly conserved among G protein-coupled receptors (GPCRs) and have been shown to impair cell surface trafficking, often causing misfolding of the receptors. The mechanisms involved in post-translational processing and trafficking of GPCRs from endoplasmic reticulum (ER) to the cell surface are not fully understood, but it has been shown that chaperone proteins play an important role in the intracellular trafficking of GPCRs. We hypothesize that mutations in PROKR2 that interfere with cell surface expression have impaired interactions with chaperone proteins and instead may interact with proteins targeting them to degradation pathways. The goal of our studies is to identify and compare the proteins involved in PROKR2 intracellular trafficking by performed immunoprecipitation followed by mass spectrometry (MS) analysis of wild-type (WT) PROKR2 and trafficking defective mutants.
- Abreu AP, Noel SD, Xu S, Carroll RS, Latronico AC, Kaiser UB. Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function. Mol Endocrinol 2012;26:1417-27.
- Noel SD, Kaiser UB. G protein-coupled receptors involved in GnRH regulation: Molecular insights from human disease. Mol Cell Endocrinol 2011;346:91-101. https://www.ncbi.nlm.nih.gov/pubmed/21736917
- Abreu AP, Kaiser UB, Latronico AC. The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism. Neuroendocrinology. 2010;91(4):283-90. https://www.ncbi.nlm.nih.gov/pubmed/20502053
Basic laboratory techniques including mammalian cell culture, protein isolation, western blot analysis are preferred but not mandatory.
Learning outcome: Students will have the opportunity to learn basic laboratory techniques including but not limited to mammalian cell culture, western blot, immunoprecipitation, bioimaging, and molecular cloning. In addition, they will learn how to design scientifically rigorous research experiments and perform data analysis. Students will also be given the opportunity to present their work at our laboratory meeting and/or scientific meetings.
Number of hours students are expected to work is negotiable.
Mentoring: Dr. Yong Bhum Song, a postdoctoral fellow in Dr. Kaiser’s lab, will serve as the primary mentor. He will meet with the student on a daily basis.
Students are encouraged to apply to the HCRP, PRISE or register for a course-credit with their concentration advisers.
Contact: Ursula Kaiser, M.D.
Chief, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School
221 Longwood Avenue
Boston, MA 02115
Undergraduate Student Internships for 2017 at the Center for Stem Cell Therapeutics Imaging
The Center for Stem Cell Therapeutics Imaging at Brigham and Women’s Hospital, Harvard Medical School in Boston, MA is seeking highly motivated undergraduate students interested in oncology research.
Our research is based on simultaneously targeting cell death and proliferation pathways in tumor cells in an effort to eradicate both primary and metastatic tumors in the brain using therapeutically engineered stem cells. We have engineered different adult stem cells types to release (i) pro-apoptotic proteins to specifically induce apoptosis in tumor cells; (ii) anti-proliferative nanobodies (ENb) to inhibit tumor cell proliferation; (iii) anti-angiogenic proteins to target blood vessels supplying the tumor; (iv) oncolytic viruses to induce viral oncolysis; and demonstrated the therapeutic efficacy of these engineered stem cells both in vitro and in vivo. Inherently linked to our tumor therapy paradigm, we employ fluorescent/bioluminescent imaging markers and optical imaging techniques to track the fate of stem cells and tumor cells in real time in vivo. In an effort to translate these therapeutics into clinical settings, we have developed and utilized immuno-deficient and -competent mouse tumor models that mimic clinical settings of primary tumors and their secondary micro-invasive deposits in the brain.
We offer an excellent training program in a collaborative research environment including molecular biology, stem cell biology, gene delivery to brain tumors, and imaging disciplines. The student interns will be working under guidance from a senior lab member on a research project and will be supervised by the Director.
Applicants should be currently enrolled in an undergraduate program within the Greater Boston area, with experience in one or more of the following techniques: stem cell biology, gene cloning, viral vector construction and/or animal surgeries. The student interns are expected to commit at least 15-hours/week during regular academic year and apply for full-time summer internship. They will receive training in various scientific areas including but not limited to experimental design, conduct, data interpretation and analysis, writing scientific reports and manuscripts.
Interested candidates can email the Center Director, Dr. Khalid Shah with a copy of their most recent resume and two letters of recommendation at firstname.lastname@example.org . http://www.shahmnil.mgh.harvard.edu
Location: Brigham and Women’s Hospital
Department: Neurosurgery Research
Work Location: 60 Fenwood Road, Boston, MA 02115
Duration of Internship: 2 years
Undergraduate Research Assistant, Laboratory of Bacterial Biophysics, Rowland Institute at Harvard
In nature, bacteria often move through complex media like soil or mucus which are very different from the aqueous solutions typically used in laboratory experiments. The aim of the project is to learn whether the different kinds of motility appendages of bacteria are advantageous for traversing specific kinds of media.
The undergraduate researcher will use a newly developed automated imaging setup to quantify how colonies of bacterial with different types of motility appendages explore new territories consisting of various complex media in Petri dishes. Duties include preparing bacterial cultures and Petri dishes with complex media, setting up automated imaging experiments, and analyzing the resulting data.
Skills involved in the research are:
- culturing bacteria
- general wet bench work
- some ImageJ and Matlab-based data analysis
It would be advantageous for the undergraduate researcher to bring along some experience related to some of these skills.
- lab skills as above
- data presentation
Number of hours students are expected to work: 8-10h per week for the spring term initially.
We encourage students to explore opportunities for course credit, work-study, and fellowships, but can offer a salary.
To apply: please email a resume along with a brief statement explaining why you would like to join the lab, which skills you bring along, and which you would like to learn.
Undergraduate Research Assistant, Laboratory of Host Microbiome and Toxicity, Rowland Institute at Harvard
Projects are related to looking at environmental toxins effect on the microbiome, using honey bees and wasps.
Skills required: Comfort with insects, ideal candidate would have microbiology or computer programing experience.
Learning outcome: opportunities to present work at scientific conferences as well as author scientific publications
Number of hours students are expected to work: 10-20hr/week
Does laboratory provide any funds to pay student’s stipend? yes
To apply send CV and a cover letter regarding your interest in science and science research as well as highlighting their longterm career goals.
Undergraduate Research Assistant, Laboratory of Systems and Behavioral Neuroscience, Rowland Institute at Harvard
Our lab is primarily focused in studying learning and memory using innovative imaging and optogenetic techniques in larval zebrafish. In particular, we are looking for a student interested in understanding how an animal learns to assemble complex motor sequences.
Expectations and Responsibilities: Responsibilities can include designing and conducting behavioral and imaging experiments, as well as zebrafish genetics and husbandry. The student will be immersed in a multidisciplinary lab that utilizes expertise from a diverse array of fields, and given ample opportunities to expand his/her knowledge and skills. To provide mentorship and support, each student will be paired with either a postdoc in the lab or work directly with the Principal Investigators.
Ideal candidates are driven, independent and interested in obtaining a deeper understanding of the neural basis of learning and memory. Programming skills and previous lab experience are preferred, but not required.
Learning outcome: all aspects of scientific work including laboratory skills, scientific writing and presentation
Students are expected to work at least 8 hours per week during semesters.
Partial funding possible; candidates encouraged to apply for HCRP, PRISE, etc.
Please send your CV and one-page motivation letter to Dr Jennifer Li (email@example.com). Please specify whether you are interested in a volunteer or work-study position.
Undergraduate Research Assistant, Laboratory of Renewable Energy Materials, Rowland Institute at Harvard
To developing highly efficient artificial photosynthesis system
No prior research experience required. Looking for highly motivated students.
Learning outcome: problem-solving, oral presentations, writing
Number of hours students are expected to work: depends on the student's schedule, very flexible
Partial funding possible; candidates encouraged to apply for HCRP, PRISE, etc.
To apply send Resume and cover letter would be fine.
Undergraduate Research Assistant, Laboratory of Excitonic Materials and Devices, Rowland Institute at Harvard
Upconversion is the process of converting low energy (infrared) light into high energy (visible) light. This has a number of very useful applications, from building higher efficiency solar cells, to better imaging cameras, to infrared and night vision, to three dimensional displays. Critical to the process, however, are the materials used. Here, the undergraduate researcher will examine a set of materials to find the most successful combinations and build effective devices. See doi.org/10.1038/nphoton.2015.226 for more information.
The student is expected to have experience in a scientific lab and good scientific hygiene. Specific skills, including but not limited to spin coating, thermal evaporation, packaging, lasers, spectrometers, etc, will be taught by the PI.
Learning outcome: The student will learn how to plan and execute a scientific experiment, from design to fabrication to testing and compiling the results. The student will present their work to the PI and others and gain experience with technical presentations. The student will publish their results, if applicable, in a peer-reviewed journal with assistance from the PI.
5-10 hours per week, January - May with extensions over the summer possible.
Partial funding possible; Candidates encouraged to apply for HCRP, PRISE, etc.
Submit a resume and cover letter to firstname.lastname@example.org.
Undergraduate Research Assistant, Laboratory of Nanoscale MRI, Rowland Institute at Harvard
The Tao Lab seeks structure-property relationships in nanoscale, heterogeneous matter through the development of single-nucleon magnetic resonance imaging. On this journey toward direct, 3D imaging of atomic structures, we are compelled to lift the performances of force-sensing and magnetic gradient-generating systems to new heights. We expand the tool boxes of nanofabrication and material synthesis, for the existing arsenal of sample preparation methods usually proves inadequate to support this nano-engineering tour de force. This multidisciplinary adventure will continue to enable discoveries and understanding of new physical phenomena and chemical processes.
A detailed description of our philosophy regarding undergraduate laboratory education:
Learning outcome: Instrumentation development; Material Synthesis; Presentation skills; Computer graphics
10h during term time and full-time during summers and winter semesters.
Partial funding possible; candidates encouraged to apply for HCRP, PRISE, etc.
Please email a CV along with a brief statement explaining why you would like to join this particular lab, which skills you bring along, which you would like to learn, and what your long-term career plans are. We are especially interested in your extracurricular interests as well!
Undergraduate research opportunity, Department of Ophthalmology at MEEI-HMS
Description of the project and duties: Age-related macular degeneration (AMD) affects more than 1.7 million individuals in the US and it will reach 3 million by 2020. Current therapies can improve vision only in some patients with advanced AMD; unfortunately, there is no effective therapy that prevents disease progression in patients with early disease or genetic predisposition. Our aim is to create a cell-based model using induced pluripotent stem cells (iPSC)- derived retinal pigment epithelial (RPE) cells carrying AMD risk variants in complement genes. The mutations will be generated by genomic engineering with CRISPR/Cas 9. So the student will learn this technique, which includes cloning and molecular biology techniques. The student will also learn cell cultures, specifically iPSC cultures. Our final aim is to discover the primary mechanisms activated by the combination of aging and genetic variants in complement genes in patients with early AMD.
Skills required: No prior research experience is required. Sophomores, Juniors and Seniors are encouraged to apply
Learning outcome: you will learn typical laboratory skills: cell biology and molecular biology skills (including genomic engineering, stem cell cultures and primary cell cultures), and research skills: study design, data analysis method, presentations, scientific writing, etc. Also, you will have the chance to attend interesting lab meetings and lectures from international researchers.
Number of hours students are expected to work, length of the project: this is an ongoing project, so the student can join us for a variable amount of time (at least 3 months). We can discuss every case.
Mentoring: The student will be under the supervision of Dr. Fernandez-Godino, but Dr. Pierce will be available eventually as a mentor.
We do not have funds for stipend. Students are encouraged to apply to HCRP, other Harvard fellowships or register for a course credit.
Email your resume and a cover letter to email@example.com.
Principal Investigator: Dr. Rosario Fernández Godino, Instructor in Ophthalmology
Massachusetts Eye and Ear Infirmary, Ocular Genomics Insitute- Harvard Medical School, 243 Charles st, Boston, MA
Lab website: https://oculargenomics.meei.harvard.edu/index.php/pierce-home
Undergraduate research opportunity, Kirby Center for Neurobiology, HMS
Project duties: The goal of this project is to develop new viral based tools that remove the need of transgenic animals and eventually open up experimental possibilities in higher vertebrate species that are currently impossible. The workflow currently consists of adeno-associated virus production, injection of virus into mice by tail vein, perfusion of mice, dissection and tissue section of brain and spinal cord, immunofluorescence staining of sections, and confocal microscopy of stained samples. In the coming months we hope to expand experiments into areas of flow cytometry, DNAse hypersensity screening and next generation sequencing.
No prior research experience is required.
Learning outcome: Depth of involvement is entirely up to the individual. Students can participate in any of the procedures currently involved in these experiments that they may be interested in gaining expertise. For example a range of techniques are involved including viral production, histology, microscopy and data analysis. If cell type specific enhancers elements are identified, functional experiments could also be undertaken for a more in depth project (ie. examine how stimulating labeled neurons effects animal behavior). A motivated student could also undertake projects to set up new techniques to apply to these experiments like sample clearing and whole brain imaging by light sheet microscopy, for example.
Opportunities for practicing scientific writing and presentation would be available and strongly encouraged for students that wish to continue in academic research in their future.
Working hours are flexible but would need to be at least 5 hr on most weeks but more hours would certainly be available. Length of the current iteration of this project is expected to be at least 1 year, but ‘next generation’ techniques are currently being designed for future experiments to reach the overall goal.
Mentoring: The primary mentor for this project is Dr. Philip Williams, and Instructor in the lab. He has over 17 years of laboratory experience and has strong expertise in histological and microscopy techniques, as well as a depth of knowledge about both developmental and degenerative neurobiology. The lab has lab meetings once a week on Friday mornings that students are encouraged to attend if they do not conflict with coursework. Project meetings are scheduled every few months.
The laboratory can provide a stipend for interested students.
Application: Please send a brief description of what your scientific interests are and what you hope to achieve through undergraduate research to: Philip.firstname.lastname@example.org and Zhigang.email@example.com
Principal Investigator: Dr. Zhigang He, Department: Neurology Research
Kirby Center for Neurobiology, 13060; Center for Life Sciences; 3 Blackfan Circle, Boston 02115
Posted November 4, 2016
Undergraduate Research Opportunity, Division of Nuclear Medicine and Molecular Imaging, Gordon Center for Medical Imaging, Athinoula A. Martinos Center for Biomedical Imaging, MGH
The Sepulcre lab focuses on brain imaging studies aiming at the understanding of large-scale brain networks implicated in human cognition and neurodegenerative disorders. We also devote a substantial part of our work developing cutting-edge network methodologies for different brain imaging modalities such as functional connectivity MRI and PET imaging. We currently have several line in which students can enroll depending on their interest, including working with functional connectivity MRI in blind children, PET tracers and MRI in Alzheimer disease, fMRI of language networks and the developing of graph theory analyses to get a better understanding of the relationships of the brain networks.
No laboratory skills are required, the student will learn all the skills needed in the lab, also no prior research experience is needed, just enthusiasm.
Learning outcome: Depending on the project the student wish to enroll he will learn how to design a study, write a proposal, process data and any laboratory skill that would be needed for the work.
Number of hours students are expected to work: As much as he/she is willing to be involved.
Length of the project: is variable, but if data is already collected it takes a 3 months for the analysis and 3 more for further elaborations.
Mentoring: the PI and any of the members of the lab will be helping the student to accomplish his/her needs. Lab meetings are help every other Friday, but the PI's door is always open for any questions or concerns.
Compensation: this is a volunteer position. Student are encouraged to apply for HCRP and other Harvard Research Fellowships or obtain a research or thesis course credit.
To apply, email your resume to the PI and a small statement on why you would like to join the lab as well as the students expectations. firstname.lastname@example.org
Contact: Jorge Sepulcre MD PhD
Asst Professor of Radiology, Harvard Medical School
Division of Nuclear Medicine and Molecular Imaging
Gordon Center for Medical Imaging
Athinoula A. Martinos Center for Biomedical Imaging
Department of Radiology, Massachusetts General Hospital
Mind/Brain/Behavior, Harvard University
149 13th St, Suite 5.209, Charlestown 02129
Undergraduate Research Opportunity – Laboratory for Affective and Translational Neuroscience, McLean Hospital
Volunteer positions are available in the Laboratory for Affective and Translational Neuroscience (LATN), at McLean Hospital, directed by Diego A. Pizzagalli, Ph.D. LATN is part of McLean’s Center for Depression, Anxiety and Stress Research, which embraces a multi-disciplinary approach to improve our understanding of the psychological, environmental, and neurobiological factors associated with affective disorders (http://cdasr.mclean.harvard.edu/). Among our current research projects are an exploration of the psychological and neurobiological traits associated with resilience; an assessment of the role of early adversities such as maltreatment and trauma as precursors to depression and anxiety; and investigation of the cognitive and emotional processes that contribute to incentive-guided decision making, emotion regulation, and psychopathology.
Responsibilities: Volunteers will participate in all phases of our research utilizing multiple methodologies such as MRI, fMRI, EEG, and behavioral testing, to study emotional and cognitive processing in both healthy and psychiatric populations. Volunteers will assist with recruiting, interviewing participants, behavioral and cognitive testing, and administration of EEG and MRI experiments. Volunteers will also work with LATN researchers to analyze data and prepare results.
Expectations and Qualifications: Volunteers work 10 to 15 hours per week for two semesters, and may apply for course credit in PSY 910r or Neurobio 98r. Candidates must be highly motivated and reliable. Both undergraduate students and recent college graduates can be research volunteers.
Supervising Professor: Diego Pizzagalli, Ph.D., Professor of Psychiatry, Harvard Medical School, is the supervising professor. Dr. Pizzagalli is a Board of Honors Tutor member in the Psychology Department at FAS.
Location: This lab is located at McLean Hospital, in Belmont MA, which is easily accessible via the T (a 25-minute bus ride from Harvard). McLean is the principal psychiatric teaching hospital of Harvard Medical School, and is ranked as the nation’s #1 Psychiatric Hospital in the U.S. News & World Report’s 2014-2015 survey. See http://www.mclean.harvard.edu/ for more information.
To Apply: Please visit the lab web site at http://cdasr.mclean.harvard.edu/index.php/about-us/current-openings to download an application form, and then send the completed form along with a copy of your CV to Dave Crowley at email@example.com.
Undergraduate research opportunity “Aggression in the Fruit Fly Fight Club”, Department of Neurobiology, Harvard Medical School
Our laboratory studies aggression using a fruit fly model system. The studies link quantitative behavioral experiments with powerful genetic methods in explorations of how higher-level aggression is generated in the nervous system. We are interested in having 1-2 undergraduate students work with us part time (possibly for academic credit) during the academic year and full time during summers. While we are mainly interested in students looking for a senior honors thesis project, but will consider all applications. References: 1. Review: Fernández MP and Kravitz EA. (2015) Aggression in Drosophila. Behav Neurosci. 2015 Oct;129(5):549-563. 2. Article: Alekseyenko OV, Chan Y-B, Fernandez MP, Bülow T, Pankratz M and Kravitz EA (2014) Single serotonergic neurons that modulate aggression in Drosophila. Curr Biol 24: 2700-2707.
Skills required: We prefer students who have had introductory Neurobiology and Genetics courses. Laboratory experience is helpful but not required.
Learning outcome: Hopefully an honors thesis in a concentration field. Detailed understanding of state of the art genetic methods applied to the understanding of an important biological problem.
Number of hours students are expected to work, length of the project: These are negotiable during the academic year. Hopefully full time during summers. Sophomores and Juniors are encouraged to apply and the ultimate goal will be an honors thesis in a specialty area.
Mentoring: Student will be trained and working under close supervision of a post-doctoral fellow at start. Then student will carry out project on his/her own with guidance and input from lab head and other members of lab. There are weekly laboratory meetings that all laboratory members attend during which ongoing research of lab members are presented.
Compensation: Students are encouraged to apply for various Harvard Funds for salary during summers—Laboratory covers all summer stipends that are not covered by Harvard summer research awards. During Academic year, students are encouraged to take concentration Research Classes for academic credit.
To apply email resume (cv) to Dr. Kravitz with contact names for recommendation letters.
Edward A. Kravitz, PhD
George Packer Berry Professor of Neurobiology
Department of Neurobiology, Harvard Medical School
Goldenson Building, room 353
Undergraduate research opportunity in Cancer Immunology, Department of Dermatology and MGH Cancer Center
The focus of the Demehri laboratory is to determine the role of the immune system in regulating the early stages of cancer development in order to harness its anti-tumor potential for cancer therapy. To date, several cancer immunotherapies have been developed with proven efficacy against late-stage cancers; however, the role of the immune system in preventing the early development of cancer remains uncertain. The research in our laboratory is focused on identifying the immune mechanisms that drive an immune activation sufficient to prevent cancer formation from pre-cancerous lesions. This approach raises a great opportunity to discover novel immune pathways that can be leveraged in cancer therapy and prevention.
The student is expected to focus on project oriented research. The magnitude of duties and responsibilities depends largely on the student’s ability to learn and intellectually contribute to the research project on hand.
Skills required: no prior research experience is required.
Learning outcome: research skills: laboratory techniques, study design, data analysis and project oriented research leading to presentations and publications
Number of hours students are expected to work, length of the project: Negotiable depending on students classwork but in an ideal case, student will continue his or her work on the project over 2-3yrs to be able to produce publications etc.
Mentoring: Student will be directly mentored by a graduate student or postdoc on daily basis and meet with the PI on at least weekly basis
Compensation: Funding depends on the student’s contribution level to research and other sources of funding available.
To apply, email CV to Dr. Shawn Demehri
Shadmehr (Shawn) Demehri, M.D., Ph.D.
Department of Dermatology and MGH Cancer Center
Massachusetts General Hospital
Harvard Medical School
Center for Cancer Immunology
Cutaneous Biology Research Center
Building 149 13th Street, 3rd floor
Charlestown MA 02129
Phone: 617-643-6436, Fax: 617-726-4453
Undergraduate Research Opportunity, Department of Psychiatry, Division of Basic Neurosciences, McLean Hospital
The project is focused on extracellular matrix abnormalities in the brain of people with schizophrenia or bipolar disorder. Human postmortem investigations include tissue preparation, quantitative microscopy, protein and gene expression, data collection and analysis. No prior research experience is required. Training will be provided.
Learning outcome: Laboratory skills including processing of human brain tissue,immunocytochemistry, Western blotting, RNAscope, quantitative microscopy. Research skills: study design, data analysis method, presentations, scientific writing. Number of hours and length of stay are negotiable. However, there is a minimum required of 16 hr/week (during regular office hours) for at least 3 months. Mentoring will be provided by the PI as well as senior researchers in the laboratory. In addition to regular lab meeting once a week, students will meet with the PI on a regular basis and will be trained and mentored daily by senior lab members.
Compensation: A stipend may be available depending on the student's time commitment.
Email your resume to Dr. Berretta at firstname.lastname@example.org
Contact: Sabina Berretta, M.D., Department of Psychiatry, Division of Basic Neuroscience, McLean Hospital
Posted November 3, 2016
Research position with Dr. Gidon Eshel, Radcliffe Institute
The Radcliffe Institute’s Radcliffe Research Partnership Program has a new project with Gidon Eshel, who is best known for his work quantifying the geophysical consequences of agriculture and diet. In the Degree of Human Impact Project, he and Harvard College students that he hires will collaborate with scientists at the Weizmann Institute of Science in Israel, to set out to 1) devise a defensible index capturing the degree of human impact at a particular location at a specific time, taking note of a long and expanding list of impacts; and 2) derive a global dataset of this index now and, later, at various other times.
Posted November 2, 2016
Position Available (on-going) for New World Primate Caregiver/Documentarian at Pacific Primate Sanctuary, Maui, Hawaii
This is truly a Sanctuary, a beautiful place for someone with a background and interest in animal husbandry, welfare and conservation, exotic veterinary medicine, biology, and related fields, who is a mature team player with respect for others. We need a good, clear communicator (written and spoken English), and coordinator with a minimal personal agenda, who seeks mutual growth for all and is able to make a long-term commitment to the primates and the staff. The Pacific Primate Sanctuary Internship is an in-depth, all encompassing, immersion experience. This is more than a full-time position and includes on-call duties. A one-year commitment is requested.
The residency requires a self-starter and hard worker, someone who is humble, compassionate, self-reliant, organized, professional, computer literate (Mac), open to learning, capable of problem solving and completing a task. We need someone who can function independently as well as in a group. Our Resident Intern would need to be physically fit, with no communicable diseases or criminal record, who would enjoy a rural lifestyle with simple amenities. Citizens of foreign countries must secure their own visas and permits independently.
The internship is organized into three training modules. The first module focuses on animal care giving (providing daily care, preparing food, cleaning enclosures, administering medications, providing enrichment, and nurturing to 45+/- monkeys), an introduction to primate behavior, facility maintenance, and documentation. Documentation responsibilities include: data entry (Mac- Excel, Word, Mail), PPS Manual updates, detailed record-keeping, literature review and research, and providing shift reports utilizing the SOAP format to report on the medical status of each animal. In the second module, the concentration is on emergency care and behavioral conditioning, and the third on colony management, volunteer training, and an Independent project. The Independent Intern Project is an opportunity for advanced study in a chosen area, depending on an Intern’s interests and skills. For those interns wanting to remain at PPS, a fourth module, in sanctuary management, may be offered.
Pacific Primate Sanctuary is a 501(C)(3) nonprofit organization. Our staff is made up of 3-7 local volunteer caregivers, 1- 4 resident Interns, and an off-site support system of veterinary and other professionals. Since the wellbeing of the monkeys is our primary focus, they are not on exhibit, the facility is not open to the public and they are not subjected to any medical research.
As a result, our organization is not eligible for funding from any governmental agencies nor do we receive funds from admission, as would a public zoo. Therefore, we must rely solely upon donations from compassionate individuals and organizations. Our operating budget is extremely small. Financial independence for personal expenses is required (estimated by interns to be as low as $25-$35 a week).
We provide a fully furnished and equipped 24-foot Yurt or a 16-foot Yurt (traditional round structures designed specifically for tropical living) and utilities. An organic garden and fruit orchard are available on-site. The Yurt is adjacent to the Sanctuary on a large piece of rainforest property with its own bathroom facilities. You would be trained by experienced members of our staff in all aspects of New World primate care (Callitrichidae, Cebus, and Ateles) and may become eligible for certification as a Primary Animal Caregiver.
Please begin making application for the position by submitting the following: your letter of intent in making application, your resume/CV, and three Letters of reference (from instructors, employers etc.). All documents should be sent via email as they become available. The PPS Team looks forward to hearing from you.
Me Ke Aloha No Na Holoholona [With Love For The Animals]
Pacific Primate Sanctuary, Inc. Sanctuary Phone & Fax: 808. 572.8089
Blog: http://pacificprimate.blogspot.com Internet: http://www.pacificprimate.org
Research Opportunity: Surgery Meets Molecular Biology in Mice.
This project involves implementing CRISPR/Cas-9 to produce transgenic wild mice to test hypotheses about morphological and behavioral traits. Appropriate for students interested in learning about gene editing techniques in whole organisms, as well as the physiology and reproductive biology of rodents. The student would primarily be helping with the surgical component of the project, with the possibility of expanding to molecular work later on. Availability for a whole morning or afternoon (~4 hrs) per week and an additional 6 hours distributed through the week is needed.
Contact Brock Wooldridge <email@example.com>, Hoekstra Lab, OEB
Posted on October 21, 2016
Research Technician- Anesthesia Center for Critical Care Research
The Anesthesia Center for Critical Care Research (ACCCR) of the Department of Anesthesia, Critical Care and Pain Medicine (DACCPM) of the Massachusetts General Hospital (MGH) and Harvard Medical School is recruiting a highly-motivated Research Technician with experience in chemistry and biochemistry.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
The ACCR is an exciting and fast-paced research laboratory. The Research Technician will work on a number of ongoing and projected projects within the ACCCR.
He/she will conduct laboratory experiments under the supervision of staff PI’s, research fellows and medical students. Duties and Responsibilities include but are not limited to:
· handle chemicals, blood samples, measure function of blood proteins and cells using biochemical and biophysical techniques.
· assist in the data collection and analysis of the data during laboratory experiments.
· maintain a clear and cohesive laboratory notebook so that he/she may report the status of ongoing research projects; note the technical procedures, results, and possible conclusions.
· maintain written research protocols, data and results accurately and securely.
· attend/report updates at laboratory meetings and work-related lectures.
· assist in maintenance of lab/bench areas and equipment to maintain an overall safe and clean environment.
· assist in ordering lab supplies.
Interested? Contact Dr. Donald Bloch at Dbloch@partners.org
Posted October 3, 2016
Research Assistant - Population & Family Health (PFH) cluster, Department of Global Health & Population (GHP)
The PFH cluster at the GHP is seeking a paid Student Research Assistant for the 2016-2017 academic year beginning immediately and working through the end of May 2017. In collaboration with Dr. Ana Langer, faculty and staff of the Department and the Women and Health Initiative, the Student Research Assistant will contribute to multiple activities planned for this year, as described below: 1. A continuous scan of the literature on urban health, with a special focus on women and children and the last 5 years 2. Identification of global or regional conferences on urban health in connection with our most relevant topics 3. A scan of other academic institutions (In the US and elsewhere) active in this field and the events and activities they hold. 4. Identification of faculty, students, projects and initiatives at HSPH and other Harvard schools focused on areas of interest, including those that offer opportunities for students to participate in them as paid and unpaid research assistants, in winter session courses and as summer interns. 5. Organization and implementation of key activities, especially a symposium in the spring of 2017 focused on women and children’s health in urban areas; development of the agenda and logistics for regular meetings of the cluster; interviews of key players and other activities, as required.
Qualifications − Excellent verbal and written communication skills − Previous experience with literature reviews and organization of events − Experience in web site management and/or familiarity with WordPress preferred − Attention to detail, excellent organizational skills − Demonstrated interest in the topic area − Knowledge of women and children’s health and/or urban health
Time commitment: up to 20 hours per week
Duration: October 2016-May 2017 If you are a current student at the Harvard Chan School and are interested in working in a dynamic, action-oriented environment, please submit your resume and a cover letter describing how your skills and background relate to the scope of work to firstname.lastname@example.org.
Posted September 29, 2016
Undergraduate Research Opportunity - Bischoff Laboratory, Boston Children's Hospital
We are recruiting undergraduate students who are interested in conducting independent study, summer research or those who have federal work-study.
Our lab studies the role of endothelial cells and pericytes in vasculogenic and/or angiogenic diseases. We have three main areas: (1) vascular tumors (infantile hemangioma) and vascular malformations (e.g., capillary malformation), (2) endothelial to mesenchymal transition in mitral valve endothelium after myocardial infarction, and (3) how to use endothelial cells isolated from blood to build new vascular networks in diseased tissues to restore blood flow and also stimulate tissue regeneration.
Undergraduate Research Opportunity Eric Lander Laboratory
Project Description: This computational biology project is a unique opportunity to join the laboratory of Professor Eric Lander (Founder and Director of the Broad Institute of MIT and Harvard) to study genome biology. The Lander Lab seeks to understand fundamental mechanisms of genome regulation and apply these insights to transform the treatment of human disease.
With the sequencing of the human genome, we discovered that protein-coding genes comprise only 2% of our genome sequence and that much of the critical regulatory information resides in the remaining 98%. These noncoding regulatory regions control gene expression and thereby human phenotypes including susceptibility to disease. Yet, our understanding of this regulatory information is preliminary: for example, we do not know which noncoding regulatory elements control any given gene or set of genes. Answering this question would provide critical insight into how our genomes control cellular behavior and human disease.
In this project, we aim to decode this fundamental regulatory wiring and define the principles that guide the connections between regulatory elements and the genes they control. The successful UROP will apply statistical and computational approaches to integrate massive datasets derived of DNA sequencing, RNA sequencing, and CRISPR/Cas9-derived experimental datasets to predict how the noncoding genome controls gene expression. Predictions will be validated in collaboration with a team of experimental and computational biologists in the Lander Lab.
Prerequisites: The ideal candidate will have a strong background in programming, statistics, and/or molecular biology, and working knowledge of one or more of the following: Unix/Bash, R, Python, Java.
Contact: Please send information regarding relevant experience, completed courses, and interests to Jesse Engreitz (email@example.com). We look forward to hearing from you.
Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA
See the description here.
African Ant Population Genetics
Posted: April 21, 2016
Mentor: Moha Shahjamali, Postdoctoral Research Fellow, working at Prof. Vinny Manoharan lab. @ 9 Oxford Street, Gordon Mckay 530
Project description: The main goal of this project is to study the DNA-mediated self-assembly of flexible high aspect ratio nanowires for electronic applications including ultra-low loss radio-frequency (RF) components.
Prerequisites: Background on nanotechnology, DNA fuctionalization, self-assembly, lithography and soft lithography will be useful but not necessary. Each applicant will have complete training on the related instruments and methods before starting the project individually. Feel free to contact Moha Shahjamali (firstname.lastname@example.org)to arrange a short meeting if you are interested to know more about this project.
This is a one-year project with roughly 10-15 hours per week commitment (except exam period and midterm periods of semester) but depending on the interest of the applicant the time commitment can be modified. This position may be suitable for students who are interested in a Senior Thesis, depending on departmental requirements. Candidates with Harvard College Research Program funding or Federal Work Study Program funding are encouraged to apply for this position.
Posted: April 6, 2016
Undergraduate research position available for human genetics research in the lab of Dr. Christopher Walsh in the Longwood Medical Area. Learn genetic analysis and cell culture techniques to identify new mutations in patients with a Rasopathy phenotype which includes autism-like features, intellectual disability, and dysmorphisms. Work directly under supervision of a Harvard M.D./Ph.D. graduate and premedical advisor currently conducting this exciting postdoctoral research, and interact with scientists and physicians in the laboratory. Must have at least 6 months prior research experience. Ideally suited to students interested in research applications to medical problems who would like a longitudinal experience. Must be available full time 6 weeks 7/18-8/26, and intend to work 2-3 partial days (2-6 hours) per week over the following year. I am very accomodating of schedule flexibility, but student must be interested in achieving results. I am happy to support applications to fund this research through undergraduate grants, and this position may include a stipend depending on funding. If interested, please email Diane.Shao@childrens.harvard.edu.
Posted: April 5, 2016
Research Assistant Positions: Sensory, Motor, and Cognitive Processing
Professor John Assad, Department of Neurobiology, Harvard Medical School
Start in Spring 2016 semester
We are looking for highly motivated undergraduate students to participate in experiments in John Assad’s lab at the Department of Neurobiology at Harvard Medical School. Our lab uses a variety of experimental approaches to study sensory, motor and cognitive processing in the brain, in both animal models and human subjects. We also have projects ongoing at the Research Imaging Center at Harvard College in Cambridge. Our lab provides an engaging environment with a strong emphasis on training of students. We don’t plan to “plug you into a project”, but rather to find the right fit for your interests, ranging from electrophysiology to fMRI to computational neuroscience. Qualifications: Some basic background in neuroscience would be helpful, as well as experience with computer programming (especially Matlab) — but we’ll "teach you up” otherwise. Students in many areas or majors are welcome, including neuroscience, biology, computer science, physics and engineering. Expectations: Expected hours per week will vary with the particular project, but we’ll of course be flexible to accommodate class schedules, etc. We hope that the undergraduate projects can develop into summer research and/or senior theses. Course Credit: Can be arranged through MBB before the start of the winter/spring semester.
Additional Information, and To Apply: Please send a brief resume (or any questions) to email@example.com, or call John at 617-432-2804.