Research Associate: Stem Cell Biology & Genetics
Brigham & Women's Hospital and Harvard Medical School
I am looking for a research technician to work in my stem cell biology and genomics laboratory at Brigham and Women’s Hospital/ Harvard Medical School. Our lab uses advanced genome editing and genomics techniques to understand how transcription factors dictate cell fate. Our eventual goal is to build computationally predictive models of cell differentiation that would enable us to turn stem cells into therapeutically relevant cell types such as pancreatic beta cells. We have invented several high-throughput genome editing assays that we are now applying to this goal, and we collaborate closely with David Gifford’s computational lab at MIT to build computational algorithms that predict stem cell activity. The research technician position would involve stem cell culture, genome editing, genomic analysis, and molecular biology. A strong biology background and prior lab experience are required but not necessarily in the techniques mentioned above. I have previously trained several technicians who have moved on to MD/PhD programs, so I am looking for someone who could commit 2 years to an exciting research position to prepare them for graduate school. If interested, please email your resume to Rich Sherwood at firstname.lastname@example.org.
Posted: April 17, 2015
RESEARCH ASSOCIATE I position at the Broad Institute
A Research Associate I position focused on drug discovery is available at the Broad Institute.
Posted: March 20, 2015
Post-bac Research in Genetics of Autism Spectrum Disorders (ASD) at Yale University
Post-graduate research associate in a basic science laboratory studying the genetics of autism spectrum disorders (ASD). The appointee will assist the principal investigator in multiple aspects of the research project. These include: 1. Genotyping zebrafish carrying mutations in genes that are strongly associated with autism spectrum disorders (ASD); 2. Maintaining zebrafish mutant lines; and 3. Performing phenotyping assays to identify abnormalities in brain development and behavior in zebrafish mutants of ASD risk genes. The post-graduate associate will gain skills in light microscopy as well as confocal microscopy. The appointee will assist in high-resolution imaging of the zebrafish brain using confocal microscopy.
Bachelor's Degree in Biological Sciences, Biochemistry, or a related field
Demonstrated record of academic achievement
Past experience in basic science research
Send resume, cover letter describing interest in the position, unofficial transcript, and two letters of recommendation to email@example.com.
Posted March 10, 2015
The target date for employment is June 2015, but there are also opportunities for individuals who wish to being now, or participate part time now in a trial capacity, or carry out research projects this semester
Post-undergraduate Research Technician position in the Calarco lab in the Center for Systems Biology, Harvard University
Posted: January 16, 2015
Research Technician Positions at MGH: for a complete listing and to apply, visit the Careers website at MGH
Research Technician at MGH: The Psychiatric & Neurodevelopmental Genetics Unit Core Laboratory at MGH seeks a research technician to work with investigators and other laboratory staff to perform laboratory-based research aimed at identifying genetic variants involved in psychiatric disorders and associated neurocognitive impairments. The PNGU Core Lab specializes in custom genotyping (SNP, other), qPCR for CNV detection/confirmation, DNA extraction, quantification, sample preparation, tracking, and storage, and related services to further the PNGU mission of identifying and characterizing the genetic basis of complex disorders and to translate these discoveries to improvements in clinical care and public health.
We are seeking a highly motivated individual to join our team of talented and intellectually diverse researchers and engineers in a collaborative research environment. The ideal candidate would have strong attention to detail and excellent time management, organizational, and communication skills. S/he would also have a background and/or interest in clinical/biomedical research and/or human genetics and genomics.
Start date of this position is the Spring or Summer of 2015.
Responsibilities: Conduct small projects at the bench level as well as in a high-throughput production setting using a variety of techniques and methodologies. Perform standard molecular biological techniques, including PCR, DNA extraction, genotyping, and qPCR. Run quality control assays and other sample preparation techniques on samples in preparation of downstream genetic analysis. Analyze experimental findings using statistical methods, database queries, and other tools. Assist in sample tracking by updating and querying local databases.
Contribute to troubleshooting experiments and developing new laboratory processes and technologies.
Document, compile, and assist with analyzing and interpreting experimental data.
Attend and participate in lab meetings, including preparing reports and presenting progress.
Assist in preparation of manuscripts, poster presentations, and project reports.
Requirements: Bachelor’s Degree in Cell Biology, Molecular Biology, or Biochemistry, or related field required
Proficiency in molecular and cell biology techniques and previous experience with PCR, genotyping, and/or DNA extraction a plus.
Familiarity with statistical methods and bioinformatics tools (e.g. NCBI, UCSC Genome Browser) a plus.
Ability to handle a variety of tasks amid shifting priorities.
Strong analytical skills with a high degree of initiative.
Creative and highly motivated individual with strong organizational and management skills.
Excellent written and verbal communication skills.
Ability to multi-task in a dynamic multi-disciplinary research environment.
A Two-year commitment is required.
Posted: January 14, 2015
Research Technician: MGH
The Research Technician II will work independently under general supervision of Dr Hyman a postdoctoral fellow and/or junior faculty member. Will participate in the execution of neuroscience experiments aimed at better understanding of Neurological diseases. Experimental approaches include molecular, anatomical, and physiological studies of cells in culture, animal models, and human biospecimens. There is an emphasis on microscopy and related techniques as well as biochemical studies.
· Executes protocols of non-routine experiments
· Assists PI with determining the most suitable methodology
· Performs basic design and modification of protocols
· Calculates, transcribes and analyzes data; presents data at weekly meetings
· Prepares and presents reports
· Organizes and summaries acquired data, using scientific and statistical techniques
· Participates in the design of experiments or field work
· Precise execution of surgical procedures including post-operative checks
· Molecular biology techniques including PCR, rtPCR, genotyping, Western blotting and ELISA
· Maintain colony of mouse lines with meticulous care animal surgical techniques
· Section tissue with cryostat, immunohistochemistry, quantitative microscopy, and uploading of micrographs to the laboratory’s dedicated server
· Performance of microsurgery
· Assist other researchers with general duties or in experiments requiring multiple investigators.
· Tissue processing for histology, in situ hybridization,
· Image analysis with computer programs, data management, laboratory notebook maintenance
· Procurement of supplies, the scientific maintenance of the laboratory and the organization of research material
· Library research and database analysis, upkeep of written records of experimental procedures and preparation of manuscripts
· Instruct students and others in histology methodology and lab instrument operation
• Ability to work independently and as team member
• Ability to multi-task
• Analytical skills and ability to resolve technical problems
• Ability to interpret acceptability of data results
• Working knowledge of data management programs
• High degree of computer literacy
• Demonstrated competence in research techniques and methodologies
• Ability to translate, adapt and apply science
• Bachelor degree required, preferably in Biology or related field
• A minimum of 1 year of experience is required.
EEO Statement: Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Posted: January 13, 2015
Research Coordinator: A full-time Research Coordinator position is available in the laboratory of Dr. Daphne Holt at the Martinos Center for Biomedical Imaging and MGH Psychiatry Department. The laboratory focuses on the study of emotion and social cognition abnormalities in schizophrenia and in people at risk for neuropsychiatric illnesses. The studies primarily involve the collection and analysis of functional MRI (fMRI) data, including task-based, resting-state and arterial spin labeling fMRI, as well as psychophysiology and behavioral data. The position responsibilities include acquiring and analyzing data for these studies, and recruiting and characterizing study subjects. The position is an excellent one for someone interested in getting research experience prior to medical school or graduate school.
REQUIREMENTS: Undergraduate degree in Neuroscience, Cognitive Neuroscience/Psychology, Biomedical Engineering, Computer Science, Physics or related fields. Applicants must have good computer skills and be adept at trouble-shooting and problem-solving. Proficiency in Word, Excel and Powerpoint is required, and some knowledge of FreeSurfer, MATLAB or UNIX is desirable. Previous experience with analysis of neuroimaging data is preferred but not required. Candidates must be able to work independently and should have strong communication and interpersonal skills.
CONTACT: Interested applicants should send a curriculum vitae with a description of research and/or computing experience and cumulative and major GPA, a statement of goals and interests, a recent transcript, and the names and contact details of three references to: Ms. Stephanie DeCross, firstname.lastname@example.org. Please include in the subject line of the e-mail: research coordinator position.
A two-year time commitment is requested. Salary will be based on qualifications and experience. Full-time employees receive full benefits. The Massachusetts General Hospital is an equal opportunity and affirmative action employer.
Posted: January 14, 2015
Research Assistant I-Molecular Medicine
A Full-time Research Assistant in Professor Stephen Harrison's lab at Boston Children's Hospital in the Laboratory of Molecular Medicine. We seek a laboratory technician at the level of a Research Assistant 1 to support a project on the human immune response to HIV. The project involves methods in biochemistry, immunology, and structural biology. Duties and Responsibilities: - Antibody and virus envelope cloning and mutagenesis
- Maintenance of mammalian cells - Large-scale protein expression in mammalian cells and protein purification
- Binding experiments - Crystallization trials of protein complexes Required education, lab experience and skills: The candidate must have a BA or BS in the biological sciences or a similar field. We will provide extensive mentoring and training. A one-year minimum commitment is required. The position is ideal for a recent graduate (December 2014/January 2015) planning to work in research before entering graduate or professional school. Attention to detail, high motivation, and effective communication skills are essential. Boston Children’s Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.
Posted: January 14, 2015
Research Technician: MGH
Note: This position is funded for one year with benefits. The research laboratory technician position is available in the MGH Department of Urology to investigate novel protein biomarkers in prostate cancer and kidney stone disease using standard and cutting edge proteomic techniques. Proteomic laboratory work will be performed in collaboration with the Zetter Lab at Children’s Hospital/Harvard Medical School and the Gygi lab at Harvard Medical School. Clinical data collection and management will be performed at MGH. The position offers the ability to work autonomously, but with sufficient guidance and mentorship from PI and laboratory PhD researchers. This is an ideal position for someone looking to eventually pursue graduate training in medicine or biological research.
PRINCIPAL DUTIES AND RESPONSIBILITIES: Proteomic processing and analysis of clinical specimens using standard methods of protein isolation, Mass Spectrometry, Western Blot, ELISA, and Immunohistochemistry. Maintenance of clinical patient data and specimen database. Notifies and seeks assistance from senior lab personnel or supervisor for any questions, unusual experimental conditions or results or needed training. Collection of additional clinical data and specimens. Collects and records study data.Synthesizes and interprets information obtained from graphs, charts, laboratory experiments, statistical summaries and other data collection methods in order to develop new investigative techniques and/or to determine the most appropriate direction of research.Synthesis may involve use of computer programs as well as data entry into databases. Prepares written reports on status of research, determination of technical procedures, sequence of operations, including statistical and graphic summaries of findings and possible conclusions. Collaborates with supervisor in writing and editing material for publication and may appear as principal or secondary author on publications. Participates in the upkeep of the lab; this includes keeping both direct and general work spaces clean and tidy and helping maintain an overall safe and clean environment. May perform, or refer as needed, routine maintenance of lab equipment to include cleaning and replacing of parts. Report equipment malfunctions and needs to management. Work safely within the lab environment and in performing work duties. Wear personal protective equipment as required. Attend and may make presentations at lab meetings and journal clubs. May teach moderately difficult to complex lab techniques to students and research personnel.
SKILLS/ ABILITIES/ COMPETENCIES REQUIRED: Must be highly motivated, willing to learn, able to multitask, and interested in contributing to an exciting and collaborative environment. Must be able to work independently Ability to work carefully, accurate and consistent with instruction or protocol Must be able to work safely and properly use protective equipment Excellent verbal and written communication skills Proficiency in Word, Powerpoint, Excel, and Internet searches helpful Is knowledgeable and compliant in all hospital, State and Federal regulatory requirements, including hospital policy and procedures (where applicable to the performance of the job), Joint Commission on Accreditation of Healthcare Organizations (JCAHO), and Health Insurance Portability and Accountability Act of 1996 (HIPAA).
EDUCATION: B.A., B.S. or M.S. in Biology, Biochemistry, Molecular Biology, Cell Biology, or equivalent. Research experience involving basic proteomic, cell and molecular biology is preferred but not required.
EXPERIENCE: Research experience involving basic proteomic, cell and molecular biology techniques preferred but not required. Related experience as obtained through a baccalaureate degree program is a plus.
Posted: January 8, 2015
Research Technician: MGH
Anticipated Start Date: Summer/Fall 2015
The Cardiovascular Research Center at Massachusetts General Hospital and Harvard Medical School (CVRC: http://www2.massgeneral.org/cvrc/faculty_jaffer_about.html and at the Center for Molecular Imaging Research: http://cmir.mgh.harvard.edu/cmip) is recruiting a research technician (BS/MS) with experience in histology (tissue embedding and sectioning, microscopy, immunohistochemistry), cell culture, and molecular/cell biology (e.g., flow cytometry, RNA/protein extraction, RT-PCR, ELISA). The technician will also assist in large animal surgeries.
The major focus of the laboratory is to develop and apply molecular imaging optical and MRI approaches to visualize biological processes in atherosclerosis, thrombosis, and arteriovenous fistula biology in vivo. The lab environment is highly collaborative with other investigators, postdoctoral fellows, and research technicians.
The position would ideally be a two year commitment. A strong applicant will have a Bachelors’ or Masters’ degree in Biology, Biochemistry, Molecular Biology or related discipline, plus one to three years of laboratory experience. Additionally, excellent organizational and communication skills, and the ability to work independently and as part of a team, are required.
An application package should include (i) curriculum vitae and (ii) a brief statement about your previous experiences in laboratories (such as laboratory courses at college, or summer employment opportunities in for-profit companies or academic laboratories). (iii) Names and contact information of three references.
Posted: January 8, 2015
The Raychaudhuri Lab at Harvard Medical School invites applications for a research technician position in an immunogenomics laboratory with an interest in understanding the basis of autoimmune disease.
Posted December 8, 2014