Neurobio Theses

Thesis Winners

Class of 2015 Neurobiology Thesis Prize Winners (front left to right: Ms. Bianca Nfonoyim - Hoopes Prize and Dowling Prize, Ms. Marissa Shoji - Hoopes Prize, Mr. Dan Dou - Hoopes Prize)


Digital files of all thesis listed below are available. Please email jp@mcb.harvard.edu to request a copy (include the thesis title and year in your request).

Neurobio Theses 2015

FOR A .PDF CONTAINING THE FULL ABSTRACTS FOR THESE THESES, GO TO THE "NEUROBIO THESIS ABSTRACTS" TAB

• Analyzing the behavior and neuronal circuits associated with the learning and memory related to aggression in Drosophila melanogaster.
Research Director: Dr. Edward A. Kravitz

• Characterization of a Novel Family of Odorant Receptors Associated with Innate Behavior.
Research Director: Dr. Sandeep Robert Datta

• Characterization of the Activity of Glutamatergic Neurons in the Pedunculopontine Tegmentum During Decision-Making.
Research Director: Dr. Naoshige Uchida

• Comparison of the nest-building behavior of Peromyscus polionotus and Peromyscus maniculatus as a mechanism of thermoregulation.
Research Director: Dr. Hopi Hoekstra

• Development and neural bases of happy and angry facial processing in infants: A study in NIRS and eye tracking.
Research Director: Dr. Charles A. Nelson

• Differential Susceptibility to Early Adverse Experiences: The Effects of Oxytocin Receptor Gene Variations and Institutional Rearing on Emotional Processing.
Research Director: Dr. Charles A. Nelson

• Evaluating the effects of candidate proteins on APP cleavage and Alzheimer’s disease phenotypes in human iPSC derived neurons.
Research Director: Dr. Dennis Selkoe

• Evidence for Synchronous Theta and Gamma Oscillations during Ketamine-induced General Anesthesia.
Research Director: Dr. Emery Brown

• Examining Differences in the Default Mode Network between Individuals at Clinical High Risk for Psychosis and Healthy Controls in China.
Research Director: Dr. Larry Seidman

• Functional Investigation and Spatial Regulation of Chr15qD3 Imprinted Genes in the Brain.
Research Director: Dr. Catherine Dulac

• Inducible chronic overexpression of transcription factor Krüppel-like factor 9 (Klf-9) as a model for neurodegeneration.
Research Director: Dr. Amar Sahay

• Investigating Differences in Neural Activity of Young Children with and without Attention Deficit/Hyperactivity Disorder.
Research Director: Dr. Margaret Sheridan

• Investigating Intrinsic Brain Networks in Adult and Pediatric Patients with Complex Regional Pain Syndrome.
Research Director: Dr. David Borsook

• Localizing subtypes of impulsivity to subregions of the striatum.
Research Director: Dr. Joshua Buckholtz

• Longitudinal Analysis of Depressive Symptoms and Neurocognitive Function in Men with and without HIV Infection and Heavy Cocaine Use.
Research Director: Dr. Dana Gabuzda

• Maternal care or neuronal despair? Impact of fragmented maternal care and the BDNF Val66Met polymorphism on the prefrontal cortex in mice.
Research Director: Dr. Takao Hensch

• Microglia Mediate Synapse Loss in Early Stage Alzheimer’s Disease Via the Classical Complement Cascade.
Research Director: Dr. Beth Stevens

• Microglia-Specific Contribution to Rett Syndrome Behavioral Phenotypes.
Research Director: Dr. Beth Stevens

• Microglial Responses to Environmental Enrichment in Alzheimer’s Disease Models.
Research Director: Dr. Dennis Selkoe

• Mindfulness meditation as a potential intervention to improve future self-continuity.
Research Director: Dr. Sara Lazar

• Neural Correlates of Imitation in Children with ASD.
Research Director: Dr. Charles A. Nelson

• Optogenetic manipulation of hippocampal place cells causes impairment of stereotyped tracking behavior.
Research Director: Dr. Venkatesh N. Murthy

• Optogenetic stimulation of auditory corticofugal projections modulates activity in the auditory midbrain.
Research Director: Dr. Daniel Polley

• Plasticity of dopaminergic neural circuits in the mouse olfactory bulb.
Research Director: Dr. Venkatesh N. Murthy

• Potential Contributor to Learning at the Intersection of Wakefulness and Sleep: The Role of Alpha Wave Activity in Spatial Memory Consolidation.
Research Director: Dr. Robert Stickgold

• Role of ABCD1 in Human Brain Microvascular Endothelium: Implications for Cerebral X-linked Adrenoleukodystrophy.
Research Director: Dr. Florian Eichler

• Role of Kif21a in peripheral spinal motor and sensory neuron development.
Research Director: Dr. Elizabeth Engle

• Role of Ror  in retinal development and Age-related Macular Degeneration pathophysiology.
Research Director: Dr. Neena Haider

• Role of Vomeronasal Receptors Vmn2r65 and Vmn2r88 in Pheromone Detection.
Research Director: Dr. Catherine Dulac

• Selectively Altering Intertemporal Decision-Making Using Transcranial Direct Current Stimulation.
Research Director: Dr. Joshua Buckholtz

• Small molecule that binds Max, inhibits Myc activity and reduces the viability of human cancer cell lines.
Research Director: Dr. Angela Koehler

• Social Isolation Stress in Male and Female Rats: Role of Kappa Opioid Receptors.
Research Director: Dr. Elena Chartoff

• Sound Asleep: Auditory Reactivation of Emotional Memory Consolidation During Sleep.
Research Director: Dr. Robert Stickgold

• Use Of Stem Cells Loaded With Hyaluronidase-Expressing Oncolytic Viruses To Treat Malignant Brain Tumors.
Research Director: Dr. Khalid Shah

• Using Functional Connectivity to Understand Memory System Communication During Off-line Learning.
Research Director: Dr. Edwin Robertson

• Winner Effect in Female Dendrobates tinctorius Dominance Contests.
Research Director: Dr. Lauren O'Connell


Neurobio Theses 2014

FOR A .PDF CONTAINING THE FULL ABSTRACTS FOR THESE THESES, GO TO THE "NEUROBIO THESIS ABSTRACTS" TAB

• Characterization of the Differences in Food Odor Naive Preference and Learning in C. elegans Males and Hermaphrodites.
Research Director: Dr. Yun Zhang

• Characterizing the Roles of Cholinergic and GABAergic Neurons in C. elegans Head Movement.
Research Director: Dr. Yun Zhang

• Circadian Activity Rhythm Disturbances and Suprachiasmatic Nucleus Cell Population Size in Elderly Humans.
Research Director: Dr. Clifford Saper

• Consolidation of Motor and Spatial Memory during Sleep in Relation to EEG Features, The.
Research Director: Dr. Erin Wamsley

• Contributions of estrogen and oral contraceptive use to sex differences in functional responding during fear extinction recall.
Research Director: Dr. Mohammed Milad

• Deconstructing the Moral Mind: An fMRI Investigation Mapping the Foundations of Moral Judgment.
Research Director: Dr. Joshua Greene

• Development and neural bases of happy face processing in infants: A study in fNIRS and temperament.
Research Director: Dr. Charles A. Nelson

• Development of Spatial Memory Abilities in Infants and Children: A Behavioral and Electrophysiological Study, The.
Research Director: Dr. Charles A. Nelson

• Developmental Regulation of TRP Channel Expression in Oligodendrocytes, The.
Research Director: Dr. Paul A. Rosenberg

• Diffusion tensor imaging of the stria terminalis in first episode schizophrenia.
Research Director: Dr. Martha E. Shenton

• Effects of CFEOM3 mutations in beta tubulin isotype III on cranial nerve development.
Research Director: Dr. Elizabeth Engle

• Emergence of Orientation Invariant Representations Within the Visual Cortex, The.
Research Director: Dr. George Alvarez

• Expert Symbol Learning, Invariant Visual Object Recognition and Value-Based Generalization.
Research Director: Dr. Margaret Livingstone

• How does Socioeconomic Status Affect Children’s Executive Function? Examining Motivation and Neural Structure as Possible Mediating Factors.
Research Director: Dr. Margaret Sheridan

• Hyper-aggression, Long-term Consequences of Social Defeat, and Resilience in Drosophila melanogaster.
Research Director: Dr. Edward A. Kravitz

• Impact of Stress on Reward Responsiveness in Individuals with Remitted Major Depressive Disorder: An EEG Study, The.
Research Director: Dr. Diego A. Pizzagalli

• Interfacing three-dimensional macroporous nanowire nanoelectronic scaffolds with neural tissue in vivo.
Research Director: Dr. Charles M. Lieber

• Investigating Cell Surface Receptors of the Vagus Nerve.
Research Director: Dr. Stephen Liberles

• Investigating effects of the Behavioral Inhibition temperament construct on stimulus-driven affective attention and attention-shifting in 7-month old infants: An ERP study.
Research Director: Dr. Charles A. Nelson

• Investigating molecular mechanisms over subtype-specific neocortical projection neuron dendritic development.
Research Director: Dr. Jeffrey Macklis

• Investigating Neural Activation to Repetition and Non-Repetition Grammar Patterns in 7-Month Olds at High Risk for Autism.
Research Director: Dr. Charles A. Nelson

• Investigating the carboxypeptidase function of Alzheimer’s gamma secretase through substrate deletion mutants.
Research Director: Dr. Michael S. Wolfe

• Mapping a Signal Transduction Pathway for Olfactory Preference in C. elegans.
Research Director: Dr. Yun Zhang

• Multimodal Neuroimaging and Behavioral Studies on Auditory-Motor Deficiencies and Compensatory Mechanisms.
Research Director: Dr. Gottfried Schlaug

• Neuron type specific tracing from Dopaminergic neurons in the Ventral Tegmental Area in Transgenic Mice.
Research Director: Dr. Naoshige Uchida

• Novel study on miR-505 in glioblastoma metabolism and cell survival, A.
Research Director: Dr. Mark Johnson

• Optogenetic interrogation of the role of the hippocampal CA3 region in fear learning.
Research Director: Dr. Uwe Rudolph

• Phase-Amplitude Coupling in Infant Resting-State EEG as a Potential Marker for Compensatory Activity in Autism Spectrum Disorder.
Research Director: Dr. Charles A. Nelson

• Role of the Retrograde Response Gene Bcl-w in the Auditory System, The.
Research Director: Dr. Rosalind A. Segal

• Visual Feedback Latency Reduces the Retention of Visuomotor Learning and Alters Its Internal Representation.
Research Director: Dr. Maurice Smith

• Your Brain on SET: An Exploration of the Neural Basis of Expertise in Rule-Based Pattern Recognition.
Research Director: Dr. George Alvarez

Neurobio Theses 2013

FOR A .PDF CONTAINING THE FULL ABSTRACTS FOR THESE THESES, GO TO THE "NEUROBIO THESIS ABSTRACTS" TAB

• Anxiety and Future Thinking: Effects of Emotion on Repeated and Alternative Episodic Future Event Simulation. Research Director: Dr. Daniel L. Schacter

• Association of Socioeconomic Status with Prefrontal Cortical Thickness and Subcortical Volumes in Children and Adolescents.
Research Director: Dr. Margaret Sheridan

• Behavioral and electrophysiological study of social and nonsocial orienting in children at-risk for ASD, A.
Research Director: Dr. Charles A. Nelson

• Behavioral cues as triggers for aggression in Drosophila melanogaster.
Research Director: Dr. Edward A. Kravitz

• Characterizing transcriptional regulation of the DYT6 dystonia gene, THAP1.
Research Director: Dr. Cristopher Bragg

• Clinical and neuropsychological correlates of diffusion tensor imaging indices in first-episode schizophrenia.
Research Director: Dr. Martha E. Shenton

• Discovering The Development Of The Blood Brain Barrier: Visualizing Gene Expression.
Research Director: Dr. Chenghua Gu

• Early detection of Preclinical Alzheimer’s disease with the Face Name Associative Memory Exam.
Research Director: Dr. Dorene M. Rentz

• Effect of Striatal Deep-Brain Stimulation on Cognitive Recovery After Traumatic Brain Injury, The .
Research Director: Dr. Emad Eskandar

• Effects of Early Institutionalization on Emotional Face Processing, The .
Research Director: Dr. Charles A. Nelson

• Effects of Soluble Amyloid-β[beta] Peptides on Transmission and Plasticity in the Hippocampus.
Research Director: Dr. Venkatesh N. Murthy

• Exploring Multisensory Facilitation Using Functional Connectivity MRI in Humans.
Research Director: Dr. Randy Lee Buckner

• Fish food: neuromodulatory systems involved with feeding behaviors in larval zebrafish.
Research Director: Dr. Florian Engert

• Investigating the fidelity of axolotl forebrain regeneration.
Research Director: Dr. Jeffrey Macklis

• Investigating the role of the lateral habenula in reinforcement learning.
Research Director: Dr. Naoshige Uchida

• Mapping the Brain’s Connections to Midbrain Dopamine Neurons Using Modified Rabies Virus in Transgenic Mice.
Research Director: Dr. Naoshige Uchida

• Meditate to Create: A Neurobiological View on the Effects of Mindfulness Meditation on Creativity.
Research Director: Dr. Sara Lazar

• Neuro-Development in Post-Fontan Adolescents.
Research Director: Dr. Michael J. Rivkin

• Observational Learning of Complex Procedural Tasks in Octopus Vulgaris.
Research Director: Dr. Florian Engert

• Oncogenic Properties of an Epidermal Growth Factor Receptor Mutant in Glioblastoma Multiforme.
Research Director: Dr. Matthew Meyerson

• Optogenetic control of hippocampal oscillations.
Research Director: Dr. Sydney Cash

• Organization of Retinal Ganglion Cell Axons in Larval Zebrafish.
Research Director: Dr. Florian Engert

• Role of ionic zinc in neuronal cell death and regeneration after axonal injury, The.
Research Director: Dr. Larry I. Benowitz

• Role of Posttranslational Modifications in the Regulation of the Stability and Function of the Survival of Motor Neuron Protein in Response to Oxidative Stress, The .
Research Director: Dr. Lee L. Rubin

• Role of RalA and RalB in the Mammalian Hippocampus.
Research Director: Dr. Thomas L. Schwarz

• Sensitivity of the Human Circadian Clock to Phase-Resetting Stimuli: Interactions of Melatonin, Light, and Sleep.
Research Director: Dr. Elizabeth B. Klerman

• Spatial memory development: a behavioral and electrophysiological study.
Research Director: Dr. Charles A. Nelson

• TorsinA assists in the folding and secretion of wild-type α1-antitrypsin.
Research Director: Dr. Xandra O. Breakefield

• Unified Model for a Functional Algorithm Underlying Behaviors of the Cerebellum and Cerebellum-Like Structures, A .
Research Director: Dr. Florian Engert

• Vascular, Astrocyte, and Microglial Involvement in Cerebral Malaria.
Research Director: Dr. Ryan Carroll

• Visualizing the functional integration of newborn granule cells in the adult mouse olfactory bulb by long-term in vivo imaging.
Research Director: Dr. Venkatesh N. Murthy

Neurobio Theses 2012

FOR A .PDF CONTAINING THE FULL ABSTRACTS FOR THESE THESES, GO TO THE "NEUROBIO THESIS ABSTRACTS" TAB

• Aberrant development of parvalbumin inhibitory circuits underlies cortical dysfunction in Rett Syndrome. Research Director: Dr. Michela Fagiolini

• Abnormalities in Neural Structures of Attention and their Relation to Impaired Social and Role Functioning in Schizophrenia.
Research Director: Dr. Christine Hooker

• Alterations in Excitatory Input to Retinal Ganglion Cells in DBA/2J Glaucoma and Optic Nerve Crush Mouse Models.
Research Director: Dr. Tatjana Jakobs

• BTC family proteins as critical controls over cortical projection neuron development.
Research Director: Dr. Jeffrey Macklis

• Contribution of secretory leukocyte protease inhibitor to the generation and maintenance of inflammatory pain, The.
Research Director: Dr. Clifford Woolf

• Development of the Implicit Learning Mechanism in Children: An fMRI Study.
Research Director: Dr. Margaret Sheridan

• Directed Differentiation of Human Pluripotent Stem Cells into Hypothalamic Arcuate Nucleus Neurons.
Research Director: Dr. Chad Cowan

• Downstream effects of mTOR hyperactivation in Tsc2-deficient neurons increase Eph receptor degradation.
Research Director: Dr. Mustafa Sahin

• Dreaming hinders overnight motor skill improvement in extended learning while high-frequency spindle activity predicts such improvement in the short-term.
Research Director: Dr. Robert Stickgold

• Effect of Firing State on Gap Junction Strength in the Thalamic Reticular Nucleus, The.
Research Director: Dr. Carole Landisman

• Emotional Experiences during Motor Task Acquisition and their Relationship to Sleep-Dependent Learning, Task-Related Dreaming, and Sleep Architecture.
Research Director: Dr. Robert Stickgold

• Epigenetic Pathways in Zebrafish Hair Cell Regeneration.
Research Director: Dr. Zheng-Yi Chen

• Evidence for Neuroplasticity after Neurocognitive Training in Individuals At‐Risk for Developing Psychosis.
Research Director: Dr. Christine Hooker

• Examining the Role of the mu-crystallin gene Crym in oxidative stress metabolism and connectivity in the CNS.
Research Director: Dr. Paola Arlotta

• Exploring the brain's potential for an immune response to metastases.
Research Director: Dr. Lois Lampson

• How Abstractions Affect Image Discrimination in Monkeys.
Research Director: Dr. Margaret Livingstone

• Identifying Neural Substrates of GSK-3 Involved in Neuroplasticity and Mood Regulation.
Research Director: Dr. Stephen J. Haggarty

• Improving Detection of fMRI-based Brain Activity in Addiction Networks: Methods and Application to Nicotine Addiction.
Research Director: Dr. Anne Eden Evins

• Influence of the Median Raphe on Hippocampal Theta Oscillations as Revealed by Electrophysiology and Optogenetics, The.
Research Director: Dr. Bernat Kocsis

• Investigating the use of Electroencephalography (EEG) as a diagnostic tool in the predictor of ADHD in early childhood.
Research Director: Dr. Margaret Sheridan

• Investigation of Bilateral Innervation by the Facial Nerve on the Interscutularis Muscle.
Research Director: Dr. Jeff W. Lichtman

• Maternal separation effects in GABA-deficient GAD65 KO mice.
Research Director: Dr. Takao Hensch

• Neural responses to facial expressions of emotion: A comparison study in three developmental populations.
Research Director: Dr. Charles A. Nelson

• NKCC1 Expression on Oligodendrocytes During Development and Following Perinatal Hypoxia-Ischemia: Conferring Vulnerability to Periventricular Leukomalacia?.
Research Director: Dr. Frances E. Jensen

• Novel model of social defeat: The divergent effects of lithium, valproic acid, and resveratrol in Drosophila melanogaster.
Research Director: Dr. Edward A. Kravitz

• Optical control of behavior in the trained mouse: Neuronal processing examined through psychometric slope and reaction time.
Research Director: Dr. John Maunsell

• Quantitative behavioral analysis of central brain circuits for light avoidance in Drosophila larvae.
Research Director: Dr. Aravi Samuel

• Searching for molecular markers of feedback neurons in mouse visual cortex.
Research Director: Dr. Richard T. Born

• Significance of the putative dsRNA transporter SidT2 in mammalian behavior.
Research Director: Dr. Craig P. Hunter

• Sleep and ecological memory.
Research Director: Dr. Robert Stickgold

• Sleep and Motor Memory.
Research Director: Dr. Robert Stickgold

• Study of ERP response in word recognition by toddlers at risk for Autism Spectrum Disorders.
Research Director: Dr. Charles A. Nelson

• Studying the role of the striatum in a DARPP-32 Tsc1 mouse model of autism.
Research Director: Dr. Mustafa Sahin

• Transdifferentiation of Nociceptive Neurons from Mouse Embryonic Fibroblasts.
Research Director: Dr. Clifford Woolf

• Using Brain Electrical Source Analysis (BESA) to Localize Areas of Development of Face Processing in Infants at Risk for Developing Autism Spectrum Disorder (ASD).
Research Director: Dr. Charles A. Nelson

• Visual Function in the Neuroligin-3 R451C Autism Mouse Model.
Research Director: Dr. Michela Fagiolini

• Weight of Reward: The Neurobiology of Deception.
Research Director: Dr. Joshua Greene

• Why Plasticity Matters: The Effects of Music Exposure during a “Critical Period” of Anxiety Circuit Development.
Research Director: Dr. Takao Hensch